hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: kinase_hmms Sequence file: hKD_nps_99nr.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: kb|TTBK2_Hsap|CK1/TTBK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 75.0 5.2e-23 1 Pkinase_Tyr Protein tyrosine kinase -95.9 3.3e-10 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 242 [. 1 272 [] -95.9 3.3e-10 Pkinase 1/1 1 256 [] 1 287 [] 75.0 5.2e-23 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 242: score -95.9, E = 3.3e-10 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie k ++k+G G FGe+y + t+ VA K+ +a ++ kb|TTBK2_H 1 WKVLRKIGGGGFGEIYDALDM----LTRENVALKVE---SAQQP--- 37 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL ++ + E++++kkl +++ r++G+ ++ y+V+ + +g +L kb|TTBK2_H 38 KQVLKMEVAVLKKLQGKDHVCRFIGCGRN-DRF----NYVVMQL-QGRNL 81 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs d r++ +++ +t+++ l +Qi + e +s +f HRD+ kb|TTBK2_H 82 ADLRRSQ-SRGTFTISTTLRLGRQILESIESIHSVGFLHRDI-------- 122 e............nlvVKIsDFGLaRdiysddyYvrkrgggklPv..... ++++ ++ +++ +++ DFGLaR+ + + g P + + kb|TTBK2_H 123 KpsnfamgrfpstCRKCYMLDFGLARQF-------TNSCGDVRPPravag 165 .....kWmAPEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsnee +++ + + + ++++ D WS +L E + G+ P + +++ e kb|TTBK2_H 166 frgtvRYASINAHRNREMGRHDDLWSLFYMLVEFVV-GQLP-WRKIKDKE 213 vlellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* + + +++y ++ P P Fs + ++ kb|TTBK2_H 214 QVGSI-KERYDHRLML--------------KHLP---PEFSIFLDHI 242 Pkinase: domain 1 of 1, from 1 to 256: score 75.0, E = 5.2e-23 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++l+k+G G+fG+ y a + t++ VA+K+ + + k ++ kb|TTBK2_H 1 WKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKM---- 43 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls E+++lk+L++ ++++r+i++ ++++ y+V+ + + ++dL kb|TTBK2_H 44 --EVAVLKKLqGKDHVCRFIGCGRNDRFNYVVMQLQGRN--LADLR---- 85 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng +++++g++ + + + +Qil+ +e +Hs g++HRD+KP+N+ + + + kb|TTBK2_H 86 RSQSRGTF--TISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFP 133 vvdaflKiaDFGlAkkls.....t.sss.lttfvGTpwYmAPEvllggng ++ + DFGlA+++ ++ ++ ++ + +f GT +Y++ ++ +++ kb|TTBK2_H 134 STCRKCYMLDFGLARQFTnscgdVrPPRaVAGFRGTVRYASINAHR-NRE 182 ygtkvDvWSlGvilyelltGkpPFsgev.q.ds.ldqlqlirkilgpple g+ D WSl +l e++ G++P++ ++++++ + +++++ +l+ + kb|TTBK2_H 183 MGRHDDLWSLFYMLVEFVVGQLPWR-KIkDkEQvGSIKERYDHRLMLK-- 229 fdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPw l++e+ +++ + +D + q kb|TTBK2_H 230 ------------------HLPPEFSIFLDHISSLDYFTKPD----YQL-- 255 f<-* + kb|TTBK2_H 256 L 256 // Query sequence: kb|TTBK1_Hsap|CK1/TTBK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 84.4 7.9e-26 1 Pkinase_Tyr Protein tyrosine kinase -89.6 1.4e-10 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 245 [. 1 272 [] -89.6 1.4e-10 Pkinase 1/1 1 256 [] 1 287 [] 84.4 7.9e-26 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 245: score -89.6, E = 1.4e-10 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie k +kk+G G FGe+y++ t+ VA K+ +a ++ kb|TTBK1_H 1 WKVLKKIGGGGFGEIYEAMDL----LTRENVALKVE---SAQQP--- 37 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL ++ + E++++kkl +++ r++G+ ++ y+V+ + +g +L kb|TTBK1_H 38 KQVLKMEVAVLKKLQGKDHVCRFIGCGRN-EKF----NYVVMQL-QGRNL 81 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs d r++ +++ +tl++ l Qi + e +s +f HRD+ kb|TTBK1_H 82 ADLRRSQ-PRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDI-------- 122 e...........nl.vVKIsDFGLaRdiysddyYvrkrgggklPv..... ++++ ++ +++ +++ DFGLaR+ + ++g P ++ + kb|TTBK1_H 123 KpsnfamgrlpsTYrKCYMLDFGLARQY-------TNTTGDVRPPrnvag 165 .....kWmAPEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsnee +++ + + + k+++ D WS +L E G+ P + +++ e kb|TTBK1_H 166 frgtvRYASVNAHKNREMGRHDDLWSLFYMLVEFAV-GQLP-WRKIKDKE 213 vlellyedGyRLpr.PenCPdelYdlMlqCWaedPedRPtFselveeL<- + ++ ++ y + ++ P e + + + + L kb|TTBK1_H 214 QVGMI-KEKYEHRMlLKHMPSEFHLFLDH---------------IASL 245 * kb|TTBK1_H - - Pkinase: domain 1 of 1, from 1 to 256: score 84.4, E = 7.9e-26 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++l+k+G G+fG+ y+a++ t++ VA+K+ + + k ++ kb|TTBK1_H 1 WKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKM---- 43 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls E+++lk+L++ ++++r+i++ ++++ y+V+ + + ++dL kb|TTBK1_H 44 --EVAVLKKLqGKDHVCRFIGCGRNEKFNYVVMQLQGRN--LADLR---- 85 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng +++ +g++ + + + +Qil+ +e +Hs g++HRD+KP+N+ + + + kb|TTBK1_H 86 RSQPRGTF--TLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLP 133 vvdaflKiaDFGlAkkls.....t.sss.lttfvGTpwYmAPEvllggng + + DFGlA+++ +++++ ++ ++ +f GT +Y++ ++ +++ kb|TTBK1_H 134 STYRKCYMLDFGLARQYTnttgdVrPPRnVAGFRGTVRYASVNAHK-NRE 182 ygtkvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefd g+ D WSl +l e++ G++P++ ++ q +i+++ + ++ kb|TTBK1_H 183 MGRHDDLWSLFYMLVEFAVGQLPWRKI---KdKEQVGMIKEKYE---HRM 226 spewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf< + + +e+ +++ + +D + q + kb|TTBK1_H 227 LLKHMP-------------SEFHLFLDHIASLDYFTKPD----YQL--I 256 -* kb|TTBK1_H - - // Query sequence: kb|TSSK4_Hsap|CAMK/TSSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 251.0 5.7e-76 1 Pkinase_Tyr Protein tyrosine kinase 58.3 1.2e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 267 [. 1 272 [] 58.3 1.2e-19 Pkinase 1/1 1 269 [] 1 287 [] 251.0 5.7e-76 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 267: score 58.3, E = 1.2e-19 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei + gk +G+G++G+Vy++ ++ ++++ VAVK+++k+ +as++ kb|TSSK4_H 1 YEVGKAIGHGSYGSVYEAFYT----KQKVMVAVKIIsKK-KASDDY- 41 eredFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG + +Fl +E+++Mk l +H+ +++++ ++ +yi++E+++gG kb|TSSK4_H 42 -LNKFLPrEIQVMKVL-RHKYLINFYRAIES-TSR----VYIILELAQGG 84 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL d l+ ++ ++ + + ++ Q G +YL+sk +vHRDL N L kb|TSSK4_H 85 DVLEWIQRY---GACSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLL 131 VsenlvVKIsDFGLaRdiysddyYvrkrgggklPv............... +++ VKIsDFG a+ + + Pv+ +++ ++ + ++ kb|TSSK4_H 132 LDKWENVKISDFGFAKMV-----------PSNQPVgcspsyrqvncfshl 170 ........kWmAPEslkygkFt.skSDVWSFGVlLWEiftlGeqPFYpgm +++ ++ PE l+ +++ SD WS GV L+ ++ P + + kb|TSSK4_H 171 sqtycgsfAYACPEILRGLPYNpFLSDTWSMGVILYTLVV-AHLP-FDDT 218 sneevlellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFselvee +l ++ p+ + ++e +l+lq +++ +R t +++ + kb|TSSK4_H 219 NLKKLLRET-QKEVTFPANHTISQECKNLILQML-RQATKRATILDIIKD 266 L<-* kb|TSSK4_H 267 S 267 Pkinase: domain 1 of 1, from 1 to 269: score 251.0, E = 5.7e-76 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ye+++ +G Gs+G+Vy+a + +VAvKii+k+k+++ d+ + kb|TSSK4_H 1 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASD--DYLNKF 45 l.sEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls l++Eiq++k L+H++ + ++++ e+ +++y++lE+++gG d ++++ kb|TSSK4_H 46 LpREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGG----DVLEWIQ 91 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng r+g+ se a k++ Q+ g++YLHs++i+HRDLK+eN+Lld+ kb|TSSK4_H 92 ---RYGAC--SEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWE 136 vvdaflKiaDFGlAkkls..............t.sss.lttfvGTpwYmA +v Ki+DFG+Ak + ++++ + +++ ++ + s+ +t++G+ Y+ kb|TSSK4_H 137 NV----KISDFGFAKMVPsnqpvgcspsyrqvNcFSHlSQTYCGSFAYAC 182 PEvllggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirki PE+l+g ++ + +D WS+Gvily l+ ++PF++ + ++l+r++ kb|TSSK4_H 183 PEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDT-----NLKKLLRET 227 lgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaee + ++ f+ +++s +e+k Li +L++ +kR t+ + kb|TSSK4_H 228 QK-EVTFPANHTIS-------------QECKNLILQMLRQ-ATKRATILD 262 ilqHPwf<-* i ++ w+ kb|TSSK4_H 263 IIKDSWV 269 // Query sequence: kb|TSSK3_Hsap|CAMK/TSSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 280.0 1.1e-84 1 Pkinase_Tyr Protein tyrosine kinase 30.1 6.6e-18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 256 [] 1 272 [] 30.1 6.6e-18 Pkinase 1/1 1 256 [] 1 287 [] 280.0 1.1e-84 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 256: score 30.1, E = 6.6e-18 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei +lgk++GeG + +V ++ k +++ kVA+K+++k g ee kb|TSSK3_H 1 YQLGKTIGEGTYSKVKEAFSK----KHQRKVAIKVIdKM-GGPEEF- 41 eredFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG ++ Fl +E++i ++l dH+Ni++ + +++ +++V+E++egG kb|TSSK3_H 42 -IQRFLPrELQIVRTL-DHKNIIQVYEMLESADGK----ICLVMELAEGG 85 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL d d + g+pL+ ++ +Q ++ Y + + HRDL + N L kb|TSSK3_H 86 DVFDCVLN---GGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENAL 132 VsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygk.. + ++ K +DFG a+ + +++ r + + APE g+++ kb|TSSK3_H 133 LQ-GFNLKLTDFGFAKVL-PKS-H-RELSQTFcGSTAYAAPE-VLQGIph 177 FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPen + k DVWS GV+L+ ++ P + + + +l + ++G p kb|TSSK3_H 178 DSKKGDVWSMGVVLYVMLC-ASLP-FDDTDIPKMLWQQ-QKGVSFPTHLS 224 CPdelYdlMlqCWaedPedRPtFsel..veeL<-* +++ dl+++ ++d RP+ +e++ + L kb|TSSK3_H 225 ISADCQDLLKRLLEPDMILRPSIEEVswHPWL 256 Pkinase: domain 1 of 1, from 1 to 256: score 280.0, E = 1.1e-84 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y+l++++G+G++++V++a k+ +++VA+K+i+k + +++ ++ + kb|TSSK3_H 1 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLP 47 lsEiqilkrLsHpNIvrlidvfed.kdhlylVlEycegGLrvldLfdyls + E+qi + L+H+NI++ +++ e+ +++++lV+E++egG d fd + kb|TSSK3_H 48 R-ELQIVRTLDHKNIIQVYEMLESaDGKICLVMELAEGG----DVFDCVL 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng ++gpl +e ak ++Q+++++ Y+H +g+ HRDLK eN Ll kb|TSSK3_H 93 ---NGGPL--PESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQ-GF 136 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv ++ K++DFG+Ak+l ++ + +tf+G+ Y+APEvl+g +++++k kb|TSSK3_H 137 NL----KLTDFGFAKVLPKsHRElSQTFCGSTAYAAPEVLQGIPHDSKKG 182 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds DvWS+Gv+ly +l+ +PF++ d +++ + + ++p+ s kb|TSSK3_H 183 DVWSMGVVLYVMLCASLPFDDT-----DIPKMLWQQQK---GVSFPTHLS 224 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* is +++dL+k++L++D+ R+++ee+ HPw+ kb|TSSK3_H 225 IS-----------ADCQDLLKRLLEPDMILRPSIEEVSWHPWL 256 // Query sequence: kb|TSSK2_Hsap|CAMK/TSSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 258.0 4.4e-78 1 Pkinase_Tyr Protein tyrosine kinase 31.3 5.6e-18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 261 [] 1 272 [] 31.3 5.6e-18 Pkinase 1/1 1 261 [] 1 287 [] 258.0 4.4e-78 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 261: score 31.3, E = 5.6e-18 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei + g LG+G++ +V ++ + VAVK+++++ ++ + kb|TSSK2_H 1 YIVGINLGKGSYAKVKSAYSE----RLKFNVAVKIIdRK-KTPTDF- 41 eredFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG e Fl +E+ i+ + +H i++ + + +++ +yi++E+ G kb|TSSK2_H 42 -VERFLPrEMDILATV-NHGSIIKTYEIFETSDGR----IYIIMELGVQG 85 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL dLl+f + +++L ++ +Q +++ Y ++ +vHRDL + N L kb|TSSK2_H 86 DLLEFIKC---QGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLL 132 VsenlvVKIsDFGLaRdiysddyYvrkrgggklPv........kWmAPEs +++++ +K sDFG ++ ++g++ +++ ++ APE+ kb|TSSK2_H 133 LDKDFNIKLSDFGFSKRC-------LRDSNGRIILsktfcgsaAYAAPEV 175 lkygkFtskS.DVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyR l+ + k D+WS GV L+ ++ G +P Y + + + ++ ++ +R kb|TSSK2_H 176 LQSIPYQPKVyDIWSLGVILYIMVC-GSMP-YDDSDIRK-MLRI-QKEHR 221 ..LprPenCPdelYdlMlqCWaedPedRPtFsel..veeL<-* + pr +n + e dl+ + ++d ++R e+ +++ L kb|TSSK2_H 222 vdFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEIlsHSWL 261 Pkinase: domain 1 of 1, from 1 to 261: score 258.0, E = 4.4e-78 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y ++ lG+Gs+++V+ a+ VAvKii+++k+ ++ ++ + kb|TSSK2_H 1 YIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLP 47 lsEiqilkrLsHpNIvrlidvfed.kdhlylVlEycegGLrvldLfdyls + E il+ ++H I++++++fe++++++y+++E+ G dL ++++ kb|TSSK2_H 48 R-EMDILATVNHGSIIKTYEIFETsDGRIYIIMELGVQG----DLLEFIK 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng +g+l ed+a+k+++Q+ ++++Y+H+ i+HRDLK eN+Lld++ kb|TSSK2_H 93 ---CQGAL--HEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDF 137 vvdaflKiaDFGlAkkls...t.sss.lttfvGTpwYmAPEvllggngyg ++ K++DFG++k ++++++ +tf+G+ Y+APEvl+ + +y kb|TSSK2_H 138 NI----KLSDFGFSKRCLrdsNgRIIlSKTFCGSAAYAAPEVLQ-SIPYQ 182 tkv.DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdsp +kv D+WSlGvily++++G P++++ d ++++r ++ +++f++ kb|TSSK2_H 183 PKVyDIWSLGVILYIMVCGSMPYDDS-----DIRKMLRIQKEHRVDFPRS 227 ewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* + + e+kdLi+++L++D s+Rl ++eil H w+ kb|TSSK2_H 228 KNLT-------------CECKDLIYRMLQPDVSQRLHIDEILSHSWL 261 // Query sequence: kb|TSSK1_Hsap|CAMK/TSSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 242.8 1.6e-73 1 Pkinase_Tyr Protein tyrosine kinase 37.5 2.3e-18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 259 [. 1 272 [] 37.5 2.3e-18 Pkinase 1/1 1 261 [] 1 287 [] 242.8 1.6e-73 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 259: score 37.5, E = 2.3e-18 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei lg LGeG++ +V ++ + VA+K+++++ +a + kb|TSSK1_H 1 YLLGINLGEGSYAKVKSAYSE----RLKFNVAIKIIdRK-KAPADF- 41 eredFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG +e+Fl +E++i+ l +H i++ + + + + +yiV+E++ G kb|TSSK1_H 42 -LEKFLPrEIEILAML-NHCSIIKTYEIFETSHGK----VYIVMELAVQG 85 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL dLl+ ++ +++L + + +Q + + Y ++ vHRDL + N L kb|TSSK1_H 86 DLLELIKT---RGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLL 132 VsenlvVKIsDFGLaRdiysddyYvrkrgggklPv........kWmAPEs +++++ +K sDF ++ ++g++ +++ +++ APE+ kb|TSSK1_H 133 LDKDFNIKLSDFSFSKRC-------LRDDSGRMALsktfcgspAYAAPEV 175 lkygkFtskS.DVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyR l+ + k D+WS GV L+ ++ G +P Y + + ++ ++ +R kb|TSSK1_H 176 LQGIPYQPKVyDIWSLGVILYIMVC-GSMP-YDDSNIKK-MLRI-QKEHR 221 ..LprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* + pr ++ + e dl+ + ++d ++R e++++ kb|TSSK1_H 222 vnFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHC 259 Pkinase: domain 1 of 1, from 1 to 261: score 242.8, E = 1.6e-73 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y l+ lG+Gs+++V+ a+ VA+Kii+++k+ ++++ + kb|TSSK1_H 1 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLP 47 lsEiqilkrLsHpNIvrlidvfed.kdhlylVlEycegGLrvldLfdyls + Ei+il++L+H+ I++++++fe++++++y+V+E++ G dL ++++ kb|TSSK1_H 48 R-EIEILAMLNHCSIIKTYEIFETsHGKVYIVMELAVQG----DLLELIK 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng +g+l edea+k + Q+ +++Y+H+ ++HRDLK +N+Lld++ kb|TSSK1_H 93 ---TRGAL--HEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDF 137 vvdaflKiaDFGlAkkls...t.sss.lttfvGTpwYmAPEvllggngyg ++ K++DF ++k +++ ++ +tf+G+p Y+APEvl+ g +y kb|TSSK1_H 138 NI----KLSDFSFSKRCLrddSgRMAlSKTFCGSPAYAAPEVLQ-GIPYQ 182 tkv.DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdsp +kv D+WSlGvily++++G P++++ + ++++r ++ ++ f++ kb|TSSK1_H 183 PKVyDIWSLGVILYIMVCGSMPYDDS-----NIKKMLRIQKEHRVNFPRS 227 ewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* + + e+kdLi+ +L++D ++Rl ++eil H w+ kb|TSSK1_H 228 KHLT-------------GECKDLIYHMLQPDVNRRLHIDEILSHCWM 261 // Query sequence: kb|TRRAP_Hsap|Atypical/PIKK/TRRAP|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain -189.6 0.57 1 Pkinase_Tyr Protein tyrosine kinase -258.0 1.5 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 5 226 .. 1 287 [] -189.6 0.57 Pkinase_Tyr 1/1 24 181 .. 1 272 [] -258.0 1.5 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 5 to 226: score -189.6, E = 0.57 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ++e++ + + + ++ ++ +g Ki ++ ++ ++ + rr kb|TRRAP_H 5 MPRVEIVQKHNTAARRLYIRGHNG-----KIYPYLVMNDACLTESRR 46 lsEiqilkrLsHpNIvrlidvfed......kdhlylVlEycegGLrvldL E ++l+ L rl+ + +++++++k+hl + + + v kb|TRRAP_H 47 --EERVLQLL------RLLNPCLEkrkettKRHLFFTVPRVVA---VSPQ 85 fdylsetrrkgpll.fsedeakkialQilrgleYLHsngiiHRDLKPeNI ++++ ++ + l++ e +++a+ +g+e H+n i kb|TRRAP_H 86 MRLVE---DNPSSLsLVEIYKQRCAK---KGIE--HDNPI---------- 117 LldnngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvll... ++ ++ lA + +++++++ v l++ kb|TRRAP_H 118 --SRYYDR----------LATV--QaRGTqASHQV----------LRdil 143 ...ggngygtkvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkil ++ +n+ +++ +l e ++ F+++ +++ + +++ i kb|TRRAP_H 144 kevQSNMVPRS--------MLKEWAL--HTFPNA---TdYWTFRKMFTIQ 180 gpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPsk.Rltaee + + f ++ + ++ l++e++++ + +++ + R + + kb|TRRAP_H 181 LALIGFAEFVLHLNR---------LNPEMLQIAQDTGKLNVAYfRFDIND 221 ilqHPwf<-* + + + kb|TRRAP_H 222 ATGD--L 226 Pkinase_Tyr: domain 1 of 1, from 24 to 181: score -258.0, E = 1.5 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie +G+ G++y ++ + kb|TRRAP_H 24 --------RGHNGKIYPYLVM---------------ND-AC------ 40 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL + + rE +++ l rLl c++ ++ E + kb|TRRAP_H 41 LTESRREERVLQLL-------RLLNPCLE-KRK---------ETTKR--- 70 ldfLrkhr..........egrpLtlkdLlsfalQiAkGMeYLesknfvHR + f +r +++ + +++++ L+++ kb|TRRAP_H 71 HLFFTVPRvvavspqmrlVEDNPSSLSLVEI------------------- 101 DLAARNcLVsenlvVKIsDFGLaRdi...ysddyYvrkrgggklPvkWmA +++++K + i+++ + + Y + r kb|TRRAP_H 102 ---------YKQRCAK-------KGIehdNPISRY-YDR----------- 123 PEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedG + t q ++vl + ++ kb|TRRAP_H 124 ------------------------LAT--VQA-RGTQASHQVLRDILKEV 146 yRLprPenCPdelYdlMlqCWaedPedRPtFsel.veeL<-* + P+ l + l+ +++ d tF+ +L kb|TRRAP_H 147 QSNMVPR---SMLKEWALHTF-PNATDYWTFRKMfTIQL 181 // Query sequence: kb|TRKC_Hsap|TK/Trk|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 479.0 1.3e-144 1 Pkinase Protein kinase domain 174.4 6.2e-53 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 272 [] 1 272 [] 479.0 1.3e-144 Pkinase 1/1 1 272 [] 1 287 [] 174.4 6.2e-53 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 272: score 479.0, E = 1.3e-144 *->lklgkkLGeGaFGeVykGtlkg.sgdgteikVAVKtLkeigaseeei ++l ++LGeGaFG+V++++++ s+ ++++ VAVK Lk+ + kb|TRKC_Hs 1 IVLKRELGEGAFGKVFLAECYNlSPTKDKMLVAVKALKD-PTLAA-- 44 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd r+dF rEA+++++l +H++iV+++Gvc + g+P l++V+Eym++Gd kb|TRKC_Hs 45 -RKDFQREAELLTNL-QHEHIVKFYGVCGD-GDP----LIMVFEYMKHGD 87 LldfLrkhr.............egrpLtlkdLlsfalQiAkGMeYLeskn L +fLr+h ++ ++++++ ++ L l+++l++a QiA+GM YL+s++ kb|TRKC_Hs 88 LNKFLRAHGpdamilvdgqprqAKGELGLSQMLHIASQIASGMVYLASQH 137 fvHRDLAARNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm fvHRDLA+RNcLV+ nl VKI+DFG++Rd+ys+dyY r++g+++lP++Wm kb|TRKC_Hs 138 FVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYY-RVGGHTMLPIRWM 186 APEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyed +PEs++y+kFt++SDVWSFGV LWEift+G+qP + +sn+ev+e + + kb|TRKC_Hs 187 PPESIMYRKFTTESDVWSFGVILWEIFTYGKQP-WFQLSNTEVIECI-TQ 234 GyRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* G+ L+rP+ CP+e+Yd+Ml CW+++P++R +e++ ++ kb|TRKC_Hs 235 GRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIY-KI 272 Pkinase: domain 1 of 1, from 1 to 272: score 174.4, E = 6.2e-53 *->yelleklGsGsfGtV.....ykakhkgtgkiVAvKiikkr.kekskk ++l++ lG+G+fG+V + y ++ +VAvK +k ++ + k kb|TRKC_Hs 1 IVLKRELGEGAFGKVflaecYNLSPTKDKMLVAVKALKDPtLAARKD 47 dktarrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldL ++ E+++l +L+H++Iv++++v+ d+d l +V+Ey+ +G dL kb|TRKC_Hs 48 FQR-----EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG----DL 88 fdyls..........e...trrkgpllfsedeakkialQilrgleYLHsn +l+ ++++ ++++ ++kg l + +ia Qi++g+ YL s+ kb|TRKC_Hs 89 NKFLRahgpdamilvDgqpRQAKGEL--GLSQMLHIASQIASGMVYLASQ 136 giiHRDLKPeNILldnngvvdaflKiaDFGlAkkls...t.sss.lttfv ++HRDL N+L+ n v Ki+DFG ++ ++++++ + ++ t + kb|TRKC_Hs 137 HFVHRDLATRNCLVGANLLV----KIGDFGMSRDVYstdYyRVGgHTMLP 182 GTpwYmAPEvllggngygtkvDvWSlGvilyellt.GkpPFsgevqds.l +++m+PE ++ +++ +t++DvWS+Gvil+e +t Gk P+ + s+ kb|TRKC_Hs 183 --IRWMPPESIM-YRKFTTESDVWSFGVILWEIFTyGKQPWFQL---SnT 226 dqlqlirkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkD +++i + + + ++ +p +e d++ +c+++ kb|TRKC_Hs 227 EVIECITQGRVLERPRVCP-----------------KEVYDVMLGCWQRE 259 PskRltaeeilqHPwf<-* P++Rl+++ei + kb|TRKC_Hs 260 PQQRLNIKEIYKI--- 272 // Query sequence: kb|TRKB_Hsap|TK/Trk|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 504.3 3.1e-152 1 Pkinase Protein kinase domain 157.1 1.1e-47 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 270 [] 1 272 [] 504.3 3.1e-152 Pkinase 1/1 1 270 [] 1 287 [] 157.1 1.1e-47 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 270: score 504.3, E = 3.1e-152 *->lklgkkLGeGaFGeVykGtlkg.sgdgteikVAVKtLkeigaseeei ++l ++LGeGaFG+V++++++ ++++++i VAVKtLk+ ++ kb|TRKB_Hs 1 IVLKRELGEGAFGKVFLAECYNlCPEQDKILVAVKTLKD-ASDNA-- 44 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd r+dF rEA+++++l +H++iV+++Gvc++ g+P l++V+Eym++Gd kb|TRKB_Hs 45 -RKDFHREAELLTNL-QHEHIVKFYGVCVE-GDP----LIMVFEYMKHGD 87 LldfLrkhr..........egrpLtlkdLlsfalQiAkGMeYLesknfvH L +fLr+h ++ +++++ Lt +++l++a+QiA+GM YL+s++fvH kb|TRKB_Hs 88 LNKFLRAHGpdavlmaegnPPTELTQSQMLHIAQQIAAGMVYLASQHFVH 137 RDLAARNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPE RDLA+RNcLV+enl VKI+DFG++Rd+ys+dyY r++g+++lP++Wm+PE kb|TRKB_Hs 138 RDLATRNCLVGENLLVKIGDFGMSRDVYSTDYY-RVGGHTMLPIRWMPPE 186 slkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyR s++y+kFt++SDVWS GV+LWEift+G+qP ++ +sn+ev+e + +G+ kb|TRKB_Hs 187 SIMYRKFTTESDVWSLGVVLWEIFTYGKQP-WYQLSNNEVIECI-TQGRV 234 LprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* L rP+ CP+e+Y+lMl CW+++P +R + ++ L kb|TRKB_Hs 235 LQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 270 Pkinase: domain 1 of 1, from 1 to 270: score 157.1, E = 1.1e-47 *->yelleklGsGsfGtV.....ykakhkgtgkiVAvKiikkrkekskkd ++l++ lG+G+fG+V + y + + ++VAvK++k +++ kd kb|TRKB_Hs 1 IVLKRELGEGAFGKVflaecYNLCPEQDKILVAVKTLKDASDNARKD 47 ktarrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLf +++ E+++l +L+H++Iv++++v+ ++d l +V+Ey+ +G dL kb|TRKB_Hs 48 ---FHR-EAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG----DLN 89 dyls....e...trrkgpll.fsedeakkialQilrgleYLHsngiiHRD +l+ ++++ +++p ++++ + +ia Qi+ g+ YL s+ ++HRD kb|TRKB_Hs 90 KFLRahgpDavlMAEGNPPTeLTQSQMLHIAQQIAAGMVYLASQHFVHRD 139 LKPeNILldnngvvdaflKiaDFGlAkkls...t.sss.lttfvGTpwYm L N+L+ +n v Ki+DFG ++ ++++++ + ++ t + +++m kb|TRKB_Hs 140 LATRNCLVGENLLV----KIGDFGMSRDVYstdYyRVGgHTMLP--IRWM 183 APEvllggngygtkvDvWSlGvilyellt.GkpPFsgevqds.ldqlqli +PE ++ +++ +t++DvWSlGv+l+e +t Gk P+++ s++ +++i kb|TRKB_Hs 184 PPESIM-YRKFTTESDVWSLGVVLWEIFTyGKQPWYQL---SnNEVIECI 229 rkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlt + + + ++ +p +e +L+ +c+++ P+ R + kb|TRKB_Hs 230 TQGRVLQRPRTCP-----------------QEVYELMLGCWQREPHMRKN 262 aeeilqHPwf<-* ++ i + kb|TRKB_Hs 263 IKGIHTL--L 270 // Query sequence: kb|TRKA_Hsap|TK/Trk|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 477.8 2.9e-144 1 Pkinase Protein kinase domain 161.3 5.7e-49 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 272 [. 1 272 [] 477.8 2.9e-144 Pkinase 1/1 1 272 [. 1 287 [] 161.3 5.7e-49 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 272: score 477.8, E = 2.9e-144 *->lklgkkLGeGaFGeVykGtlkg.sgdgteikVAVKtLkeigaseeei ++l +LGeGaFG+V++++++ +++++++ VAVK Lke + + kb|TRKA_Hs 1 IVLKWELGEGAFGKVFLAECHNlLPEQDKMLVAVKALKE-ASESA-- 44 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd r+dF rEA++++ l +H++iVr+ Gvct+ g+P l++V+Eym +Gd kb|TRKA_Hs 45 -RQDFQREAELLTML-QHQHIVRFFGVCTE-GRP----LLMVFEYMRHGD 87 LldfLrkhr............egrpLtlkdLlsfalQiAkGMeYLesknf L fLr+h ++ + ++++ ++pL l +Ll a Q+A+GM YL+ +f kb|TRKA_Hs 88 LNRFLRSHGpdakllaggedvAPGPLGLGQLLAVASQVAAGMVYLAGLHF 137 vHRDLAARNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmA vHRDLA+RNcLV+ +lvVKI+DFG++Rdiys+dyY r++g ++lP++Wm+ kb|TRKA_Hs 138 VHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYY-RVGGRTMLPIRWMP 186 PEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedG PEs+ y+kFt++SDVWSFGV+LWEift+G+qP ++ +sn+e ++ + +G kb|TRKA_Hs 187 PESILYRKFTTESDVWSFGVVLWEIFTYGKQP-WYQLSNTEAIDCI-TQG 234 yRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* + L+rP+ CP+e+Y +M+ CW+++P++R + ++++ +L kb|TRKA_Hs 235 RELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 272 Pkinase: domain 1 of 1, from 1 to 272: score 161.3, E = 5.7e-49 *->yelleklGsGsfGtVykakhkg.....tgkiVAvKiikkrkekskkd ++l+ lG+G+fG+V++a ++ ++++ +VAvK +k +e+ +d kb|TRKA_Hs 1 IVLKWELGEGAFGKVFLAECHNllpeqDKMLVAVKALKEASESARQD 47 ktarrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLf ++ E+++l +L+H +Ivr+++v+++++ l +V+Ey+++G dL kb|TRKA_Hs 48 FQR----EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHG----DLN 89 dyls.........e...trrkgpllfsedeakkialQilrgleYLHsngi ++l++++++ + +++++ + gpl ++ +a Q++ g+ YL + kb|TRKA_Hs 90 RFLRshgpdakllAggeDVAPGPL--GLGQLLAVASQVAAGMVYLAGLHF 137 iHRDLKPeNILldnngvvdaflKiaDFGlAkkls...t.sss.lttfvGT +HRDL N+L+ + vv Ki+DFG ++ ++++++ + ++ t + kb|TRKA_Hs 138 VHRDLATRNCLVGQGLVV----KIGDFGMSRDIYstdYyRVGgRTMLP-- 181 pwYmAPEvllggngygtkvDvWSlGvilyellt.GkpPFsgevqds.ldq +++m+PE +l +++ +t++DvWS+Gv+l+e +t Gk P+++ s+ kb|TRKA_Hs 182 IRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTyGKQPWYQL---SnTEA 227 lqlirkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPs + +i + ++ + ++ +p +e ++++c+++ P+ kb|TRKA_Hs 228 IDCITQGRELERPRACP-----------------PEVYAIMRGCWQREPQ 260 kRltaeeilqHPwf<-* +R +++++ + kb|TRKA_Hs 261 QRHSIKDVHAR--L 272 // Query sequence: kb|Trio_Hsap|CAMK/Trio|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 231.6 3.7e-70 1 Pkinase_Tyr Protein tyrosine kinase -18.9 6.5e-15 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 254 [. 1 272 [] -18.9 6.5e-15 Pkinase 1/1 1 255 [] 1 287 [] 231.6 3.7e-70 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 254: score -18.9, E = 6.5e-15 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + +LG+G F +V k+ k gt+ VA K +++ + + + kb|Trio_Hs 1 YSEVAELGRGRFSVVKKCDQK----GTKRAVATKFVNK-KLMKR--- 39 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL + +E+ i+ +l +Hp +V Ll + +++V+E++ G L kb|Trio_Hs 40 -DQVTHELGILQSL-QHPLLVGLLDTFE--TPTS---YILVLEMADQGRL 82 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs ld + ++Lt + ++ ++ YL++ ++ H DL N+LV+ kb|Trio_Hs 83 LDCVVR---WGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVD 129 e...nlvVKIsDFGLaRdiysddyY.vrkrgggklPvkWmAPEslkygkF e+ + ++K +DFG a ++ ++ yY ++ g APE + + kb|Trio_Hs 130 EslaKPTIKLADFGDAVQL-NTTYYiHQLLG----NPEFAAPEIILGNPV 174 tskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyed...GyRLprP + SD WS GVl + +++ G +P + + s+ee++ + + + + kb|Trio_Hs 175 SLTSDTWSVGVLTYVLLS-GVSP-FLDDSVEETCLNI-CRldfSFPDDYF 221 enCPdelYdlMlqCWaedPedRPtFs.elveeL<-* ++ +++ + + +edP++RP+ + +l+e+ kb|Trio_Hs 222 KGVSQKAKEFVCFLLQEDPAKRPSAAlALQEQW 254 Pkinase: domain 1 of 1, from 1 to 255: score 231.6, E = 3.7e-70 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y + lG+G f++V+k+ kgt + VA K ++k+ k ++ + kb|Trio_Hs 1 YSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTH--- 44 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+ il++L+Hp v l+d+fe+++++ lVlE ++ G L d + kb|Trio_Hs 45 --ELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQG----RLLDCVV- 87 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv r g+l +e ++ + ++l+++ YLH+++i H DLKPeNIL+d + kb|Trio_Hs 88 --RWGSL--TEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVD-ESL 132 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD ++++K+aDFG A + ++ + + G p+++APE++l gn+ + +D kb|Trio_Hs 133 AKPTIKLADFGDAVQ--LnTTYyIHQLLGNPEFAAPEIIL-GNPVSLTSD 179 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi WS+Gv+ y ll+G PF ++ + + +i + +++f+ ++ + kb|Trio_Hs 180 TWSVGVLTYVLLSGVSPFLDD-----SVEETCLNICRLDFSFPDDYFKGV 224 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* s + ak++++ +L+ DP+kR++a+ +lq w+ kb|Trio_Hs 225 S-----------QKAKEFVCFLLQEDPAKRPSAALALQEQWL 255 // Query sequence: kb|Trb3_Hsap|CAMK/Trbl|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 40.2 1e-14 1 Pkinase_Tyr Protein tyrosine kinase -139.0 1.4e-07 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 1 245 [] 1 287 [] 40.2 1e-14 Pkinase_Tyr 1/1 31 245 .] 1 272 [] -139.0 1.4e-07 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 1 to 245: score 40.2, E = 1e-14 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y+lle+ G+ y+a h tg ++ +K+ +++++ kb|Trb3_Hs 1 YVLLEPE---EGGRAYQALHCPTGTEYTCKVYPVQEALA-------- 36 lsEiqilkrL.sHpNIvrlidvfedkdhly.lVlEycegGLrvldLfdyl ++ +rL+ H+++ r +v + ly + + + G d ++++ kb|Trb3_Hs 37 --VLEPYARLpPHKHVARPTEVLAGTQLLYaFFTRTH--G----DMHSLV 78 setrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnn + ++ ++ +e ea ++Q++ +l+++H++g + RDLK+ + + ++ kb|Trb3_Hs 79 R---SRHRI--PEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADR 123 gvvdaflKiaDFGlAkkls.....t.sss.lttfvGTpwYmAPEvll.gg K+ l + l+++ t+++ +l++ p Y+ PE+l + + kb|Trb3_Hs 124 ERK----KLV---L-ENLEdscvlTgPDDsLWDKHACPAYVGPEILSsRA 165 ngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplef ++ g+++DvWSlGv l+ +l G+ PF+++ + l+ ki+++ + kb|Trb3_Hs 166 SYSGKAADVWSLGVALFTMLAGHYPFQDS-----EPVLLFGKIRRGAYAL 210 dspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf + + +a+ L++++L++ P++Rlta+ il HPw+ kb|Trb3_Hs 211 PAGLS---------------APARCLVRCLLRREPAERLTATGILLHPWL 245 <-* kb|Trb3_Hs - - Pkinase_Tyr: domain 1 of 1, from 31 to 245: score -139.0, E = 1.4e-07 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie V ++ + L + +a + kb|Trb3_Hs 31 --------------VQEALAV--------------LEP-YARLPP-- 46 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL ++ r +++ + L+++ t+ +Gd+ kb|Trb3_Hs 47 HKHVARPTEVLAGT-Q-----LLYAFFTR----------------THGDM 74 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs ++ r+ +++++ ++ +Q A ++++ +++++v RDL + kb|Trb3_Hs 75 HSLVRS---RHRIPEPEAAVLFRQMATALAHCHQHGLVLRDL-------K 114 enlvVKIsDFGLaRdiysddyYvrkrgggklPv................. L+R + + r+ kl ++ +++ ++++++ kb|Trb3_Hs 115 -----------LCRFV------FADRERKKLVLenledscvltgpddslw 147 ......kWmAPEslkygk.Ft.skSDVWSFGVlLWEiftlGeqPFYpgms +++ + PE l+ + ++++ + DVWS GV L+ ++ G P +++ kb|Trb3_Hs 148 dkhacpAYVGPEILSSRAsYSgKAADVWSLGVALFTMLA-GHYP-FQDSE 195 neevlellyedGyR.LprPenCPdelYdlMlqCWaedPedRPtFsel..v + ++ ++ ++G Lp+ +++ l + +++P++R t + + + kb|Trb3_Hs 196 PVLLFGKI-RRGAYaLPAGL--SAPARCLVRCLLRREPAERLTATGIllH 242 eeL<-* L kb|Trb3_Hs 243 PWL 245 // Query sequence: kb|Trb2_Hsap|CAMK/Trbl|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 95.7 3.1e-29 1 Pkinase_Tyr Protein tyrosine kinase -96.2 3.5e-10 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 243 [. 1 272 [] -96.2 3.5e-10 Pkinase 1/1 1 245 [] 1 287 [] 95.7 3.1e-29 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 243: score -96.2, E = 3.5e-10 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei l++ L eG +V++++ + + + K+ + + e+ kb|Trb2_Hs 1 YLLLEPL-EGD--HVFRAVHL----HSGEELVCKVFdIS-CYQESL- 38 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd A + H Ni + +++ ge y+ +E +Gd kb|Trb2_Hs 39 --------APCFCLS-AHSNINQITEIIL--GETK---AYVFFE-RSYGD 73 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV +++f r+ ++L ++ +QiA++ ++ ++ ++v RDL R kb|Trb2_Hs 74 MHSFVRTC---KKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIF 120 senlvVKIsDFGLaRdiysddyYvrkrgggk.lPv.....kWmAPEslky +++ ++ ++ +d Y rg+ +l +++ + +PE l++ kb|Trb2_Hs 121 KDEERTRV------KLESLEDAY-ILRGDDDsLSDkhgcpAYVSPEILNT 163 gk.Ft.skSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLp + ++++ + DVWS GV+L+ ++ G+ P + ++ ++ ++ ++ ++++ kb|Trb2_Hs 164 SGsYSgKAADVWSLGVMLYTMLV-GRYP-FHDIEPSSLFSKI--RRGQFN 209 rPenCPdelYdlMlqCWaedPedRPtFselveeL<-* +Pe +++ l+++ +++P++R t +e++ + kb|Trb2_Hs 210 IPETLSPKAKCLIRSILRREPSERLTSQEILDHP 243 Pkinase: domain 1 of 1, from 1 to 245: score 95.7, E = 3.1e-29 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y lle+l +G V++a+h +g++ ++K+++ + + kb|Trb2_Hs 1 YLLLEPL-EGD--HVFRAVHLHSGEELVCKVFDISCYQE-------- 36 lsEiqilkrLs...HpNIvrlidvfedkdhlylVlEycegGLrvldLfdy ++ ++ + H NI ++ ++ +++ y+ +E g d +++ kb|Trb2_Hs 37 ----SLAPCFClsaHSNINQITEIILGETKAYVFFERSYG-----DMHSF 77 lsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldn ++ ++l e+ea + ++Qi+++++++H+ g + RDLK+ + +++ kb|Trb2_Hs 78 VR---TCKKL--REEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKD 122 ngvvdaflKiaDFGlAkkls.....t.sss.lttfvGTpwYmAPEvll.g + + ++K+ + l++ + + +l++ G p Y++PE+l+++ kb|Trb2_Hs 123 EERT--RVKL------ESLEdayilRgDDDsLSDKHGCPAYVSPEILNtS 164 gngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpple g++ g+++DvWSlGv+ly +l G+ PF + + l+ ki+++++ kb|Trb2_Hs 165 GSYSGKAADVWSLGVMLYTMLVGRYPFHDI-----EPSSLFSKIRRGQFN 209 fdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPw +++ + + ak Li+++L++ Ps+Rlt +eil HPw kb|Trb2_Hs 210 IPETLS---------------PKAKCLIRSILRREPSERLTSQEILDHPW 244 f<-* f kb|Trb2_Hs 245 F 245 // Query sequence: kb|Trb1_Hsap|CAMK/Trbl|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 75.4 3.9e-23 1 Pkinase_Tyr Protein tyrosine kinase -114.0 4.3e-09 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 11 245 .] 1 287 [] 75.4 3.9e-23 Pkinase_Tyr 1/1 18 245 .] 1 272 [] -114.0 4.3e-09 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 11 to 245: score 75.4, E = 3.9e-23 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr V +a + tg++ +K+++ ++ + kb|Trb1_Hs 11 -------------HVSRALCIHTGRELRCKVFPIKHYQD-------- 36 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls i+ L+sH NI + +v +++ y+ +E g d ++y++ kb|Trb1_Hs 37 --KIRPYIQLpSHSNITGIVEVILGETKAYVFFEKDFG-----DMHSYVR 79 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng ++++l e+ea + ++Qi+++++++H+ i+ DLK+ + ++ + kb|Trb1_Hs 80 ---SRKRL--REEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEE 124 vvdaflKiaDFGlAkkls..........t.sss.lttfvGTpwYmAPEvl + +l+ ++ ++++ + + l++ G p Y++PE+l kb|Trb1_Hs 125 RT-------------QLRlesledthimKgEDDaLSDKHGCPAYVSPEIL 161 l.ggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgp +++g++ g+++DvWSlGv+ly ll G+ PF ++ d+ +l+ ki+++ kb|Trb1_Hs 162 NtTGTYSGKAADVWSLGVMLYTLLVGRYPFHDS-----DPSALFSKIRRG 206 plefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilq ++ +++ + + a+ Li+++L++ Ps+Rlta+eil kb|Trb1_Hs 207 QFCIPEHIS---------------PKARCLIRSLLRREPSERLTAPEILL 241 HPwf<-* HPwf kb|Trb1_Hs 242 HPWF 245 Pkinase_Tyr: domain 1 of 1, from 18 to 245: score -114.0, E = 4.3e-09 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie ++ g++L +++ + +K + + + kb|Trb1_Hs 18 IHTGREL---------RCKVF----------PIKHYQD-KIRPY--- 41 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL +l++H Ni v++ ge y+ +E Gd+ kb|Trb1_Hs 42 -----------IQLPSHSNITGIVEVIL--GETK---AYVFFE-KDFGDM 74 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs +++ r+ +++L ++ Qi ++ ++ kb|Trb1_Hs 75 HSYVRS---RKRLREEEAARLFKQIVSAVAH------------------C 103 enlvVKIsDFGLaRdiysddyYvrkrgggklPv................. ++ + +D L + + + + + + l ++ ++++ +++++ + kb|Trb1_Hs 104 HQSAIVLGDLKLRKFV------FSTEERTQLRLesledthimkgeddals 147 ......kWmAPEslkygkFts..kSDVWSFGVlLWEiftlGeqPFYpgms ++++ + +PE l++ s+++ DVWS GV+L+ ++ G+ P + + + kb|Trb1_Hs 148 dkhgcpAYVSPEILNTTGTYSgkAADVWSLGVMLYTLLV-GRYP-FHDSD 195 neevlellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFsel..ve ++ ++ ++ ++++ +Pe+ +++ l+++ +++P++R t e+ + kb|Trb1_Hs 196 PSALFSKI--RRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEIllHP 243 eL<-* + kb|Trb1_Hs 244 WF 245 // Query sequence: kb|Trad_Hsap|CAMK/Trio|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 236.4 1.4e-71 1 Pkinase_Tyr Protein tyrosine kinase -45.0 2.6e-13 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 253 [. 1 272 [] -45.0 2.6e-13 Pkinase 1/1 1 255 [] 1 287 [] 236.4 1.4e-71 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 253: score -45.0, E = 2.6e-13 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + + ++G+G F V k++ k t+ +VAVK + + + +e kb|Trad_Hs 1 YTELNEIGRGRFSIVKKCIHK----ATRKDVAVKFVSK-KMKKKE-- 40 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL +++ +EA+++ +l +Hp + L+ + + +++++E+m G L kb|Trad_Hs 41 QAA--HEAALLQHL-QHPQYITLHDTYE--SPTS---YILILELMDDGRL 82 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs ld+L +h + L + + ++i ++++YL++ + H D+ N L++ kb|Trad_Hs 83 LDYLMNH---DELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLID 129 e...nlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm.......APEs + + VK d+ +d +++ + + + ++++ APE+ kb|Trad_Hs 130 LripVPRVKL------IDL-EDAVQ-ISGH---FHIHHLlgnpefaAPEV 168 lkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyed...G ++ + +D+WS GVl + +++ G +P + + s ee++ + + + kb|Trad_Hs 169 IQGIPVSLGTDIWSIGVLTYVMLS-GVSP-FLDESKEETCINV-CRvdfS 215 yRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* + + + d + +ed +RPt + ++++ kb|Trad_Hs 216 FPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHP 253 Pkinase: domain 1 of 1, from 1 to 255: score 236.4, E = 1.4e-71 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y+ l +G+G f+ V+k++hk t+k VAvK ++k+ +k+++ + kb|Trad_Hs 1 YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAH--- 44 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+++l++L+Hp ++l+d++e+++++ l+lE+++ G L dyl+ kb|Trad_Hs 45 --EAALLQHLQHPQYITLHDTYESPTSYILILELMDDG----RLLDYLM- 87 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld.nng ++ l e+ + ++++ i ++l+YLH++++ H D+KPeN+L+d + + kb|Trad_Hs 88 --NHDEL--MEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDlRIP 133 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv v+ ++K++D A + ++ + +++ G p+++APEv++ g + + kb|Trad_Hs 134 VP--RVKLIDLEDAVQ--IsGHFhIHHLLGNPEFAAPEVIQ-GIPVSLGT 178 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+WS+Gv+ y +l+G PF +e + + ++ + +++f+ ++ + kb|Trad_Hs 179 DIWSIGVLTYVMLSGVSPFLDE-----SKEETCINVCRVDFSFPHEYFCG 223 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +s +a+d+i+ +L+ D +R+ta+ +lqHPw+ kb|Trad_Hs 224 VS-----------NAARDFINVILQEDFRRRPTAATCLQHPWL 255 // Query sequence: kb|TNK1_Hsap|TK/Ack|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 396.2 1.1e-119 1 Pkinase Protein kinase domain 100.7 9.8e-31 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 262 [] 1 272 [] 396.2 1.1e-119 Pkinase 1/1 1 262 [] 1 287 [] 100.7 9.8e-31 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 262: score 396.2, E = 1.1e-119 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLk...eigasee + g+ LG+G+FG+V++G ++ +++g+ ++VAVK+L+ ++e g + kb|TNK1_Hs 1 VCRGELLGSGCFGVVHRGLWT-LPSGKSVPVAVKSLRvgpE-GPMGT 45 eieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymeg e + dFlrE+s+M++l Hp+++rL+G ++ g+P l +V+E++++ kb|TNK1_Hs 46 E--LGDFLREVSVMMNL-EHPHVLRLHGLVL--GQP----LQMVMELAPL 86 GdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNc G+L+ L ++ + +pL + L+ f +Q A +M+YL ++++vHRDLA+RN kb|TNK1_Hs 87 GSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNL 136 LVsenlvVKIsDFGLaRdi.ysddyYvrkrgggklPvkWmAPEslkygkF L+++++++K++DFGL R ++ + Y +++g +++P W+APEsl++g F kb|TNK1_Hs 137 LLASPRTIKVADFGLVRPLgGARGRY-VMGGPRPIPYAWCAPESLRHGAF 185 tskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenC +s+SDVW+FGV+LWE+f+ Ge+P ++g++++ +l++l ed+ RLprP++C kb|TNK1_Hs 186 SSASDVWMFGVTLWEMFSGGEEP-WAGVPPYLILQRL-EDRARLPRPPLC 233 PdelYdlMlqCWaedPedRPtFselveeL<-* + lY+l l+CWa+ P+dRP+Fs l L kb|TNK1_Hs 234 SRALYSLALRCWAPHPADRPSFSHLEGLL 262 Pkinase: domain 1 of 1, from 1 to 262: score 100.7, E = 9.8e-31 *->yelleklGsGsfGtVykakh.kgtgk..iVAvKiikk..rkekskkd +++e lGsG fG+V ++ ++ +gk+ VAvK +++++++ ++ kb|TNK1_Hs 1 VCRGELLGSGCFGVVHRGLWtLPSGKsvPVAVKSLRVgpEGPMGTEL 47 ktarrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLf +r E++++ +L Hp+++rl++ + ++ l +V+E+++ G +L+ kb|TNK1_Hs 48 GDFLR--EVSVMMNLEHPHVLRLHGLVL-GQPLQMVMELAPLG----SLH 90 dylsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILl ++l++ pl ++ +++Q++ +++YL ++g +HRDL N+Ll kb|TNK1_Hs 91 ARLTAPAPTPPL--LVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLL 138 dnngvvdaflKiaDFGlAkklst.sss.lttfvGTpw....YmAPEvllg + ++ K+aDFGl + ++ ++ ++ G ++ + ++APE l+ kb|TNK1_Hs 139 ASPRTI----KVADFGLVRP--LgGARgRYVMGGPRPipyaWCAPESLR- 181 gngygtkvDvWSlGvilyellt.GkpPFsgevqdsldqlqlirkilgppl + ++++DvW +Gv+l+e++++G+ P+ g + +li ++l+ + kb|TNK1_Hs 182 HGAFSSASDVWMFGVTLWEMFSgGEEPWAGV------PPYLILQRLEDRA 225 efdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHP + ++p +s +++ +L +c+++ P++R+++ ++ kb|TNK1_Hs 226 RLPRPPLCS-------------RALYSLALRCWAPHPADRPSFSHLEGL- 261 wf<-* + kb|TNK1_Hs 262 -L 262 // Query sequence: kb|TLK2_Hsap|Other/TLK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 238.9 2.5e-72 1 Pkinase_Tyr Protein tyrosine kinase 55.9 1.7e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 278 [. 1 272 [] 55.9 1.7e-19 Pkinase 1/1 1 280 [] 1 287 [] 238.9 2.5e-72 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 278: score 55.9, E = 1.7e-19 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLk.......... l++ LG+G F eVyk+ ++ VAVK+ +++ +++++ kb|TLK2_Hs 1 YLLLHLLGRGGFSEVYKAFDL----TEQRYVAVKIHQlnknwrdekk 43 eigaseeeieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyi e +++ ++ rE +i k+l dHp iV+L+ + + ++ + kb|TLK2_Hs 44 E-NYHKHA------CREYRIHKEL-DHPRIVKLYDYFSLDTDS----FCT 81 VtEymegGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLeskn..fv V+Ey+eg dL+ +L++h + + k+ s+ +Qi +++ YL + +++++ kb|TLK2_Hs 82 VLEYCEGNDLDFYLKQH---KLMSEKEARSIIMQIVNALKYLNEIKppII 128 HRDLAARNcLVse...nlvVKIsDFGLaRdiysddyYvrkrgggklPv.. H DL N+L+ +++ + +KI+DFGL++ + +d+y + g + kb|TLK2_Hs 129 HYDLKPGNILLVNgtaCGEIKITDFGLSKIMDDDSYN-SVDGMELTSQga 177 ..kWm.APEslkygk....FtskSDVWSFGVlLWEiftlGeqPF.....Y ++ W+ +PE++ gk++++ + k DVWS GV + + G++PF+++++ kb|TLK2_Hs 178 gtYWYlPPECFVVGKeppkISNKVDVWSVGVIFYQCLY-GRKPFghnqsQ 226 pgmsneevlellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFsel +++ e ++ + +e ++ ++e +++C a+ edR ++l kb|TLK2_Hs 227 QDILQENTILKATEVQFPPKPVV--TPEAKAFIRRCLAYRKEDRIDVQQL 274 veeL<-* + kb|TLK2_Hs 275 ACDP 278 Pkinase: domain 1 of 1, from 1 to 280: score 238.9, E = 2.5e-72 *->yelleklGsGsfGtVykakhkgtgkiVAvKi..ikkrkekskkdkta y ll lG+G+f++Vyka + +++ VAvKi++++k +++kk+ ++ kb|TLK2_Hs 1 YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIhqLNKNWRDEKKENYH 47 rrl.sEiqilkrLsHpNIvrlidvfed.kdhlylVlEycegGLrvldLfd ++ +E +i+k+L+Hp Iv+l+d+f + d+ + VlEyceg dL kb|TLK2_Hs 48 KHAcREYRIHKELDHPRIVKLYDYFSLdTDSFCTVLEYCEGN----DLDF 93 ylsetrrkgpllfsedeakkialQilrgleYLHsn..giiHRDLKPeNIL yl+ +++ + se+ea++i+ Qi+ +l+YL + ++ iiH DLKP NIL kb|TLK2_Hs 94 YLK---QHKLM--SEKEARSIIMQIVNALKYLNEIkpPIIHYDLKPGNIL 138 ldnngvvdaflKiaDFGlAkkls......t.sss.lttfvGTpwYmAPEv l+ ng+ + +Ki+DFGl+k +++++ ++ + + ++ +GT+wY++PE kb|TLK2_Hs 139 LV-NGTACGEIKITDFGLSKIMDddsynsVdGMElTSQGAGTYWYLPPEC 187 ll...ggngygtkvDvWSlGvilyelltGkpPFs.gevqds.ldqlqlir +++ ++++ kvDvWS+Gvi+y+ l G+ PF +++ s+ d lq kb|TLK2_Hs 188 FVvgkEPPKISNKVDVWSVGVIFYQCLYGRKPFGhNQ---SqQDILQENT 234 kilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlta + +++ f+ + +eak +i++cL++ ++R+ kb|TLK2_Hs 235 ILKATEVQFPPKPVVT-------------PEAKAFIRRCLAYRKEDRIDV 271 eeilqHPwf<-* +++ ++P++ kb|TLK2_Hs 272 QQLACDPYL 280 // Query sequence: kb|TLK1_Hsap|Other/TLK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 229.2 2e-69 1 Pkinase_Tyr Protein tyrosine kinase 38.7 2e-18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 277 [. 1 272 [] 38.7 2e-18 Pkinase 1/1 1 279 [] 1 287 [] 229.2 2e-69 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 277: score 38.7, E = 2e-18 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLk.......... l++ LG+G F eVyk+ ++ AVK+ +++ +++++ kb|TLK1_Hs 1 YLLLHLLGRGGFSEVYKAFDL----YEQRYAAVKIHQlnkswrdekk 43 eigaseeeieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyi e +++ ++ rE +i k+l dHp iV+L+ + + + + kb|TLK1_Hs 44 E-NYHKHA------CREYRIHKEL-DHPRIVKLYDYFSLDTDT----FCT 81 VtEymegGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLeskn..fv V+Ey+eg dL+ +L++h + + k+ s+ +Qi +++ YL + +++++ kb|TLK1_Hs 82 VLEYCEGNDLDFYLKQH---KLMSEKEARSIVMQIVNALRYLNEIKppII 128 HRDLAARNcLVse...nlvVKIsDFGLaRdiysddyYvrkrgggklPv.. H DL N+L+ +++ + +KI+DFGL++ + +dd Y + g + kb|TLK1_Hs 129 HYDLKPGNILLVDgtaCGEIKITDFGLSKIM-DDDSY-GVDGMDLTSQga 176 ..kWm.APEslkygk....FtskSDVWSFGVlLWEiftlGeqPF.....Y ++ W+ +PE++ gk++++ + k DVWS GV + + G++PF+++++ kb|TLK1_Hs 177 gtYWYlPPECFVVGKeppkISNKVDVWSVGVIFFQCLY-GRKPFghnqsQ 225 pgmsneevlellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFsel +++ e ++ + +e ++ + e +++C a+ edR +l kb|TLK1_Hs 226 QDILQENTILKATEVQFPVKPVV--SSEAKAFIRRCLAYRKEDRFDVHQL 273 veeL<-* ++ kb|TLK1_Hs 274 ANDP 277 Pkinase: domain 1 of 1, from 1 to 279: score 229.2, E = 2e-69 *->yelleklGsGsfGtVykakhkgtgkiVAvKi..ikkrkekskkdkta y ll lG+G+f++Vyka + +++ AvKi++++k+ +++kk+ ++ kb|TLK1_Hs 1 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIhqLNKSWRDEKKENYH 47 rrl.sEiqilkrLsHpNIvrlidvfed.kdhlylVlEycegGLrvldLfd ++ +E +i+k+L+Hp Iv+l+d+f + d + VlEyceg dL kb|TLK1_Hs 48 KHAcREYRIHKELDHPRIVKLYDYFSLdTDTFCTVLEYCEGN----DLDF 93 ylsetrrkgpllfsedeakkialQilrgleYLHsn..giiHRDLKPeNIL yl+ +++ + se+ea++i+ Qi+ +l YL + ++ iiH DLKP NIL kb|TLK1_Hs 94 YLK---QHKLM--SEKEARSIVMQIVNALRYLNEIkpPIIHYDLKPGNIL 138 ldnngvvdaflKiaDFGlAkkls.....t.sss.lttfvGTpwYmAPEvl l+ +g+ + +Ki+DFGl+k +++++ + + ++ +GT+wY++PE kb|TLK1_Hs 139 LV-DGTACGEIKITDFGLSKIMDddsygVdGMDlTSQGAGTYWYLPPECF 187 l...ggngygtkvDvWSlGvilyelltGkpPFs.gevqds.ldqlqlirk +++ ++++ kvDvWS+Gvi+++ l G+ PF +++ s+ d lq kb|TLK1_Hs 188 VvgkEPPKISNKVDVWSVGVIFFQCLYGRKPFGhNQ---SqQDILQENTI 234 ilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltae + +++ f+ s +eak +i++cL++ ++R + kb|TLK1_Hs 235 LKATEVQFPVKPVVS-------------SEAKAFIRRCLAYRKEDRFDVH 271 eilqHPwf<-* ++ ++P++ kb|TLK1_Hs 272 QLANDPYL 279 // Query sequence: kb|TIE2_Hsap|TK/Tie|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 475.0 2.1e-143 1 Pkinase Protein kinase domain 164.7 5.2e-50 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 269 [] 1 272 [] 475.0 2.1e-143 Pkinase 1/1 1 269 [] 1 287 [] 164.7 5.2e-50 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 269: score 475.0, E = 2.1e-143 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie +k++ ++GeG+FG V k++ k +dg +++ A+K +ke +as ++ kb|TIE2_Hs 1 IKFQDVIGEGNFGQVLKARIK--KDGLRMDAAIKRMKE-YASKDD-- 42 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL ++dF E+++++klG+HpNi++LlG+c + ++ ly+ Ey+++G+L kb|TIE2_Hs 43 HRDFAGELEVLCKLGHHPNIINLLGACEH-RGY----LYLAIEYAPHGNL 87 ldfLrkhr.............egrpLtlkdLlsfalQiAkGMeYLesknf ldfLrk r ++++ ++ L+ ++Ll+fa+++A+GM+YL++k+f kb|TIE2_Hs 88 LDFLRKSRvletdpafaiansTASTLSSQQLLHFAADVARGMDYLSQKQF 137 vHRDLAARNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmA +HRDLAARN+LV+en v+KI+DFGL+R + Y +k++ g+lPv+WmA kb|TIE2_Hs 138 IHRDLAARNILVGENYVAKIADFGLSRGQ---EVY-VKKTMGRLPVRWMA 183 PEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedG Esl+y+++t+ SDVWS+GVlLWEi++lG++P Y gm+ +e++e+l +G kb|TIE2_Hs 184 IESLNYSVYTTNSDVWSYGVLLWEIVSLGGTP-YCGMTCAELYEKL-PQG 231 yRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* yRL++P nC de+YdlM+qCW+e+P +RP+F++++ L kb|TIE2_Hs 232 YRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL 269 Pkinase: domain 1 of 1, from 1 to 269: score 164.7, E = 5.2e-50 *->yelleklGsGsfGtVykakhkgtgk..iVAvKiikkrkekskkdkta +++ ++G+G+fG+V ka+ k++g + A+K++k k+ d ++ kb|TIE2_Hs 1 IKFQDVIGEGNFGQVLKARIKKDGLrmDAAIKRMKEYASKD--DHRD 45 rrlsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdy + E+++l +L++HpNI+ l++++e +++lyl Ey+++G L d+ kb|TIE2_Hs 46 FAG-ELEVLCKLgHHPNIINLLGACEHRGYLYLAIEYAPHG----NLLDF 90 ls.....e........trrkgpllfsedeakkialQilrgleYLHsngii l++++ e+++ + +l s +++ ++a ++rg++YL ++ +i kb|TIE2_Hs 91 LRksrvlEtdpafaiaNSTASTL--SSQQLLHFAADVARGMDYLSQKQFI 138 HRDLKPeNILldnngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYm HRDL NIL+ +n+v KiaDFGl++ + +++ t ++m kb|TIE2_Hs 139 HRDLAARNILVGENYVA----KIADFGLSRG--QeVYVkKTMGRLPVRWM 182 APEvllggngygtkvDvWSlGvilyellt.GkpPFsgevqds.ldqlqli A E l+ ++ y+t +DvWS+Gv+l+e ++ G +P++g + + ++++ kb|TIE2_Hs 183 AIESLN-YSVYTTNSDVWSYGVLLWEIVSlGGTPYCGM---TcAELYEKL 228 rkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlt + + + + +++ +e dL++ c++ +P++R++ kb|TIE2_Hs 229 PQGYRLEKPLNCD-----------------DEVYDLMRQCWREKPYERPS 261 aeeilqHPwf<-* +++il + + kb|TIE2_Hs 262 FAQILVS--L 269 // Query sequence: kb|TIE1_Hsap|TK/Tie|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 457.5 3.9e-138 1 Pkinase Protein kinase domain 139.6 1.9e-42 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 269 [] 1 272 [] 457.5 3.9e-138 Pkinase 1/1 1 269 [] 1 287 [] 139.6 1.9e-42 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 269: score 457.5, E = 3.9e-138 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie +++ +GeG+FG V ++ k +dg ++ A+K+Lke +ase + kb|TIE1_Hs 1 ITFEDLIGEGNFGQVIRAMIK--KDGLKMNAAIKMLKE-YASEND-- 42 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL ++dF E+++++klG+HpNi++LlG+c ++ lyi Ey+++G+L kb|TIE1_Hs 43 HRDFAGELEVLCKLGHHPNIINLLGACKN-RGY----LYIAIEYAPYGNL 87 ldfLrkhr.............egrpLtlkdLlsfalQiAkGMeYLesknf ldfLrk r ++++ ++++ L+ +Ll fa + A+GM+YL++k+f kb|TIE1_Hs 88 LDFLRKSRvletdpafarehgTASTLSSRQLLRFASDAANGMQYLSEKQF 137 vHRDLAARNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmA +HRDLAARN+LV+enl KI+DFGL+R ++ Y +k++ g+lPv+WmA kb|TIE1_Hs 138 IHRDLAARNVLVGENLASKIADFGLSR---GEEVY-VKKTMGRLPVRWMA 183 PEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedG Esl+y+++t+kSDVWSFGVlLWEi++lG++P Y gm+ +e++e+l +G kb|TIE1_Hs 184 IESLNYSVYTTKSDVWSFGVLLWEIVSLGGTP-YCGMTCAELYEKL-PQG 231 yRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* yR+++P+nC de+Y+lM+qCW+ P +RP F+++ +L kb|TIE1_Hs 232 YRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL 269 Pkinase: domain 1 of 1, from 1 to 269: score 139.6, E = 1.9e-42 *->yelleklGsGsfGtVykakhkgtgk..iVAvKiikkr..kekskkdk ++++ +G+G+fG+V +a+ k++g + A+K +k +++++ kb|TIE1_Hs 1 ITFEDLIGEGNFGQVIRAMIKKDGLkmNAAIKMLKEYasENDHRDFA 47 tarrlsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLf E+++l +L++HpNI+ l++++ ++++ly+ Ey++ G L kb|TIE1_Hs 48 G-----ELEVLCKLgHHPNIINLLGACKNRGYLYIAIEYAPYG----NLL 88 dyls.....e.....trrkgpll.fsedeakkialQilrgleYLHsngii d+l++++ e+++ +r++g+ +++s +++ ++a + g++YL ++ +i kb|TIE1_Hs 89 DFLRksrvlEtdpafAREHGTAStLSSRQLLRFASDAANGMQYLSEKQFI 138 HRDLKPeNILldnngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYm HRDL N+L+ +n KiaDFGl++ ++ +++ t ++m kb|TIE1_Hs 139 HRDLAARNVLVGENLAS----KIADFGLSRG--EeVYVkKTMGRLPVRWM 182 APEvllggngygtkvDvWSlGvilyellt.GkpPFsgevqds.ldqlqli A E l+ ++ y+tk+DvWS+Gv+l+e ++ G +P++g + + ++++ kb|TIE1_Hs 183 AIESLN-YSVYTTKSDVWSFGVLLWEIVSlGGTPYCGM---TcAELYEKL 228 rkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlt + + + +++++ +e +L++ c++ P++R+ kb|TIE1_Hs 229 PQGYRMEQPRNCD-----------------DEVYELMRQCWRDRPYERPP 261 aeeilqHPwf<-* +++i + kb|TIE1_Hs 262 FAQIALQ--L 269 // Query sequence: kb|TGFbR2_Hsap|TKL/STKR/Type2|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 183.0 1.6e-55 1 Pkinase_Tyr Protein tyrosine kinase 74.6 7.1e-23 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 295 [. 1 272 [] 74.6 7.1e-23 Pkinase 1/1 1 295 [. 1 287 [] 183.0 1.6e-55 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 295: score 74.6, E = 7.1e-23 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie ++l+ G+G F eVyk++lk +++ +VAVK+ + e kb|TGFbR2_ 1 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIF---PYEE---- 40 redFlrEAsiMk..klGdHpNiVrLlGvct...kegePggpglyiVtEym ++ E i ++ +l +H+Ni+++l + ++++ g+ ++++t + kb|TGFbR2_ 41 YASWKTEKDIFSdiNL-KHENILQFLTAEErktELGKQ----YWLITAFH 85 egGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLeskn......... ++G+L ++L +h ++ +dL + A+G ++L+s +++ ++++ + kb|TGFbR2_ 86 AKGNLQEYLTRH----VISWEDLRKLGSSLARGIAHLHSDHtpcgrpkmp 131 fvHRDLAARNcLVsenlvVKIsDFGLaRdi....ysddyYvrkrgggklP +vHRDL N+LV+++l++ +DFGL+ ++++ dd + +g kb|TGFbR2_ 132 IVHRDLKSSNILVKNDLTCCLCDFGLSLRLdptlSVDD---LANSGQVGT 178 vkWmAPEslkygk.......FtskSDVWSFGVlLWEiftlGeqPFYpgms + mAPE+l + + ++ ++F ++DV+S +LWE+ +++ +++ kb|TGFbR2_ 179 ARYMAPEVLESRMnlenvesF-KQTDVYSMALVLWEMTSRC-NA-VGEVK 225 nee...............vlellyedGyRLprPenCP.....delYdlMl ++e++ +++ ++++ +++++ + +d++R ++P ++++ + + + ++ kb|TGFbR2_ 226 DYEppfgskvrehpcvesMKDNVLRDRGRPEIPSFWLnhqgiQMVCETLT 275 qCWaedPedRPtFselveeL<-* +CW++dPe R t + + e++ kb|TGFbR2_ 276 ECWDHDPEARLTAQCVAERF 295 Pkinase: domain 1 of 1, from 1 to 295: score 183.0, E = 1.6e-55 *->yelleklGsGsfGtVykakhkgtgk....iVAvKiikkrkekskkdk +el +G+G f++Vykak k + ++ ++VAvKi+++++ s+k kb|TGFbR2_ 1 IELDTLVGKGRFAEVYKAKLKQNTSeqfeTVAVKIFPYEEYASWKT- 46 tarrlsEiqilkrLs..HpNIvrlidvfed....kdhlylVlEycegGLr E i ++ +H+NI++++ + e++++ ++ ++l++ ++ +G kb|TGFbR2_ 47 ------EKDIFSDINlkHENILQFLTAEERktelGKQYWLITAFHAKG-- 88 vldLfdylsetrrkgpllfsedeakkialQilrgleYLHsn......... L +yl+ + ++ s+++++k ++rg+++LHs +++ ++++ kb|TGFbR2_ 89 --NLQEYLT----RHVI--SWEDLRKLGSSLARGIAHLHSDhtpcgrpkm 130 giiHRDLKPeNILldnngvvdaflKiaDFGlAkkls...t.sss.lttfv i+HRDLK++NIL++n+ ++ +++DFGl+ l+++ + +++ v kb|TGFbR2_ 131 PIVHRDLKSSNILVKNDLTC----CLCDFGLSLRLDptlSvDDLaNSGQV 176 GTpwYmAPEvll.....ggngygtkvDvWSlGvilyelltGk........ GT +YmAPEvl ++ + ++ + + Dv+S+ ++l+e+ ++ + ++ ++ kb|TGFbR2_ 177 GTARYMAPEVLEsrmnlENVESFKQTDVYSMALVLWEMTSRCnavgevkd 226 ..pPFsgev.q.ds.ldqlqlirkilgpplefdspewdsisrsefrrlpn +pPF ++v+ ++ +++ + +++g+p +++ + + kb|TGFbR2_ 227 yePPFGSKVrEhPCvESMKDNVLRDRGRPEIPSFWLNHQGI--------- 267 lseeakdLikkcLnkDPskRltaeeilqHPwf<-* + ++ ++ c++ DP+ Rlta+++ + f kb|TGFbR2_ 268 --QMVCETLTECWDHDPEARLTAQCVAER--F 295 // Query sequence: kb|TGFbR1_Hsap|TKL/STKR/Type1|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 213.0 1.6e-64 1 Pkinase_Tyr Protein tyrosine kinase 48.4 5e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 288 [] 1 272 [] 48.4 5e-19 Pkinase 1/1 1 288 [] 1 287 [] 213.0 1.6e-64 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 288: score 48.4, E = 5e-19 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie ++l++ +G+G FGeV++G+++ + +VAVK+ ++ ee kb|TGFbR1_ 1 IVLQESIGKGRFGEVWRGKWR------GEEVAVKIF---SSREE--- 35 redFlrEAsiMk..klGdHpNiVrLlGvctkegePggpg.lyiVtEymeg ++ +rEA+i + l +H+Ni+ ++++ k+ + +l++V y e+ kb|TGFbR1_ 36 -RSWFREAEIYQtvML-RHENILGFIAADNKDNGT--WTqLWLVSDYHEH 81 GdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfv......... G+L d+L + +t++ +++ al A+G+++L+ + +v++++++ kb|TGFbR1_ 82 GSLFDYLNRY----TVTVEGMIKLALSTASGLAHLH-MEIVgtqgkpaia 126 HRDLAARNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPv...k HRDL +N+LV++n+++ I+D GLa + d+ + + +++ v++++ kb|TGFbR1_ 127 HRDLKSKNILVKKNGTCCIADLGLAVRH--DSAT-DTIDIAPnHRVgtkR 173 WmAPEslkygk....Fts..kSDVWSFGVlLWEiftlG.........eqP mAPE+l ++++ ++F s + D+++ G + WEi +++ ++ +++ + P kb|TGFbR1_ 174 YMAPEVLDDSInmkhFESfkRADIYAMGLVFWEIARRCsiggihedyQLP 223 FYpgmsnee.....vlellyedGyRLprPe.....nCPdelYdlMlqCWa Y+++ +++++ +++ + + e+ R +P + ++ + + ++M++CW kb|TGFbR1_ 224 -YYDLVPSDpsveeMRKVVCEQKLRPNIPNrwqscEALRVMAKIMRECWY 272 edPedRPtFselveeL<-* ++ + R t + L kb|TGFbR1_ 273 ANGAARLTALRIKKTL 288 Pkinase: domain 1 of 1, from 1 to 288: score 213.0, E = 1.6e-64 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ++l e +G+G fG+V+++k++g++ VAvKi++ r+e+s+++++ kb|TGFbR1_ 1 IVLQESIGKGRFGEVWRGKWRGEE--VAVKIFSSREERSWFREA--- 42 lsEiqilkrLsHpNIvrlidvfed....kdhlylVlEycegGLrvldLfd Ei+ +L+H+NI+ +i + ++++ + l+lV +y+e+G +Lfd kb|TGFbR1_ 43 --EIYQTVMLRHENILGFIAADNKdngtWTQLWLVSDYHEHG----SLFD 86 ylsetrrkgpllfsedeakkialQilrgleYLHsn........giiHRDL yl + ++ + + +k al +++gl++LH + ++++++ i HRDL kb|TGFbR1_ 87 YLN----RYTV--TVEGMIKLALSTASGLAHLHMEivgtqgkpAIAHRDL 130 KPeNILldnngvvdaflKiaDFGlAkkls...t.sss.lttfvGTpwYmA K+ NIL+++ng++ +iaD GlA +++ + + + ++++vGT +YmA kb|TGFbR1_ 131 KSKNILVKKNGTC----CIADLGLAVRHDsatDtIDIaPNHRVGTKRYMA 176 PEvll.....ggngygtkvDvWSlGvilyelltGk..........pPFsg PEvl ++ + ++ + +++D++++G++++e + + + ++ +++ ++P+++ kb|TGFbR1_ 177 PEVLDdsinmKHFESFKRADIYAMGLVFWEIARRCsiggihedyqLPYYD 226 ev.q.ds.ldqlqlirkilgpplefdspewdsisrsefrrlpnlseeakd v++++s +++++++ + +p+ +++++++ + + + + kb|TGFbR1_ 227 LVpSdPSvEEMRKVVCEQKLRPNIPNRWQSCEAL-----------RVMAK 265 LikkcLnkDPskRltaeeilqHPwf<-* +++ c+ + + Rlta i++ + kb|TGFbR1_ 266 IMRECWYANGAARLTALRIKKT--L 288 // Query sequence: kb|TESK2_Hsap|TKL/LISK/TESK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 157.2 9.2e-48 1 Pkinase_Tyr Protein tyrosine kinase 125.3 3.7e-38 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 1 251 [] 1 287 [] 157.2 9.2e-48 Pkinase_Tyr 1/1 2 251 .] 1 272 [] 125.3 3.7e-38 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 1 to 251: score 157.2, E = 9.2e-48 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++ ek+GsG f++V+k +h+ +g++ A+K +++++ +++k kb|TESK2_H 1 FTC-EKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLK---- 42 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+q+++rLsHpNI+r+ +v+ + l+ +Ey + G L +l kb|TESK2_H 43 --EVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSG----NLEQLLD- 85 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++ l ++ + k a+ i+ gl YLH +gi HRDL + N+L++ +++ kb|TESK2_H 86 --SNLHL--PWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIK-RDE 130 vdaflKiaDFGlAkkls.t.sss.lttfvGTpwYmAPEvllggngygtkv ++ + +aDFGlA+k+ + + +s+ +vG+p++mAPEvl+ +++y k+ kb|TESK2_H 131 NGYSAVVADFGLAEKIPdVsMGSeKLAVVGSPFWMAPEVLR-DEPYNEKA 179 DvWSlGvilyelltGk......pPFsgevqds.ldqlqlirkilgpplef Dv+S+G+il e + + + +++ +P + +ld ++ +++ +p kb|TESK2_H 180 DVFSYGIILCEIIARIqadpdyLPRTEN---FgLDYDAFQHMVGDCP--- 223 dspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf +++++L +c+n+DP+ R+++ ei + + kb|TESK2_H 224 --------------------PDFLQLTFNCCNMDPKLRPSFVEIGKT--L 251 <-* kb|TESK2_H - - Pkinase_Tyr: domain 1 of 1, from 2 to 251: score 125.3, E = 3.7e-38 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie +k+G+G F eV+k + + ++ A K+ + s+ kb|TESK2_H 2 --TCEKIGSGFFSEVFKVRHR----ASGQVMALKMN---TLSSN--- 36 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL r+ +l+E+++M +l +HpNi+r++Gvc++ ++ l tEy G+L kb|TESK2_H 37 RANMLKEVQLMNRL-SHPNILRFMGVCVH-QGQ----LHALTEYINSGNL 80 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs L + + +L+ ++ a++iA G++YL+ k++ HRDL +NcL++ kb|TESK2_H 81 EQLLDS---NLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIK 127 e...nlvVKIsDFGLaRdiysddyYvrkrgggklPv....kWmAPEslky +++++ + ++DFGLa i + ++ g+ kl v ++++WmAPE+l++ kb|TESK2_H 128 RdenGYSAVVADFGLAEKIPD-----VSMGSEKLAVvgspFWMAPEVLRD 172 gkFtskSDVWSFGVlLWEiftlGe.qP........FYpgmsneevlelly +++k DV S+G+ L Ei+ + + P+ +++++F g++ + ++++ kb|TESK2_H 173 EPYNEKADVFSYGIILCEIIARIQaDPdylprtenF--GLDYDAFQHMVG 220 edGyRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* +CP++ +l C + dP+ RP+F e+ L kb|TESK2_H 221 ----------DCPPDFLQLTFNCCNMDPKLRPSFVEIGKTL 251 // Query sequence: kb|TESK1_Hsap|TKL/LISK/TESK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 164.0 8.4e-50 1 Pkinase_Tyr Protein tyrosine kinase 142.3 2.8e-43 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 255 [. 1 272 [] 142.3 2.8e-43 Pkinase 1/1 1 255 [. 1 287 [] 164.0 8.4e-50 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 255: score 142.3, E = 2.8e-43 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie ++ +k+G+G F eVyk + + + ++ K+ + + kb|TESK1_H 1 FHCAEKIGAGFFSEVYKVRHR----QSGQVMVLKMN---KLPSN--- 37 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL r lrE+++M +l +HpNi+r++Gvc++ ++ l tEym gG L kb|TESK1_H 38 RGNTLREVQLMNRL-RHPNILRFMGVCVH-QGQ----LHALTEYMNGGTL 81 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs L + ++pL+ + l+ al+iA+G+ YL+sk+ HRDL +NcLV kb|TESK1_H 82 EQLLSS---PEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVR 128 e...nlvVKIsDFGLaRdiysddyYvrkrgggk.lPv......kWmAPEs ++++++++ ++DFGLa i Y r+g+++ P +++ WmAPE+ kb|TESK1_H 129 RedrGFTAVVGDFGLAEKI---PVY---REGARkEPLavvgspYWMAPEV 172 lkygkFtskSDVWSFGVlLWEiftlGeqP...........FYpgmsneev l+ + +k DV +FG++L E++ + P +++ +++++F g+++ + kb|TESK1_H 173 LRGELYDEKADVFAFGIVLCELIA--RVPadpdylprtedF--GLDVPAF 218 lellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* l+ d+ Lp l +C + +P+ R F+e+ ++L kb|TESK1_H 219 RTLV-GDDCPLPFLL--------LAIHCCNLEPSTRAPFTEITQHL 255 Pkinase: domain 1 of 1, from 1 to 255: score 164.0, E = 8.4e-50 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++ ek+G+G f++Vyk +h+ +g++ ++K k+++++ + ++ kb|TESK1_H 1 FHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLR---- 43 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+q+++rL+HpNI+r+ +v+ + l+ +Ey++gG L +ls kb|TESK1_H 44 --EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGG----TLEQLLS- 86 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld..nn + pl s+ + + al i+rgl YLHs+g+ HRDL + N+L+ ++++ kb|TESK1_H 87 --SPEPL--SWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRreDR 132 gvvdaflKiaDFGlAkkls...t.sss.lttfvGTpwYmAPEvllggngy g ++ ++DFGlA+k+ +++ ++ +vG+p++mAPEvl+ g+ y kb|TESK1_H 133 GFTA---VVGDFGLAEKIPvyrEgARKePLAVVGSPYWMAPEVLR-GELY 178 gtkvDvWSlGvilyelltGkpPFsgevq.ds.ldqlqlirkilgpplefd + k+Dv+++G++l el+ + + +++ ++ ++ l + ++ + d kb|TESK1_H 179 DEKADVFAFGIVLCELIAR---VPADPDyLPrTEDFGLDVPAFRTLVGDD 225 spewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf< +p +++ L c+n+ Ps R ++ei qH + kb|TESK1_H 226 CP-----------------LPFLLLAIHCCNLEPSTRAPFTEITQH--L 255 -* kb|TESK1_H - - // Query sequence: kb|TEC_Hsap|TK/Tec|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 499.4 9.4e-151 1 Pkinase Protein kinase domain 165.4 3.3e-50 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 250 [] 1 272 [] 499.4 9.4e-151 Pkinase 1/1 1 250 [] 1 287 [] 165.4 3.3e-50 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 250: score 499.4, E = 9.4e-151 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie l+++++LG+G FG+V +G+++ ++kVA+K ++e ga+ e kb|TEC_Hsa 1 LTFMRELGSGLFGVVRLGKWR-----AQYKVAIKAIRE-GAMCE--- 38 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL edF++EA++M+kl Hp++V+L+Gvct+ ++P +yiVtE+me G+L kb|TEC_Hsa 39 -EDFIEEAKVMMKL-THPKLVQLYGVCTQ-QKP----IYIVTEFMERGCL 81 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs l+fLr++ +++++ Lls+++++++GMeYLe++ f+HRDLAARNcLVs kb|TEC_Hsa 82 LNFLRQR--QGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVS 129 enlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkFtskS e +vVK+sDFG+aR++ dd Y ++++g+k+PvkW++PE+++y++F+skS kb|TEC_Hsa 130 EAGVVKVSDFGMARYV-LDDQY-TSSSGAKFPVKWCPPEVFNYSRFSSKS 177 DVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPdel DVWSFGVl+WE+ft G++P ++ +n+ev+ ++ +G+RL +P++++ + kb|TEC_Hsa 178 DVWSFGVLMWEVFTEGRMP-FEKYTNYEVVTMV-TRGHRLYQPKLASNYV 225 YdlMlqCWaedPedRPtFselveeL<-* Y++Ml+CW+e+Pe RP+F++l++ + kb|TEC_Hsa 226 YEVMLRCWQEKPEGRPSFEDLLRTI 250 Pkinase: domain 1 of 1, from 1 to 250: score 165.4, E = 3.3e-50 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++ + lGsG fG+V+++k++ k VA+K i+ ++ ++ kb|TEC_Hsa 1 LTFMRELGSGLFGVVRLGKWRAQYK-VAIKAIREGAMCEEDFIE--- 43 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E++++ +L Hp v+l++v++ + +y+V+E++e G L +l+ kb|TEC_Hsa 44 --EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERG----CLLNFLR- 86 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv +r+g + s d++ +++ +++g+eYL +n++iHRDL N+L+++ gv kb|TEC_Hsa 87 -QRQGHF--SRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGV 133 vdaflKiaDFGlAkklst.sss.lttfvGTpw...YmAPEvllggngygt v K++DFG A+ + + ++t+ G ++ ++++PEv + ++ ++ kb|TEC_Hsa 134 V----KVSDFGMAR---YvLDDqYTSSSGAKFpvkWCPPEVFN-YSRFSS 175 kvDvWSlGvilyellt.GkpPFsgevqdsldqlqlirkilgpplefdspe k+DvWS+Gv+++e++t+G+ PF + ++++ ++ ++ + kb|TEC_Hsa 176 KSDVWSFGVLMWEVFTeGRMPFEKY-----TNYEVVTMVTRGHRLYQPK- 219 wdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* ++s +++ +c++ +P+ R+++e++l + kb|TEC_Hsa 220 -------------LASNYVYEVMLRCWQEKPEGRPSFEDLLRT--I 250 // Query sequence: kb|TBK1_Hsap|Other/IKK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 140.6 9.6e-43 1 Pkinase_Tyr Protein tyrosine kinase -42.9 1.9e-13 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 269 [. 1 272 [] -42.9 1.9e-13 Pkinase 1/1 1 293 [. 1 287 [] 140.6 9.6e-43 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 269: score -42.9, E = 1.9e-13 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie l LG+Ga +V++G+ k +t+ A+K+ ++ + + kb|TBK1_Hs 1 WLLSDILGQGATANVFRGRHK----KTGDLFAIKVFNN-ISFLR--- 39 redFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd d +E +++kkl +H+NiV+L ++ ++ + +++E++++G+ kb|TBK1_Hs 40 PVDVQMrEFEVLKKL-NHKNIVKLFAIEEETTTRH---KVLIMEFCPCGS 85 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL. L++ L ++++ L+ ++ l +++ GM++L ++++vHRD+ N+++ kb|TBK1_Hs 86 LYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMr 135 .Vse..nlvVKIsDFGLaRdiysddyY.vrkrgggklPvkWmAPEslkyg ++e+++ v K +DFG aR + +dd+ v g ++ kb|TBK1_Hs 136 vIGEdgQSVYKLTDFGAAREL-EDDEQfVSLYG-------------TEEY 171 k.................FtskSDVWSFGVlLWEiftlGeqPF..Ypgm. +++ ++ ++++++++ D WS GV+ + t G PF++++g + kb|TBK1_Hs 172 LhpdmyeravlrkdhqkkYGATVDLWSIGVTFYHAAT-GSLPFrpFEGPr 220 sneevlellyedGyR......LprPenCPdelYdlMlqCWaedPedRPtF n ev+ ++ G ++ ++ + en P + M kb|TBK1_Hs 221 RNKEVMYKI-ITGKPsgaisgVQKAENGPIDWSGDMPVSCSLS------- 262 selveeL<-* + l+ L kb|TBK1_Hs 263 RGLQVLL 269 Pkinase: domain 1 of 1, from 1 to 293: score 140.6, E = 9.6e-43 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + l +lG+G+ + V++++hk+tg+++A+K+++ + +d + r kb|TBK1_Hs 1 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR- 46 lsEiqilkrLsHpNIvrlidvfedkdhly..lVlEycegGLrvldLfdyl E ++lk+L+H+NIv+l+ + e+ + ++ l++E+c++G +L+++l kb|TBK1_Hs 47 --EFEVLKKLNHKNIVKLFAIEEETTTRHkvLIMEFCPCG----SLYTVL 90 setrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNIL..ld + ++++ ++e e +++ ++ g+++L +ngi+HRD+KP NI++ + kb|TBK1_Hs 91 E--EPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMrvIG 138 nngvvdafl.KiaDFGlAkklst.sss.lttfvGTpwYmAP...Ev..ll ++g+ + K++DFG A+ ++ ++++ ++ GT +Y+ P+ E l+ kb|TBK1_Hs 139 EDGQS---VyKLTDFGAARE--LeDDEqFVSLYGTEEYLHPdmyERavLR 183 ..ggngygtkvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilg ++++++yg vD WS+Gv++y +tG +PF+ +++++ +++++ki kb|TBK1_Hs 184 kdHQKKYGATVDLWSIGVTFYHAATGSLPFRPF--EGpRRNKEVMYKIIT 231 pplefdspewdsisrse.fr....................r.l.pnlsee ++++ + +++++ ++++ + +++ + + + +r+l+++l++ kb|TBK1_Hs 232 GKPSGAI---------SgVQkaengpidwsgdmpvscslsRgLqVLLTP- 271 akdLikkcLnkDPskRltaeeilqHPwf<-* ++ ++L+ D +k +++++ + kb|TBK1_Hs 272 ---VLANILEADQEKCWGFDQFFAE--- 293 // Query sequence: kb|TBCK_Hsap|Other/TBCK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 71.7 5.1e-22 1 Pkinase_Tyr Protein tyrosine kinase -27.0 2.1e-14 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 4 255 .. 1 272 [] -27.0 2.1e-14 Pkinase 1/1 9 256 .] 1 287 [] 71.7 5.1e-22 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 4 to 255: score -27.0, E = 2.1e-14 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.ke.igaseee + +++ +++ ++ kb|TBCK_Hs 4 -------------------HD-------------VCgSNgLPLTPN- 17 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG + l +i+k++ Hp + ++ + e l +V E++e kb|TBCK_Hs 18 --SIKILGRFQILKTI-THPRLCQYVDISRGKHER----LVVVAEHCER- 59 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL +L d Lr+ ++p++ ++ l++a+++ +G++Y +++vHR L N+L kb|TBCK_Hs 60 SLEDLLRE---RKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNIL 106 VsenlvVKIsDFGLaRdi.ysddyYvrkrgggklPv...kWmAPEslkyg +++++++K + FGL + dd +P++ + +APE+++ g kb|TBCK_Hs 107 LDRKGHIKLAKFGLYHMTaHGDDVD--------FPIgypSYLAPEVIAQG 148 k..............FtskSDVWSFGVlLWEiftlGeqPFYpgmsnee.. + +++++ +++++ + kSDVWS G+ L+E++ G++ ++ ++ +e+ kb|TBCK_Hs 149 IfkttdhmpskkplpSGPKSDVWSLGIILFELCV-GRKL-FQSLDISErl 196 ............vlellyedGyRLprPenCPdelYdlMlqCWaedPedRP + + + +++++ l e+ + L++ + P+ + dl+ +C + P++RP kb|TBCK_Hs 197 kflltldcvddtLIVLA-EEHGCLDIIKELPETVIDLLNKCLTFHPSKRP 245 tFsel.veeL<-* t +l + kb|TBCK_Hs 246 TPDQLmKDKV 255 Pkinase: domain 1 of 1, from 9 to 256: score 71.7, E = 5.1e-22 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ++g +++ ++ k + + kb|TBCK_Hs 9 ---------------------SNG-------LPLTPNSIKILGR--- 24 lsEiqilkrLsHpNIvrlidvfed.kdhlylVlEycegGLrvldLfdyls qilk + Hp +++ d+ + ++ +l +V E+ce +L d+l+ kb|TBCK_Hs 25 ---FQILKTITHPRLCQYVDISRGkHERLVVVAEHCER-----SLEDLLR 66 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng +++p+ s ++ +ia ++l+gl+Y+ ++gi+HR L P NILld++g kb|TBCK_Hs 67 ---ERKPV--SCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKG 111 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvll......... ++ K+a FGl ++ t ++ + + + G p Y+APEv+ ++ +++++ kb|TBCK_Hs 112 HI----KLAKFGL-YHM-TaHGDdVDFPIGYPSYLAPEVIAqgifkttdh 155 ....ggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkil ++++ + g+k+DvWSlG+il+el+ G+ +F++ d ++++ l kb|TBCK_Hs 156 mpskKPLPSGPKSDVWSLGIILFELCVGRKLFQSL-----DISERLKFLL 200 gpplefdspewdsisrse.fr.r.l.pnlseeakdLikkcLnkDPskRlt d+ + i + e+ + ++l+e+ +dL++kcL++ PskR+t kb|TBCK_Hs 201 T----LDCVDDTLIVLAEeHGcLdIiKELPETVIDLLNKCLTFHPSKRPT 246 aeeilqHPwf<-* ++++++++ f kb|TBCK_Hs 247 PDQLMKDKVF 256 // Query sequence: kb|TAK1_Hsap|TKL/MLK/TAK1|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 221.3 4.8e-67 1 Pkinase_Tyr Protein tyrosine kinase 201.0 6.2e-61 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 248 [] 1 272 [] 201.0 6.2e-61 Pkinase 1/1 1 248 [] 1 287 [] 221.3 4.8e-67 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 248: score 201.0, E = 6.2e-61 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie ++ ++ G+GaFG+V+k++++ +VA+K + + +e kb|TAK1_Hs 1 IEVEEVVGRGAFGVVCKAKWR------AKDVAIKQI---ESESE--- 35 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL r++F+ E++ +++ +HpNiV+L+G+c+ P +++V+Ey+egG+L kb|TAK1_Hs 36 RKAFIVELRQLSRV-NHPNIVKLYGACL---NP----VCLVMEYAEGGSL 77 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLeskn...fvHRDLAARNc ++ L+ + + t + s++lQ ++G +YL+s++++ ++HRDL N kb|TAK1_Hs 78 YNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQpkaLIHRDLKPPNL 127 LVsenl.vVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkF L+ +++v KI+DFG a di + ++ k WmAPE++ + + kb|TAK1_Hs 128 LLVAGGtVLKICDFGTACDI-----Q-THMTNNKGSAAWMAPEVFEGSNY 171 tskSDVWSFGVlLWEiftlGeqPFYpgm..sneevlellyedGyRLprPe ++k DV S G+ LWE++t ++P + +++++ ++++ + +G R p + kb|TAK1_Hs 172 SEKCDVFSWGIILWEVIT-RRKP-FDEIggPAFRIMWAV-HNGTRPPLIK 218 nCPdelYdlMlqCWaedPedRPtFselveeL<-* n P+++ +lM++CW +dP++RP+++e+v ++ kb|TAK1_Hs 219 NLPKPIESLMTRCWSKDPSQRPSMEEIV-KI 248 Pkinase: domain 1 of 1, from 1 to 248: score 221.3, E = 4.8e-67 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +e++e++G+G+fG+V+kak++ VA+K+i+ ++e++ + kb|TAK1_Hs 1 IEVEEVVGRGAFGVVCKAKWRAKD--VAIKQIESESERKAFIV---- 41 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E++ l r++HpNIv+l++++ + ++lV+Ey+egG +L+ +l+ kb|TAK1_Hs 42 --ELRQLSRVNHPNIVKLYGACL--NPVCLVMEYAEGG----SLYNVLH- 82 trrkgpll.fsedeakkialQilrgleYLHsn...giiHRDLKPeNILld pl + +a +++lQ +g++YLHs++++ iHRDLKP N+Ll+ kb|TAK1_Hs 83 --GAEPLPyYTAAHAMSWCLQCSQGVAYLHSMqpkALIHRDLKPPNLLLV 130 nngvvdaflKiaDFGlAkklstsss.lttfvGTpwYmAPEvllggngygt g+v lKi+DFG A+ + ++++t G+ +mAPEv g+ y+ kb|TAK1_Hs 131 AGGTV---LKICDFGTACDI---QThMTNNKGSAAWMAPEVFE-GSNYSE 173 kvDvWSlGvilyelltGkpPFs..gevqds.ldqlqlirkilgpplefds k+Dv+S G+il+e++t++ PF++ g + + ++ + + +ppl + kb|TAK1_Hs 174 KCDVFSWGIILWEVITRRKPFDeiGG---PaFRIMWAVHNGTRPPLIKNL 220 pewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<- p ++ +L+++c+ kDPs+R++ eei++ kb|TAK1_Hs 221 P-----------------KPIESLMTRCWSKDPSQRPSMEEIVKI--- 248 * kb|TAK1_Hs - - // Query sequence: kb|SYK_Hsap|TK/Syk|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 408.7 1.9e-123 1 Pkinase Protein kinase domain 127.2 1e-38 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 249 [] 1 272 [] 408.7 1.9e-123 Pkinase 1/1 1 249 [] 1 287 [] 127.2 1e-38 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 249: score 408.7, E = 1.9e-123 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie +k+LG+G+FG+V kG++ +++ +VAVK+Lk+ a ++++ kb|SYK_Hsa 1 TLEDKELGSGNFGTVKKGYYQ--MKKVVKTVAVKILKN-EANDPAL- 43 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL ++++l+EA++M +l d+p iVr++G+c e+ +++V+E++e+G L kb|SYK_Hsa 44 KDELLAEANVMQQL-DNPYIVRMIGICE--AES----WMLVMEMAELGPL 86 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs ++L++ +r+++ k +++ +Q+++GM YLe+ nfvHRDLAARN+L+ kb|SYK_Hsa 87 NKYLQQ---NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV 133 enlvVKIsDFGLaRdi.ysddyYvrkrgggklPvkWmAPEslkygkFtsk ++ +KIsDFGL+++++ ++ yY +++++gk+PvkW+APE+++y+kF+sk kb|SYK_Hsa 134 TQHYAKISDFGLSKALrADENYY-KAQTHGKWPVKWYAPECINYYKFSSK 182 SDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPde SDVWSFGVl+WE f++G++P Y gm+ +ev ++l e+G+R+ +P +CP e kb|SYK_Hsa 183 SDVWSFGVLMWEAFSYGQKP-YRGMKGSEVTAML-EKGERMGCPAGCPRE 230 lYdlMlqCWaedPedRPtFselveeL<-* +YdlM +CW +d e+RP F kb|SYK_Hsa 231 MYDLMNLCWTYDVENRPGF------- 249 Pkinase: domain 1 of 1, from 1 to 249: score 127.2, E = 1e-38 *->yelleklGsGsfGtVykakh..kgtgkiVAvKiikkrkekskkdkta + lGsG+fGtV+k++ + k+ k+VAvKi+k + +++ + ++ kb|SYK_Hsa 1 TLEDKELGSGNFGTVKKGYYqmKKVVKTVAVKILKNEANDPALKDEL 47 rrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyl + E+ +++ L+ p+Ivr+i+++e ++++ V+E +e G L yl kb|SYK_Hsa 48 LA--EANVMQQLDNPYIVRMIGICEAESWML-VMEMAELG----PLNKYL 90 setrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnn + +++ + ++ ++ + Q+ g++YL + +++HRDL N+Ll+ + kb|SYK_Hsa 91 Q---QNRHV--KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ 135 gvvdaflKiaDFGlAkkls.....t.sss.lttfvGTpwYmAPEvllggn + Ki+DFGl+k l+ +++ ++ +++ +++v + APE ++ + kb|SYK_Hsa 136 HYA----KISDFGLSKALRadenyYkAQThGKWPV---KWYAPECIN-YY 177 gygtkvDvWSlGvilyellt.GkpPFsgevqds.ldqlqlirkilgpple + ++k+DvWS+Gv+++e ++ G+ P++g ++ ++++k + + kb|SYK_Hsa 178 KFSSKSDVWSFGVLMWEAFSyGQKPYRGM---KgSEVTAMLEKGERMGCP 224 fdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPw +p +e+ dL++ c+++D + R++ kb|SYK_Hsa 225 AGCP-----------------REMYDLMNLCWTYDVENRPG--------- 248 f<-* f kb|SYK_Hsa 249 F 249 // Query sequence: kb|SuRTK106_Hsap|TK/TK-Unique|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 207.3 8.1e-63 1 Pkinase Protein kinase domain 87.6 8.5e-27 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 267 [] 1 272 [] 207.3 8.1e-63 Pkinase 1/1 1 267 [] 1 287 [] 87.6 8.5e-27 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 267: score 207.3, E = 8.1e-63 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + ++++ +G+ G ++++ ++ + ++ V K Lke a +e kb|SuRTK10 1 SEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKE-PAGLHE-- 44 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL +dFl ++ lG+H+N+V+L G+ct+ + P ly+V+E ++ GdL kb|SuRTK10 45 VQDFLGRIQFHQYLGKHKNLVQLEGCCTE-KLP----LYMVLEDVAQGDL 89 ldfLrkhr........egrpLtlkdLlsfalQiAkGMeYLesknfvHRDL l+fL + r++ + ++ Lt k+ ++ Q+ ++e+L +k++ H D+ kb|SuRTK10 90 LSFLWTCRrdvmtmdgLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDV 139 AARNcLVsenlvVKIsDFGLaRdiysddyY.vrkrgggk.lPvkWmAPEs AARN+L ++l++K + GLa + Y+ + +++ ++P kW+APE kb|SuRTK10 140 AARNILMQSDLTAKLCGLGLAYEV-----YtRGAISSTQtIPLKWLAPER 184 lkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRL l + ++ DVWSFG+lL+E++tlG++P Yp+++++ +le+l +++ + kb|SuRTK10 185 LLLRPASIRADVWSFGILLYEMVTLGAPP-YPEVPPTSILEHL-QRRKIM 232 prPenCPdelYdlMlqCWaedPedRPtFselveeL<-* +rP C+ +Y++M++CW++ +dRP+ +el+ +L kb|SuRTK10 233 KRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRL 267 Pkinase: domain 1 of 1, from 1 to 267: score 87.6, E = 8.5e-27 *->yelleklGsGsfGtVyka.khkgtgk...iVAvKiikkrkekskkdk e+le++ sGs G ++a+++ g++ +++ V +K +k + ++++ kb|SuRTK10 1 SEVLEQICSGSCGPIFRAnMNTGDPSkpkSVILKALKEPAGLHEVQD 47 tarrlsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLf + r iq ++ L++H+N v+l +++++k ly+VlE + G dL kb|SuRTK10 48 FLGR---IQFHQYLgKHKNLVQLEGCCTEKLPLYMVLEDVAQG----DLL 90 dyls...e..trrkgpll.fsedeakkialQilrgleYLHsngiiHRDLK ++l + +++ ++g l++++e+++ +i +Q+l +le+L ++ H D+ kb|SuRTK10 91 SFLWtcrRdvMTMDGLLYdLTEKQVYHIGKQVLLALEFLQEKHLFHGDVA 140 PeNILldnngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvl NIL+ ++ + K++ GlA + ++++ +t + + ++APE l kb|SuRTK10 141 ARNILMQSDLTA----KLCGLGLAYEV-YtRGAiSSTQTIPLKWLAPERL 185 lggngygtkvDvWSlGvilyellt.GkpPFsgevqds.ldqlqlirkilg l ++ + ++DvWS+G++lye++t G pP+++ ++ + l+ +++++ kb|SuRTK10 186 L-LRPASIRADVWSFGILLYEMVTlGAPPYPEV---PpTSILEHLQRRKI 231 pplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeil + ++++ ++ +++k+c+++ ++R++++e+ kb|SuRTK10 232 MKRPSSCT-----------------HTMYSIMKSCWRWREADRPSPRELR 264 qHPwf<-* + kb|SuRTK10 265 LR--L 267 // Query sequence: kb|TAO1_Hsap|STE/STE20/TAO|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 274.9 3.4e-83 1 Pkinase_Tyr Protein tyrosine kinase 96.7 1.5e-29 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 1 254 [] 1 287 [] 274.9 3.4e-83 Pkinase_Tyr 1/1 1 252 [. 1 272 [] 96.7 1.5e-29 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 1 to 254: score 274.9, E = 3.4e-83 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar ++ l+ +G GsfG Vy a+++ t+++VA+K++++++k++ +k++ + kb|TAO1_Hs 1 FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSgKQSTEKWQDII 47 rlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGL.rvldLfdyl + E++ l+r++HpN +++++++ ++ +lV+Eyc g +++l+ + kb|TAO1_Hs 48 K--EVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSAsDLLEVH--- 92 setrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnn k+pl +e e+ i l+gl+YLHs+ iHRD+K NILl + kb|TAO1_Hs 93 -----KKPL--QEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEP 135 gvvdaflKiaDFGlAkklstsss.lttfvGTpwYmAPEvll..ggngygt g+v K+aDFG+A s++++fvGTp++mAPEv+l + y+ kb|TAO1_Hs 136 GQV----KLADFGSASM----ASpANSFVGTPYWMAPEVILamDEGQYDG 177 kvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspe kvDvWSlG++++el+ +kpP + + + l+ i+++ +p l ++++ kb|TAO1_Hs 178 KVDVWSLGITCIELAERKPPLFNM---NaMSALYHIAQNESPTLQSNEW- 223 wdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* s+ ++ ++++cL+k P++R+t ee+l+H ++ kb|TAO1_Hs 224 ---------------SDYFRNFVDSCLQKIPQDRPTSEELLKHIFV 254 Pkinase_Tyr: domain 1 of 1, from 1 to 252: score 96.7, E = 1.5e-29 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeei. ++ ++++G+G+FG Vy ++ t+ VA+K++ ++s ++ + kb|TAO1_Hs 1 FTDLREIGHGSFGAVYFARDV----RTNEVVAIKKM---SYSGKQSt 40 e.redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG e+++d ++E++ + ++ +HpN + + G+ ++ + ++V+Ey+ +G kb|TAO1_Hs 41 EkWQDIIKEVKFLQRI-KHPNSIEYKGCYLR-EHT----AWLVMEYC-LG 83 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL + d L h ++pL ++ + + +G++YL+s+ ++HRD+ A N+L kb|TAO1_Hs 84 SASDLLEVH--KKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNIL 131 VsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygk... ++e+++VK +DFG a + WmAPE++ + +++ kb|TAO1_Hs 132 LTEPGQVKLADFGSASMA-------SPANSFVGTPYWMAPEVILAMDegq 174 FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPen + k DVWS G+++ E+ ++P +m l +++++ + kb|TAO1_Hs 175 YDGKVDVWSLGITCIELAE-RKPP-LFNMNAMSALYHIAQNESPTLQSNE 222 CPdelYdlMlqCWaedPedRPtFselveeL<-* +d + +C ++ P+dRPt +el+ ++ kb|TAO1_Hs 223 WSDYFRNFVDSCLQKIPQDRPTSEELLKHI 252 // Query sequence: kb|TAO2_Hsap|STE/STE20/TAO|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 262.8 1.6e-79 1 Pkinase_Tyr Protein tyrosine kinase 94.5 7.3e-29 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 254 [] 1 272 [] 94.5 7.3e-29 Pkinase 1/1 1 254 [] 1 287 [] 262.8 1.6e-79 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 254: score 94.5, E = 7.3e-29 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeei. ++ ++++G+G+FG Vy ++ + VA+K++ ++s ++ + kb|TAO2_Hs 1 FSDLREIGHGSFGAVYFARDV----RNSEVVAIKKM---SYSGKQSn 40 e.redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG e+++d ++E++ + kl +HpN +++ G+ ++ + ++V+Ey+ +G kb|TAO2_Hs 41 EkWQDIIKEVRFLQKL-RHPNTIQYRGCYLR-EHT----AWLVMEYC-LG 83 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL + d L h ++pL ++ + +G++YL+s+n++HRD+ A N+L kb|TAO2_Hs 84 SASDLLEVH--KKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNIL 131 VsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygk.. +se++ VK +DFG a + + ++ WmAPE++ + ++ kb|TAO2_Hs 132 LSEPGLVKLGDFGSASIM--------APANSFvGTPYWMAPEVILAMDeg 173 .FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPe ++ k DVWS G+++ E+ ++P +m l +++++ + kb|TAO2_Hs 174 qYDGKVDVWSLGITCIELAE-RKPP-LFNMNAMSALYHIAQNESPVLQSG 221 nCPdelYdlMlqCWaedPedRPtFsel..veeL<-* + ++ + +C ++ P+dRPt + l ++++ kb|TAO2_Hs 222 HWSEYFRNFVDSCLQKIPQDRPTSEVLlkHRFV 254 Pkinase: domain 1 of 1, from 1 to 254: score 262.8, E = 1.6e-79 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar + l+ +G GsfG Vy a+++ ++++VA+K++++++k++ +k++ + kb|TAO2_Hs 1 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSgKQSNEKWQDII 47 rlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGL.rvldLfdyl + E++ l++L+HpN +++++++ ++ +lV+Eyc g +++l+ + kb|TAO2_Hs 48 K--EVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSAsDLLEVH--- 92 setrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnn k+pl +e e+ + l+gl+YLHs++ iHRD+K NILl++ kb|TAO2_Hs 93 -----KKPL--QEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEP 135 gvvdaflKiaDFGlAkklstsss.lttfvGTpwYmAPEvll..ggngygt g v K++DFG+A + ++++fvGTp++mAPEv+l + y+ kb|TAO2_Hs 136 GLV----KLGDFGSASIM----ApANSFVGTPYWMAPEVILamDEGQYDG 177 kvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspe kvDvWSlG++++el+ +kpP + + + l+ i+++ +p l + + kb|TAO2_Hs 178 KVDVWSLGITCIELAERKPPLFNM---NaMSALYHIAQNESPVLQSGHW- 223 wdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* se ++ ++++cL+k P++R+t e +l+H ++ kb|TAO2_Hs 224 ---------------SEYFRNFVDSCLQKIPQDRPTSEVLLKHRFV 254 // Query sequence: kb|TAO3_Hsap|STE/STE20/TAO|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 266.7 1.1e-80 1 Pkinase_Tyr Protein tyrosine kinase 94.8 6e-29 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 253 [. 1 272 [] 94.8 6e-29 Pkinase 1/1 1 254 [] 1 287 [] 266.7 1.1e-80 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 253: score 94.8, E = 6e-29 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeei. ++ ++++G+G+FG Vy +t +t VA+K++ ++s ++ + kb|TAO3_Hs 1 FIGLHEIGHGSFGAVYFATNA----HTSEVVAIKKM---SYSGKQTh 40 e.redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG e+++d l+E++ +++l +HpN + + G+ +k + ++V+Ey+ +G kb|TAO3_Hs 41 EkWQDILKEVKFLRQL-KHPNTIEYKGCYLK-EHT----AWLVMEYC-LG 83 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL + d L h ++pL ++ + + G++YL+s+ ++HRD+ A N+L kb|TAO3_Hs 84 SASDLLEVH--KKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNIL 131 VsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygk... ++e+++VK +DFG a + WmAPE++ + +++ kb|TAO3_Hs 132 LTEPGQVKLADFGSASMA-------SPANSFVGTPYWMAPEVILAMDegq 174 FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPen + k D+WS G+++ E+ ++P +m l ++++++ + kb|TAO3_Hs 175 YDGKVDIWSLGITCIELAE-RKPP-LFNMNAMSALYHIAQNDSPTLQSNE 222 CPdelYdlMlqCWaedPedRPtFsel.veeL<-* +d + C ++ P++RPt +el ++++ kb|TAO3_Hs 223 WTDSFRRFVDYCLQKIPQERPTSAELlRHDF 253 Pkinase: domain 1 of 1, from 1 to 254: score 266.7, E = 1.1e-80 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar + l +G GsfG Vy a++ t+++VA+K++++++k+ ++k++ + kb|TAO3_Hs 1 FIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSgKQTHEKWQDIL 47 rlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGL.rvldLfdyl + E++ l+ L+HpN +++++++ + +lV+Eyc g +++l+ + kb|TAO3_Hs 48 K--EVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSAsDLLEVH--- 92 setrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnn k+pl +e e+ i l gl+YLHs+ iHRD+K NILl + kb|TAO3_Hs 93 -----KKPL--QEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEP 135 gvvdaflKiaDFGlAkklstsss.lttfvGTpwYmAPEvll..ggngygt g+v K+aDFG+A s++++fvGTp++mAPEv+l + y+ kb|TAO3_Hs 136 GQV----KLADFGSASM----ASpANSFVGTPYWMAPEVILamDEGQYDG 177 kvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspe kvD+WSlG++++el+ +kpP + + + l+ i+++ +p l ++++ kb|TAO3_Hs 178 KVDIWSLGITCIELAERKPPLFNM---NaMSALYHIAQNDSPTLQSNEW- 223 wdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +++++ ++++cL+k P++R+t +e+l H+++ kb|TAO3_Hs 224 ---------------TDSFRRFVDYCLQKIPQERPTSAELLRHDFV 254 // Query sequence: kb|STLK6_Hsap|STE/STE20/STLK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 105.5 3.5e-32 1 Pkinase_Tyr Protein tyrosine kinase 17.1 4.1e-17 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 310 [. 1 272 [] 17.1 4.1e-17 Pkinase 1/1 1 312 [] 1 287 [] 105.5 3.5e-32 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 310: score 17.1, E = 4.1e-17 *->lklgkkLGeG..aFGeVykGtlkgsgdgteikVAVKtL.keigasee +l+ ++G+G ++ +V++++ + t++ V +K+ + e ++ ee kb|STLK6_H 1 YELQVEIGRGfdNLTSVHLARHT----PTGTLVTIKITnLE-NCNEE 42 eieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymeg r + l+ A i++++ +HpNi + v t g l+++ ++m++ kb|STLK6_H 43 ---RLKALQKAVILSHFFRHPNITTYWTVFTV-GSW----LWVISPFMAY 84 GdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNc G+ Lr+ ++ + + ++ + +G++YL++++++HR + A + kb|STLK6_H 85 GSASQLLRTY-FPEGMSETLIRNILFGAVRGLNYLHQNGCIHRSIKASHI 133 LVsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPv...........kW L+s ++ V s GL+ ++ +++g ++ v + ++ +++ + W kb|STLK6_H 134 LISGDGLVTLS--GLSHLH-----S-LVKHGQRhRAVydfpqfstsvqPW 175 mAPEslkygk..FtskSDVWSFGVlLWEiftlGeqPFYpgmsnee..... ++PE l+ +++++kSD++S G++ E+ + G+ P +++m ++ ++ kb|STLK6_H 176 LSPELLRQDLhgYNVKSDIYSVGITACELAS-GQVP-FQDMHRTQmllqk 223 .........................................vlellyedG ++++ ++ + + ++++++ ++++++ +++ +++ ++++ d+ kb|STLK6_H 224 lkgppyspldisifpqsesrmknsqsgvdsgigesvlvssgTHTVN-SDR 272 yRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* p + ++ +l ++C + dPe+RP+ s l+++ kb|STLK6_H 273 LHTPSSKTFSPAFFSLVQLCLQQDPEKRPSASSLLSHV 310 Pkinase: domain 1 of 1, from 1 to 312: score 105.5, E = 3.5e-32 *->yelleklGsG..sfGtVykakhkgtgkiVAvKiikkrkekskkdkta yel +G+G ++ +V +a+h tg +V +Ki ++++ +++ +k++ kb|STLK6_H 1 YELQVEIGRGfdNLTSVHLARHTPTGTLVTIKITNLENCNEERLKAL 47 rrlsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdy + + il ++ +HpNI +++ vf+ +++l+++ +++ G + + + kb|STLK6_H 48 QK---AVILSHFfRHPNITTYWTVFTVGSWLWVISPFMAYG----SASQL 90 lsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldn l+ t ++ se +++i+ +rgl+YLH+ng+iHR +K + IL++ kb|STLK6_H 91 LR-TYFPEGM--SETLIRNILFGAVRGLNYLHQNGCIHRSIKASHILISG 137 ngvvdaflKiaDFGlAkkls........t.sss.lttfvGTpwYmAPEvl +g v ++ Gl+ ++s ++++++ + ++ + ++++PE+l kb|STLK6_H 138 DGLV----TLS--GLSHLHSlvkhgqrhRaVYDfPQFSTSVQPWLSPELL 181 l.ggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgp +++ gy k+D++S+G++ el++G+ PF++ q++ ++l++ kb|STLK6_H 182 RqDLHGYNVKSDIYSVGITACELASGQVPFQDM-----HRTQMLLQKLKG 226 plefdspewdsisrse.fr.............................r. p+ ++ + ++ ++ +++ ++++++ +++ +++ ++++++ ++++ +++ kb|STLK6_H 227 PPYSPLDISIFPQSESrMKnsqsgvdsgigesvlvssgthtvnsdrlhTp 276 l.pnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* ++ s+++ +L+ cL++DP+kR++a +l H +f kb|STLK6_H 277 SsKTFSPAFFSLVQLCLQQDPEKRPSASSLLSHVFF 312 // Query sequence: kb|STLK5_Hsap|STE/STE20/STLK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 90.4 1.2e-27 1 Pkinase_Tyr Protein tyrosine kinase -30.7 3.4e-14 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 311 [] 1 272 [] -30.7 3.4e-14 Pkinase 1/1 1 311 [] 1 287 [] 90.4 1.2e-27 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 311: score -30.7, E = 3.4e-14 *->lklgkkLGeGa..FGeVykGtlkgsgdgteikVAVKtL.keigasee +l+ ++G+G ++ +V ++++k t+ V V ++ e +s e kb|STLK5_H 1 YELLTVIGKGFedLMTVNLARYK----PTGEYVTVRRInLE-ACSNE 42 eieredFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEyme + Fl++E+ + k + +HpNiV + + + + l++Vt +m+ kb|STLK5_H 43 ---MVTFLQgELHVSKLF-NHPNIVPYRATFIA-DNE----LWVVTSFMA 83 gGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARN +G+ +d +h + + + + + + k+++Y + +++vHR + A kb|STLK5_H 84 YGSAKDLICTH-FMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASH 132 cLVsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPv............ +L+s +++V s GL + + ++g + v ++ ++ + + kb|STLK5_H 133 ILISVDGKVYLS--GLRSNL-------SMISHGQrQRVvhdfpkysvkvl 173 kWmAPEslkygk..FtskSDVWSFGVlLWEiftlGeqPFYpgmsnee... W++PE+l+ + +++ kSD++S G++ E+ G P +++m+ ++ kb|STLK5_H 174 PWLSPEVLQQNLqgYDAKSDIYSVGITACELAN-GHVP-FKDMPATQmll 221 .................................vlellyedGyR...... ++ +++ + ++++ + ++ + +++++ ++++ + l+ + R++++++ kb|STLK5_H 222 eklngtvpclldtstipaeeltmspsrsvansgLSDSLTTSTPRpsngds 271 ..LprPenCPdelYdlMlqCWaedPedRPtFsel..veeL<-* ++ p + ++ ++ qC +++P+ RP+ s l +++++ kb|STLK5_H 272 psHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLlnHSFF 311 Pkinase: domain 1 of 1, from 1 to 311: score 90.4, E = 1.2e-27 *->yelleklGsG..sfGtVykakhkgtgkiVAvKiikkrkekskkdkta yell ++G+G + tV +a+ k tg+ V v +i+++ + ++ kb|STLK5_H 1 YELLTVIGKGfeDLMTVNLARYKPTGEYVTVRRINLEACSNEM--VT 45 rrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyl ++++E+++ k ++HpNIv ++ +f +++l++V+ ++ G + +d++ kb|STLK5_H 46 FLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYG----SAKDLI 91 setrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnn t+ ++ e + i+ +l++l+Y+H +g +HR +K + IL++ + kb|STLK5_H 92 C-THFMDGM--NELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVD 138 gvvdaflKiaDFGlAkkls.........t.sss.lttfvGTpwYmAPEvl g v ++ Gl ls +++++++ ++ + +++ + +++++PEvl kb|STLK5_H 139 GKV----YLS--GLRSNLSmishgqrqrVvHDFpKYSVKV-LPWLSPEVL 181 l.ggngygtkvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilg ++ +gy+ k+D++S+G++ el++G+ PF++ + + l+++ + + kb|STLK5_H 182 QqNLQGYDAKSDIYSVGITACELANGHVPFKDM--PAtQMLLEKLNGTVP 229 pplefdspewdsisrse.fr.............................r + l+ + +i+ +e +++++++ +++ +++ ++++++++++++++ kb|STLK5_H 230 CLLDTS-----TIPAEElTMspsrsvansglsdslttstprpsngdspsH 274 .l.pnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* + + s+ + ++++ cL+++P R++a +l+H +f kb|STLK5_H 275 pYhRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFF 311 // Query sequence: kb|STLK3_Hsap|STE/STE20/FRAY|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 243.7 8.8e-74 1 Pkinase_Tyr Protein tyrosine kinase 117.6 8e-36 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 275 [] 1 272 [] 117.6 8e-36 Pkinase 1/1 1 275 [] 1 287 [] 243.7 8.8e-74 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 275: score 117.6, E = 8e-36 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei +l++++G+Ga +V + +k + VA+K ++ e ++ + kb|STLK3_H 1 YELQEVIGSGATAVVQAALCK----PRQERVAIKRInLE-KCQTS-- 40 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd ++++l+E++ M++ +HpN+V ++ + ++ l++V+ + gG+ kb|STLK3_H 41 -MDELLKEIQAMSQC-SHPNVVTYYTSFVV-KDE----LWLVMKLLSGGS 83 LldfLrkhr.....egrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAA +ld + +++++ ++ L + + ++ +G++YL++++ +HRDL A kb|STLK3_H 84 MLDIIKYIVnrgehKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKA 133 RNcLVsenlvVKIsDFGLaRdi.ysddyY.vrkrgggklPvkWmAPEslk N+L++e++ V I+DFG + + + d + ++r+ WmAPE++ kb|STLK3_H 134 GNILLGEDGSVQIADFGVSAFLaTGGDVTrNKVRKTFVGTPCWMAPEVME 183 ygk.FtskSDVWSFGVlLWEiftlGeqPFYpgmsnee............v +++ k D WSFG++ E+ t G+ P Y ++ + +++++++ kb|STLK3_H 184 QVRgYDFKADMWSFGITAIELAT-GAAP-YHKYPPMKvlmltlqndpptL 231 lellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFsel..veeL<- + ed + +++ + +l+ +C ++dP++RPt +el + ++ kb|STLK3_H 232 ETGV-EDKEMMKKY---GKSFRKLLSLCLQKDPSKRPTAAELlkCKFF 275 * kb|STLK3_H - - Pkinase: domain 1 of 1, from 1 to 275: score 243.7, E = 8.8e-74 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr yel e++GsG+ ++V a k +++VA+K+i+++k ++d+ + kb|STLK3_H 1 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLK- 46 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls. Eiq + +sHpN+v+++ +f kd+l+lV+ ++ gG + d+++ kb|STLK3_H 47 --EIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGG----SMLDIIKy 90 ...e.trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILl +++ +++g+l +e + i++++l+gl+YLH+ng iHRDLK NILl kb|STLK3_H 91 ivnRgEHKNGVL--EEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILL 138 dnngvvdaflKiaDFGlAkkls....t.sss.lttfvGTpwYmAPEvllg ++g v iaDFG++++l ++++ +++ +tfvGTp +mAPEv kb|STLK3_H 139 GEDGSV----QIADFGVSAFLAtggdVtRNKvRKTFVGTPCWMAPEVMEQ 184 gngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpple +gy+ k+D+WS+G++ +el+tG P+ +++++ ++l+ +++ kb|STLK3_H 185 VRGYDFKADMWSFGITAIELATGAAPYHKY-----PPMKVLMLTLQNDPP 229 fdspewdsisrsefrr.l.pnlseeakdLikkcLnkDPskRltaeeilqH + + ++ ++ +++++L++ cL+kDPskR+ta+e+l+ kb|STLK3_H 230 TLETGVED-------KeMmKKYGKSFRKLLSLCLQKDPSKRPTAAELLKC 272 Pwf<-* ++f kb|STLK3_H 273 KFF 275 // Query sequence: kb|STK33_Hsap|CAMK/CAMK-Unique|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 311.2 4.3e-94 1 Pkinase_Tyr Protein tyrosine kinase 111.5 5.6e-34 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 264 [. 1 272 [] 111.5 5.6e-34 Pkinase 1/1 1 266 [] 1 287 [] 311.2 4.3e-94 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 264: score 111.5, E = 5.6e-34 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei ++g+ LG+G+FG V ++t k +te+k A+K+++ke +a +++ kb|STK33_H 1 YTFGRILGKGSFGIVIEATDK----ETETKWAIKKVnKE-KAGSSA- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd + + rE++i+k+ +H++i+ L v +++ +y+V+E++e G kb|STK33_H 42 -VKLLEREVNILKSV-KHEHIIHLEQVFETPKK-----MYLVMELCEDGE 84 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L++ L + +++++ + + + A++ +YL+++ +vHRDL N++V kb|STK33_H 85 LKEILDR---KGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMV 131 se.........nlvVKIsDFGLaRdiysddyY.vrkrgggklPvkWmAPE +++ +++++ nl +K++DFGLa +s ++ ++++ g+++ mAPE kb|STK33_H 132 KSsliddnneiNLNIKVTDFGLAVKKQSRSEAmLQATCGTPI---YMAPE 178 slkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyR +++ ++ + D+WS GV+++ ++ Ge+P + s e ++el+ ++G+ kb|STK33_H 179 VISAHDYSQQCDIWSIGVVMYMLLR-GEPP-FLASSEEKLFELI-RKGEL 225 LprPenC...PdelYdlMlqCWaedPedRPtFselveeL<-* ++ +d ++++q ++ dP++R t +el+ kb|STK33_H 226 HFENAVWnsiSDCAKSVLKQLMKVDPAHRITAKELLDNQ 264 Pkinase: domain 1 of 1, from 1 to 266: score 311.2, E = 4.3e-94 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y+++++lG+GsfG V +a++k t+ ++A+K+++k+k+ s+ k + r kb|STK33_H 1 YTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLER 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+ ilk+++H++I+ l vfe+++++ylV+E+ce G +L+++l kb|STK33_H 48 --EVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDG----ELKEILD- 90 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv rkg + se+e + i+ ++++++YLH+n i+HRDLK+eNI+++ kb|STK33_H 91 --RKGHF--SENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVK-SSL 135 vda......flKiaDFGlAkklst.sss..lttfvGTpwYmAPEvllggn +d++++ + +K++DFGlA k+ ++s+ l+ +GTp YmAPEv+ + kb|STK33_H 136 IDDnneinlNIKVTDFGLAVKK-QsRSEamLQATCGTPIYMAPEVIS-AH 183 gygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefd +y++ +D+WS+Gv++y ll G+pPF + ++ +l+++i++++l+f+ kb|STK33_H 184 DYSQQCDIWSIGVVMYMLLRGEPPFLAS-----SEEKLFELIRKGELHFE 228 spewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf< w+sis + ak+++k + ++DP+ R+ta+e+l w+ kb|STK33_H 229 NAVWNSIS-----------DCAKSVLKQLMKVDPAHRITAKELLDNQWL 266 -* kb|STK33_H - - // Query sequence: kb|SSTK_Hsap|CAMK/TSSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 250.7 6.6e-76 1 Pkinase_Tyr Protein tyrosine kinase 37.8 2.2e-18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 254 [. 1 272 [] 37.8 2.2e-18 Pkinase 1/1 1 256 [] 1 287 [] 250.7 6.6e-76 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 254: score 37.8, E = 2.2e-18 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei klg+++GeG++ +V +t k + + +VA+K++++ a ++ kb|SSTK_Hs 1 YKLGRTIGEGSYSKVKVATSK----KYKGTVAIKVVdRR-RAPPDF- 41 eredFlr.EAsiMkklGdHpNiV...rLlGvctkegePggpglyiVtEym +Fl +E+si++ +Hp+iV+ ++ vc g+ lyiV+E + kb|SSTK_Hs 42 -VNKFLPrELSILRGV-RHPHIVhvfEFIEVCN--GK-----LYIVMEAA 82 egGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAAR + dLl ++ +++++ + + +QiA + YL+++++vHRDL + kb|SSTK_Hs 83 AT-DLLQAVQR---NGRIPGVQARDLFAQIAGAVRYLHDHHLVHRDLKCE 128 NcLVs.enlvVKIsDFGLaRdiysddyY.vrkrgggk.lPvkWmAPEslk N+L+s++++ VK +DFG R+ ++ + + +PE+l kb|SSTK_Hs 129 NVLLSpDERRVKLTDFGFGRQA-----HgYPDLSTTYcGSAAYASPEVLL 173 ygkFts.kSDVWSFGVlLWEiftlGeqPF....YpgmsneevlellyedG + +k DVWS GV+L+ ++t + +PF++++ +g++ + ly +G kb|SSTK_Hs 174 GIPYDPkKYDVWSMGVVLYVMVTGC-MPFddsdIAGLPRRQKRGVLYPEG 222 yRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* L ++ l+ + ++ P+ RP+ ++ + kb|SSTK_Hs 223 LEL------SERCKALIAELLQFSPSARPSAGQVARNC 254 Pkinase: domain 1 of 1, from 1 to 256: score 250.7, E = 6.6e-76 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y+l++++G+Gs+++V+ a+ k++ +VA+K++++r++ +++ + kb|SSTK_Hs 1 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLP 47 lsEiqilkrLsHpNIvrlidvfed.kdhlylVlEycegGLrvldLfdyls + E++il+ ++Hp+Iv +++ e +++ly+V+E + dL +++ kb|SSTK_Hs 48 R-ELSILRGVRHPHIVHVFEFIEVcNGKLYIVMEAAAT-----DLLQAVQ 91 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng r+g++ + +a++ + Qi+ ++ YLH++ +HRDLK eN+Ll+ + kb|SSTK_Hs 92 ---RNGRI--PGVQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDE 136 vvdaflKiaDFGlAkklst.sss..lttfvGTpwYmAPEvllggngygtk +K++DFG+ ++ + +++ tt++G+ Y++PEvllg +++++k kb|SSTK_Hs 137 RR---VKLTDFGFGRQ--AhGYPdlSTTYCGSAAYASPEVLLGIPYDPKK 181 vDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewd DvWS+Gv+ly ++tG PF+++ +++ + ++ ++ + +++ + kb|SSTK_Hs 182 YDVWSMGVVLYVMVTGCMPFDDS------DIAGLPRRQKRGVLYPEGLEL 225 sisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* s e +k Li +L++ Ps R++a ++ w+ kb|SSTK_Hs 226 S-------------ERCKALIAELLQFSPSARPSAGQVARNCWL 256 // Query sequence: kb|SRPK2_Hsap|CMGC/SRPK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 133.8 1.1e-40 1 Pkinase_Tyr Protein tyrosine kinase -157.8 2e-06 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 226 [. 1 272 [] -157.8 2e-06 Pkinase 1/1 1 606 [] 1 287 [] 133.8 1.1e-40 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 226: score -157.8, E = 2e-06 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLke.igaseeei + ++kLG G+F +V+++ +++ VA K++k +++e + kb|SRPK2_H 1 YHVIRKLGWGHFSTVWLCWDM----QGKRFVAMKVVKSaQHYTETA- 42 eredFlrEAsiMkklGdHpNiVrLlGvct..................... l E++++k ++++++++++ + ++ + kb|SRPK2_H 43 -----LDEIKLLKCV-------------Resdpsdpnkdmvvqliddfki 74 ..kegePggpglyiVtEymegGdLldfLrkhregrpLtlkdLlsfalQiA ++ +g +++V+E + Ll+ k + + L++ s+ +Q+ kb|SRPK2_H 75 sgMNGIH----VCMVFEVLGH-HLLKWIIKS-NYQGLPVRCVKSIIRQVL 118 kGMeYLeskn.fvHRDLAARNcLVsenlvVKIsDFGLaRdiysddyYvrk +G++YL+sk +++H D+ N+L + dd Y kb|SRPK2_H 119 QGLDYLHSKCkIIHTDIKPENILMC---------------V--DDAY--- 148 rgggklPvkWmAPEslkygk..........FtskSDVWSFGVlLWEiftl v+ mA E+ k + ++++++ +++ kb|SRPK2_H 149 -------VRRMAAEATEWQKagapppsgsaVSTA---------------- 175 Ge.qPFYpgmsneevlellyedGyR....LprPenCPdelYdlMlqCWae +++P +s + +++l ++ R+ + L++ +e+ +l ++ kb|SRPK2_H 176 PQqKP-IGKISKNK-KKKLKKKQKRqaelLEKRL---QEIEEL-----ER 215 dPedRPtFselveeL<-* ++e+ + + e + kb|SRPK2_H 216 EAER----KIIEENI 226 Pkinase: domain 1 of 1, from 1 to 606: score 133.8, E = 1.1e-40 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar y++++klG G f+tV+++ + + VA+K++k ++ + + kb|SRPK2_H 1 YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAqHYTETALD--- 44 rlsEiqilkrLs.....HpN...Ivrlidvfed....kdhlylVlEyceg Ei++lk +++++++ pN++ +v+lid f ++ ++ h+++V+E +++ kb|SRPK2_H 45 ---EIKLLKCVResdpsDPNkdmVVQLIDDFKIsgmnGIHVCMVFEVLGH 91 GLrvldLfdylsetrrkgpllfsedeakkialQilrgleYLHs.ngiiHR L ++ +++ +l + + +k+i++Q+l+gl+YLHs+++iiH kb|SRPK2_H 92 -----HLLKWII-KSNYQGL--PVRCVKSIIRQVLQGLDYLHSkCKIIHT 133 DLKPeNILldnngvvda................................. D+KPeNIL+ vd+ ++ + ++ ++ + ++++++ ++ ++++ kb|SRPK2_H 134 DIKPENILMC----VDDayvrrmaaeatewqkagapppsgsavstapqqk 179 .................................................. + ++ +++++++ +++++++ + +++ ++ ++ +++ +++ +++ ++ kb|SRPK2_H 180 pigkisknkkkklkkkqkrqaellekrlqeieelereaerkiieenitsa 229 .................................................. ++++++++ ++ + ++++ ++ + ++ +++++ ++++++++ ++++ kb|SRPK2_H 230 apsndqdgeycpevklkttgleeaaeaetakdngeaedqeekedaekeni 279 .................................................. ++++++ +++ + +++ ++++++++ ++++ + +++ +++++++++ + kb|SRPK2_H 280 ekdeddvdqelanidptwiespktnghiengpfsleqqlddedddeedcp 329 .................................................. ++++ + ++++ +++ + +++ ++ +++ ++++++ ++++ ++ +++ + kb|SRPK2_H 330 npeeynldepnaesdytysssyeqfngelpngrhkipesqfpefstslfs 379 .................................................. ++ ++ ++ +++++ +++++++++++++++ + +++++ ++ +++ kb|SRPK2_H 380 gslepvacgsvlsegsplteqeesspshdrsrtvsasstgdlpkaktraa 429 ...............flKiaDFGlAkklst.sss.lttfvGTpwYmAPEv + ++ ++++ ++ ++KiaD G A+ + +++ + ++ T+ Y++ Ev kb|SRPK2_H 430 dllvnpldprnadkiRVKIADLGNAC---WvHKHfTEDIQ-TRQYRSIEV 475 llggngygtkvDvWSlGvilyelltGkpPFs.gev.q.ds.ldqlqlirk l g gy+t++D+WS ++ +el+tG +F ++++++ ++ d+++ i + kb|SRPK2_H 476 LI-GAGYSTPADIWSTACMAFELATGDYLFEpHSGeDySRdEDHIAHIIE 524 ilgpplefdspewdsisrse.fr.....................r.l.pn lg +++ + ++++r++ ++ ++ ++ + + ++ + +++ kb|SRPK2_H 525 LLGSIPRHFALSGKYSREFFnRRgelrhitklkpwslfdvlvekYgWpHE 574 lseeakdLikkcLnkDPskRltaeeilqHPwf<-* + d++ +L++ P+kR +a e+l HPw+ kb|SRPK2_H 575 DAAQFTDFLIPMLEMVPEKRASAGECLRHPWL 606 // Query sequence: kb|SRPK1_Hsap|CMGC/SRPK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 134.9 5e-41 1 Pkinase_Tyr Protein tyrosine kinase -147.8 5e-07 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 572 [. 1 272 [] -147.8 5e-07 Pkinase 1/1 1 574 [] 1 287 [] 134.9 5e-41 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 572: score -147.8, E = 5e-07 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLk..eigaseee + ++kLG G+F +V++ +++ VA K++k+ e +++e + kb|SRPK1_H 1 YHVIRKLGWGHFSTVWLSWDI----QGKKFVAMKVVKsaE-HYTETA 42 ieredFlrEAsiMkklGdH........pNiVrLlGvctkegePggpg.ly l E++++k+ +++++++++++ +V+Ll ++ + +++ kb|SRPK1_H 43 ------LDEIRLLKSV-RNsdpndpnrEMVVQLLDDFKI-SGV-NGThIC 83 iVtEymegGdLldfLrkhr............................... +V+E + Ll+ k ++ + + ++ ++ ++ + +++ + + kb|SRPK1_H 84 MVFEVLGH-HLLKWIIKSNyqglplpcvkkiiqqvlqgldylhtkcriih 132 .................................................. ++ ++++ + +++ ++ + ++ ++++ ++++++ ++ +++++ + kb|SRPK1_H 133 tdikpenillsvneqyirrlaaeatewqrsgapppsgsavstapqpkpad 182 .................................................. + +++++++ +++++++ + +++ ++ ++ +++++++++++++++++++ kb|SRPK1_H 183 kmsknkkkklkkkqkrqaellekrmqeieemekesgpgqkrpnkqeeses 232 .................................................. + +++ +++++++ ++++ +++++ +++++ +++++++ + + ++ + kb|SRPK1_H 233 pverplkenppnkmtqekleesstigqdqtlmerdteggaaeincngvie 282 .................................................. + ++++++++ +++++ ++ ++ + ++ +++++ +++++++++++++ kb|SRPK1_H 283 vinytqnsnnetlrhkedlhnandcdvqnlnqessflssqngdsstsqet 332 .................................................. ++ ++ +++ +++ +++++ +++ ++++ ++ +++ + + + ++++++ kb|SRPK1_H 333 dsctpitsevsdtmvcqssstvgqsfseqhisqlqesiraeipcedeqeq 382 .................egrpLtlkdLlsfalQiAkGMeYLesknfvHRD +++++ +++++++ ++ +pL k kb|SRPK1_H 383 ehngpldnkgkstagnfLVNPLEPKN------------------------ 408 LAARNcLVsenlvVKIsDFGLaRdiysddyY.vrkrgggklPvkWmAPEs +e+l+VKI+D G a +++ + ++++r+ ++E+ kb|SRPK1_H 409 --------AEKLKVKIADLGNACWVHKHFTEdIQTRQ-------YRSLEV 443 lkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsnee............ l + +++ D+WS ++ +E+ t G+ ++ s ee ++++++ kb|SRPK1_H 444 LIGSGYNTPADIWSTACMAFELAT-GDYL-FEPHSGEEytrdedhialii 491 .....................................vlellyedGyRLp + ++ +++ ++ +++ +++++ ++ ++ ++ +++e l + y kb|SRPK1_H 492 ellgkvprklivagkyskefftkkgdlkhitklkpwgLFEVL-VEKYEWS 540 rPenCPdelYdlMlqCWaedPedRPtFselveeL<-* + e + d +l + Pe+R t +e++++ kb|SRPK1_H 541 QEE--AAGFTDFLLPMLELIPEKRATAAECLRHP 572 Pkinase: domain 1 of 1, from 1 to 574: score 134.9, E = 5e-41 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar y++++klG G f+tV++ ++ k VA+K++k ++ + + kb|SRPK1_H 1 YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAeHYTETALD--- 44 rlsEiqilkrLs.....HpN...Ivrlidvfed....kdhlylVlEyceg Ei++lk++++++++ pN++ +v+l+d f ++ +++h+++V+E +++ kb|SRPK1_H 45 ---EIRLLKSVRnsdpnDPNremVVQLLDDFKIsgvnGTHICMVFEVLGH 91 GLrvldLfdylsetrrkgpllfsedeakkialQilrgleYLHs.ngiiHR L ++ +++ +l + +kki+ Q+l+gl+YLH +++iiH kb|SRPK1_H 92 -----HLLKWII-KSNYQGL--PLPCVKKIIQQVLQGLDYLHTkCRIIHT 133 DLKPeNILld.nngvvda................................ D+KPeNILl+ n+ ++ + ++ ++++ ++++++ ++ +++++ ++ kb|SRPK1_H 134 DIKPENILLSvNEQYIRRlaaeatewqrsgapppsgsavstapqpkpadk 183 .................................................. +++++++ +++++++ + +++ ++ ++ ++++++++++++++++++++ kb|SRPK1_H 184 msknkkkklkkkqkrqaellekrmqeieemekesgpgqkrpnkqeesesp 233 .................................................. +++ +++++++ ++++ +++++ +++++ +++++++ + + ++ + kb|SRPK1_H 234 verplkenppnkmtqekleesstigqdqtlmerdteggaaeincngviev 283 .................................................. + ++++++++ +++++ ++ ++ + ++ +++++ ++++++++++++++ kb|SRPK1_H 284 inytqnsnnetlrhkedlhnandcdvqnlnqessflssqngdsstsqetd 333 .................................................. + ++ +++ +++ +++++ +++ ++++ ++ +++ + + + +++++++ kb|SRPK1_H 334 sctpitsevsdtmvcqssstvgqsfseqhisqlqesiraeipcedeqeqe 383 .............................flKiaDFGlAkklst.sss.l ++++ +++++++ ++ ++ ++++ ++ ++KiaD G A+ + +++ + kb|SRPK1_H 384 hngpldnkgkstagnflvnplepknaeklKVKIADLGNAC---WvHKHfT 430 ttfvGTpwYmAPEvllggngygtkvDvWSlGvilyelltGkpPFs.gev. ++ T+ Y++ Evl g+gy t++D+WS ++ +el+tG +F +++++ kb|SRPK1_H 431 EDIQ-TRQYRSLEVLI-GSGYNTPADIWSTACMAFELATGDYLFEpHSGe 478 q.ds.ldqlqlirkilgpplefdspewdsisrse.fr............. ++ d+++li + lg + ++ + +s++f++++++ ++ ++ + kb|SRPK1_H 479 EyTRdEDHIALIIELLG---KVPRKLIVAGKYSKeFFtkkgdlkhitklk 525 ............r.lpnlseeakdLikkcLnkDPskRltaeeilqHPwf< + + + ++ + + + d++ +L++ P+kR ta+e+l HPw+ kb|SRPK1_H 526 pwglfevlvekyEwSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL 574 -* kb|SRPK1_H - - // Query sequence: kb|SRM_Hsap|TK/Src/SRM|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 465.8 1.2e-140 1 Pkinase Protein kinase domain 149.8 1.7e-45 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 251 [] 1 272 [] 465.8 1.2e-140 Pkinase 1/1 1 251 [] 1 287 [] 149.8 1.7e-45 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 251: score 465.8, E = 1.2e-140 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + lg+kLGeG FGeV++G + + ++VA+K++k + kb|SRM_Hsa 1 FALGRKLGEGYFGEVWEGLWL-----GSLPVAIKVIKS-ANMKL--- 38 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL d+ +E++++k l +H+ ++rL++vc+ geP +yiVtE+m +G+L kb|SRM_Hsa 39 -TDLAKEIQTLKGL-RHERLIRLHAVCSG-GEP----VYIVTELMRKGNL 81 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs fL ++ egr+L l+ Ll+fa Q+A+GM+YLe+++ vHRDLAARN+LV+ kb|SRM_Hsa 82 QAFLGTP-EGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVD 130 enlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkFtskS ++l +K++DFGLaR++ +dd Y ++++k+PvkW+APE+ +y++F+ kS kb|SRM_Hsa 131 DGLACKVADFGLARLL-KDDIY-SPSSSSKIPVKWTAPEAANYRVFSQKS 178 DVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPdel DVWSFGVlL E+ft+G+ P Y+gm+n+e+l+++ ++GyRLprP CP+e+ kb|SRM_Hsa 179 DVWSFGVLLHEVFTYGQCP-YEGMTNHETLQQI-MRGYRLPRPAACPAEV 226 YdlMlqCWaedPedRPtFselveeL<-* Y lMl+CW+ Pe+RP+F+ l+e+L kb|SRM_Hsa 227 YVLMLECWRSSPEERPSFATLREKL 251 Pkinase: domain 1 of 1, from 1 to 251: score 149.8, E = 1.7e-45 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + l++klG+G fG+V+++ + g+ VA+K+ik + k + kb|SRM_Hsa 1 FALGRKLGEGYFGEVWEGLWLGS-LPVAIKVIKSANMKLTDLAK--- 43 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse Eiq lk L+H+ +rl+ v+ + +y+V+E++++G L ++l kb|SRM_Hsa 44 --EIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKG----NLQAFLG- 86 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv t ++++l + +a Q+++g+ YL +++++HRDL N+L+d+ kb|SRM_Hsa 87 TPEGRAL--RLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLA 134 vdaflKiaDFGlAkkls...t.sss.lttfvGTpwYmAPEvllggngygt + K+aDFGlA++l+++ +++ss+ + +v + APE + ++ ++ kb|SRM_Hsa 135 C----KVADFGLARLLKddiYsPSSsSKIPV---KWTAPEAAN-YRVFSQ 176 kvDvWSlGvilyellt.GkpPFsgevqdsldqlqlirkilgpplefdspe k+DvWS+Gv+l+e++t G+ P+ g + + +++i++ ++ ++p kb|SRM_Hsa 177 KSDVWSFGVLLHEVFTyGQCPYEGM-----TNHETLQQIMR-GYRLPRPA 220 wdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* ++ e L+ c++ P++R++++ + + + kb|SRM_Hsa 221 ACP-------------AEVYVLMLECWRSSPEERPSFATLREK--L 251 // Query sequence: kb|SRC_Hsap|TK/Src/SrcA|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 496.5 7.1e-150 1 Pkinase Protein kinase domain 166.8 1.3e-50 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 249 [] 1 272 [] 496.5 7.1e-150 Pkinase 1/1 1 249 [] 1 287 [] 166.8 1.3e-50 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 249: score 496.5, E = 7.1e-150 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie l+l kLG+G+FGeV++Gt++ +++ VA+KtLk+ g++++ kb|SRC_Hsa 1 LRLEVKLGQGCFGEVWMGTWN-----GTTRVAIKTLKP-GTMSP--- 38 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL e+Fl+EA++Mkkl +H+++V+L++v++ +eP +yiVtEym +G+L kb|SRC_Hsa 39 -EAFLQEAQVMKKL-RHEKLVQLYAVVS--EEP----IYIVTEYMSKGSL 80 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs ldfL+ g+ L l++L+++a+QiA+GM+Y e++n+vHRDL+A N+LV+ kb|SRC_Hsa 81 LDFLKGE-TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 129 enlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkFtskS enlv+K++DFGLaR+i +d +Y ++r+g+k+P+kW+APE+ yg+Ft+kS kb|SRC_Hsa 130 ENLVCKVADFGLARLI-EDNEY-TARQGAKFPIKWTAPEAALYGRFTIKS 177 DVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPdel DVWSFG+lL E+ t G+ P Ypgm n evl+++ e+GyR+p+P+ CP+ l kb|SRC_Hsa 178 DVWSFGILLTELTTKGRVP-YPGMVNREVLDQV-ERGYRMPCPPECPESL 225 YdlMlqCWaedPedRPtFselveeL<-* +dlM+qCW+++Pe+RPtF++l+ + kb|SRC_Hsa 226 HDLMCQCWRKEPEERPTFEYLQAF- 249 Pkinase: domain 1 of 1, from 1 to 249: score 166.8, E = 1.3e-50 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ++l+ klG+G fG+V+ +++ gt + VA+K++k + +++ + kb|SRC_Hsa 1 LRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQ--- 43 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+q++k+L+H+ v+l+ v+ ++ +y+V+Ey+ +G +L d+l+ kb|SRC_Hsa 44 --EAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKG----SLLDFLK- 85 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv + ++ l ++ ++a Qi++g++Y +++ +HRDL +NIL+ +n v kb|SRC_Hsa 86 GETGKYL--RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLV 133 vdaflKiaDFGlAkklst.ssslttfvGTpw...YmAPEvllggngygtk + K+aDFGlA++ ++ +++t + G ++ ++ APE l + + k kb|SRC_Hsa 134 C----KVADFGLARL--IeDNEYTARQGAKFpikWTAPEAAL-YGRFTIK 176 vDvWSlGvilyellt.GkpPFsgevqdsldqlqlirkilgpplefdspew +DvWS+G++l el t+G+ P++g ++ +l + +g ++ ++p + kb|SRC_Hsa 177 SDVWSFGILLTELTTkGRVPYPGM----VNREVLDQVERG--YRMPCPPE 220 dsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* ++ e++ dL++ c++k P++R+t e lq f kb|SRC_Hsa 221 CP-------------ESLHDLMCQCWRKEPEERPT-FEYLQA--F 249 // Query sequence: kb|SPEG_Hsap|CAMK/Trio|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 200.4 9.1e-61 1 Pkinase_Tyr Protein tyrosine kinase -70.3 9.1e-12 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 236 [. 1 272 [] -70.3 9.1e-12 Pkinase 1/1 1 254 [] 1 287 [] 200.4 9.1e-61 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 236: score -70.3, E = 9.1e-12 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + +++G+GaF + + + + +++ A K ++ +a ++ kb|SPEG_Hs 1 YDIHQEIGRGAFSYLRRIVER----SSGLEFAAKFIPS-QAKPK--- 39 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL ++ rEA+++ +l +H+ ++ ++ + + ++ l iVtE++ L kb|SPEG_Hs 40 -ASARREARLLARL-QHDCVLYFHEAFER-RRG----LVIVTELCTE-EL 81 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs l+ + ++ ++ +++ +++Q+ +G YL++ + H D+ N LV kb|SPEG_Hs 82 LERIAR---KPTVCESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVW 128 e....nlvVKIsDFGLaRdi.ysddyYvrkrgggklPvkWmAPEslkygk ++ ++ +V+I+DFG a ++ + Y + g APE + + kb|SPEG_Hs 129 DgaagEQQVRICDFGNAQELtPGEPQY-CQYG----TPEFVAPEIVNQSP 173 FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPen + +D+W GV+ + +t G +P + g + +l + ++y + e kb|SPEG_Hs 174 VSGVTDIWPVGVVAFLCLT-GISP-FVGENDRTTLMNI--RNYNVAFEE- 218 CPdelYdlMlqCWaedPedRPtFselveeL<-* + e R l+ L kb|SPEG_Hs 219 ---------TTFLSLSREAR---GFLIKVL 236 Pkinase: domain 1 of 1, from 1 to 254: score 200.4, E = 9.1e-61 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y +++ +G+G+f+ ++ +++++g ++A K i+ + + + +arr kb|SPEG_Hs 1 YDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPK---ASARR 44 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+++l+rL+H++++ ++++fe+++ l +V+E+c +L +++ kb|SPEG_Hs 45 --EARLLARLQHDCVLYFHEAFERRRGLVIVTELCTE-----ELLERIA- 86 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv rk ++ e e++ +++Q+l+g+ YLH+ ++H D+KPeN+L+ +g kb|SPEG_Hs 87 --RKPTV--CESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVW-DGA 131 vda.flKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv +++ ++i+DFG A ++++++ + GTp+++APE+++ +++ + kb|SPEG_Hs 132 AGEqQVRICDFGNAQE--LtPGEpQYCQYGTPEFVAPEIVN-QSPVSGVT 178 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+W +Gv+ + ltG PF ge +++ + +i+ + f++ + s kb|SPEG_Hs 179 DIWPVGVVAFLCLTGISPFVGE-----NDRTTLMNIRNYNVAFEETTFLS 223 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* s +ea+ ++ k L +D R+taee l+HPwf kb|SPEG_Hs 224 LS-----------REARGFLIKVLVQDR-LRPTAEETLEHPWF 254 // Query sequence: kb|SPEG~b_Hsap|CAMK/Trio|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 228.0 4.5e-69 1 Pkinase_Tyr Protein tyrosine kinase -29.5 2.9e-14 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 253 [] 1 272 [] -29.5 2.9e-14 Pkinase 1/1 1 253 [] 1 287 [] 228.0 4.5e-69 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 253: score -29.5, E = 2.9e-14 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie +++++ +G FG+V ++ + t+ + K++ + +a e kb|SPEG~b_ 1 YTFLEEKARGRFGVVRACREN----ATGRTFVAKIV-P-YAAEG--- 38 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL ++ l+E +++++l +H+ i +L+ + + + l ++ E + + L kb|SPEG~b_ 39 KRRVLQEYEVLRTL-HHERIMSLHEAYIT-PRY----LVLIAESCGNREL 82 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs l L + + + + d +++Q +G++YL+ ++ H D+ N L++ kb|SPEG~b_ 83 LCGLSD---RFRYSEDDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLA 129 enlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygk.Ftsk ++ KI DFG a y+ r g++ mAPE + g++ s+ kb|SPEG~b_ 130 PDNALKIVDFGSAQP-YNPQAL-RPLGHRTGTLEFMAPE-MVKGEpIGSA 176 SDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLpr...PenC +D+W GVl + +++ G++P +++ +++e+ ++++ G+R ++ + +n+ kb|SPEG~b_ 177 TDIWGAGVLTYIMLS-GRSP-FYEPDPQETEARIV--GGRFDAfqlYPNT 222 PdelYdlMlqCWaedPedRPtFsel..veeL<-* ++ +++ P RP+ +++ + L kb|SPEG~b_ 223 SQSATLFLRKVLSVHPWSRPSLQDClaHPWL 253 Pkinase: domain 1 of 1, from 1 to 253: score 228.0, E = 4.5e-69 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y++le +G fG+V+ +++ tg++++ Ki+++ e + ++++ kb|SPEG~b_ 1 YTFLEEKARGRFGVVRACRENATGRTFVAKIVPYAAEGK----RRVL 43 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse + E ++l+ L+H+ I l++++ ++++l l+ E c++ +L ls kb|SPEG~b_ 44 Q-EYEVLRTLHHERIMSLHEAYITPRYLVLIAESCGNR----ELLCGLS- 87 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++ ++ sed++ ++ Q+l+gl+YLH + ++H D+KP+N+Ll ++ kb|SPEG~b_ 88 --DRFRY--SEDDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAPDNA 133 vdaflKiaDFGlAkkls...t.sss.lttfvGTpwYmAPEvllggngygt + Ki DFG+A ++ + + ++l +++GT+++mAPE ++ g+++g+ kb|SPEG~b_ 134 L----KIVDFGSA---QpynPqALRpLGHRTGTLEFMAPEMVK-GEPIGS 175 kvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspew + D+W++Gv+ y++l+G+ PF++ d+++ ++i g++++ ++ kb|SPEG~b_ 176 ATDIWGAGVLTYIMLSGRSPFYEP-----DPQETEARIVGGRFDAFQLYP 220 dsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* n+s++a +++k L + P +R++ +++l HPw+ kb|SPEG~b_ 221 ------------NTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL 253 // Query sequence: kb|SNRK_Hsap|CAMK/CAMKL/SNRK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 330.4 6.8e-100 1 Pkinase_Tyr Protein tyrosine kinase 71.1 7.8e-22 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 254 [] 1 272 [] 71.1 7.8e-22 Pkinase 1/1 1 254 [] 1 287 [] 330.4 6.8e-100 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 254: score 71.1, E = 7.8e-22 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei l+k+LG+G+F +V +++ t+ kVAVK+++k + + + kb|SNRK_Hs 1 YDLDKTLGRGHFAVVKLARHV----FTGEKVAVKVIdKT-KLDTLA- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd +++E++ Mk +HpNiVrL+ v+ + ly+++E+ gGd kb|SNRK_Hs 42 -TGHLFQEVRCMKLV-QHPNIVRLYEVIDT-QTK----LYLILELGDGGD 84 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV + d+ kh ++ L+ ++ +Qi + +Y + + vHRDL N+ kb|SNRK_Hs 85 MFDYIMKH--EEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVF 132 senl.vVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkFt. e+ + VK +DFG + ++ +++ APE l ++ kb|SNRK_Hs 133 FEKQgLVKLTDFGFSNKFQPGKKL-TTSC---GSLAYSAPEILLGDEYDa 178 skSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyed.GyRLprPenC + D+WS GV L+ ++ G++P +++ ++e+l ++ +d y p kb|SNRK_Hs 179 PAVDIWSLGVILFMLVC-GQPP-FQEANDSETLTMI-MDcKYTVPSHV-- 223 PdelYdlMlqCWaedPedRPtFsel..veeL<-* ++e dl+++ ++dP++R + +e++++ L kb|SNRK_Hs 224 SKECKDLITRMLQRDPKRRASLEEIenHPWL 254 Pkinase: domain 1 of 1, from 1 to 254: score 330.4, E = 6.8e-100 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y l ++lG+G f++V++a+h+ tg++VAvK+i+k k + +++ kb|SNRK_Hs 1 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQ 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E++ +k ++HpNIvrl++v + ++lyl+lE+ +gG d fdy++ kb|SNRK_Hs 48 --EVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGG----DMFDYIM- 90 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv + + +l ed akk++ Qi+ ++ Y+H+ ++HRDLKPeN+ + ++ kb|SNRK_Hs 91 -KHEEGL--NEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQG 137 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD + +K++DFG++ k +++ +ltt +G++ Y APE+llg++++ ++vD kb|SNRK_Hs 138 L---VKLTDFGFSNK--FqPGKkLTTSCGSLAYSAPEILLGDEYDAPAVD 182 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi +WSlGvil+ l++G+pPF+++ ++ + + +i+ +++ +s + kb|SNRK_Hs 183 IWSLGVILFMLVCGQPPFQEA-----NDSETLTMIMDCKYTVPSHVS--- 224 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +e+kdLi+++L++DP++R + eei +HPw+ kb|SNRK_Hs 225 ------------KECKDLITRMLQRDPKRRASLEEIENHPWL 254 // Query sequence: kb|smMLCK_Hsap|CAMK/MLCK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 353.9 5.8e-107 1 Pkinase_Tyr Protein tyrosine kinase 15.7 5e-17 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 254 [. 1 272 [] 15.7 5e-17 Pkinase 1/1 1 256 [] 1 287 [] 353.9 5.8e-107 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 254: score 15.7, E = 5e-17 *->lklgkkLGeGaFGeVykGtlkgsgdgteikV.AVKtLkeigaseeei + + LG+G FG V++ + k ++ kV A K k ++ e kb|smMLCK_ 1 YDIEERLGSGKFGQVFRLVEK-----KTRKVwAGKFFKA-YSAKE-- 39 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd +e +E+siM l +Hp++V++ + + + + +V+E + gG kb|smMLCK_ 40 -KENIRQEISIMNCL-HHPKLVQCVDAFEE-KAN----IVMVLEIVSGGE 82 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL. L + + + Lt + +++++Qi++G eY + +++vH DL N++ kb|smMLCK_ 83 LFERIIDE--DFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMc 130 Vsenl.vVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkF V+++++ +K DFGLaR +++ + ++ g++++ APE+++y kb|smMLCK_ 131 VNKTGtRIKLIDFGLARRLENAGSL-KVLFGTPeF----VAPEVINYEPI 175 tskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyed...GyRLprP ++D WS GV ++ +++ G +P + g ++e+l+ + + + + ++ kb|smMLCK_ 176 GYATDMWSIGVICYILVS-GLSP-FMGDNDNETLANV-TSatwDFDDEAF 222 enCPdelYdlMlqCWaedPedRPtFselveeL<-* + +d+ d + ++d ++R ++++++ kb|smMLCK_ 223 DEISDDAKDFISNLLKKDMKNRLDCTQCLQHP 254 Pkinase: domain 1 of 1, from 1 to 256: score 353.9, E = 5.8e-107 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y ++e+lGsG fG+V++ ++k+t+k++A K +k ++k+k++++ kb|smMLCK_ 1 YDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQ-- 45 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse Ei+i++ L+Hp v++ d+fe+k ++ +VlE + gG +Lf+++ kb|smMLCK_ 46 --EISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGG----ELFERII- 88 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld.nng +++ l +e+e++k+++Qi +g+eY+H++gi+H DLKPeNI++++++g kb|smMLCK_ 89 -DEDFEL--TERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVnKTG 135 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv + +K++DFGlA+ +++ ++l+++ GTp+++APEv++ ++++g++ kb|smMLCK_ 136 TR---IKLIDFGLARR--LeNAGsLKVLFGTPEFVAPEVIN-YEPIGYAT 179 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+WS+Gvi+y+l++G PF g+ ++++ ++++ ++ ++fd + d+ kb|smMLCK_ 180 DMWSIGVICYILVSGLSPFMGD-----NDNETLANVTSATWDFDDEAFDE 224 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* is ++akd+i+++L+kD++ Rl ++++lqHPw+ kb|smMLCK_ 225 IS-----------DDAKDFISNLLKKDMKNRLDCTQCLQHPWL 256 // Query sequence: kb|SMG1_Hsap|Atypical/PIKK/SMG1|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase -244.0 0.35 1 Pkinase Protein kinase domain -195.6 1.1 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 66 276 .. 1 287 [] -195.6 1.1 Pkinase_Tyr 1/1 151 290 .. 1 272 [] -244.0 0.35 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 66 to 276: score -195.6, E = 1.1 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++ ++++ g i +++++ + + ++r+ kb|SMG1_Hs 66 -----------YSVTPLGTRSGL-------IQWVDGATPLFGLYKRW 94 l.sEiqilkrLsHpNIvrlidvfed.........kdhlylVlEycegGLr +++E+++ + d+++++++++ +++++ly y G kb|SMG1_Hs 95 QqREAALQAQK-------AQDSYQTpqnpgivprPSELY----YSKIG-- 131 vldLfdylse......trrkgpllfsedeakkialQilrgleYLHsngii ++ + + + +++ + ++ k ++ ++ ++ kb|SMG1_Hs 132 --PAL----KtvglslDVSRRDW--PLHVMKAVLEELMEA---------- 163 HRDLKPeNILldnngvvdaflKiaDFGlAkkls...............t. +++ lAk l ++ +++++ + ++++ kb|SMG1_Hs 164 ------------TPPNL----------LAKELWsscttpdewwrvtqsYa 191 sss.lttfvGTpwYmAPEvllggngygtkvDvWSlGvilyelltGkpPFs +s+ ++ vG + g g+ + +l+ + tG+ kb|SMG1_Hs 192 RSTaVMSMVG--------YII-GLGDRHLD------NVLIDMTTGEVV-- 224 gevqdsldqlqlirkilgpplefdspewdsisrsefrrlpnlseeakdLi + d +++++k ++ ++++ p + + i kb|SMG1_Hs 225 HI-----DYNVCFEKGKSLRVPEKVP-----------------FRMTQNI 252 kkcLnkDPsk...RltaeeilqHPwf<-* + L + ++ Rl++e++l+ + kb|SMG1_Hs 253 ETALGVTGVEgvfRLSCEQVLHI--M 276 Pkinase_Tyr: domain 1 of 1, from 151 to 290: score -244.0, E = 0.35 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei +V+k++l +++ t K L ++++e kb|SMG1_Hs 151 -------------HVMKAVLEELMEATPPNLLAKELwSS-CTTPDEW 183 .e.redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymeg ++ r ++M+ G ++ g+ kb|SMG1_Hs 184 wRvTQSYARSTAVMSMV----------GYIIGLGDR-------------- 209 GdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNc L++ L + t+ + +++ + ++ kb|SMG1_Hs 210 -HLDNVLIDM------TTGEVVHIDYNVCF-------------------- 232 LVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkFt k+++ ++P kb|SMG1_Hs 233 --------------------------EKGKSLRVP--------------- 241 skSDVWSFGVlLWEiftlGeqPFYpgm.sneevlellyedGyRLprPenC + PF m+ n e+ + + r kb|SMG1_Hs 242 ------------------EKVPF--RMtQNIETALGV-TGVEGVFRLS-- 268 PdelYdlMlqCWaedPedRPtFselveeL<-* + + ++M++ R t l+e + kb|SMG1_Hs 269 CEQVLHIMRR-------GRETLLTLLEAF 290 // Query sequence: kb|Slob_Hsap|Other/Slob|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain -88.9 6e-07 1 Pkinase_Tyr Protein tyrosine kinase -175.0 2.3e-05 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 1 248 [] 1 287 [] -88.9 6e-07 Pkinase_Tyr 1/1 28 248 .] 1 272 [] -175.0 2.3e-05 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 1 to 248: score -88.9, E = 6e-07 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr e l+ +G ++ k + +Ki + +ke+ + kb|Slob_Hs 1 VEPLKDIG-----------WRIRKKYFLMKIKNQPKERLVLS----W 32 l..............sEiqilkrLsHpNI..vrlidvfedkdhly.lVlE ++ ++++ ++++ + i++l ++ Hp+I +v++ + e++ l ++ E kb|Slob_Hs 33 AdlgpdkylsdkdfqCLIKLLPSCLHPYIyrVTFATANESSALLIrMFNE 82 ycegGLrvldLfdyls.....e........trrkgpllfsedeakkialQ L+d++ + +++++ ++ + ++ +l + +++k + +Q kb|Slob_Hs 83 KG-------TLKDLIYkakpkDpflkkycnPKKIQGL--ELQQIKTYGRQ 123 ilrgleYLHsngiiHRDLKPeNILldnngvvdaflKiaDFGlAkklst.s il+ l++LH++g+ + L +N++ld +++ ++ D + ++ kb|Slob_Hs 124 ILEVLKFLHDKGFPYGHLHASNVMLD-GDTC----RLLDLENSL---LgL 165 ss.lttfvGTpwYmAPEvllggngygtkvDvWSlGvilyelltGkpPFsg s + ++ + +vDv +G +lye+ G+pP s kb|Slob_Hs 166 PSfYRSYFS--------QFR-KINTLESVDVHCFGHLLYEMTYGRPPDSV 206 ev.q.ds.ldqlqlirkilgpplefdspewdsisrsefrrlpnlseeakd v++ ++ ++ ++ ++ ++ kb|Slob_Hs 207 PVdSfPPaPSMAVVAVLEST-------------------------LSCEA 231 LikkcLnkDPskRltaeeilqHPwf<-* +k+ +t+ +lq P f kb|Slob_Hs 232 ------CKNGM--PTISRLLQMPLF 248 Pkinase_Tyr: domain 1 of 1, from 28 to 248: score -175.0, E = 2.3e-05 *->lklg.kkLGeGaFGeVykGtlkg..sgdgteikVAVKtLkeigasee l+l LG +++ ++++ ++ +K L+ kb|Slob_Hs 28 LVLSwADLG-------------PdkYLSDKDFQCLIKLLPS------ 55 eieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymeg + Hp i r + t ++ + +++ + e+ kb|Slob_Hs 56 -----------------CLHPYIYR-VTFATANESS----ALLIRMFNEK 83 GdLldfLrkhr.............egrpLtlkdLlsfalQiAkGMeYLes G L+d k +++++ ++ +++ + L l+++ + +Qi + + +L++ kb|Slob_Hs 84 GTLKDLIYKAKpkdpflkkycnpkKIQGLELQQIKTYGRQILEVLKFLHD 133 knfvHRDLAARNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPv k+f L A N++++ + ++ R++ + +lP kb|Slob_Hs 134 KGFPYGHLHASNVMLD-GDTC--------RLL-------DLENSLLgLPS 167 kWmAPEslkygkFtskS.DVWSFGVlLWEiftlGeqP.......FYpgms + + s + ++ t +S DV FG lL+E +t+G++P++ + ++F p + kb|Slob_Hs 168 FYRSYFSQFRKINTLESvDVHCFGHLLYE-MTYGRPPdsvpvdsF-PPAP 215 neevlellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFselveeL v++ l e+ ++ +n + + +l+++ + kb|Slob_Hs 216 SMAVVAVL-ESTLSCEACKNGMPTISRLLQM----------------PLF 248 <-* kb|Slob_Hs - - // Query sequence: kb|SLK_Hsap|STE/STE20/SLK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 316.7 9.2e-96 1 Pkinase_Tyr Protein tyrosine kinase 106.6 1.6e-32 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 259 [] 1 272 [] 106.6 1.6e-32 Pkinase 1/1 1 259 [] 1 287 [] 316.7 9.2e-96 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 259: score 106.6, E = 1.6e-32 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie +++ +LG GaFG+Vyk+ k +t + A K++ + + seee kb|SLK_Hsa 1 WEIIGELGDGAFGKVYKAQNK----ETSVLAAAKVI-D-TKSEEE-- 39 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL +ed + E+ i+ + dHpNiV+Ll + + + l+i E+++gG kb|SLK_Hsa 40 LEDYMVEIDILASC-DHPNIVKLLDAFYY-ENN----LWILIEFCAGGAV 83 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs + + + +rpLt +++ + Q ++++YL++++++HRDL A N+L + kb|SLK_Hsa 84 DAVMLEL--ERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT 131 enlvVKIsDFGLaRdiysddyY.vrkrgggk.lPvkWmAPEslkygk... ++ +K +DFG + ++ +r ++ WmAPE+ + +++ kb|SLK_Hsa 132 LDGDIKLADFGVSAKN-----TrTIQRRDSFiGTPYWMAPEVVMCETskd 176 ..FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyR.Lpr +++ k DVWS G++L E+ e+P ++ + +vl +++++ +L++ kb|SLK_Hsa 177 rpYDYKADVWSLGITLIEMAE-IEPP-HHELNPMRVLLKIAKSEPPtLAQ 224 PenCPdelYdlMlqCWaedPedRPtFsel..veeL<-* P + d +++C +++ + R t s+l ++ + kb|SLK_Hsa 225 PSRWSSNFKDFLKKCLEKNVDARWTTSQLlqHPFV 259 Pkinase: domain 1 of 1, from 1 to 259: score 316.7, E = 9.2e-96 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +e+++ lG G+fG+Vyka++k t+ + A K+i+ ++e++ +d+ kb|SLK_Hsa 1 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-- 45 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse Ei il++++HpNIv+l+d+f+++++l++ E+c gG +++ kb|SLK_Hsa 46 --EIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGG----AVDAVML- 88 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv + ++pl +e +++ +++Q+l +l+YLH+n+iiHRDLK NIL+ +g+ kb|SLK_Hsa 89 -ELERPL--TESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGD 135 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvll....ggngyg + K+aDFG+++k t+ ++ ++f GTp++mAPEv++ +++++++y+ kb|SLK_Hsa 136 I----KLADFGVSAKN-TrTIQrRDSFIGTPYWMAPEVVMcetsKDRPYD 180 tkvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdsp +k+DvWSlG++l+e++ +pP + ++ + l +i+k +p l +s kb|SLK_Hsa 181 YKADVWSLGITLIEMAEIEPPHHEL---NpMRVLLKIAKSEPPTLAQPSR 227 ewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* ++ +++kd++kkcL+k+ R+t ++lqHP++ kb|SLK_Hsa 228 WS---------------SNFKDFLKKCLEKNVDARWTTSQLLQHPFV 259 // Query sequence: kb|skMLCK_Hsap|CAMK/MLCK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 284.8 3.6e-86 1 Pkinase_Tyr Protein tyrosine kinase 31.4 5.5e-18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 256 [] 1 272 [] 31.4 5.5e-18 Pkinase 1/1 1 256 [] 1 287 [] 284.8 3.6e-86 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 256: score 31.4, E = 5.5e-18 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + LG G FG V+ + k t++k A K++k+ ++ + kb|skMLCK_ 1 MNSKEALGGGKFGAVCTCMEK----ATGLKLAAKVIKK-QTPKD--- 39 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL +e l E+++M +l +H N+++L++++ + e + + +Ey egG L kb|skMLCK_ 40 KEMVLLEIEVMNQL-NHRNLIQLYAAIETPHE-----IVLFMEYIEGGEL 83 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs + + + +Lt d f +Qi++G + + ++ H DL N+L kb|skMLCK_ 84 FERIVDE--DYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCV 131 e..nlvVKIsDFGLaRdiysddyYvrkrgggklPv...kWmAPEslkygk +++++ VKI DFGLaR ++ k+ +++ ++PE+ +y kb|skMLCK_ 132 NttGHLVKIIDFGLARRY-------NPNEKLKVNFgtpEFLSPEVVNYDQ 174 FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyR...Lpr + k+D WS GV + +++ G +P + g +++e+l+ + +G+ + + kb|skMLCK_ 175 ISDKTDMWSMGVITYMLLS-GLSP-FLGDDDTETLNNV-LSGNWyfdEET 221 PenCPdelYdlMlqCWaedPedRPtFsel..veeL<-* e +de d +d R +++ + L kb|skMLCK_ 222 FEAVSDEAKDFVSNLIVKDQRARMNAAQClaHPWL 256 Pkinase: domain 1 of 1, from 1 to 256: score 284.8, E = 3.6e-86 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +e lG G fG V+ +++k tg + A K+ikk++ k+k+ + kb|skMLCK_ 1 MNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLL-- 45 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse Ei++++ L+H N ++l+ + e++ ++ l +Ey egG +Lf+++ kb|skMLCK_ 46 --EIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGG----ELFERIV- 88 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld.nng +++ l +e + +++Qi+ g+ ++H+++++H DLKPeNIL+++ +g kb|skMLCK_ 89 -DEDYHL--TEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVnTTG 135 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv ++ +Ki+DFGlA+ ++++++l++ GTp++++PEv++ + ++ k kb|skMLCK_ 136 HL---VKIIDFGLARR--YnPNEkLKVNFGTPEFLSPEVVN-YDQISDKT 179 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+WS+Gvi y ll+G PF g+ d+ + + ++l++ + fd+++ kb|skMLCK_ 180 DMWSMGVITYMLLSGLSPFLGD-----DDTETLNNVLSGNWYFDEETFEA 224 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +s +eakd++++++ kD R +a+++l HPw+ kb|skMLCK_ 225 VS-----------DEAKDFVSNLIVKDQRARMNAAQCLAHPWL 256 // Query sequence: kb|SIK_Hsap|CAMK/CAMKL/QIK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 354.9 2.8e-107 1 Pkinase_Tyr Protein tyrosine kinase 97.4 9.8e-30 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 250 [. 1 272 [] 97.4 9.8e-30 Pkinase 1/1 1 252 [] 1 287 [] 354.9 2.8e-107 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 250: score 97.4, E = 9.8e-30 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei + ++LG+G+F +V +++ + t+++VA+K+++k ++++ kb|SIK_Hsa 1 YDIERTLGKGNFAVVKLARHR----VTKTQVAIKIIdKT-RLDSSN- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd +e+ rE+++Mk l +Hp+i++L+ v ++ lyiVtE++++G kb|SIK_Hsa 42 -LEKIYREVQLMKLL-NHPHIIKLYQVMET-KDM----LYIVTEFAKNGE 84 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV + d+L + +++L+ + + +Qi ++ eY +++++vHRDL + N L+ kb|SIK_Hsa 85 MFDYLTS---NGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLL 131 senlvVKIsDFGLaRdiysddyYvrkrgggklPv.......kWmAPEslk + n+ +K +DFG +k+g P ++ +++ APE++ kb|SIK_Hsa 132 DGNMDIKLADFGFGNF--------YKSG---EPLstwcgspPYAAPEVFE 170 ygkF.tskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLp ++++ + D+WS GV+L+ ++ G P + g + +++ e + R p kb|SIK_Hsa 171 GKEYeGPQLDIWSLGVVLYVLVC-GSLP-FDGPNLPTLRQRVLEGRFRIP 218 rPenCPdelYdlMlqCWaedPedRPtFselveeL<-* + +++ +l+++ dP++R t ++++++ kb|SIK_Hsa 219 FFM--SQDCESLIRRMLVVDPARRITIAQIRQHR 250 Pkinase: domain 1 of 1, from 1 to 252: score 354.9, E = 2.8e-107 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y ++++lG+G+f++V++a+h+ t +VA+Kii+k + +s+ ++ r kb|SIK_Hsa 1 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYR 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+q++k L+Hp+I++l+ v+e+kd ly+V+E++ +G + fdyl+ kb|SIK_Hsa 48 --EVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNG----EMFDYLT- 90 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++g l se+ea+k ++Qil+++eY+H++ i+HRDLK eN+Lld n++ kb|SIK_Hsa 91 --SNGHL--SENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMD 136 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD + K+aDFG+ + ++s+++l+t +G+p+Y+APEv g ++ g+ D kb|SIK_Hsa 137 I----KLADFGFGNF--YkSGEpLSTWCGSPPYAAPEVFEGKEYEGPQLD 180 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi +WSlGv+ly l++G +PF+g + l +++l+++++++++ + kb|SIK_Hsa 181 IWSLGVVLYVLVCGSLPFDGP-----NLPTLRQRVLEGRFRIPFFMS--- 222 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +++ +Li+++L +DP++R+t+++i qH w+ kb|SIK_Hsa 223 ------------QDCESLIRRMLVVDPARRITIAQIRQHRWM 252 // Query sequence: kb|SgK496_Hsap|Other/SgK496|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 132.3 3e-40 1 Pkinase_Tyr Protein tyrosine kinase 79.7 2e-24 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 2 259 .. 1 287 [] 132.3 3e-40 Pkinase_Tyr 1/1 3 256 .. 1 272 [] 79.7 2e-24 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 2 to 259: score 132.3, E = 3e-40 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +l++ lG+G +G+Vy++ + g A+K + ++ek++ d ++ kb|SgK496_ 2 PKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLAL-- 46 lsEiqilkrL.sHpNIvrlidvfed.......kdhlylVlEycegGLrvl E +++++L++H+ v l++++ d + +++++ + l++E + + kb|SgK496_ 47 --EFHYMRSLpKHERLVDLHGSVIDynygggsSIAVLLIMERL-HR---- 89 dLfdylsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeN dL++ l+ +l + ++ ial +++g+ +LHs+g +HRD+K+ N kb|SgK496_ 90 DLYTGLK-----AGL--TLETRLQIALDVVEGIRFLHSQGLVHRDIKLKN 132 ILldnngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllgg +Lld+++ Ki+D G++ + ++vGTp mAPE+ + kb|SgK496_ 133 VLLDKQNRA----KITDLGFC----KpEAMmSGSIVGTPIHMAPEL--FT 172 ngygtkvDvWSlGvilyelltGk....pPFsgevqds.ldqlqlirkilg +y+ +vDv+++G+++++ ++G + + F + + d+l+ ++++ kb|SgK496_ 173 GKYDNSVDVYAFGILFWYICSGSvklpEAFERC---AsKDHLWNNVRRGA 219 pplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlt...ae +p + + + +ee+ +L++ c++ DP kR+ + + kb|SgK496_ 220 RPERLPVF----------------DEECWQLMEACWDGDPLKRPLlgiVQ 253 eilqHPwf<-* lq + kb|SgK496_ 254 PMLQG--I 259 Pkinase_Tyr: domain 1 of 1, from 3 to 256: score 79.7, E = 2e-24 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie klg++LG+G++G+Vy++ g++ ++A K++ + +e++ kb|SgK496_ 3 -KLGQELGRGQYGVVYLCDNW----GGHFPCALKSV--VPPDEKH-- 40 redFlrEAsiMkklGdHpNiVrLlGvct.......kegePggpglyiVtE + d+ E M++l++H+ +V L+G +++ + +++ + +++++E kb|SgK496_ 41 WNDLALEFHYMRSLPKHERLVDLHGSVIdynygggS-SIA----VLLIME 85 ymegGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLA + dL++ L++ Ltl++ l++al++ +G +L+s+++vHRD+ kb|SgK496_ 86 RLHR-DLYTGLKAG-----LTLETRLQIALDVVEGIRFLHSQGLVHRDIK 129 ARNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggk..lPvkWmAPEsl +N+L+++++ +KI+D G ++ + +g+ + P+ mAPE l kb|SgK496_ 130 LKNVLLDKQNRAKITDLGFCKPE-------AMMSGSIvgTPIH-MAPE-L 170 kygkFtskSDVWSFGVlLWEiftlGe.qP..FYpgm.sneevlellyedG ++gk+ DV++FG+l W i++ + P+ F + + s + + + ++G kb|SgK496_ 171 FTGKYDNSVDVYAFGILFWYICSGSVkLPeaF-ERCaSKDHLWNNV-RRG 218 yRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* R +r + +e +lM CW+ dP +RP ++ +L kb|SgK496_ 219 ARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPML 256 // Query sequence: kb|SgK495_Hsap|CAMK/SgK495|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 29.0 4.9e-14 1 Pkinase_Tyr Protein tyrosine kinase -165.2 5.7e-06 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 171 [] 1 272 [] -165.2 5.7e-06 Pkinase 1/1 1 171 [] 1 287 [] 29.0 4.9e-14 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 171: score -165.2, E = 5.7e-06 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + kb|SgK495_ 1 --------------------N-------------------------- 1 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL l +H ++k kb|SgK495_ 2 -------------L-QH--------YVIK--------------------- 8 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs +++L+ + + + +++ + e L++kn+vHRDL N ++ kb|SgK495_ 9 ---------EKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLN 49 e.nlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkFtsk ++++ + I+ F L + + s+++ k + + +P +l+ + + k kb|SgK495_ 50 KrTHRITITNFCLGKHLVSEGDL-LKDQ--RGSPAYISPDVLSGRPYRGK 96 .SDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPd +SD W+ GV+L+ ++ G+ P +++ ++e++ ++ + y p ++ kb|SgK495_ 97 pSDMWALGVVLFTMLY-GQFP-FYDSIPQELFRKIKAAEYTIPEDGRVSE 144 elYdlMlqCWaedPedRPtFselveeL<-* l+++ dP++R ++++e L kb|SgK495_ 145 NTVCLIRKLLVLDPQQRLAAADVLEAL 171 Pkinase: domain 1 of 1, from 1 to 171: score 29.0, E = 4.9e-14 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr kb|SgK495_ - ----------------------------------------------- - lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse L +y+ kb|SgK495_ 1 ------------------------------------------NLQHYVI- 7 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++++l se+e i++ ++r +e LH+++i+HRDLK+ N l+++ + kb|SgK495_ 8 --KEKRL--SERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTH 53 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD + i+ F l k+l + + l++ G+p Y++P vl g+++ g+++D kb|SgK495_ 54 R---ITITNFCLGKHL-VsEGDlLKDQRGSPAYISPDVLSGRPYRGKPSD 99 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi +W+lGv+l+ +l G++PF+++ +++l+rki+ +++ ++++ s kb|SgK495_ 100 MWALGVVLFTMLYGQFPFYDS-----IPQELFRKIKAAEYTIPEDGRVS- 143 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* e+ Li+k+L +DP++Rl a+++l+ + kb|SgK495_ 144 ------------ENTVCLIRKLLVLDPQQRLAAADVLEA--L 171 // Query sequence: kb|SgK494_Hsap|AGC/RSKR|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 203.1 1.5e-61 1 Pkinase_Tyr Protein tyrosine kinase -40.2 1.3e-13 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 248 [. 1 272 [] -40.2 1.3e-13 Pkinase 1/1 1 253 [] 1 287 [] 203.1 1.5e-61 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 248: score -40.2, E = 1.3e-13 *->lklgkkLGeGaFGeVykGtlkgsgdgteikV.AVKtL.keigaseee lk++ +G+FG+V k +l+ t+ V AVK+++k + +++ kb|SgK494_ 1 LKILGLVAKGSFGTVLK-VLD----CTQKAVfAVKVVpKV-KVLQRD 41 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG + +E+si +++ +Hp + +L G + g+ + l+i y+ kb|SgK494_ 42 T-VRQCKEEVSIQRQI-NHPFVHSL-GDSWQ-GKRH---LFIMCSYCST- 83 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL dL++ + + ++ + fa++ + YL++ ++ HRD+ N+L kb|SgK494_ 84 DLYSLWSA---VGCFPEASIRLFAAELVLVLCYLHDLGIMHRDVKMENIL 130 VsenlvVKIsDFGLaRdi.ysddyYvrkrgggklPvkWmAPEslkygkFt ++e ++ K +DFGL+R +++ Y + g mAPE+l+ g ++ kb|SgK494_ 131 LDERGHLKLTDFGLSRHVpQGAQAY-TICG----TLQYMAPEVLSGGPYN 175 skSDVWSFGVlLWEiftlGeqPFYpgm.sneevlellyedGyRLprPenC ++ D WS GVlL+ + t G+ P + ++ +l+ ++ ++ p+ kb|SgK494_ 176 HAADWWSLGVLLFSLAT-GKFP-VAAErDHVAMLASVTHSDSEIPASL-- 221 PdelYdlMlqCWaedPedRPtFselveeL<-* + l l+ + +P +R ++l+++ kb|SgK494_ 222 NQGLSLLLHELLCQNPLHR--LRYLHHFQ 248 Pkinase: domain 1 of 1, from 1 to 253: score 203.1, E = 1.5e-61 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++l+ + +GsfGtV k + ++AvK+++k+k + + kb|SgK494_ 1 LKILGLVAKGSFGTVLKVLDCTQKAVFAVKVVPKVKVLQRDTVRQCK 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E++i + ++Hp++ l d+++ k+hl + yc dL+++ s kb|SgK494_ 48 E-EVSIQRQINHPFVHSLGDSWQGKRHLFIMCSYCST-----DLYSLWS- 90 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv + g++ +e ++ +a +++ l YLH+ gi+HRD+K eNILld++g+ kb|SgK494_ 91 --AVGCF--PEASIRLFAAELVLVLCYLHDLGIMHRDVKMENILLDERGH 136 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD + K++DFGl+++ + + +++t++GT+ YmAPEvl g +y +++D kb|SgK494_ 137 L----KLTDFGLSRH--VpQGAqAYTICGTLQYMAPEVLS-GGPYNHAAD 179 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi +WSlGv+l+ l+tGk+P e +d+ ++++ + + ++++p + + kb|SgK494_ 180 WWSLGVLLFSLATGKFPVAAE----RDHVAMLASVTH--SDSEIPASLN- 222 srsefrrlpnlseeakdLikkcLnkDPskRlt.aeeilqHPwf<-* + + L+ +L+++P Rl ++ HP+f kb|SgK494_ 223 ------------QGLSLLLHELLCQNPLHRLRyLHHFQVHPFF 253 // Query sequence: kb|SgK493_Hsap|Other/SgK493|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase -182.2 6.3e-05 1 Pkinase Protein kinase domain -131.4 0.00021 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 2 227 .. 1 287 [] -131.4 0.00021 Pkinase_Tyr 1/1 28 200 .. 1 272 [] -182.2 6.3e-05 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 2 to 227: score -131.4, E = 0.00021 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr..kekskkdkta + GsG Vy+ + g VA+K ++ ++++ s++++ kb|SgK493_ 2 ----QYMGSGYTKAVYRVRLPGGAA-VALKAVDFSghDLGSCVREFG 43 rrl...........sEiqilkrLsHpNIvrlidvfed.....kdhlylVl +r++ + ++ E +l rL+HpN+++l+++++ ++++ +d l ++ kb|SgK493_ 44 VRRgcyrlaahkllKEMVLLERLRHPNVLQLYGYCYQdsediPDTLTTIT 93 EycegGLrvldLfdylsetrrkgpllfsedeakkialQilrgleYL.Hs. E+ + +l+ s+++ +i+l + r l +L Hs+ kb|SgK493_ 94 ELGAPV----EMIQLLQ-------T--SWEDRFRICLSLGRLLHHLaHSp 130 n.giiHRDLKPeNILldnngvvdaflKiaDFGlAkklst.sss.lttfvG +++ D P + l+ +g++ K++D A+ + + + + + kb|SgK493_ 131 LgSVTLLDFRPRQFVLV-DGEL----KVTDLDDAR---VeETPcAGSTDC 172 TpwYmAPEvllggngygtkvDvWSlGvilyelltGkpPFsgevq.ds.ld +l + + +P+s + + ++ + kb|SgK493_ 173 --------ILE------------------FPARNFTLPCSAQ-GwCEgMN 195 qlqlirkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDP ++ +++ + + f + ++s + P kb|SgK493_ 196 EKRNLYNAYR--FFFTYLLPHSAP-------------------------P 218 skRltaeeilqHPwf<-* s R+ +l + + kb|SgK493_ 219 SLRP----LLDS--I 227 Pkinase_Tyr: domain 1 of 1, from 28 to 200: score -182.2, E = 6.3e-05 *->lklg.kkLGeG..aFGeVykGtlkgsgdgteikVAVKtLkeigasee + + ++ LG+ ++FG V +G ++ a ++ kb|SgK493_ 28 VDFSgHDLGSCvrEFG-VRRGCYR------------------LAAHK 55 eieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpg.lyiVtEyme +l+E+ ++ +l +HpN+++L+G c++++e p++l +tE+ + kb|SgK493_ 56 ------LLKEMVLLERL-RHPNVLQLYGYCYQDSED-IPDtLTTITELGA 97 gGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARN + L++ +d ++l + + +L+ + kb|SgK493_ 98 PVEMIQLLQTS-------WEDRFRICLSLGRLLHHLAHSP---------- 130 cLVse..............nlvVKIsDFGLaRdiysddyYvrkrgggklP +++ + + ++++ ++ K++D aR kb|SgK493_ 131 --LGSvtlldfrprqfvlvDGELKVTDLDDARVE---------------- 162 vkWmAPEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlel e+P +g ++ le+ kb|SgK493_ 163 ----------------------------------ETP-CAGSTDCI-LEF 176 lyedGyRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* ++ Lp+ q W e ++ + L kb|SgK493_ 177 P-ARNFTLPCSA-----------QGWCEGMNE-------KRNL 200 // Query sequence: kb|SgK424_Hsap|Other/NKF5|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase -263.6 1.9 1 Pkinase Protein kinase domain -248.8 2 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 77 [] 1 272 [] -263.6 1.9 Pkinase 1/1 1 77 [] 1 287 [] -248.8 2 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 77: score -263.6, E = 1.9 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie kb|SgK424_ - ----------------------------------------------- - redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL l +c kb|SgK424_ 1 -------------L-----------ICG---------------------- 4 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs + p t++dL sf+ +L+ kb|SgK424_ 5 ---------DMPTTTSDLYSFC------------------------ILIQ 21 enlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkFtskS kb|SgK424_ - -------------------------------------------------- - DVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPdel E+ft Ge P ++g ev+++l e+G+ + + P++ kb|SgK424_ 22 ----------EVFT-GELP-WAGRGGPEVKAKL-EAGESPALEPRVPAPY 58 YdlMlqCWaedPedRPtFselveeL<-* l++ P+dR L kb|SgK424_ 59 QALIRAGLGLAPADR------WGSL 77 Pkinase: domain 1 of 1, from 1 to 77: score -248.8, E = 2 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr kb|SgK424_ - ----------------------------------------------- - lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse kb|SgK424_ - -------------------------------------------------- - trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv L+ + kb|SgK424_ 1 -------------------------------------------LIC-GDM 6 vdaflKiaDFGlAkklstssslttfvGTpwYmAPEvllggngygtkvDvW + +t +D + kb|SgK424_ 7 P------------------------------------------TTTSDLY 14 SlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspewdsis S+ +++ e++tG++P+ g+ ++ +++++ +p le p kb|SgK424_ 15 SFCILIQEVFTGELPWAGR---GgPEVKAKLEAGESPALEPRVP------ 55 rsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* + + Li+ L + P++R++ + + kb|SgK424_ 56 -----------APYQALIRAGLGLAPADRWG------S--L 77 // Query sequence: kb|SgK396_Hsap|Other/Other-Unique|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain -55.9 6.1e-09 1 Pkinase_Tyr Protein tyrosine kinase -187.6 0.00013 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 7 240 .] 1 287 [] -55.9 6.1e-09 Pkinase_Tyr 1/1 22 240 .] 1 272 [] -187.6 0.00013 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 7 to 240: score -55.9, E = 6.1e-09 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + +++l + +g+ ii +++ + ++d kb|SgK396_ 7 LSSKRPL----------VRSEVNGQ-----IILLKGYSVDVDT---- 34 lsEiqilkrLsHpNIvrlidvfed....kdhlylVlEycegGLrvldLfd E+++ r ++++++++ +++++ l l++ ++ + d ++ kb|SgK396_ 35 --EAKVIERA-----ATYHRAWREaegdSGLLPLIFLFLCKS----DPMA 73 yls.....e.....trrkgpllfsedeakkialQilrgleYLHsngiiHR yl+ + ++ + + +++ pl +e k+++ +++gl LH+ iiH kb|SgK396_ 74 YLMvpyypRanlnaVQANMPL--NSEETLKVMKGVAQGLHTLHKADIIHG 121 DLKPeNIL.ldnngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmA L N++ l+++ + ++DF + k + + + vG + m+ kb|SgK396_ 122 SLHQNNVFaLNREQGI-----VGDFDFTKS--VsQRAsVNMMVGDLSLMS 164 PEvllggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirki PE+ + g++ ++ +D +++G++ +++ + q+q ++ + kb|SgK396_ 165 PELKM-GKPASPGSDLYAYGCL--------LLWLSV------QNQEFEIN 199 lgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaee + ++++ d ++ d + k+L+++++++ s tae+ kb|SgK396_ 200 KDGIPKVDQFHLD--------------DKVKSLLCSLICYRSS--MTAEQ 233 ilqHPwf<-* +l+ + f kb|SgK396_ 234 VLNAECF 240 Pkinase_Tyr: domain 1 of 1, from 22 to 240: score -187.6, E = 0.00013 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei ++l+k G+ +++ K++++ + +++ kb|SgK396_ 22 IILLK------------GYSV------DVDTEAKVIeRA-ATYHRA- 48 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd rEA+ + l + L+ + ++P y+ ++y + + kb|SgK396_ 49 -----WREAEGDSGL------LPLIFLFLCKSDPM---AYLMVPYYPRAN 84 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L ++ + pL+ ++ l+ + +A+G+ L+ ++H L kb|SgK396_ 85 LNA-VQA---NMPLNSEETLKVMKGVAQGLHTLHKADIIHGSL------- 123 senlvVKIsDFGLaRdi.ysddyYvrkrgggklPvkWm.......APEsl + n+v F L R + d ++k+ + + v m ++ + +PE l kb|SgK396_ 124 HQNNV-----FALNREQgIVGDFDFTKSVSQRASVNMMvgdlslmSPE-L 167 kygk.FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRL k gk+ + SD +++G+lL + l q + n + + +++ kb|SgK396_ 168 KMGKpASPGSDLYAYGCLL---LWLSVQN-QEFEINKDGIPKVD------ 207 prPenCPdelYdlMlqCWaedPedRPtFsel..veeL<-* d++ +l+++ + ++ t +++ + e++ kb|SgK396_ 208 QFHL--DDKVKSLLCSLICYRSSM--TAEQVlnAECF 240 // Query sequence: kb|SgK307_Hsap|Other/NKF5|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase -40.7 1.4e-13 1 Pkinase Protein kinase domain -45.3 1.4e-09 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 241 [. 1 272 [] -40.7 1.4e-13 Pkinase 1/1 1 240 [. 1 287 [] -45.3 1.4e-09 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 241: score -40.7, E = 1.4e-13 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie ++ + l t ++ + + kb|SgK307_ 1 VTVKEL------------NLP-------------THPH-CSRLRL-- 19 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpg.lyiVtEymegGd + +++E + +kl +Hp +++L++vc+ ++ + +V E G kb|SgK307_ 20 ADLLIAEQEHSSKL-RHPYLLQLMAVCLS-QDL---EkTRLVYERITIGT 64 LldfLrkhr.egrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL L + L+++r++ + L ++ +++ lQi++++ YL+ ++f+HR L + kb|SgK307_ 65 LFSVLHERRsQFPVLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVH 114 VsenlvVKIsDFGLaRdi...ysddyYvrkrgggklPv.....kWmAPEs + +++ ++ L+ + +s+d ++r+ +++P +++ W APE+ kb|SgK307_ 115 IISPGEAR-----LTNLEymlESEDRG-VQRDLTRVPLptqlyNWAAPEV 158 lkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRL + + t+kSD++SF + Ei+t ++P ++g++ + v++ + +G+ L kb|SgK307_ 159 ILQKAATVKSDIYSFSMIMQEILT-DDIP-WKGLDGSVVKKAV-VSGNYL 205 prPenCPdelYdlMlqCWaedPedRPt.FselveeL<-* ++ P++ Yd+ ++ + + +dR + ++++ +L kb|SgK307_ 206 EADVRLPKPYYDIVKSGIHVKQKDRTMnLQDIRYIL 241 Pkinase: domain 1 of 1, from 1 to 240: score -45.3, E = 1.4e-09 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar V vK+++++++ +++ ++ a kb|SgK307_ 1 --------------------------VTVKELNLPtHPHCSRLRLAD 21 rl.sEiqilkrLsHpNIvrlidvfed....kdhlylVlEycegGLrvldL +l E + +L+Hp+ ++l v+ +++ +k++l E G L kb|SgK307_ 22 LLiAEQEHSSKLRHPYLLQLMAVCLSqdleKTRLV--YERITIG----TL 65 fdylsetrrkgpll.fsedeakkialQilrgleYLHsngiiHRDLKPeNI f++l+ +r+ + + ++++ + +lQi +l YLH +g+iHR kb|SgK307_ 66 FSVLH--ERRSQFPvLHMEVIVHLLLQISDALRYLHFQGFIHR------- 106 Lld.nngvvdaflKiaDFGlAkkls...............t.sss.lttf + + + v +i+ G A++ + + ++++++ ++++++ + +t + kb|SgK307_ 107 --SlSSYAV----HIISPGEARLTNleymlesedrgvqrdLtRVPlPTQL 150 vGTpwYmAPEvllggngygtkvDvWSlGvilyelltGkpPFsgevqdsld ++++APEv+l ++ + k+D++S+ i+ e lt P++g d kb|SgK307_ 151 ---YNWAAPEVIL-QKAATVKSDIYSFSMIMQEILTDDIPWKGL-----D 191 qlqlirkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDP ++ + + ++ + + +l+++ d++k+ ++++ kb|SgK307_ 192 GSVVKKAVVSGNYLEADV--------------RLPKPYYDIVKSGIHVKQ 227 skRltaeeilqHPwf<-* ++R + + ++ kb|SgK307_ 228 KDRT--MNLQDIRYI 240 // Query sequence: kb|SGK3_Hsap|AGC/SGK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 307.5 5.3e-93 1 Pkinase_Tyr Protein tyrosine kinase 26.9 1e-17 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 258 [] 1 272 [] 26.9 1e-17 Pkinase 1/1 1 258 [] 1 287 [] 307.5 5.3e-93 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 258: score 26.9, E = 1e-17 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLke.igaseeei + ++k++G+G+FG+V +++ k ++ AVK+L ++i +e kb|SGK3_Hs 1 FDFLKVIGKGSFGKVLLAKRK----LDGKFYAVKVLQKkIVLNRKE- 42 eredFlrEAsi.MkklGdHpNiVrLlGvctkegePggpglyiVtEymegG ++ ++E ++ +k+ +Hp +V L+ e ly V+ ++ gG kb|SGK3_Hs 43 -QKHIMAERNVlLKNV-KHPFLVGLHYSFQT-TEK----LYFVLDFVNGG 85 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL L +L++ +r+++ ++ +a++iA+++ YL+s ++v RDL N+L kb|SGK3_Hs 86 ELFFHLQR---ERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENIL 132 VsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm....APEslkyg +++ ++V +DFGL++ + +++ +++ APE+++ kb|SGK3_Hs 133 LDSVGHVVLTDFGLCKEG-------IAISDTTTTFCGTpeylAPEVIRKQ 175 kFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPe + D W G +L+E++ G +P ++ +++e+++ + + rP kb|SGK3_Hs 176 PYDNTVDWWCLGAVLYEMLY-GLPP-FYCRDVAEMYDNI-LHKPLSLRP- 221 nCPdelYdlMlqCWaedPedRP....tFsel..veeL<-* + + +++ + ++d ++R + ++ F e++++ ++ kb|SGK3_Hs 222 GVSLTAWSILEELLEKDRQNRLgakeDFLEIqnHPFF 258 Pkinase: domain 1 of 1, from 1 to 258: score 307.5, E = 5.3e-93 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + +l+++G+GsfG+V +ak+k +gk +AvK++ k+ k++ ++ kb|SGK3_Hs 1 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIM 47 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls + E +l++ +Hp+ v l+++f++ +ly+Vl++++gG +Lf +l+ kb|SGK3_Hs 48 A-ERNVLLKNvKHPFLVGLHYSFQTTEKLYFVLDFVNGG----ELFFHLQ 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng r++++ +e+ a+++a +i+++l YLHs +i++RDLKPeNILld+ g kb|SGK3_Hs 93 ---RERSF--PEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVG 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv +v ++DFGl+k + s ++ttf+GTp+Y+APEv++ ++y+ v kb|SGK3_Hs 138 HV----VLTDFGLCKEG-IaISDtTTTFCGTPEYLAPEVIR-KQPYDNTV 181 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+W lG +lye+l G pPF+ + d +++++il++pl+ + kb|SGK3_Hs 182 DWWCLGAVLYEMLYGLPPFYCR-----DVAEMYDNILHKPLSLRPGVS-- 224 isrsefrrlpnlseeakdLikkcLnkDPskRlt....aeeilqHPwf<-* +a ++++ +L+kD + Rl+ ++++ ei +HP+f kb|SGK3_Hs 225 -------------LTAWSILEELLEKDRQNRLGakedFLEIQNHPFF 258 // Query sequence: kb|SgK288_Hsap|TKL/RIPK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 122.1 3.5e-37 1 Pkinase_Tyr Protein tyrosine kinase 79.0 3.2e-24 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 2 255 .] 1 272 [] 79.0 3.2e-24 Pkinase 1/1 2 255 .] 1 287 [] 122.1 3.5e-37 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 2 to 255: score 79.0, E = 3.2e-24 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLk...eigasee + +G F V++++ + +++ A+K+ + ++ +a ++ kb|SgK288_ 2 ----RLVASGGFSQVFQARHR----RWRTEYAIKCAPclpP-DAASS 39 eieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymeg + +++EA+ Mkk+ + ++iV+ +Gvc + P l iV+E+m++ kb|SgK288_ 40 D--VNYLIEEAAKMKKI-KFQHIVSIYGVCKQ---P----LGIVMEFMAN 79 GdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLeskn..fvHRDLAAR G+L + L +h +L+ k + ++ + +M++L+s ++++ H DL kb|SgK288_ 80 GSLEKVLSTH----SLCWKLRFRIIHETSLAMNFLHSIKppLLHLDLKPG 125 NcLVsenlvVKIsDFGLaRdiysddyY.vrkrgggklPvkWm....APEs N+L+++n++VKIsDFGL++ + + ++r++ + + m + +PE kb|SgK288_ 126 NILLDSNMHVKISDFGLSKWM----EQsTRMQYIERSALRGMlsyiPPEM 171 lkygk......FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlelly + ++ + +++++ DV+SF +++WE++t ++P Y g ++ ++ kb|SgK288_ 172 FLESNkapgpkY----DVYSFAIVIWELLT-QKKP-YSGFNMMMIIIRV- 214 edGyR..Lpr.PenCPde...lYdlMlqCWaedPedRPtFselveeL<-* +G R++L + + P e +++ dlM++CW+ dP++RP F L kb|SgK288_ 215 AAGMRpsLQPvSDQWPSEaqqMVDLMKRCWDQDPKKRPCF------L 255 Pkinase: domain 1 of 1, from 2 to 255: score 122.1, E = 3.5e-37 *->yelleklGsGsfGtVykakhkgtgkiVAvK...iikkrkekskkdkt + + sG+f++V++a+h+ + ++A+K ++++ + ++s++++ kb|SgK288_ 2 ----RLVASGGFSQVFQARHRRWRTEYAIKcapCLPPDAASSDVNYL 44 arrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdy E++ +k+++ +Iv +++v+ k+ l +V+E++ +G +L + kb|SgK288_ 45 IE---EAAKMKKIKFQHIVSIYGVC--KQPLGIVMEFMANG----SLEKV 85 lsetrrkgpllfsedeakkialQilrgleYLHsn..giiHRDLKPeNILl ls +l ++ +i+ ++ ++++LHs ++ +H DLKP NILl kb|SgK288_ 86 LS----THSL--CWKLRFRIIHETSLAMNFLHSIkpPLLHLDLKPGNILL 129 dnngvvdaflKiaDFGlAkkls..t.sss..lttfvGTpwYmAPEv.llg d+n++v Ki+DFGl+k ++++t+ + + + + G + Y++PE l + kb|SgK288_ 130 DSNMHV----KISDFGLSKWMEqsTrMQYieRSALRGMLSYIPPEMfLES 175 gngygtkvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgppl ++ g+k Dv+S+ ++++ellt k P+sg + + +++ ++p+l kb|SgK288_ 176 NKAPGPKYDVYSFAIVIWELLTQKKPYSGF---NmMMIIIRVAAGMRPSL 222 efdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHP s++w s+ + + dL+k+c+++DP+kR+ + kb|SgK288_ 223 QPVSDQWPSEA-----------QQMVDLMKRCWDQDPKKRP------CF- 254 wf<-* + kb|SgK288_ 255 -L 255 // Query sequence: kb|SgK269_Hsap|Other/NKF3|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain -66.7 2.8e-08 1 Pkinase_Tyr Protein tyrosine kinase -151.1 7.9e-07 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 335 [. 1 272 [] -151.1 7.9e-07 Pkinase 1/1 17 335 .. 1 287 [] -66.7 2.8e-08 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 335: score -151.1, E = 7.9e-07 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie l+ +k + G+ + t+ +++ AVK++k +a e++ kb|SgK269_ 1 LTSDKP--CCEAGDAVYYTAS-YAKDPLNNYAVKICKS-KAKESQ-Q 42 ...redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymeg + + + +++ ++ ++ + + kb|SgK269_ 43 yyhSLAVRQSLAVHFNI----------------QQD-----------CGH 65 GdLldfLrkhr....................................... fL + ++ + ++++++++++++ ++++++ +++++++++++ + kb|SgK269_ 66 -----FLAEVPnrllpwedpddpekdeddmeeteedakgetdgknpkpcs 110 .............................................egrpL + ++++++++ +++++++ +++ + + + +++ +++ + L kb|SgK269_ 111 eaassqkenqgvmskkqrshvvvitrevpcltvadfvrdslaqhgKSPDL 160 tlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVse............ + + lQ ++G+e+L + H DL+ N L+ + +++++ ++ ++ kb|SgK269_ 161 YERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHyqpggtaqgfgp 210 .........nlvVKIsDFGLaRdi.ysddyYvrkrgggklPvkWmAPEsl +++++++ + +s F a++ ++ d r+ ++l APE + kb|SgK269_ 211 aepsptssyPTRLIVSNFSQAKQKsHLVDPE-ILRDQSRL-----APEII 254 kygk......FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellye ++ ++F + G+l++E++ l PF n e++e+ kb|SgK269_ 255 TATQykkcdeFQT-------GILIYEMLHLP-NPF---DENPELKERE-Y 292 dGyRLpr.PenCPde..lYdlMlqCWaedPedRPtFselveeL<-* + Lpr P P ++l +l +++P++R s+ +L kb|SgK269_ 293 TRADLPRiPFRSPYSrgLQQLASCLLNPNPSERILISDAKGIL 335 Pkinase: domain 1 of 1, from 17 to 335: score -66.7, E = 2.8e-08 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr t ak+ ++ +AvK i+k+k+k+++++++ + kb|SgK269_ 17 -------------TASYAKDPLNN--YAVK-ICKSKAKESQQYYHSL 47 l................................................. + +++ + + +++ ++ + +++ + ++++++++++++ ++++++ kb|SgK269_ 48 Avrqslavhfniqqdcghflaevpnrllpwedpddpekdeddmeeteeda 97 ............sEiqilkrLs.........HpNIvrlidvfedkdhlyl +++++++++++ sE++ ++ +++ ++++++ +v +++v kb|SgK269_ 98 kgetdgknpkpcSEAASSQKENqgvmskkqrSHVVVITREVPC-----LT 142 VlEycegGLrvldLfdylsetrrkgpll.fsedeakkialQilrgleYLH V ++++ +L ++g+ ++ e++++ +lQ+++gle+L kb|SgK269_ 143 VADFVRD-----SLA-------QHGKSPdLYERQVCLLLLQLCSGLEHLK 180 sngiiHRDLKPeNILldnngvvda..................flKiaDFG + H+DL +eN+Ll+ +++++ + ++ ++ +++++++ +++l ++ F kb|SgK269_ 181 PYHVTHCDLRLENLLLV-HYQPGGtaqgfgpaepsptssyptRLIVSNFS 229 lAkkls......t.sss.lttfvGTpwYmAPEvllggngygtkvDvWSlG Ak++s+ ++++ ++++ +APE++ ++ y +k+D + G kb|SgK269_ 230 QAKQKShlvdpeIlRDQsR---------LAPEIIT-ATQY-KKCDEFQTG 268 vilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspewdsisrse +++ye+l PF++ ++l +++ r +l+ +++f sp++ kb|SgK269_ 269 ILIYEMLHLPNPFDEN---PeLKEREYTRADLP-RIPFRSPYS------- 307 frrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* + +++L +++Ln++Ps+R+ + +++ + kb|SgK269_ 308 --------RGLQQLASCLLNPNPSERILISDAKGI--L 335 // Query sequence: kb|SgK223_Hsap|Other/NKF3|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain -71.2 5.1e-08 1 Pkinase_Tyr Protein tyrosine kinase -150.6 7.3e-07 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 1 330 [] 1 287 [] -71.2 5.1e-08 Pkinase_Tyr 1/1 16 330 .] 1 272 [] -150.6 7.3e-07 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 1 to 330: score -71.2, E = 5.1e-08 *->yelleklGsGsfGtVykakhkgtgk............iVAvKiikkr +++ ++ +++ g+ + + ++++++++AvKi k + kb|SgK223_ 1 LTCNKP-----------CCDSGDAIyycatcsedpgsTYAVKICKAP 36 kekskkdktarrlsEiqilkrL.sHpNIvrlidvfed............. + k + +++ H NI + + f + +++ ++++ + kb|SgK223_ 37 EPKT----------VSYCSPSVpVHFNIQQDCGHFVAsvpssmlsspdap 76 ...............kdhlylVlEycegGLrvldLfdyls...e.trrkg +++ + +++++ ++ d + +++ +++ +d+++++ ++ +++ kb|SgK223_ 77 kdpvpalpthppaqeQDCVVVITREVPHQ----TASDFVRdsaAsHQAEP 122 pllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngvvda.. e+ +++ +lQ++ gle+L ++giiHRDL +eN+Ll+ ++++ a++ kb|SgK223_ 123 EA--YERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLV-HCTLQAgp 169 .................................................. ++ + + + + ++ ++ ++ +++ ++ ++ +++++++++ ++ kb|SgK223_ 170 gpapapapapaaaappcssaappaggtlspaagpaspegprekqlprlii 219 ..flKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvDv ++flK Ak+ + ++++ + +APE++ ++ y +k D kb|SgK223_ 220 snFLK------AKQ--KpGGTpNLQQKKSQARLAPEIVS-ASQY-RKFDE 259 WSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsis + G+++yell PF + ql + + + ++ + +s kb|SgK223_ 260 FQTGILIYELLHQPNPFEVR-----AQLRERDYRQEDLPPLPALSLYS-- 302 rsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* + +++L +L+ DP kR+ + e++ + kb|SgK223_ 303 -----------PGLQQLAHLLLEADPIKRIRIGEAKRV--L 330 Pkinase_Tyr: domain 1 of 1, from 16 to 330: score -150.6, E = 7.3e-07 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie y +t+ ++++ + AVK++ +a e+ kb|SgK223_ 16 ---------------YCATCS---EDPGSTYAVKIC---KAPEP--- 38 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL k v + + + kb|SgK223_ 39 ------------KT-----------VSYC-SPS----------------- 47 ldfLrkhr.......................................... h + +++ ++ + +++ ++++ ++++ + +++++ ++++ kb|SgK223_ 48 ---VPVHFniqqdcghfvasvpssmlsspdapkdpvpalpthppaqeqdc 94 ........................egrpLtlkdLlsf.alQiAkGMeYLe +++ ++++ ++ +++ +++ +p ++ ++f lQ ++G+e+L kb|SgK223_ 95 vvvitrevphqtasdfvrdsaashQAEPEAYERRVCFlLLQLCNGLEHLK 144 sknfvHRDLAARNcLVse................................ +++++HRDL+ N L+ + + + ++++ + + + + ++ ++ ++ + kb|SgK223_ 145 EHGIIHRDLCLENLLLVHctlqagpgpapapapapaaaappcssaappag 194 ..................nl.vVKIsDFGLaRdi.ysddyYvrkrgggkl ++ ++ ++ +++++++++l+ Is F a++ + + + ++++ kb|SgK223_ 195 gtlspaagpaspegprekQLpRLIISNFLKAKQKpGGTPNL-QQKK---- 239 PvkWmAPEslkygk......FtskSDVWSFGVlLWEiftlGeqPFYpgms +APE + + ++ ++F + G+l++E++ qP kb|SgK223_ 240 SQARLAPEIVSASQyrkfdeFQT-------GILIYELLH---QP-----N 274 neevlellyedGyR......LprPenCPdelYdlMlqCWaedPedRPtFs ++ev ++l e++yR+++ ++Lp+ + ++ l +l + ++dP +R + kb|SgK223_ 275 PFEVRAQLRERDYRqedlppLPALSLYSPGLQQLAHLLLEADPIKRIRIG 324 elveeL<-* e + L kb|SgK223_ 325 EAKRVL 330 // Query sequence: kb|SGK2_Hsap|AGC/SGK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 315.7 1.8e-95 1 Pkinase_Tyr Protein tyrosine kinase 29.4 7.3e-18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 256 [. 1 272 [] 29.4 7.3e-18 Pkinase 1/1 1 258 [] 1 287 [] 315.7 1.8e-95 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 256: score 29.4, E = 7.3e-18 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.ke.igaseee + ++k++G+G++G+V +++ k +++ AVK+L+k++i e kb|SGK2_Hs 1 FDFLKVIGKGNYGKVLLAKRK----SDGAFYAVKVLqKKsILKKKE- 42 ieredFlrEAsi.MkklGdHpNiVrLlGvctkegePggpglyiVtEymeg + ++E s+ +k+ +Hp +V L +++ ly V+ y+ g kb|SGK2_Hs 43 --QSHIMAERSVlLKNV-RHPFLVGLRYSFQTPEK-----LYFVLDYVNG 84 GdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNc G L +L++ +r++ ++ +a+++A++ YL+s n++ RDL N+ kb|SGK2_Hs 85 GELFFHLQR---ERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENI 131 LVsenlvVKIsDFGLaRdi.ysddyYvrkrgggk.lPvkWmAPEslkygk L++++++V +DFGL++ +++d+ ++ +APE+l+ kb|SGK2_Hs 132 LLDCQGHVVLTDFGLCKEGvEPEDTT-----STFcGTPEYLAPEVLRKEP 176 FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPen + + D W G +L+E++ G +P ++ ++++++e + + L +P + kb|SGK2_Hs 177 YDRAVDWWCLGAVLYEMLH-GLPP-FYSQDVSQMYENIL--HQPLQIPGG 222 CPdelYdlMlqCWaedPedRP....tFselveeL<-* + dl+++ ++d +R +++ F e+ ++ kb|SGK2_Hs 223 RTVAACDLLQSLLHKDQRQRLgskaDFLEIKNHV 256 Pkinase: domain 1 of 1, from 1 to 258: score 315.7, E = 1.8e-95 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + +l+++G+G++G+V +ak+k++g +AvK++ k+++ +kk+++++ kb|SGK2_Hs 1 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIM 47 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls + E ++l++ +Hp+ v l+++f+++ +ly+Vl+y++gG +Lf +l+ kb|SGK2_Hs 48 A-ERSVLLKNvRHPFLVGLRYSFQTPEKLYFVLDYVNGG----ELFFHLQ 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng r++++ e a+++a ++++++ YLHs +ii+RDLKPeNILld +g kb|SGK2_Hs 93 ---RERRF--LEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQG 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv +v ++DFGl+k ++ +++tf+GTp+Y+APEvl+ ++y+++v kb|SGK2_Hs 138 HV----VLTDFGLCKEG-VePEDtTSTFCGTPEYLAPEVLR-KEPYDRAV 181 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+W lG +lye+l G pPF+++ d q++++il+ pl ++ + kb|SGK2_Hs 182 DWWCLGAVLYEMLHGLPPFYSQ-----DVSQMYENILHQPLQIPGGRT-- 224 isrsefrrlpnlseeakdLikkcLnkDPskRlt....aeeilqHPwf<-* +a+dL+ ++L+kD +Rl+++ ++ ei++H +f kb|SGK2_Hs 225 -------------VAACDLLQSLLHKDQRQRLGskadFLEIKNHVFF 258 // Query sequence: kb|SgK196_Hsap|Other/Other-Unique|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain -67.6 3.1e-08 1 Pkinase_Tyr Protein tyrosine kinase -130.1 4.1e-08 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 251 [] 1 272 [] -130.1 4.1e-08 Pkinase 1/1 1 250 [. 1 287 [] -67.6 3.1e-08 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 251: score -130.1, E = 4.1e-08 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie ++ +k GeGa +V++ ++k e kVA L + +s e kb|SgK196_ 1 VRQLKRVGEGAVKRVFLSEWK------EHKVA---LSQ-LTSLEM-- 35 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG.. ++dFl+ ++++k+l + ++V LlG c + + + tEy ++G+ kb|SgK196_ 36 KDDFLHGLQMLKSL-QGTHVVTLLGYCED-DNT------MLTEYHPLGsl 77 .dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNc ++L + L + ++ t ++ l+ a++ + +YL+ + kb|SgK196_ 78 sNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLHHSP----------- 116 LVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkFt V+ +R + d++ ++ l+ + t kb|SgK196_ 117 -VG------------TRVM-CDSND-LPKT-------------LSQYLLT 138 skSDVWSFGVlLWEiftlGeqP....................F....... s F +l l + P +++++ + ++++ +++F +++ kb|SgK196_ 139 SN-----FSIL---ANDLDALPlvnhssgmlvkcghrelhgdFvapeqlw 180 .Ypgmsnee.....................vlellyedGyRLprPenCPd +Y + ++ ++ ++ +++ + + ++ +++l +G + r + kb|SgK196_ 181 pYGEDVPFHddlmpsydekidiwkipdissFLLGH-IEGSDMVRFH---- 225 elYdlMlqCWaedPedRPtFselveeL<-* l d+ + C P++RPt ++++e kb|SgK196_ 226 -LFDIHKACKSQTPSERPTAQDVLETY 251 Pkinase: domain 1 of 1, from 1 to 250: score -67.6, E = 3.1e-08 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + l+++G+G+ +V++ +k VA+ ++ + k++++ kb|SgK196_ 1 VRQLKRVGEGAVKRVFLSEWKEHK--VALSQLTSLEMKDDFLH---- 41 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse +q+lk+L+ ++v+l++++ed++ + +Ey++ G +L+ kb|SgK196_ 42 --GLQMLKSLQGTHVVTLLGYCEDDNTML--TEYHPLG----SLS----N 79 .......trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNI +++ + ++++++ ++++ a ++ ++YLH + R + kb|SgK196_ 80 leetlnlSKYQNVN--TWQHRLELAMDYVSIINYLHHSPVGTR------V 121 Lldnngvvda..........flKiaDFGlAkkls....t.sss.lttfvG ++d+n+ +++ ++ +++ ++ lA l+ + ++ss++ + +G kb|SgK196_ 122 MCDSNDLPKTlsqylltsnfSI------LANDLDalplVnHSSgMLVKCG 165 Tpw....YmAPEvll.ggngygtkvDvWSlGvilyelltGkpPFsgevqd ++ +++++APE l + g++ + D P ++e kb|SgK196_ 166 HRElhgdFVAPEQLWpYGEDVPFHDDL--------------MPSYDE--- 198 sldqlqlirkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLn ++++i i + l +++ +d ++ + d+ k c kb|SgK196_ 199 -KIDIWKIPDISS-FLLGHIEGSDMVR-----------FHLFDIHKACKS 235 kDPskRltaeeilqHPwf<-* + Ps+R+ta+++l+ kb|SgK196_ 236 QTPSERPTAQDVLET--- 250 // Query sequence: kb|SgK110_Hsap|Other/NKF1|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 107.9 6.8e-33 1 Pkinase_Tyr Protein tyrosine kinase -43.3 2e-13 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 262 [] 1 272 [] -43.3 2e-13 Pkinase 1/1 1 262 [] 1 287 [] 107.9 6.8e-33 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 262: score -43.3, E = 2e-13 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie +l++kLG+G++G+V ++ + +++ VA K L+ + + kb|SgK110_ 1 YHLIRKLGSGSYGRVLLAQPH----QGGPAVALKLLRR-DLVLR--- 39 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL FlrE + + Hp +++ l+ +++ + Ey+++GdL kb|SgK110_ 40 -STFLREFCVGRCVSAHPGLLQTLAGPLQTPRY----FAFAQEYAPCGDL 84 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs L+++ L+ +Q A ++++L+s+++vH D+ N+LV kb|SgK110_ 85 SGMLQER----GLPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLVF 130 e..nlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygk.. ++ V +D GL+R + + ++++P +PE + kb|SgK110_ 131 DpvCSRVALGDLGLTRPE-------GSPTPAPpVPLPTAPPE---LCLll 170 ......FtskSDVWSFGVlLWEiftlGeqP..........FYpgmsneev ++++ + + D W GVlL+ t + P + ++++F e + kb|SgK110_ 171 ppdtlpLRPAVDSWGLGVLLFCAATAC-FPwdvalapnpeF------EAF 213 lellyedGyRLprPe.....nCPdelYdlMlqCWaedPedRPtFselvee ++ + p+P+++ ++ +P+ l l++ + dPe R +++ + kb|SgK110_ 214 AGWV-TTKPQPPQPPppwdqFAPPALA-LLQGLLDLDPETRSPPLAVLDF 261 L<-* L kb|SgK110_ 262 L 262 Pkinase: domain 1 of 1, from 1 to 262: score 107.9, E = 6.8e-33 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y+l++klGsGs+G+V +a+ + g VA+K ++++ + +r kb|SgK110_ 1 YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRSTF---LR 44 lsEiqilkrLs.HpNIvrlidvfed.kdhlylVlEycegGLrvldLfdyl E ++ + +s Hp ++++ ++++ + +Ey+++G dL+ +l kb|SgK110_ 45 --EFCVGRCVSaHPGLLQTLAGPLQtPRYFAFAQEYAPCG----DLSGML 88 setrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnn + +++l +e +k+++ Q++ +l++LHs+g +H D+KP+N+L+ + kb|SgK110_ 89 Q----ERGL--PELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLVF-D 131 gvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvll....ggng +v+ +++ ++D Gl + +s++ + + ++ ++PE++l +++ + kb|SgK110_ 132 PVC-SRVALGDLGLT----RpEGSpTPAPPVPLPTAPPELCLllppDTLP 176 ygtkvDvWSlGvilyelltGkpPFs.gevqds.ldqlqlirk..ilgppl ++vD W+lGv+l++ +t +P++ ++ +++ ++ + +p++ kb|SgK110_ 177 LRPAVDSWGLGVLLFCAATACFPWDvAL---ApNPEFEAFAGwvTTKPQP 223 efdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHP + + p wd ++a+ L+ ++L++DP+ R + +l kb|SgK110_ 224 PQPPPPWDQFA-----------PPALALLQGLLDLDPETRSPPLAVLDF- 261 wf<-* + kb|SgK110_ 262 -L 262 // Query sequence: kb|SgK085_Hsap|CAMK/MLCK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 305.1 2.9e-92 1 Pkinase_Tyr Protein tyrosine kinase 41.6 1.3e-18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 256 [] 1 272 [] 41.6 1.3e-18 Pkinase 1/1 1 256 [] 1 287 [] 305.1 2.9e-92 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 256: score 41.6, E = 1.3e-18 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie +++ + LG G FG V+k++ + t++k A K++k + + kb|SgK085_ 1 VSKTEILGGGRFGQVHKCEET----ATGLKLAAKIIKT-RGMKD--- 39 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL +e+ +E+s+M +l dH N+++L+ + + + +V+Ey+ gG L kb|SgK085_ 40 KEEVKNEISVMNQL-DHANLIQLYDAFES-KND----IVLVMEYVDGGEL 83 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL.V d + +Lt d + f+ Qi++G + +++ + H DL N+L V kb|SgK085_ 84 FDRIIDE--SYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILcV 131 senl.vVKIsDFGLaRdiysddyYvrkrgggklPv...kWmAPEslkygk +++ +++KI DFGLaR + r++ k+ +++ +APE+ +y kb|SgK085_ 132 NRDAkQIKIIDFGLARRY-------KPREKLKVNFgtpEFLAPEVVNYDF 174 FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyed...GyRLpr + +D WS GV + +++ G +P + g ++e+l+ + + + + + kb|SgK085_ 175 VSFPTDMWSVGVIAYMLLS-GLSP-FLGDNDAETLNNI-LAcrwDLEDEE 221 PenCPdelYdlMlqCWaedPedRPtFsel..veeL<-* ++ ++e + + + ++ + R + se ++ L kb|SgK085_ 222 FQDISEEAKEFISKLLIKEKSWRISASEAlkHPWL 256 Pkinase: domain 1 of 1, from 1 to 256: score 305.1, E = 2.9e-92 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + e+lG G fG+V k+ + tg + A Kiik r+ k+k++ + kb|SgK085_ 1 VSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKN-- 45 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse Ei++++ L+H N ++l+d+fe+k+++ lV+Ey++gG +Lfd++ kb|SgK085_ 46 --EISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGG----ELFDRII- 88 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv +++ +l +e + + +++Qi++g+ ++H++ i+H DLKPeNIL++n++ kb|SgK085_ 89 -DESYNL--TELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDA 135 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD +Ki+DFGlA+ +++ ++l++ GTp+++APEv++ + + + D kb|SgK085_ 136 K--QIKIIDFGLARR--YkPREkLKVNFGTPEFLAPEVVN-YDFVSFPTD 180 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi +WS+Gvi y ll+G PF g+ ++ + + +il ++++ + +e +i kb|SgK085_ 181 MWSVGVIAYMLLSGLSPFLGD-----NDAETLNNILACRWDLEDEEFQDI 225 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* s eeak++i+k+L k s R++a e+l+HPw+ kb|SgK085_ 226 S-----------EEAKEFISKLLIKEKSWRISASEALKHPWL 256 // Query sequence: kb|SgK071_Hsap|Other/SgK071|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 49.6 2.4e-15 1 Pkinase_Tyr Protein tyrosine kinase -66.2 5.1e-12 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 1 267 [. 1 287 [] 49.6 2.4e-15 Pkinase_Tyr 1/1 14 268 .. 1 272 [] -66.2 5.1e-12 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 1 to 267: score 49.6, E = 2.4e-15 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y++l +l G+ G+ + t vK + k+ e ++ +++ kb|SgK071_ 1 YQVLYQLNPGALGVNLVVEEMETK----VKHVIKQVECMDDHYASQA 43 lsEiqilkrLsHpNIvrlidvfed......kdhlylVlEycegGLrvldL l E+ l++L+H +I + + f + +++ ++ +l+lV+E+ e + kb|SgK071_ 44 LEELMPLLKLRHAHISVYQELFITwngeisSLYLCLVMEFNEL-----SF 88 fdylse.trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNI +++ ++ ++k+ + + + ++++ Q+l +leYLH iiHR LKP+NI kb|SgK071_ 89 QEVIEDkRKAKKII--DSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNI 136 LldnngvvdaflKiaDFGlAkklst.sss.lttfvGTpw.....YmAPEv l + +++ K+ D ++ + + + + + ++ ++++mAPE kb|SgK071_ 137 ILISSDHC----KLQDL-SSNV--LmTDKaKWNIRAEEDpfrksWMAPEA 179 llggngygtkvDvWSlGvilyellt............GkpPFsgevqdsl l+ ++k+D+WSlG+i+ + + + ++++ + +k + ++ kb|SgK071_ 180 LN--FSFSQKSDIWSLGCIILDMTScsfmdgteamhlRKSLRQSP----- 222 dqlqlirkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkD l+ + k+++++ d e+++ L+ +L+ D kb|SgK071_ 223 GSLKAVLKTMEEKQIPDV------------------ETFRNLLPLMLQID 254 PskRltaeeilqHPwf<-* Ps+R+t+++++ H + kb|SgK071_ 255 PSDRITIKDVV-H--I 267 Pkinase_Tyr: domain 1 of 1, from 14 to 268: score -66.2, E = 5.1e-12 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + l + ++ t++k +K + ++++++ kb|SgK071_ 14 VNLVVE------------EME-----TKVKHVIKQV---ECMDDHY- 39 redFlrEAsiMkklGdHpNi.VrLlGvctkegePggpg.lyiVtEymegG l+E+ + kl +H +i+V ++t +ge ++ l++V+E+ e+ kb|SgK071_ 40 ASQALEELMPLLKL-RHAHIsVYQELFITWNGEI-SSLyLCLVMEFNEL- 86 dLldfLrkhr.egrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNc + + ++r+ ++ ++ +++ + Q+ +++eYL+ ++HR L N+ kb|SgK071_ 87 SFQEVIEDKRkAKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNI 136 LVsenlvVKIsDFGLaRdiysddyYvrkrgggklPv.........kWmAP + ++ ++K D L+ + +++++k+ ++ ++++ ++ WmAP kb|SgK071_ 137 ILISSDHCKLQD--LSSNV-------LMTDKAKWNIraeedpfrkSWMAP 177 EslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsnee.......... E+l+++ F+ kSD+WS G+ + + + F m+ +e + +++ ++ kb|SgK071_ 178 EALNFS-FSQKSDIWSLGCIILDMTSCS---F---MDGTEamhlrkslrq 220 ....vlellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFselvee +++++++ l + + +P+ + +l+ + + dP+dR t +++v++ kb|SgK071_ 221 spgsLKAVL-KTMEEKQIPD--VETFRNLLPLMLQIDPSDRITIKDVVHI 267 L<-* kb|SgK071_ 268 T 268 // Query sequence: kb|SgK069_Hsap|Other/NKF1|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 134.0 9.1e-41 1 Pkinase_Tyr Protein tyrosine kinase -41.8 1.7e-13 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 264 [] 1 272 [] -41.8 1.7e-13 Pkinase 1/1 1 264 [] 1 287 [] 134.0 9.1e-41 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 264: score -41.8, E = 1.7e-13 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei + + LG+G++G+V + t + +++++ A K L+k+ +s + kb|SgK069_ 1 YEEVRPLGQGCYGRVLLVTHR----QKGTPLALKQLpKP-RTSLRG- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd Fl E + +lG H iV +G+ +++ + + tE + +Gd kb|SgK069_ 42 ----FLYEFCVGLSLGAHSAIVTAYGIGIESAHS----YSFLTEPVLHGD 83 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L f + + L+ + a+Q A+++eY +++++v RDL N+LV kb|SgK069_ 84 LMAFIQP---KVGLPQPAVHRCAAQLASALEYIHARGLVYRDLKPENVLV 130 se..nlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygk.. ++ + K +DFG +R + + P+ +APE + ++ kb|SgK069_ 131 CDpaCRRFKLTDFGHTRPR-----G-TLLRLAGPPIPYTAPE---LCApp 171 .......FtskSDVWSFGVlLWEiftlGeqPFYpgmsnee........vl + +++ + + D W+ GVlL+ ++t G P ++ + +e ++ ++ ++ kb|SgK069_ 172 plpeglpIQPALDAWALGVLLFCLLT-GYFP--WDRPLAEadpfyedfLI 218 ellyedGyRLprPenCP.....delYdlMlqCWaedPedRPtFselveeL + +G+ +rP+ P + + l++ ++ P +R +++e+L kb|SgK069_ 219 WQA--SGQPRDRPQ--PwfglaAAADALLRGLLDPHPRRRSAVIAIREHL 264 <-* kb|SgK069_ - - Pkinase: domain 1 of 1, from 1 to 264: score 134.0, E = 9.1e-41 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ye +++lG+G +G+V + +h+ g A+K+++k++++ + kb|SgK069_ 1 YEEVRPLGQGCYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLY--- 44 lsEiqilkrL.sHpNIvrlidvfedkdhly.lVlEycegGLrvldLfdyl E ++ ++L+ H Iv+ +++ ++ h y++ +E + +G dL++++ kb|SgK069_ 45 --EFCVGLSLgAHSAIVTAYGIGIESAHSYsFLTEPVLHG----DLMAFI 88 setrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnn + k +l + + ++a Q++++leY+H++g ++RDLKPeN+L+ + kb|SgK069_ 89 Q---PKVGL--PQPAVHRCAAQLASALEYIHARGLVYRDLKPENVLVC-D 132 gvvdaflKiaDFGlAkklst.sss.lttfvGTp.wYmAPEvll.....gg + + ++K++DFG t++ ++l ++G p +Y APE++ +++ ++g kb|SgK069_ 133 PAC-RRFKLTDFGH-----TrPRGtLLRLAGPPiPYTAPELCAppplpEG 176 ngygtkvDvWSlGvilyelltGkpPFsgev.q.ds.ldqlqlirkilgpp ++ ++ D W+lGv+l++lltG++P++ d+ + ++ + + ++p+ kb|SgK069_ 177 LPIQPALDAWALGVLLFCLLTGYFPWDRPLaEaDPfYEDFLIWQASGQPR 226 lefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqH + + +a L++++L++ P +R i +H kb|SgK069_ 227 DRPQPWFGLA-------------AAADALLRGLLDPHPRRRSAVIAIREH 263 Pwf<-* + kb|SgK069_ 264 --L 264 // Query sequence: kb|SGK_Hsap|AGC/SGK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 317.3 6.2e-96 1 Pkinase_Tyr Protein tyrosine kinase 36.6 2.7e-18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 256 [. 1 272 [] 36.6 2.7e-18 Pkinase 1/1 1 258 [] 1 287 [] 317.3 6.2e-96 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 256: score 36.6, E = 2.7e-18 *->lklgkkLGeGaFGeVykGtlkgsgdgteikV..AVKtL.ke.igase ++++k++G+G+FG+V +++ k +V AVK+L+k+ i kb|SGK_Hsa 1 FHFLKVIGKGSFGKVLLARHK------AEEVfyAVKVLqKKaILKKK 41 eeieredFlrEAsi.MkklGdHpNiVrLlGvctkegePggpglyiVtEym ee + ++E ++ +k+ +Hp +V L+ + ++ + ly V+ y kb|SGK_Hsa 42 EE---KHIMSERNVlLKNV-KHPFLVGLH-FSFQTADK----LYFVLDYI 82 egGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAAR gG L +L++ +r + ++ +a++iA+++ YL+s n+v RDL kb|SGK_Hsa 83 NGGELFYHLQR---ERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPE 129 NcLVsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkyg N+L+++++++ +DFGL++ + + +++++ +APE+l+ kb|SGK_Hsa 130 NILLDSQGHIVLTDFGLCKE--NIEHN--STTSTFcGTPEYLAPEVLHKQ 175 kFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPe + D W G +L+E++ G +P ++ +e+++ + + +L++ kb|SGK_Hsa 176 PYDRTVDWWCLGAVLYEMLY-GLPP-FYSRNTAEMYDNILNKPLQLKPNI 223 nCPdelYdlMlqCWaedPedRP....tFselveeL<-* + +l+ ++d +R + ++ F e+ ++ kb|SGK_Hsa 224 --TNSARHLLEGLLQKDRTKRLgakdDFMEIKSHV 256 Pkinase: domain 1 of 1, from 1 to 258: score 317.3, E = 6.2e-96 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++l+++G+GsfG+V +a+hk ++ +AvK++ k+ + +kk++ ++ kb|SGK_Hsa 1 FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM 47 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls + E +l++ +Hp+ v l+ +f++ d+ly+Vl+y +gG +Lf +l+ kb|SGK_Hsa 48 S-ERNVLLKNvKHPFLVGLHFSFQTADKLYFVLDYINGG----ELFYHLQ 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng r++++ e a+++a +i+++l YLHs +i++RDLKPeNILld++g kb|SGK_Hsa 93 ---RERCF--LEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQG 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv ++ ++DFGl+k ++++s+++tf+GTp+Y+APEvl ++y++ v kb|SGK_Hsa 138 HI----VLTDFGLCKEN-IeHNStTSTFCGTPEYLAPEVLH-KQPYDRTV 181 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+W lG +lye+l G pPF+++ + +++++il +pl + kb|SGK_Hsa 182 DWWCLGAVLYEMLYGLPPFYSR-----NTAEMYDNILNKPLQLKPNIT-- 224 isrsefrrlpnlseeakdLikkcLnkDPskRlt....aeeilqHPwf<-* +a++L++++L+kD +kRl+ +++++ei+ H +f kb|SGK_Hsa 225 -------------NSARHLLEGLLQKDRTKRLGakddFMEIKSHVFF 258 // Query sequence: kb|SCYL3_Hsap|Other/SCY1|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain -68.9 3.7e-08 1 Pkinase_Tyr Protein tyrosine kinase -144.6 3.2e-07 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 221 [] 1 272 [] -144.6 3.2e-07 Pkinase 1/1 1 221 [] 1 287 [] -68.9 3.7e-08 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 221: score -144.6, E = 3.2e-07 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + +L G F +V+ + +e + ++ kb|SCYL3_H 1 AVYPAVLQDGKFASVFVYKRE---------------NE-DKVNKA-- 29 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL A+ +k+l +Hp ++r+l + ++ + + +VtE ++ kb|SCYL3_H 30 -------AKHLKTL-RHPCLLRFLSCTVE-ADG----IHLVTERVQP--- 63 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLeskn.fvHRDLAARNcLV L + L+ + + ++i ++ +L++++++ H ++ + V kb|SCYL3_H 64 ---LEVA--LETLSSAEVCAGIYDILLALIFLHDRGhLTHNNVCLSSVFV 108 se.........nlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEs se+++ + ++ + v+K+s a + + r+ + +P m+PE kb|SCYL3_H 109 SEdghwklggmETVCKVSQ---ATPEFLRSIQ-SIRDPASIPPEEMSPE- 153 lkygk...FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedG ++ ++ ++ D SFG l ++t ne+v + + kb|SCYL3_H 154 -FTTLpecHGHARDAFSFGTLVESLLT-----I----LNEQVSADV---- 189 yRLprPenCPdelYdlMlqCWaedPedRPtFsel..veeL<-* L + + l++ +l ++ P+ RP l ++ ++ kb|SCYL3_H 190 --LSSFQ---QTLHSTLL---NPIPKCRPALCTLlsHDFF 221 Pkinase: domain 1 of 1, from 1 to 221: score -68.9, E = 3.7e-08 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr Vy a+ ++ +A + kr++++k++k+a + kb|SCYL3_H 1 -------------AVYPAVLQDGK--FASVFVYKRENEDKVNKAAKH 32 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse lk L+Hp+ +r++ + + d ++lV+E ++ + kb|SCYL3_H 33 ------LKTLRHPCLLRFLSCTVEADGIHLVTERVQPL----EVA----- 67 trrkgpllfsedeakkialQilrgleYLHsn......giiHRDLKPeNIL +l s e++ ++ il +l +LH++++ ++++++ ++ ++ kb|SCYL3_H 68 ---LETL--SSAEVCAGIYDILLALIFLHDRghlthnNVC-----LSSVF 107 ldnngvvdaflKiaDFGl..Akkls.......t.sss.lttfvGTpwYmA ++++g+ K++ G ++ +k+s+ +++ + +s + p+ m+ kb|SCYL3_H 108 VSEDGHW----KLG--GMetVCKVSqatpeflRsIQSiRDPASIPPEEMS 151 PEv.llggngygtkvDvWSlGvilyelltGkpPFsgevqds.ldqlqlir PE + l + +g++ D +S+G ++ llt + ++ ++d l ++ kb|SCYL3_H 152 PEFtTL-PECHGHARDAFSFGTLVESLLT---ILNEQ---VsADVLSSFQ 194 kilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlta ++l+ + +Ln+ P++R+ kb|SCYL3_H 195 QTLH--------------------------------STLLNPIPKCRPAL 212 eeilqHPwf<-* +l H++f kb|SCYL3_H 213 CTLLSHDFF 221 // Query sequence: kb|SCYL2_Hsap|Other/SCY1|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 5.8 1.2e-12 1 Pkinase_Tyr Protein tyrosine kinase -106.0 1.4e-09 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 296 [] 1 272 [] -106.0 1.4e-09 Pkinase 1/1 1 296 [] 1 287 [] 5.8 1.2e-12 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 296: score -106.0, E = 1.4e-09 *->lklgkkLGeGaFG...eVykGtlkgsgdgteikVAV....KtLk... + g+ + +G G +++ Gt k +t+++VAV +K+L ++ kb|SCYL2_H 1 FDVGRHIASGGNGlawKIFNGTKK----STKQEVAVfvfdKKLIdky 43 eigaseeeieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyi + + ++i ++++ r ++ +++l +Hp ++ t + P kb|SCYL2_H 44 Q-KFEKDQI-IDSLKRGVQQLTRL-RHPRLL------TV-QHP------- 76 VtEymegGdLldfLrkhr................................ L + r+ +++ + + ++ ++ +++ +++ kb|SCYL2_H 77 -------------LEESRdclafctepvfaslanvlgnwenlpspispdi 113 egrpLtlkdLlsfalQiAkGMeYLe.sknfvHRDLAARNcLVsenlvVKI + +L + lQ+++G+++L++s ++vH + N+ +++++ KI kb|SCYL2_H 114 KDYKLYDVETKYGLLQVSEGLSFLHsSVKMVHGNITPENIILNKSGAWKI 163 s..DFGLaRdiysddyYvrkrgggklPv...............kWmAPEs + DF + + + ++ k+P ++ +++ ++ +++ +APE kb|SCYL2_H 164 MgfDFCVSSTN-------PSEQEPKFPCkewdpnlpslclpnpEYLAPEY 206 lkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRL + + ++SD +S G +++ +f G +P ++ +++++ + ++ +L kb|SCYL2_H 207 ILSVSCETASDMYSLGTVMYAVFNKG-KP-IFEVNKQDIYKSFSRQLDQL 254 prP.....enCPdelYdlMlqCWaedPedRPtFsel..veeL<-* r ++++ n P+e+ + ++ + P RP + +++ ++ kb|SCYL2_H 255 SRLgssslTNIPEEVREHVKLLLNVTPTVRPDADQMtkIPFF 296 Pkinase: domain 1 of 1, from 1 to 296: score 5.8, E = 1.2e-12 *->yelleklGsGsfGtV...ykakhkgtgkiVAv.....Kiikkrkeks + +++ + sG+ G + + +++k+t ++VAv ++K i+k + + kb|SCYL2_H 1 FDVGRHIASGGNGLAwkiFNGTKKSTKQEVAVfvfdkKLIDKYQKFE 47 kkdktarrlsEiqilkrLsHpNIvrlidvfedkdhly.lVlEycegGL.r k ++++ + + +q l rL+Hp ++ + e+++++ +++E + L kb|SCYL2_H 48 KDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLaFCTEPVFASLaN 97 vldLfdylse........trrkgpllfsedeakkialQilrgleYLHs.n vl + e+ +++ +++ ++ +l + e k +lQ+ +gl +LHs+ kb|SCYL2_H 98 VLGNW----EnlpspispDIKDYKL--YDVETKYGLLQVSEGLSFLHSsV 141 giiHRDLKPeNILldnngvvdaflKiaDFGlAkkls.............. + +H + PeNI l++ g Ki F ++ ++++++++ + ++ kb|SCYL2_H 142 KMVHGNITPENIILNKSGAW----KIMGFDFCVSSTnpseqepkfpckew 187 ..t.sss.lttfvGTpwYmAPEvllggngygtkvDvWSlGvilyellt.G +++ +s l p+Y+APE +l + t++D++SlG ++y ++++G kb|SCYL2_H 188 dpNlPSLcLPN----PEYLAPEYIL-SVSCETASDMYSLGTVMYAVFNkG 232 kpPFs.gevqdsldqlqlirkilgpplefdspewdsisrsefrrlpnlse kp+F ++ d ++ + + l + s +i+ e kb|SCYL2_H 233 KPIFEvNK----QDIYKSFSRQLDQLSRLGSSSLTNIP-----------E 267 eakdLikkcLnkDPskRltaeeilqHPwf<-* e ++ +k +Ln+ P+ R+ a++ + P+f kb|SCYL2_H 268 EVREHVKLLLNVTPTVRPDADQMTKIPFF 296 // Query sequence: kb|SCYL1_Hsap|Other/SCY1|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase -161.1 3.2e-06 1 Pkinase Protein kinase domain -103.7 4.6e-06 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 3 230 .. 1 272 [] -161.1 3.2e-06 Pkinase 1/1 3 230 .. 1 287 [] -103.7 4.6e-06 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 3 to 230: score -161.1, E = 3.2e-06 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie l+ g+k +++ g + V +k+ ga e+ kb|SCYL1_H 3 LHRGRK------------KAT----GSPVSIFVYDVKP-GAEEQ--- 29 redFlr.EAsiMkklGdHpNiVrLl.GvctkegePggpglyiVtEymegG + + k+l +HpNi+ +++G t ++ l +VtE + kb|SCYL1_H 30 -TQVAKaAFKRFKTL-RHPNILAYIdGLET--EKC----LHVVTEAVTP- 70 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLeskn.fvHRDLAARNc L +L+++ e + L+ ++ +Qi k++++L + +++H ++ + kb|SCYL1_H 71 -LGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCsLIHNNVCMAAV 119 LVsenlvVKIsDFGLaRdiysddyYvrkrgggklPv.............. V++ + K + GL ++ Y ++g+g P +++ ++ ++ ++++ kb|SCYL1_H 120 FVDRAGEWKLG--GL-DYM-----Y-SAQGNGGGPPrkgipeleqydppe 160 ...........kWmAPEslkygkFtskSDVWSFGVlLWEiftlGeqP... +++++ ++kW A D W G+l+WE+f G P+ kb|SCYL1_H 161 ladssgrvvreKWSA-------------DMWRLGCLIWEVFN-GPLPraa 196 ..........FYpgmsneevlellyedGyRLprPenCPdelYdlMlqCWa +++++ +++ + +el+ ++ + + kb|SCYL1_H 197 alrnpgkipkT----LVPHYCELV-GANPKVRPNP--------------- 226 edPedRPtFselveeL<-* ++L kb|SCYL1_H 227 ------------ARFL 230 Pkinase: domain 1 of 1, from 3 to 230: score -103.7, E = 4.6e-06 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++++k Gs V + + + +e ++ k+a++ kb|SCYL1_H 3 LHRGRKKATGS--PVSIFVYDVKP---------GAEEQTQVAKAAFK 38 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse + k L+HpNI+ +id e+++ l++V+E + + L yl++ kb|SCYL1_H 39 R-----FKTLRHPNILAYIDGLETEKCLHVVTEAV--T----PLGIYLKA 77 trrkgpllfsedeakkialQilrgleYLHs.ngiiHRDLKPeNILldnng + g+l e e+ + Qi+++l +L ++++ iH + + +++d+ g kb|SCYL1_H 78 RVEAGGL--KELEISWGLHQIVKALSFLVNdCSLIHNNVCMAAVFVDRAG 125 vvdaflKiaDFGlAkkls...t.sss.lttfvGTpwYmAPEv......ll + K++ Gl +s ++++ +++ +++ Y +PE+ ++++++ kb|SCYL1_H 126 EW----KLG--GLDYMYSaqgNgGGPpRKGIPELEQYDPPELadssgrVV 169 ggngygtkvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpp +++++ +D+W lG++++e+++G P + + l+ +i k+l kb|SCYL1_H 170 -REKWS--ADMWRLGCLIWEVFNG--PLPRA---AaLRNPGKIPKTLV-- 209 lefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqH + ++L+ +P+ R++ kb|SCYL1_H 210 -----------------------PHYCELVGA----NPKVRPN-----PA 227 Pwf<-* ++ kb|SCYL1_H 228 RFL 230 // Query sequence: kb|SBK_Hsap|Other/NKF1|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 183.5 1.2e-55 1 Pkinase_Tyr Protein tyrosine kinase 16.5 4.5e-17 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 261 [] 1 272 [] 16.5 4.5e-17 Pkinase 1/1 1 261 [] 1 287 [] 183.5 1.2e-55 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 261: score 16.5, E = 4.5e-17 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei +l ++LG+G +G+V + ++k gt++k A K ++k ++ ++ kb|SBK_Hsa 1 YELVRELGKGTYGKVDLVVYK----GTGTKMALKFVnKS-KTKLKN- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd FlrE+si +l + p i++ v+ ++++ + Ey++ Gd kb|SBK_Hsa 42 ----FLREVSITNSLSSSPFIIKVFDVVFETEDC----YVFAQEYAPAGD 83 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L d + L+ + +Q ++++ + +++vHRD+ N+L+ kb|SBK_Hsa 84 LFDIIPP---QVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLL 130 se..nlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygk. +++ + VK +DFG++R + r ++ + + +APE+ + g+ kb|SBK_Hsa 131 FDreCRRVKLADFGMTRRV-------GCRVKRVsGTIPYTAPEVCQAGRa 173 ....FtskSDVWSFGVlLWEiftlGeqPFYpgmsnee..vlellyedGyR ++ + DVW+FGVl++ ++t G P ++ s ++ + e++ +++R kb|SBK_Hsa 174 dglaVDTGVDVWAFGVLIFCVLT-GNFP-WEAASGADafFEEFVRWQRGR 221 Lpr.PenC...PdelYdlMlqCWaedPedRPtFselveeL<-* Lp P ++ +++ ++ ++ a +Pe+R +e+ ++L kb|SBK_Hsa 222 LPGlPSQWrrfTEPALRMFQRLLALEPERRGPAKEVFRFL 261 Pkinase: domain 1 of 1, from 1 to 261: score 183.5, E = 1.2e-55 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr yel++ lG+G++G+V + + kgtg + A+K ++k+k+k k +r kb|SBK_Hsa 1 YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNF---LR 44 lsEiqilkrL.sHpNIvrlidvfedkdhly.lVlEycegGLrvldLfdyl E++i ++L+s+p+I++ +dv+ + ++y + +Ey++ G dLfd++ kb|SBK_Hsa 45 --EVSITNSLsSSPFIIKVFDVVFETEDCYvFAQEYAPAG----DLFDII 88 setrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld.n + +l +ed++k+++ Q+ +l+++H + +HRD+KPeN+Ll ++ kb|SBK_Hsa 89 P---PQVGL--PEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFdR 133 ngvvdaflKiaDFGlAkklst.sss..lttfvGTpwYmAPEvll....gg ++ +K+aDFG t++ + + + + GT++Y APEv++ ++ +g kb|SBK_Hsa 134 ECRR---VKLADFGM-----TrRVGcrVKRVSGTIPYTAPEVCQagraDG 175 ngygtkvDvWSlGvilyelltGkpPFsgevqds.ldq.lqlirkilgppl +t vDvW++Gv+++++ltG++P+ + s++d ++ +++ +++l kb|SBK_Hsa 176 LAVDTGVDVWAFGVLIFCVLTGNFPWEAA---SgADAfFEEFVRWQRGRL 222 efdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHP + +w++ e+a+ ++L++ P++R a+e++ kb|SBK_Hsa 223 PGLPSQWRRFT-----------EPALRMFQRLLALEPERRGPAKEVFRF- 260 wf<-* + kb|SBK_Hsa 261 -L 261 // Query sequence: kb|RYK_Hsap|TK/Ryk|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 400.8 4.4e-121 1 Pkinase Protein kinase domain 63.9 1.1e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 267 [] 1 272 [] 400.8 4.4e-121 Pkinase 1/1 1 267 [] 1 287 [] 63.9 1.1e-19 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 267: score 400.8, E = 4.4e-121 *->lklgkkLGeGaFGeVykGtlkg.sgdgteikVAVKtLkeigaseeei ++l +L eG FG++++G+l ++++ ++e + VKt+k+ +ase + kb|RYK_Hsa 1 ITLKDVLQEGTFGRIFHGILIDeKDPNKEKQAFVKTVKD-QASEIQ- 45 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd +l E ++ l +H N++ vc++ege ++++++ym G+ kb|RYK_Hsa 46 -VTMMLTESCKLRGL-HHRNLLPITHVCIEEGEK----PMVILPYMNWGN 89 LldfLrkhr.....egrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAA L+ fLr+ + + +++++++ +dL+++a QiA+GM+YL+++ +H DLAA kb|RYK_Hsa 90 LKLFLRQCKlveanNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAA 139 RNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkyg RNc ++++l+VKI+D L+Rd+++ dy +++ Pv+WmA+Esl ++ kb|RYK_Hsa 140 RNCVIDDTLQVKITDNALSRDLFPMDYH-CLGDNENRPVRWMALESLVNN 188 kFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPe +F+s+SDVW+FGV+LWE++tlG++P Y +++++e+ ++l +dGyR ++P kb|RYK_Hsa 189 EFSSASDVWAFGVTLWELMTLGQTP-YVDIDPFEMAAYL-KDGYRIAQPI 236 nCPdelYdlMlqCWaedPedRPtFselveeL<-* nCPdel +M CWa dPe+RP F++lv++L kb|RYK_Hsa 237 NCPDELFAVMACCWALDPEERPKFQQLVQCL 267 Pkinase: domain 1 of 1, from 1 to 267: score 63.9, E = 1.1e-19 *->yelleklGsGsfGtVykakhkgtgk.....iVAvKiikkrkekskkd ++l+ +l +G+fG+ ++++ +++ +++++++ vK++k + + ++ kb|RYK_Hsa 1 ITLKDVLQEGTFGRIFHGILIDEKDpnkekQAFVKTVKDQASEIQVT 47 ktarrlsEiqilkrLsHpNIvrlidvfed.kdhlylVlEycegGLrvldL + ++ E + l+ L+H N + + +v+ +++ ++ ++l+y++ G L kb|RYK_Hsa 48 MMLT---ESCKLRGLHHRNLLPITHVCIEeGEKPMVILPYMNWG----NL 90 fdyls....e.trrkgpllfsedeakkialQilrgleYLHsngiiHRDLK + +l++ + +++ + ++ s +++ ++a Qi++g+ YL ++ +iH DL kb|RYK_Hsa 91 KLFLRqcklVeANNPQAI--SQQDLVHMAIQIACGMSYLARREVIHKDLA 138 PeNILldnngvvdaflKiaDFGlAkkls......t.sss.lttfvGTpwY N+ +d++ +v Ki+D l++ l + + + ++ +++ + ++ kb|RYK_Hsa 139 ARNCVIDDTLQV----KITDNALSRDLFpmdyhcLgDNEnRPV-----RW 179 mAPEvllggngygtkvDvWSlGvilyellt.GkpPFsgevqdsldqlqli mA E l +n+ ++++DvW++Gv+l+el+t G++P+ + d++++ kb|RYK_Hsa 180 MALESLV-NNEFSSASDVWAFGVTLWELMTlGQTPYVDI-----DPFEMA 223 rkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlt + + +++ p ++ +e+ ++ +c+++DP++R+ kb|RYK_Hsa 224 AYLKD-GYRIAQPINCP-------------DELFAVMACCWALDPEERPK 259 aeeilqHPwf<-* +++++q + kb|RYK_Hsa 260 FQQLVQC--L 267 // Query sequence: kb|RSKL2_Hsap|AGC/RSKL|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 24.3 9.3e-14 1 Pkinase_Tyr Protein tyrosine kinase -105.2 1.2e-09 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 1 387 [] 1 287 [] 24.3 9.3e-14 Pkinase_Tyr 1/1 5 381 .. 1 272 [] -105.2 1.2e-09 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 1 to 387: score 24.3, E = 9.3e-14 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ++++++ +V + ++ tg +++vK +++++ s ++ kb|RSKL2_H 1 CRVVGVIE-----KVQLVQDPATGGTFVVKSLPRCHMVSRER----- 37 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls. + i + p+ +l+++f ++d++ l lE+++gG L+++l + kb|RSKL2_H 38 ---LTIIPHG-VPYMTKLLRYFVSEDSIFLHLEHVQGG----TLWSHLLs 79 .................................................. + ++++++ ++++++++ + + +++ + ++ + ++++ +++++ +++ kb|RSKL2_H 80 qahsrhsglssgstqermkaqlnphlnlltparlpsghapgqdrialepp 129 .................................................. +++++ ++ ++++++++ +++++ +++++++++ ++ ++++ + + + kb|RSKL2_H 130 rtspnlllageapstrpqreaegeptartstsgssdlpkapgghlhlqar 179 ...........................................e..trrk + +++++ +++++ + +++ ++ ++ +++ +++ + ++ +++ r+ kb|RSKL2_H 180 ragqnsdagpprgltwvpegagpvlggcgrgmdqsclsadgagRgcGRAT 229 gpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngvvdaf ++ e+++k +a ++l +le LH++g++ RDL P N+Lld+ g++ kb|RSKL2_H 230 WSV--REEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHI--- 274 lKiaDFGlAkklst.sss..lttfvGTpwYmAPEvllggngygtkvDvWS +++ FG ++ ++++ + ++ Y APEv ++ + ++D+WS kb|RSKL2_H 275 -RLTYFGQ-----WsEVEpqCCGEAVDNLYSAPEVGG-ISELTEACDWWS 317 lGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsisrs +G +lyelltG + +++ + +q + + pew s kb|RSKL2_H 318 FGSLLYELLTGMALSQSH----PSGIQAHTQLQL-------PEWLS---- 352 efrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf<-* ++a +L++ +L++ P++Rl+ ++++ ++ HP+f kb|RSKL2_H 353 ---------RPAASLLTELLQFEPTRRLGmgeggVSKLKSHPFF 387 Pkinase_Tyr: domain 1 of 1, from 5 to 381: score -105.2, E = 1.2e-09 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei G++ k l ++ t+ + VK+L++ + ++e kb|RSKL2_H 5 ------------GVIEKVQLV-QDPATGGTFVVKSLpRC-HMVSRE- 36 eredFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG r + + + M+kl L +++ +++ +++ +E+++gG kb|RSKL2_H 37 -RLTIIPhGVPYMTKL--------LRYFVS--EDS----IFLHLEHVQGG 71 dLldfLrkhr........................................ L ++L ++ ++++++ ++++++++ + + +++ + ++ + ++++ +++ kb|RSKL2_H 72 TLWSHLLSQAhsrhsglssgstqermkaqlnphlnlltparlpsghapgq 121 .................................................. ++ ++++++++ ++ ++++++++ +++++ +++++++++ ++ ++ kb|RSKL2_H 122 drialepprtspnlllageapstrpqreaegeptartstsgssdlpkapg 171 .................................................. ++ + + ++ +++++ +++++ + +++ ++ ++ +++ +++ + ++ kb|RSKL2_H 172 ghlhlqarragqnsdagpprgltwvpegagpvlggcgrgmdqsclsadga 221 ......egrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVsen +++ ++ ++ ++ ++a++ ++e L++++ RDL N L++ kb|RSKL2_H 222 grgcgrATWSVREEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQA 271 lvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygk..Ftsk ++++ + FG + + g + APE g+++ t++ kb|RSKL2_H 272 GHIRLTYFGQWSEV-------EPQCCGEaVDNLYSAPE--VGGIseLTEA 312 SDVWSFGVlLWEiftlGe.qPFYpgmsneevlellyedGyRLprPenCPd D WSFG lL+E++t G+ s + +l + + L rP kb|RSKL2_H 313 CDWWSFGSLLYELLT-GMaLS-QSHPSGIQAHTQL-QLPEWLSRPA---- 355 elYdlMlqCWaedPedRPtFsel.veeL<-* +l+++ +++P +R + e +v++L kb|RSKL2_H 356 --ASLLTELLQFEPTRRLGMGEGgVSKL 381 // Query sequence: kb|RSKL1_Hsap|AGC/RSKL|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 13.1 4.4e-13 1 Pkinase_Tyr Protein tyrosine kinase -163.3 4.4e-06 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 17 229 .. 1 272 [] -163.3 4.4e-06 Pkinase 1/1 17 235 .] 1 287 [] 13.1 4.4e-13 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 17 to 229: score -163.3, E = 4.4e-06 *->lklgkkLGeGaFGeVykGtlkg.sgdgteikVAVKtL.keigaseee lk ++L l+ ++ d+ L ke ++ kb|RSKL1_H 17 LKTEEVL------------LFTdQTDD---------LaKE-EPTSL- 40 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG F r ++ + G +++ g+ + + ++E kb|RSKL1_H 41 -----FQRDSETKGES----------GLVLE-GDKE---IHQIFE----- 66 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL dL++ L ++ ++ + +a++ +++ L++ ++v RDL N+L kb|RSKL1_H 67 DLDKKLALA-SRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNIL 115 VsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPv..kWmAPEslkygk +++ +++ + F +R + +++ + +++ +APE+ + + kb|RSKL1_H 116 LNDRGHIQLTYF--SRWS-------EVEDSCDsDAIerMYCAPEVGAITE 156 FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPen t++ D WS G +L+E++t G + ++ ++ + L +Pe kb|RSKL1_H 157 ETEACDWWSLGAVLFELLT-G-KT-LVECHPAG----I-NTHTTLNMPEC 198 CPdelYdlMlqCWaedPedRPtFsel.veeL<-* ++e +l++q +++P +R +ve++ kb|RSKL1_H 199 VSEEARSLIQQLLQFNPLERLGAGVAgVEDI 229 Pkinase: domain 1 of 1, from 17 to 235: score 13.1, E = 4.4e-13 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar ++++e V + +++ + K+ + + +++++ k kb|RSKL1_H 17 LKTEE---------VLLFTDQTDDL---AKEEPTSlFQRDSETKG-- 49 rlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls E + ++ +++++ ++E +++ L l kb|RSKL1_H 50 ---ESGLVLEG--------------DKEIHQIFEDLDK-----KLA--LA 75 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng ++ + +e ++++a +++ +l+ LH++gi+ RDL P NILl+++g kb|RSKL1_H 76 ---SRFYI--PEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRG 120 vvdaflKiaDFGlAkklst.sss..lttfvGTpwYmAPEvllggngygtk ++ ++ F ++ ++ ++++++ + + Y+APEv ++ + + kb|RSKL1_H 121 HI----QLTYF--SR---WsEVEdsCDSDAIERMYCAPEVGA-ITEETEA 160 vDvWSlGvilyelltGkpPFs.gevqdsldqlqlirkilgpplefdspew +D+WSlG +l+elltGk++ + + + ++++ kb|RSKL1_H 161 CDWWSLGAVLFELLTGKTLVEcHP----AGINTHTTLNMP---------- 196 dsisrsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf ++s eea++Li +L+++P +Rl+ + + e+i+ HP+f kb|RSKL1_H 197 ECVS-----------EEARSLIQQLLQFNPLERLGagvagVEDIKSHPFF 235 <-* kb|RSKL1_H - - // Query sequence: kb|RSK4_Hsap|AGC/RSK/RSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 325.5 2.1e-98 1 Pkinase_Tyr Protein tyrosine kinase 84.2 9.3e-26 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 256 [. 1 272 [] 84.2 9.3e-26 Pkinase 1/1 1 258 [] 1 287 [] 325.5 2.1e-98 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 256: score 84.2, E = 9.3e-26 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei ++l+k+LG+G+FG+V++ + k g + ++ A K+L+k + ++ kb|RSK4_Hs 1 FELLKVLGQGSFGKVFLVRKK-TGPDAGQLYAMKVLkKA-SLKVRD- 44 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd r E i+ + +Hp iV+L+ + ++ ly+++ + gGd kb|RSK4_Hs 45 -RVRTKMERDILVEV-NHPFIVKLHYAFQT-EGK----LYLILDFLRGGD 87 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV + L k + +t +d + ++ A ++++L++ ++v RDL N+L+ kb|RSK4_Hs 88 VFTRLSK---EVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILL 134 senlvVKIsDFGLaRdi..ysddyYvrkrgggklPvkWmAPEslkygkFt +e +++K +DFGL++ ++++ Y g v mAPE+ + + + kb|RSK4_Hs 135 DEIGHIKLTDFGLSKESvdQEKKAY-SFCG----TVEYMAPEVVNRRGHS 179 skSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCP D WS+GVl++E++t G P ++g + +e+++++ ++ +p+ + kb|RSK4_Hs 180 QSADWWSYGVLMFEMLT-GTLP-FQGKDRNETMNMILKAKLGMPQFL--S 225 delYdlMlqCWaedPedRP...tFselveeL<-* +e +l+++ +++P++R +++ +e+ ++L kb|RSK4_Hs 226 AEAQSLLRMLFKRNPANRLgseGVEEIKRHL 256 Pkinase: domain 1 of 1, from 1 to 258: score 325.5, E = 2.1e-98 *->yelleklGsGsfGtVykakhkgtgk...iVAvKiikkrkekskkdkt +ell++lG+GsfG+V++ ++k ++ ++++A+K++kk + k + + kb|RSK4_Hs 1 FELLKVLGQGSFGKVFLVRKKTGPDagqLYAMKVLKKASLKVRDRVR 47 arrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdy E il +++Hp+Iv+l+++f+++++lyl+l++++gG d f++ kb|RSK4_Hs 48 TKM--ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGG----DVFTR 91 lsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldn ls ++ + +e+++k+++ +++ +l++LH+ gi++RDLKPeNILld+ kb|RSK4_Hs 92 LS---KEVLF--TEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDE 136 ngvvdaflKiaDFGlAkklst.sss..lttfvGTpwYmAPEvllggngyg g++ K++DFGl+k +++++++f+GT +YmAPEv++ ++g++ kb|RSK4_Hs 137 IGHI----KLTDFGLSKE--SvDQEkkAYSFCGTVEYMAPEVVN-RRGHS 179 tkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspe +++D+WS+Gv+++e+ltG +PF+g+ d ++ + +il+++l + + kb|RSK4_Hs 180 QSADWWSYGVLMFEMLTGTLPFQGK-----DRNETMNMILKAKLGMPQFL 224 wdsisrsefrrlpnlseeakdLikkcLnkDPskRlt...aeeilqHPwf< + ea++L++ +++++P+ Rl++++ eei+ H +f kb|RSK4_Hs 225 S---------------AEAQSLLRMLFKRNPANRLGsegVEEIKRHLFF 258 -* kb|RSK4_Hs - - // Query sequence: kb|RSK4~b_Hsap|AGC/RSK/RSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 361.2 3.7e-109 1 Pkinase_Tyr Protein tyrosine kinase 47.9 5.4e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 258 [] 1 272 [] 47.9 5.4e-19 Pkinase 1/1 1 258 [] 1 287 [] 361.2 3.7e-109 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 258: score 47.9, E = 5.4e-19 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei +l + +G G++ + +++ t+++ AVK+++k + +++e kb|RSK4~b_ 1 YELKEDIGVGSYSVCKRCIHA----TTNMEFAVKIIdKS-KRDPSE- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd E++i++++G+HpNi+ L v + g+ +y+Vt +m+gG kb|RSK4~b_ 42 -------EIEILMRYGQHPNIITLKDVFDD-GRY----VYLVTDLMKGGE 79 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV Lld k ++ ++ + ++ + i+k +YL+ ++ vHRDL N+L kb|RSK4~b_ 80 LLDRILK---QKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILY 126 se....nlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm....APEsl +++ + ++I+DFG a+++ r g l + + APE+l kb|RSK4~b_ 127 MDesasADSIRICDFGFAKQL-------RGENGLLLTPCYTanfvAPEVL 169 kygkFtskSDVWSFGVlLWEiftlGeqPFY...pgmsneevlellyedGy + + + D+WS GVl + ++ G +P + ++p+ ++ee+l +++ kb|RSK4~b_ 170 MQQGYDAACDIWSLGVLFYTMLA-GYTP-FangPNDTPEEILLRIGNGKF 217 RLpr..PenCPdelYdlMlqCWaedPedRPtFsel..veeL<-* L ++ +n +d dl+ + + dP +R t +++ +++ + kb|RSK4~b_ 218 SLSGgnWDNISDGAKDLLSHMLHMDPHQRYTAEQIlkHSWI 258 Pkinase: domain 1 of 1, from 1 to 258: score 361.2, E = 3.7e-109 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr yel+e +G Gs++++++++h t+ ++AvKii+k+k+++++ kb|RSK4~b_ 1 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSE------ 41 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls Ei+il r ++HpNI++l+dvf d++++ylV++++ gG +L d++ kb|RSK4~b_ 42 --EIEILMRYgQHPNIITLKDVFDDGRYVYLVTDLMKGG----ELLDRIL 85 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng +++++ se+ea +i++ i + ++YLH +g++HRDLKP+NIL+ ++ kb|RSK4~b_ 86 ---KQKCF--SEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDES 130 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv +++++i+DFG+Ak+l + ++ l t++ T +++APEvl+ ++gy+ ++ kb|RSK4~b_ 131 ASADSIRICDFGFAKQL-RgENGlLLTPCYTANFVAPEVLM-QQGYDAAC 178 DvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspewd D+WSlGv++y +l G++PF + +++++ +++ +i+ ++++ + +wd kb|RSK4~b_ 179 DIWSLGVLFYTMLAGYTPFANG---PnDTPEEILLRIGNGKFSLSGGNWD 225 sisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +is + akdL++ +L++DP++R+tae+il+H w+ kb|RSK4~b_ 226 NIS-----------DGAKDLLSHMLHMDPHQRYTAEQILKHSWI 258 // Query sequence: kb|RSK3_Hsap|AGC/RSK/RSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 330.6 5.9e-100 1 Pkinase_Tyr Protein tyrosine kinase 88.1 6.1e-27 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 258 [. 1 272 [] 88.1 6.1e-27 Pkinase 1/1 1 258 [. 1 287 [] 330.6 5.9e-100 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 258: score 88.1, E = 6.1e-27 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei ++l+k+LG+G+FG+V++ + +d++++ A K+L+k + ++ kb|RSK3_Hs 1 FELLKVLGQGSFGKVFLVRKVTRPDSGHLY-AMKVLkKA-TLKVRD- 44 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd r E i+ +Hp +V+L+ + ++ ly+++ + gGd kb|RSK3_Hs 45 -RVRTKMERDILADV-NHPFVVKLHYAFQT-EGK----LYLILDFLRGGD 87 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L + L k + +t +d + ++ A G+++L+s +++ RDL N+L+ kb|RSK3_Hs 88 LFTRLSK---EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILL 134 senlvVKIsDFGLaRdi..ysddyYvrkrgggklPvkWmAPEslkygkFt +e++++K +DFGL++ ++++ Y g v mAPE+ + + kb|RSK3_Hs 135 DEEGHIKLTDFGLSKEAidHEKKAY-SFCG----TVEYMAPEVVNRQGHS 179 skSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCP + D WS+GVl++E++t G P ++g + e++ l+ ++ +p+ + kb|RSK3_Hs 180 HSADWWSYGVLMFEMLT-GSLP-FQGKDRKETMTLILKAKLGMPQFL--S 225 delYdlMlqCWaedPedRP.....tFselveeL<-* e +l++ +++P++R +++++ +e+ ++ kb|RSK3_Hs 226 TEAQSLLRALFKRNPANRLgsgpdGAEEIKRHV 258 Pkinase: domain 1 of 1, from 1 to 258: score 330.6, E = 5.9e-100 *->yelleklGsGsfGtV...ykakhkgtgkiVAvKiikkrkekskkdkt +ell++lG+GsfG+V +k ++ ++g+++A+K++kk + k + + kb|RSK3_Hs 1 FELLKVLGQGSFGKVflvRKVTRPDSGHLYAMKVLKKATLKVRDRVR 47 arrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdy E il+ ++Hp++v+l+++f+++++lyl+l++++gG dLf++ kb|RSK3_Hs 48 TKM--ERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGG----DLFTR 91 lsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldn ls ++ + +e+++k+++ +++ gl++LHs gii+RDLKPeNILld+ kb|RSK3_Hs 92 LS---KEVMF--TEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE 136 ngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygt +g++ K++DFGl+k + +++ ++++f+GT +YmAPEv++ ++g+++ kb|RSK3_Hs 137 EGHI----KLTDFGLSKEA-IdHEKkAYSFCGTVEYMAPEVVN-RQGHSH 180 kvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspew ++D+WS+Gv+++e+ltG +PF+g+ d ++ + +il+++l + + + kb|RSK3_Hs 181 SADWWSYGVLMFEMLTGSLPFQGK-----DRKETMTLILKAKLGMPQFLS 225 dsisrsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf ea++L++ +++++P+ Rl++++++aeei+ H + kb|RSK3_Hs 226 ---------------TEAQSLLRALFKRNPANRLGsgpdgAEEIKRH--V 258 <-* kb|RSK3_Hs - - // Query sequence: kb|RSK3~b_Hsap|AGC/RSK/RSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 391.1 3.8e-118 1 Pkinase_Tyr Protein tyrosine kinase 60.7 8.9e-20 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 256 [. 1 272 [] 60.7 8.9e-20 Pkinase 1/1 1 258 [] 1 287 [] 391.1 3.8e-118 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 256: score 60.7, E = 8.9e-20 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei + +++G G++ e +++ k t+++ AVK+++k + +++e kb|RSK3~b_ 1 YVVKETIGVGSYSECKRCVHK----ATNMEYAVKVIdKS-KRDPSE- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd E++i+ ++G+HpNi+ L v + g+ +y+VtE+m gG kb|RSK3~b_ 42 -------EIEILLRYGQHPNIITLKDVYDD-GKH----VYLVTELMRGGE 79 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV Lld + ++ ++ + + i k eYL+s++ vHRDL N+L kb|RSK3~b_ 80 LLDKILR---QKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILY 126 se....nlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm....APEsl ++++++ + +I+DFG a+++ r+ g + + + APE+l kb|RSK3~b_ 127 VDesgnPECLRICDFGFAKQL-------RAENGLLMTPCYTanfvAPEVL 169 kygkFtskSDVWSFGVlLWEiftlGeqPFYpg...msneevlellyedGy k + + D+WS G+lL+ ++ G +P ++++++ ++ee+l +++ kb|RSK3~b_ 170 KRQGYDEGCDIWSLGILLYTMLA-GYTP-FANgpsDTPEEILTRIGSGKF 217 RLpr..PenCPdelYdlMlqCWaedPedRPtFselveeL<-* L ++ ++ dl + + dP +R t ++++++ kb|RSK3~b_ 218 TLSGgnWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHP 256 Pkinase: domain 1 of 1, from 1 to 258: score 391.1, E = 3.8e-118 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y+++e++G Gs++++++++hk t+ ++AvK+i+k+k+++++ kb|RSK3~b_ 1 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE------ 41 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls Ei+il+r ++HpNI++l+dv+ d++h+ylV+E+++gG +L d + kb|RSK3~b_ 42 --EIEILLRYgQHPNIITLKDVYDDGKHVYLVTELMRGG----ELLDKIL 85 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng r++ + se+ea +++ i + +eYLHs+g++HRDLKP+NIL++++ kb|RSK3~b_ 86 ---RQKFF--SEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDES 130 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv ++++l+i+DFG+Ak+l ++ l+t++ T +++APEvl+ ++gy+ + kb|RSK3~b_ 131 GNPECLRICDFGFAKQL-RaENGlLMTPCYTANFVAPEVLK-RQGYDEGC 178 DvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspewd D+WSlG++ly +l G++PF + +++++ +++ +i+++++ + +w+ kb|RSK3~b_ 179 DIWSLGILLYTMLAGYTPFANG---PsDTPEEILTRIGSGKFTLSGGNWN 225 sisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* ++s e+akdL++k+L++DP++Rlta+++lqHPw+ kb|RSK3~b_ 226 TVS-----------ETAKDLVSKMLHVDPHQRLTAKQVLQHPWV 258 // Query sequence: kb|RSK2_Hsap|AGC/RSK/RSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 335.5 2.1e-101 1 Pkinase_Tyr Protein tyrosine kinase 90.5 1.1e-27 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 260 [] 1 272 [] 90.5 1.1e-27 Pkinase 1/1 1 260 [] 1 287 [] 335.5 2.1e-101 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 260: score 90.5, E = 1.1e-27 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei ++l+k+LG+G+FG+V++ + sg++ ++ A K+L+k + ++ kb|RSK2_Hs 1 FELLKVLGQGSFGKVFLVKKI-SGSDARQLYAMKVLkKA-TLKVRD- 44 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd r E i+ + +Hp iV+L+ + ++ ly+++ + gGd kb|RSK2_Hs 45 -RVRTKMERDILVEV-NHPFIVKLHYAFQT-EGK----LYLILDFLRGGD 87 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L + L k + +t +d + ++ A ++++L+s +++ RDL N+L+ kb|RSK2_Hs 88 LFTRLSK---EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILL 134 senlvVKIsDFGLaRdi..ysddyYvrkrgggklPvkWmAPEslkygkFt +e++++K +DFGL++ ++++ Y g v mAPE+ + + t kb|RSK2_Hs 135 DEEGHIKLTDFGLSKESidHEKKAY-SFCG----TVEYMAPEVVNRRGHT 179 skSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCP D WSFGVl++E++t G P ++g + e++ ++ ++ +p+ + kb|RSK2_Hs 180 QSADWWSFGVLMFEMLT-GTLP-FQGKDRKETMTMILKAKLGMPQFL--S 225 delYdlMlqCWaedPedRPtF.....sel..veeL<-* +e +l+++ +++P++R ++++ +e+++++++ kb|RSK2_Hs 226 PEAQSLLRMLFKRNPANRLGAgpdgvEEIkrHSFF 260 Pkinase: domain 1 of 1, from 1 to 260: score 335.5, E = 2.1e-101 *->yelleklGsGsfGtVykakhkgtgk...iVAvKiikkrkekskkdkt +ell++lG+GsfG+V++ k+++ ++ ++++A+K++kk + k + + kb|RSK2_Hs 1 FELLKVLGQGSFGKVFLVKKISGSDarqLYAMKVLKKATLKVRDRVR 47 arrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdy E il +++Hp+Iv+l+++f+++++lyl+l++++gG dLf++ kb|RSK2_Hs 48 TKM--ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGG----DLFTR 91 lsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldn ls ++ + +e+++k+++ +++ +l++LHs gii+RDLKPeNILld+ kb|RSK2_Hs 92 LS---KEVMF--TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDE 136 ngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygt +g++ K++DFGl+k +++ ++++f+GT +YmAPEv++ ++g+++ kb|RSK2_Hs 137 EGHI----KLTDFGLSKES-IdHEKkAYSFCGTVEYMAPEVVN-RRGHTQ 180 kvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspew ++D+WS+Gv+++e+ltG +PF+g+ d ++ + +il+++l + + + kb|RSK2_Hs 181 SADWWSFGVLMFEMLTGTLPFQGK-----DRKETMTMILKAKLGMPQFLS 225 dsisrsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf +ea++L++ +++++P+ Rl+ ++++ eei+ H +f kb|RSK2_Hs 226 ---------------PEAQSLLRMLFKRNPANRLGagpdgVEEIKRHSFF 260 <-* kb|RSK2_Hs - - // Query sequence: kb|RSK2~b_Hsap|AGC/RSK/RSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 376.4 1e-113 1 Pkinase_Tyr Protein tyrosine kinase 61.7 7.7e-20 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 256 [. 1 272 [] 61.7 7.7e-20 Pkinase 1/1 1 258 [] 1 287 [] 376.4 1e-113 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 256: score 61.7, E = 7.7e-20 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei + + +G G++ + +++ k t+++ AVK+++k + ++ e kb|RSK2~b_ 1 YEVKEDIGVGSYSVCKRCIHK----ATNMEFAVKIIdKS-KRDPTE- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd E++i+ ++G+HpNi+ L v + g+ +y+VtE+m+gG kb|RSK2~b_ 42 -------EIEILLRYGQHPNIITLKDVYDD-GKY----VYVVTELMKGGE 79 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV Lld + ++ ++ + + i k eYL++++ vHRDL N+L kb|RSK2~b_ 80 LLDKILR---QKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILY 126 se....nlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm....APEsl ++++++ ++I+DFG a+++ r+ g + + + APE+l kb|RSK2~b_ 127 VDesgnPESIRICDFGFAKQL-------RAENGLLMTPCYTanfvAPEVL 169 kygkFtskSDVWSFGVlLWEiftlGeqPFY...pgmsneevlellyed.. k + + D+WS GVlL+ ++t G +P + ++p+ ++ee+l+++ +++ kb|RSK2~b_ 170 KRQGYDAACDIWSLGVLLYTMLT-GYTP-FangPDDTPEEILARI-GSgk 216 .....GyRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* + ++Gy + dl + + dP +R t + ++++ kb|RSK2~b_ 217 fslsgGYWNSVSD----TAKDLVSKMLHVDPHQRLTAALVLRHP 256 Pkinase: domain 1 of 1, from 1 to 258: score 376.4, E = 1e-113 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ye++e +G Gs++++++++hk t+ ++AvKii+k+k+++ + kb|RSK2~b_ 1 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE------ 41 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls Ei+il+r ++HpNI++l+dv+ d++++y+V+E++ gG +L d + kb|RSK2~b_ 42 --EIEILLRYgQHPNIITLKDVYDDGKYVYVVTELMKGG----ELLDKIL 85 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng r++ + se+ea ++ i + +eYLH++g++HRDLKP+NIL++++ kb|RSK2~b_ 86 ---RQKFF--SEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDES 130 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv ++++++i+DFG+Ak+l ++ l+t++ T +++APEvl+ ++gy+ ++ kb|RSK2~b_ 131 GNPESIRICDFGFAKQL-RaENGlLMTPCYTANFVAPEVLK-RQGYDAAC 178 DvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspewd D+WSlGv+ly +ltG++PF + +++++ +++++i++++++ + +w+ kb|RSK2~b_ 179 DIWSLGVLLYTMLTGYTPFANG---PdDTPEEILARIGSGKFSLSGGYWN 225 sisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* s+s ++akdL++k+L++DP++Rlta+ +l HPw+ kb|RSK2~b_ 226 SVS-----------DTAKDLVSKMLHVDPHQRLTAALVLRHPWI 258 // Query sequence: kb|RSK1_Hsap|AGC/RSK/RSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 340.6 6e-103 1 Pkinase_Tyr Protein tyrosine kinase 91.9 4.4e-28 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 254 [. 1 272 [] 91.9 4.4e-28 Pkinase 1/1 1 260 [] 1 287 [] 340.6 6e-103 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 254: score 91.9, E = 4.4e-28 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei ++l+k+LG+G++G+V++ + +g++ ++ A K+L+k + ++ kb|RSK1_Hs 1 FELLKVLGQGSYGKVFLVRKV-KGSDAGQLYAMKVLkKA-TLKVRD- 44 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd r E i+ + +Hp iV+L+ + ++ ly+++ + gGd kb|RSK1_Hs 45 -RVRSKMERDILAEV-NHPFIVKLHYAFQT-EGK----LYLILDFLRGGD 87 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L + L k + +t +d + ++ A ++++L+s +++ RDL N+L+ kb|RSK1_Hs 88 LFTRLSK---EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILL 134 senlvVKIsDFGLaRdiysddyY.vrkrgggklPvkWmAPEslkygkFts +e++++KI+DFGL++ + d + g + mAPE+ + + t kb|RSK1_Hs 135 DEEGHIKITDFGLSKEAIDHDKRaYSFCG----TIEYMAPEVVNRRGHTQ 180 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPd D WSFGVl++E++t G P ++g + e+++l+ ++ +p+ + kb|RSK1_Hs 181 SADWWSFGVLMFEMLT-GSLP-FQGKDRKETMALILKAKLGMPQFL--SG 226 elYdlMlqCWaedPedRPtFsel..veeL<-* e +l++ +++P +R + +++vee+ kb|RSK1_Hs 227 EAQSLLRALFKRNPCNRLG-AGIdgVEEI 254 Pkinase: domain 1 of 1, from 1 to 260: score 340.6, E = 6e-103 *->yelleklGsGsfGtVykakhkgtgk...iVAvKiikkrkekskkdkt +ell++lG+Gs+G+V++ ++++ ++ ++++A+K++kk + k + + kb|RSK1_Hs 1 FELLKVLGQGSYGKVFLVRKVKGSDagqLYAMKVLKKATLKVRDRVR 47 arrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdy E il++++Hp+Iv+l+++f+++++lyl+l++++gG dLf++ kb|RSK1_Hs 48 SKM--ERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGG----DLFTR 91 lsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldn ls ++ + +e+++k+++ +++ +l++LHs gii+RDLKPeNILld+ kb|RSK1_Hs 92 LS---KEVMF--TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDE 136 ngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygt +g++ Ki+DFGl+k + ++++ ++++f+GT++YmAPEv++ ++g+++ kb|RSK1_Hs 137 EGHI----KITDFGLSKEA-IdHDKrAYSFCGTIEYMAPEVVN-RRGHTQ 180 kvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspew ++D+WS+Gv+++e+ltG +PF+g+ d ++ +++il+++l + + + kb|RSK1_Hs 181 SADWWSFGVLMFEMLTGSLPFQGK-----DRKETMALILKAKLGMPQFLS 225 dsisrsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf ea++L++ +++++P Rl+ + ++ eei+ HP+f kb|RSK1_Hs 226 ---------------GEAQSLLRALFKRNPCNRLGagidgVEEIKRHPFF 260 <-* kb|RSK1_Hs - - // Query sequence: kb|RSK1~b_Hsap|AGC/RSK/RSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 369.5 1.2e-111 1 Pkinase_Tyr Protein tyrosine kinase 64.8 5e-20 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 256 [. 1 272 [] 64.8 5e-20 Pkinase 1/1 1 258 [] 1 287 [] 369.5 1.2e-111 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 256: score 64.8, E = 5e-20 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei ++ + +G G++ + +++ k t+++ AVK+++k + +++e kb|RSK1~b_ 1 YEIKEDIGVGSYSVCKRCVHK----ATDTEYAVKIIdKS-KRDPSE- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd E++i+ ++G+HpNi+ L v + g+ +y+V+E+m gG kb|RSK1~b_ 42 -------EIEILLRYGQHPNIITLKDVYDD-GKF----VYLVMELMRGGE 79 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV Lld + +r ++ + + i k M+YL+s++ vHRDL N+L kb|RSK1~b_ 80 LLDRILR---QRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILY 126 se....nlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm....APEsl ++++++ ++++DFG a+++ r++ g + + + APE+l kb|RSK1~b_ 127 RDesgsPESIRVCDFGFAKQL-------RAGNGLLMTPCYTanfvAPEVL 169 kygkFtskSDVWSFGVlLWEiftlGeqPFY...pgmsneevlellyedGy k + + D+WS G+lL+ ++ G +P + ++p+ ++ee+l++++ y kb|RSK1~b_ 170 KRQGYDAACDIWSLGILLYTMLA-GFTP-FangPDDTPEEILARIGSGKY 217 RLpr..PenCPdelYdlMlqCWaedPedRPtFselveeL<-* L ++ + +d d+ + + dP +R t +++ + kb|RSK1~b_ 218 ALSGgnWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHP 256 Pkinase: domain 1 of 1, from 1 to 258: score 369.5, E = 1.2e-111 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ye++e +G Gs++++++++hk t ++AvKii+k+k+++++ kb|RSK1~b_ 1 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSE------ 41 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls Ei+il+r ++HpNI++l+dv+ d++ +ylV+E+++gG +L d++ kb|RSK1~b_ 42 --EIEILLRYgQHPNIITLKDVYDDGKFVYLVMELMRGG----ELLDRIL 85 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng r++ + se+ea +++ i + ++YLHs+g++HRDLKP+NIL+ ++ kb|RSK1~b_ 86 ---RQRYF--SEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDES 130 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv +++++++DFG+Ak+l ++ l+t++ T +++APEvl+ ++gy+ ++ kb|RSK1~b_ 131 GSPESIRVCDFGFAKQL-RaGNGlLMTPCYTANFVAPEVLK-RQGYDAAC 178 DvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspewd D+WSlG++ly +l G +PF + +++++ +++++i+++++ + +wd kb|RSK1~b_ 179 DIWSLGILLYTMLAGFTPFANG---PdDTPEEILARIGSGKYALSGGNWD 225 sisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* sis ++akd+++k+L++DP++Rlta+++l+HPw+ kb|RSK1~b_ 226 SIS-----------DAAKDVVSKMLHVDPHQRLTAMQVLKHPWV 258 // Query sequence: kb|ROS_Hsap|TK/Sev|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 511.7 1.9e-154 1 Pkinase Protein kinase domain 138.5 4e-42 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 271 [] 1 272 [] 511.7 1.9e-154 Pkinase 1/1 1 271 [] 1 287 [] 138.5 4e-42 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 271: score 511.7, E = 1.9e-154 *->lklgkkLGeGaFGeVykGtlkg..sgdgteikVAVKtLkeigaseee l+l LG+GaFGeVy+Gt+ + +++eikVAVKtLk+ g++++e kb|ROS_Hsa 1 LTLRLLLGSGAFGEVYEGTAVDilGVGSGEIKVAVKTLKK-GSTDQE 46 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG + +Fl+EA +M+k+ +HpNi++ lGvc+ eP yi++E+megG kb|ROS_Hsa 47 --KIEFLKEAHLMSKF-NHPNILKQLGVCLL-NEP----QYIILELMEGG 88 dLldfLrkhr....egrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAA dLl++Lrk r + g+ Ltl dL++ +++i+kG+ YLe+++f+HRDLAA kb|ROS_Hsa 89 DLLTYLRKARmatfYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAA 138 RNcLVs.....enlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPE RNcLVs ++ +++++VKI+DFGLaRdiy+ dyY rkrg+g lPv+WmAPE kb|ROS_Hsa 139 RNCLVSvkdytSPRIVKIGDFGLARDIYKNDYY-RKRGEGLLPVRWMAPE 187 slkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyR sl++g+Ft++SDVWSFG+l+WEi+tlG qP Yp sn +vl+++ + G+R kb|ROS_Hsa 188 SLMDGIFTTQSDVWSFGILIWEILTLGHQP-YPAHSNLDVLNYV-QTGGR 235 LprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* L++P+nCPd+l +lM+qCWa +P++RPtF ++ +L kb|ROS_Hsa 236 LEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL 271 Pkinase: domain 1 of 1, from 1 to 271: score 138.5, E = 4e-42 *->yelleklGsGsfGtVykakhkgtgk......iVAvKiikkrkekskk ++l lGsG+fG+Vy+++ ++ ++++ +VAvK++kk +++ +k kb|ROS_Hsa 1 LTLRLLLGSGAFGEVYEGTAVDILGvgsgeiKVAVKTLKKGSTDQEK 47 dktarrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldL ++ ++ E++++ +++HpNI++ ++v+ + y++lE++egG dL kb|ROS_Hsa 48 -IEFLK--EAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGG----DL 90 fdyls..e.trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPe +yl++ + + +gpl ++ ++ + + i +g YL ++ +iHRDL kb|ROS_Hsa 91 LTYLRkaRmATFYGPL-LTLVDLVDLCVDISKGCVYLERMHFIHRDLAAR 139 NILldnngvvda.flKiaDFGlAkkls.....t.sss.lttfvGTpwYmA N+L++ +++++++++Ki+DFGlA+ +++++ +++++l + ++mA kb|ROS_Hsa 140 NCLVSVKDYTSPrIVKIGDFGLARDIYkndyyRkRGEgLLPV----RWMA 185 PEvllggngygtkvDvWSlGvilyellt.GkpPFsgevqds.ldqlqlir PE l+ + +t +DvWS+G++++e lt G+ P++ + s+ld l ++ kb|ROS_Hsa 186 PESLM-DGIFTTQSDVWSFGILIWEILTlGHQPYPAH---SnLDVLNYVQ 231 kilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlta ++ ++++++p +++ L++ c+++ P +R+t+ kb|ROS_Hsa 232 TGGRLEPPRNCP-----------------DDLWNLMTQCWAQEPDQRPTF 264 eeilqHPwf<-* + i + kb|ROS_Hsa 265 HRIQDQ--L 271 // Query sequence: kb|ROR2_Hsap|TK/Ror|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 462.3 1.4e-139 1 Pkinase Protein kinase domain 102.4 2.9e-31 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 274 [. 1 272 [] 462.3 1.4e-139 Pkinase 1/1 1 274 [. 1 287 [] 102.4 2.9e-31 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 274: score 462.3, E = 1.4e-139 *->lklgkkLGeGaFGeVykGtlkg.sgdgteikVAVKtLkeigaseeei ++++++LGe FG+VykG+l+g+ ++++++ VA+KtLk+ +a + kb|ROR2_Hs 1 VRFMEELGEDRFGKVYKGHLFGpAPGEQTQAVAIKTLKD-KAEGPL- 45 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd re+F +EA + +l +HpN+V+LlGv+tk ++P l +++ y+ +Gd kb|ROR2_Hs 46 -REEFRHEAMLRARL-QHPNVVCLLGVVTK-DQP----LSMIFSYCSHGD 88 LldfLrkhr.............egrpLtlkdLlsfalQiAkGMeYLeskn L++fL ++++++ ++++++++ + +L +d ++ +QiA+GMeYL+s++ kb|ROR2_Hs 89 LHEFLVMRSphsdvgstdddrtVKSALEPPDFVHLVAQIAAGMEYLSSHH 138 fvHRDLAARNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm vH DLA+RN+LV ++l VKIsD GL R +y dyY + g++ lP++Wm kb|ROR2_Hs 139 VVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYY-KLLGNSLLPIRWM 187 APEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyed APE+++ygkF++ SD+WS+GV+LWE+f++G qP Y g sn++v+e++ ++ kb|ROR2_Hs 188 APEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQP-YCGYSNQDVVEMI-RN 235 GyRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* ++ Lp+P++CP+ +Y lM +CW+e P++RP+F++++++L kb|ROR2_Hs 236 RQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL 274 Pkinase: domain 1 of 1, from 1 to 274: score 102.4, E = 2.9e-31 *->yelleklGsGsfGtVykakh......kgtgkiVAvKiikkrkekskk ++ e lG+ fG+Vyk++ ++ ++ t+ VA+K++k + e + kb|ROR2_Hs 1 VRFMEELGEDRFGKVYKGHLfgpapgEQTQA-VAIKTLKDKAEGP-L 45 dktarrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldL +++ r+ E+ + +rL+HpN+v l++v++ ++ l +++ yc +G dL kb|ROR2_Hs 46 REEFRH--EAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHG----DL 89 fdyls......e....trrkgpll.fsedeakkialQilrgleYLHsngi +++l ++++++ +++++++++ + +++ + + + Qi+ g+eYL s+ + kb|ROR2_Hs 90 HEFLVmrsphsDvgstDDDRTVKSaLEPPDFVHLVAQIAAGMEYLSSHHV 139 iHRDLKPeNILldnngvvdaflKiaDFGlAkkls.t.sss.lttfvGTpw +H DL N+L+ ++ +v Ki+D Gl + ++ + + l ++ kb|ROR2_Hs 140 VHKDLATRNVLVYDKLNV----KISDLGLFREVYaAdYYKlLGNSLLPIR 185 YmAPEvllggngygtkvDvWSlGvilyellt.GkpPFsgevqds.ldqlq +mAPE ++ + + + +D+WS+Gv+l+e+++ G P++g s+ d + kb|ROR2_Hs 186 WMAPEAIM-YGKFSIDSDIWSYGVVLWEVFSyGLQPYCGY---SnQDVVE 231 lirkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskR +ir++ p + d+p + L+ c+n Ps+R kb|ROR2_Hs 232 MIRNRQVLPCPDDCP-----------------AWVYALMIECWNEFPSRR 264 ltaeeilqHPwf<-* + +++i + kb|ROR2_Hs 265 PRFKDIHSR--L 274 // Query sequence: kb|ROR1_Hsap|TK/Ror|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 484.4 3e-146 1 Pkinase Protein kinase domain 130.5 1e-39 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 274 [. 1 272 [] 484.4 3e-146 Pkinase 1/1 1 274 [. 1 287 [] 130.5 1e-39 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 274: score 484.4, E = 3e-146 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie ++++++LGe aFG++ykG+l+ +g ++ + VA+KtLk+ + +++ kb|ROR1_Hs 1 VRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKD-YNNPQQ-- 44 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL + +F +EAs+M +l +HpNiV+LlG++t+ ++P +++ +Ey GdL kb|ROR1_Hs 45 WTEFQQEASLMAEL-HHPNIVCLLGAVTQ-EQP----VCMLFEYINQGDL 88 ldfLrkhr..............egrpLtlkdLlsfalQiAkGMeYLeskn ++fL ++++++ + +++++++ + +L++ d l++a QiA+GMeYL+s+ kb|ROR1_Hs 89 HEFLIMRSphsdvgcssdedgtVKSSLDHGDFLHIAIQIAAGMEYLSSHF 138 fvHRDLAARNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm fvH DLAARN+L++e+l+VKIsD GL+R iys dyY r+++++ lP++Wm kb|ROR1_Hs 139 FVHKDLAARNILIGEQLHVKISDLGLSREIYSADYY-RVQSKSLLPIRWM 187 APEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyed +PE+++ygkF+s SD+WSFGV+LWEif++G qP Y+g sn+ev+e++ ++ kb|ROR1_Hs 188 PPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQP-YYGFSNQEVIEMV-RK 235 GyRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* ++ Lp+ e+CP+ +Y+lM++CW+e P++RP+F++++ +L kb|ROR1_Hs 236 RQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRL 274 Pkinase: domain 1 of 1, from 1 to 274: score 130.5, E = 1e-39 *->yelleklGsGsfGtVykakhkgtgk....iVAvKiikkr..kekskk ++ e lG+ +fG+ yk++ g ++ ++VA+K++k ++ + + + kb|ROR1_Hs 1 VRFMEELGECAFGKIYKGHLYLPGMdhaqLVAIKTLKDYnnPQQWTE 47 dktarrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldL ++ E++++++L+HpNIv l+++++ ++ +++ +Ey + G dL kb|ROR1_Hs 48 FQQ-----EASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQG----DL 88 fdyls......e.....trrkgpll.fsedeakkialQilrgleYLHsng +++l ++++++ + ++++++++ ++++ + +ia Qi+ g+eYL s+ kb|ROR1_Hs 89 HEFLImrsphsDvgcssDEDGTVKSsLDHGDFLHIAIQIAAGMEYLSSHF 138 iiHRDLKPeNILldnngvvdaflKiaDFGlAkkls......t.sss.ltt ++H DL NIL+ ++ +v Ki+D Gl++ +++ + + +s+s l kb|ROR1_Hs 139 FVHKDLAARNILIGEQLHV----KISDLGLSREIYsadyyrVqSKSlLP- 183 fvGTpwYmAPEvllggngygtkvDvWSlGvilyellt.GkpPFsgevqds +++m+PE ++ + + ++ +D+WS+Gv+l+e ++ G P++g s kb|ROR1_Hs 184 ----IRWMPPEAIM-YGKFSSDSDIWSFGVVLWEIFSfGLQPYYGF---S 225 .ldqlqlirkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLn + ++++rk+ p ++d+p + + +L++ c+n kb|ROR1_Hs 226 nQEVIEMVRKRQLLPCSEDCP-----------------PRMYSLMTECWN 258 kDPskRltaeeilqHPwf<-* Ps+R+ +++i + kb|ROR1_Hs 259 EIPSRRPRFKDIHVR--L 274 // Query sequence: kb|RON_Hsap|TK/Met|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 429.3 1.2e-129 1 Pkinase Protein kinase domain 124.7 5.7e-38 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 253 [] 1 272 [] 429.3 1.2e-129 Pkinase 1/1 1 253 [] 1 287 [] 124.7 5.7e-38 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 253: score 429.3, E = 1.2e-129 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + ++++G+G+FG+Vy+G++ ++ +++i++A+K+L + ++ kb|RON_Hsa 1 THSDRVIGKGHFGVVYHGEYI-DQAQNRIQCAIKSLSR-ITEMQQ-- 43 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL e+FlrE +M+ l +HpN++ L+G+ + +++ + + ++ym++GdL kb|RON_Hsa 44 VEAFLREGLLMRGL-NHPNVLALIGIMLPPEGL----PHVLLPYMCHGDL 88 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs l f r++ +r++t+kdL+sf lQ+A+ MeYL++++fvHRDLAARNc+++ kb|RON_Hsa 89 LQFIRSP--QRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLD 136 enlvVKIsDFGLaRdiysddyY.vrkrgggklPvkWmAPEslkygkFtsk e+++VK++DFGLaRdi + +yY+v+++ +++lPvkWmA+Esl++++Ft+k kb|RON_Hsa 137 ESFTVKVADFGLARDILDREYYsVQQHRHARLPVKWMALESLQTYRFTTK 186 SDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPde SDVWSFGVlLWE++t+G++P Y ++++++ ++l +G+RLp+Pe+CPd kb|RON_Hsa 187 SDVWSFGVLLWELLTRGAPP-YRHIDPFDLTHFL-AQGRRLPQPEYCPDS 234 lYdlMlqCWaedPedRPtFselveeL<-* lY++M+qCW++dP+ RPtF kb|RON_Hsa 235 LYQVMQQCWEADPAVRPTF------- 253 Pkinase: domain 1 of 1, from 1 to 253: score 124.7, E = 5.7e-38 *->yelleklGsGsfGtVykakhkgtgk...iVAvKiikkrkekskkdkt + +++G+G fG+Vy++ ++ +++ + A+K +++++ + ++ + kb|RON_Hsa 1 THSDRVIGKGHFGVVYHGEYIDQAQnriQCAIK--SLSRITEMQQVE 45 arrlsEiqilkrLsHpNIvrlidvfed.kdhlylVlEycegGLrvldLfd a+++ E +++ L+HpN++ li+++ +++ +++ l+y+ +G dL kb|RON_Hsa 46 AFLR-EGLLMRGLNHPNVLALIGIMLPpEGLPHVLLPYMCHG----DLLQ 90 ylsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld +++ + +++ + ++++++ lQ++r +eYL +++++HRDL N++ld kb|RON_Hsa 91 FIR--SPQRNP--TVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLD 136 nngvvdaflKiaDFGlAkkls...t.sss.lttfvGTpwYmAPEvllggn + +v K+aDFGlA+ + ++++ s ++ + +mA E l+ kb|RON_Hsa 137 ESFTV----KVADFGLARDILdreYySVQqHRHARLPVKWMALESLQ-TY 181 gygtkvDvWSlGvilyellt.GkpPFsgevqds.ldqlqlirkilgpple +tk+DvWS+Gv+l+ellt+G pP+++ ++ d + +++ ++ kb|RON_Hsa 182 RFTTKSDVWSFGVLLWELLTrGAPPYRHI---DpFDLTHFLAQGRR---- 224 fdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPw + pe ++ +++ +++ c++ DP+ R+t kb|RON_Hsa 225 LPQPEYCP-------------DSLYQVMQQCWEADPAVRPT--------- 252 f<-* f kb|RON_Hsa 253 F 253 // Query sequence: kb|ROCK2_Hsap|AGC/DMPK/ROCK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 245.1 3.3e-74 1 Pkinase_Tyr Protein tyrosine kinase 4.1 2.5e-16 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 249 [. 1 272 [] 4.1 2.5e-16 Pkinase 1/1 1 263 [] 1 287 [] 245.1 3.3e-74 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 249: score 4.1, E = 2.5e-16 *->lklgkkLGeGaFGeVykGtlkgsgdgteikV.AVKtL.keigaseee k++G+GaFGeV + + k +kV A K L+k + kb|ROCK2_H 1 YDVVKVIGRGAFGEVQLVRHK-----ASQKVyAMKLLsKF-EMIKRS 41 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG +F+ E + + + + p +V+L + + ++ ly+V+Eym+gG kb|ROCK2_H 42 --DSAFFWEERDIMAFANSPWVVQLFYAFQD-DRY----LYMVMEYMPGG 84 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL dL + + + ++ k+ + +++ +++ +s++++HRD+ N L kb|ROCK2_H 85 DLVNLMSNY----DVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNML 130 VsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygk.. +++ ++ K +DFG + + d++ ++ ++ +PE+lk ++ kb|ROCK2_H 131 LDKHGHLKLADFGTCMKM--DETG-MVHCDTAvGTPDYISPEVLKSQGgd 177 ..FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprP + + + D WS GV L+E++ G++P ++ s ++ ++ ++ + L P kb|ROCK2_H 178 gfYGRECDWWSVGVFLYEMLV-GDTP-FYADSLVGTYSKIMDHKNSLCFP 225 enCPdelYdlMlqCWaedPedRPtFselveeL<-* e +e+ + + + dR +L kb|ROCK2_H 226 E--DAEISKHAKNLICAFLTDR------EVRL 249 Pkinase: domain 1 of 1, from 1 to 263: score 245.1, E = 3.3e-74 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y +++++G+G+fG+V + +hk ++k++A+K ++k + + d + ++ kb|ROCK2_H 1 YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFW 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E i++ ++p +v+l+++f+d+++ly+V+Ey++gG dL ++s kb|ROCK2_H 48 E-ERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGG----DLVNLMS- 91 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv + + +e+ ak++ +++ +l+ +Hs+g iHRD+KP+N Lld++g+ kb|ROCK2_H 92 ---NYDV--PEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGH 136 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvll...ggngygt + K+aDFG + k++++ ++++t vGTp+Y++PEvl++++g+ yg+ kb|ROCK2_H 137 L----KLADFGTCMKMDEtGMVhCDTAVGTPDYISPEVLKsqgGDGFYGR 182 kvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspew ++D+WS+Gv lye+l G +PF+ + + + ki+ +++ +pe+ kb|ROCK2_H 183 ECDWWSVGVFLYEMLVGDTPFYAD-----SLVGTYSKIMDHKNSLCFPED 227 dsisrsefrrlpnlseeakdLikkcLnkDPskRlt...aeeilqHPwf<- +is + ak Li+ L+ D + Rl++++ eei qHP+f kb|ROCK2_H 228 AEIS-----------KHAKNLICAFLT-DREVRLGrngVEEIRQHPFF 263 * kb|ROCK2_H - - // Query sequence: kb|ROCK1_Hsap|AGC/DMPK/ROCK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 253.5 9.7e-77 1 Pkinase_Tyr Protein tyrosine kinase 10.7 1e-16 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 249 [. 1 272 [] 10.7 1e-16 Pkinase 1/1 1 263 [] 1 287 [] 253.5 9.7e-77 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 249: score 10.7, E = 1e-16 *->lklgkkLGeGaFGeVykGtlkgsgdgteikV.AVKtL.keigaseee + k++G+GaFGeV + + k + kV A K L+k + kb|ROCK1_H 1 YEVVKVIGRGAFGEVQLVRHK-----STRKVyAMKLLsKF-EMIKRS 41 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG +F+ E + + + + p +V+L + + ++ ly+V+Eym+gG kb|ROCK1_H 42 --DSAFFWEERDIMAFANSPWVVQLFYAFQD-DRY----LYMVMEYMPGG 84 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL dL + + + ++ k+ + +++ +++ +s++f+HRD+ N L kb|ROCK1_H 85 DLVNLMSNY----DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNML 130 VsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygk.. ++++++ K +DFG + + +++ +r ++ +PE+lk ++ kb|ROCK1_H 131 LDKSGHLKLADFGTCMKMNKEG---MVRCDTAvGTPDYISPEVLKSQGgd 177 ..FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprP + + + D WS GV L+E++ G++P ++ s ++ ++ + + L P kb|ROCK1_H 178 gyYGRECDWWSVGVFLYEMLV-GDTP-FYADSLVGTYSKIMNHKNSLTFP 225 enCPdelYdlMlqCWaedPedRPtFselveeL<-* + ++ + + + dR +L kb|ROCK1_H 226 D--DNDISKEAKNLICAFLTDR------EVRL 249 Pkinase: domain 1 of 1, from 1 to 263: score 253.5, E = 9.7e-77 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ye+++++G+G+fG+V + +hk+t+k++A+K ++k + + d + ++ kb|ROCK1_H 1 YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFW 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E i++ ++p +v+l+++f+d+++ly+V+Ey++gG dL ++s kb|ROCK1_H 48 E-ERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGG----DLVNLMS- 91 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv + + +e+ a+++ +++ +l+ +Hs+g+iHRD+KP+N Lld+ g+ kb|ROCK1_H 92 ---NYDV--PEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGH 136 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvll...ggngygt + K+aDFG + k++ + ++++t vGTp+Y++PEvl++++g+ +yg+ kb|ROCK1_H 137 L----KLADFGTCMKMNKeGMVrCDTAVGTPDYISPEVLKsqgGDGYYGR 182 kvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspew ++D+WS+Gv lye+l G +PF+ + + + ki+ +++ +p + kb|ROCK1_H 183 ECDWWSVGVFLYEMLVGDTPFYAD-----SLVGTYSKIMNHKNSLTFPDD 227 dsisrsefrrlpnlseeakdLikkcLnkDPskRlt...aeeilqHPwf<- ++is +eak Li+ L+ D + Rl++++ eei+ H +f kb|ROCK1_H 228 NDIS-----------KEAKNLICAFLT-DREVRLGrngVEEIKRHLFF 263 * kb|ROCK1_H - - // Query sequence: kb|RNAseL_Hsap|Other/Other-Unique|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain -38.8 5.8e-10 1 Pkinase_Tyr Protein tyrosine kinase -147.3 4.6e-07 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 1 218 [] 1 287 [] -38.8 5.8e-10 Pkinase_Tyr 1/1 9 218 .] 1 272 [] -147.3 4.6e-07 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 1 to 218: score -38.8, E = 5.8e-10 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y++ + s G y++ + + VAvK+++ + + + kb|RNAseL_ 1 YKIADT----SEGGIYLGFYEKQE--VAVKTFCEGSPRAQR------ 35 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGL.rvldLfdyl E++ l++ + + v+++++ ++hl ++ +ce +L+ +ld + kb|RNAseL_ 36 --EVSCLQSSrENSHLVTFYGSESHRGHLFVCVTLCEQTLeACLDVH--- 80 setrrkgpllfsede.akkialQilrgleYLHs.ngiiHRDLKPeNILld ++ +ede a++++ i+++++ LH ++g H DL P+NIL+d kb|RNAseL_ 81 --RGEDVEN--EEDEfARNVLSSIFKAVQELHLsCGYTHQDLQPQNILID 126 nngvvdaflKiaDFGlAkklstssslttfvGTpwYmAPEvllggngygtk ++ ++aDF + k + g + k kb|RNAseL_ 127 SKKAA----HLADFDKSIK--------------------W--AGDPQEVK 150 vDvWSlG.vilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspe D lG+++ly + G F + + + +++++ kb|RNAseL_ 151 RDLEDLGrLVLYVVKKGSISFEDL---KaQSNEEVVQLSPD--------- 188 wdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* ee kdLi +++++ + R ++l HP+f kb|RNAseL_ 189 ----------------EETKDLIHRLFHPGEHVRDCLSDLLGHPFF 218 Pkinase_Tyr: domain 1 of 1, from 9 to 218: score -147.3, E = 4.6e-07 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie G +y+G + +++VAVKt e g+ + kb|RNAseL_ 9 ------------GGIYLGFYE------KQEVAVKTFCE-GSPRAQ-- 34 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL rE+s + + + ++V ++G ++ ++ l++ + ++e L kb|RNAseL_ 35 -----REVSCLQSSRENSHLVTFYGSESH-RGH----LFVCVTLCEQ-TL 73 ldfLrkhr......egrpLtlkdLlsfalQiAkGMeYLeskn.fvHRDLA L hr+++ ++e++ + L s+ k+ + L+ ++ H DL kb|RNAseL_ 74 EACLDVHRgedvenEEDEFARNVLSSIF----KAVQELHLSCgYTHQDLQ 119 ARNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm..APEsl N+L+++++ + +DF d +kW +++ E+ kb|RNAseL_ 120 PQNILIDSKKAAHLADF----DK---------------SIKWAgdPQEVK 150 kygk.......FtskSDVWSFGVlLWEiftlGeqPF..Ypgmsneevlel ++ ++ ++ + ++ G + F++ + sneev++l kb|RNAseL_ 151 RDLEdlgrlvlY---------------VVKKGSISFedLKAQSNEEVVQL 185 lyedGyRLprPenCPdelYdlMlqCWaedPedRPtFsel..veeL<-* P+ +e dl+ + ++ R s+l ++ ++ kb|RNAseL_ 186 S---------PD---EETKDLIHRLFHPGEHVRDCLSDLlgHPFF 218 // Query sequence: kb|RIPK3_Hsap|TKL/RIPK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 170.7 8.4e-52 1 Pkinase_Tyr Protein tyrosine kinase 107.5 8.8e-33 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 263 [. 1 272 [] 107.5 8.8e-33 Pkinase 1/1 1 267 [] 1 287 [] 170.7 8.4e-52 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 263: score 107.5, E = 8.8e-33 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie l+ ++ G+G FG+V+++ + + +++VAVK+++ +a ++ kb|RIPK3_H 1 LENQELVGKGGFGTVFRAQHR----KWGYDVAVKIVNS-KAISR--- 39 redFlrEAsiMkklGdHpNiVrLlGvct....kegePggpglyiVtEyme E++ M +l d++ ++rL Gv+ + + + ++P + +Vt +me kb|RIPK3_H 40 ------EVKAMASL-DNEFVLRLEGVIEkvnwD-QDPK---PALVTKFME 78 gGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLeskn..fvHRDLAA +G+L L++ + p + + L+ ++ GM YL+++n+ + HRDL kb|RIPK3_H 79 NGSLSGLLQS---QCPRPWPLLCRLLKEVVLGMFYLHDQNpvLLHRDLKP 125 RNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslky N+L++ +l+VK +DFGL+ + +++g ++ +APE l+ kb|RIPK3_H 126 SNVLLDPELHVKLADFGLSTFQ-GGSQS-GTGSGEPgGTLGYLAPE-LFV 172 gk...FtskSDVWSFGVlLWEiftlGeqP...FYpgmsneevlellyedG +++++ +++SDV+SFG+l+W ++ G++ + ++ ++ v+e + + kb|RIPK3_H 173 NVnrkASTASDVYSFGILMWAVLA-GREVelpT----EPSLVYEAVCNRQ 217 yR..LprPenCPde......lYdlMlqCWaedPedRPtFselveeL<-* +R++L+ + + +e+++ ++l +lM++CW +P+dRP+F+e++ + kb|RIPK3_H 218 NRpsLAELPQAGPEtpglegLKELMQLCWSSEPKDRPSFQECLPKT 263 Pkinase: domain 1 of 1, from 1 to 267: score 170.7, E = 8.4e-52 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +e e +G+G+fGtV++a+h++ g VAvKi++ + ++ kb|RIPK3_H 1 LENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISR-------- 39 lsEiqilkrLsHpNIvrlidvfed.....kdhlylVlEycegGLrvldLf E++ +++L+ ++++rl +v e + ++++++ lV+ ++e+G +L+ kb|RIPK3_H 40 --EVKAMASLDNEFVLRLEGVIEKvnwdqDPKPALVTKFMENG----SLS 83 dylsetrrkgpllfsedeakkialQilrgleYLHsn..giiHRDLKPeNI +l+ +++p ++ +++ +++++ g+ YLH++++ +HRDLKP+N+ kb|RIPK3_H 84 GLLQ---SQCPR--PWPLLCRLLKEVVLGMFYLHDQnpVLLHRDLKPSNV 128 LldnngvvdaflKiaDFGlAkkls..t.sss.lttfvGTpwYmAPEv.ll Lld + +v K+aDFGl+ ++++ +s+++ + GT++Y+APE+ ++ kb|RIPK3_H 129 LLDPELHV----KLADFGLST-FQggSqSGTgSGEPGGTLGYLAPELfVN 173 ggngygtkvDvWSlGvilyelltGk........pPFsgevqdsldqlqli +++ +t++Dv+S+G++++ +l G++ + ++++ + +++ ++ kb|RIPK3_H 174 VNRKASTASDVYSFGILMWAVLAGRevelptepSLVYEA--------VCN 215 rkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlt r++++ e + + ++ + e +k+L+ c+ P++R++ kb|RIPK3_H 216 RQNRPSLAELPQAGPETPGL----------EGLKELMQLCWSSEPKDRPS 255 aeeil..qHPwf<-* ++e+l++ ++ f kb|RIPK3_H 256 FQECLpkTDEVF 267 // Query sequence: kb|RIPK2_Hsap|TKL/RIPK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 143.7 1.1e-43 1 Pkinase_Tyr Protein tyrosine kinase 66.0 2.7e-20 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 267 [] 1 272 [] 66.0 2.7e-20 Pkinase 1/1 1 266 [. 1 287 [] 143.7 1.1e-43 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 267: score 66.0, E = 2.7e-20 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie l ++ L +Ga G+V ++ + +++VAVK L ++ + kb|RIPK2_H 1 LADLRYLSRGASGTVSSARHA----DWRVQVAVKHLHI-HTPLLD-S 41 .redFlrEAsiMkklGdHpNiVrLlGvctkegePggpg.lyiVtEymegG +r+d lrEA+i+ k + i+ lG+c eP l iVtEym++G kb|RIPK2_H 42 eRKDVLREAEILHKA-RFSYILPILGICN---EP---EfLGIVTEYMPNG 84 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLeskn..fvHRDLAARN +L + L+++ e + + + + ++iA G +YL+++ +++ H DL + N kb|RIPK2_H 85 SLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTppLLHHDLKTQN 134 cLVsenlvVKIsDFGLa..Rdi.ysddyYvrkrgggklPvkWmAPEslky +L++++++VKI+DFGL++ R ++ s + k+ + m+PE + kb|RIPK2_H 135 ILLDNEFHVKIADFGLSkwRMMsLSQSRS-SKSAPEGGTIIYMPPE---N 180 gk......FtskSDVWSFGVlLWEiftlGeqPFYpgm.sneevlellyed ++++++++ ++k D++S+ V WE+++ +qP +++++ + +++ + + kb|RIPK2_H 181 YEpgqksrASIKHDIYSYAVITWEVLS-RKQP-FEDVtNPLQIMYSV-SQ 227 GyR.........LprPenCPdelYdlMlqCWaedPedRPtFselveeL<- G+R+ ++++ + ++P+ + + +l+ + Wa +P++RP+F L kb|RIPK2_H 228 GHRpvineeslpYDIPH--RARMISLIESGWAQNPDERPSF------L 267 * kb|RIPK2_H - - Pkinase: domain 1 of 1, from 1 to 266: score 143.7, E = 1.1e-43 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + l+ l +G++GtV a+h + + +VAvK + ++ + ++ +++ kb|RIPK2_H 1 LADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVL 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse + E++il++ + +I+ +++++ ++ l +V+Ey+++G +L ++l+ kb|RIPK2_H 48 R-EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNG----SLNELLH- 91 trrkgpll.fsedeakkialQilrgleYLHsn..giiHRDLKPeNILldn rk+ + + + +i+ +i+ g++YLH++++ +H DLK +NILldn kb|RIPK2_H 92 --RKTEYPdVAWPLRFRILHEIALGVNYLHNMtpPLLHHDLKTQNILLDN 139 ngvvdaflKiaDFGlAk..kls..t.sss.lttfvGTpwYmAPEvll..g + +v KiaDFGl+k + +s + ++ss+ GT+ Ym+PE ++ kb|RIPK2_H 140 EFHV----KIADFGLSKwrMMSlsQsRSSkSAPEGGTIIYMPPENYEpgQ 185 gngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgp... + + k D++S+ vi +e+l++k PF + ++lq+++ + +++++ kb|RIPK2_H 186 KSRASIKHDIYSYAVITWEVLSRKQPFEDV----TNPLQIMYSVSQGhrp 231 .plefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeil ++e++ p++++ + +++Li++ ++++P +R++ kb|RIPK2_H 232 vINEESLPYDIPHR-----------ARMISLIESGWAQNPDERPS----- 265 qHPwf<-* f kb|RIPK2_H 266 ----F 266 // Query sequence: kb|RIPK1_Hsap|TKL/RIPK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 181.8 3.9e-55 1 Pkinase_Tyr Protein tyrosine kinase 140.1 1.3e-42 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 269 [] 1 272 [] 140.1 1.3e-42 Pkinase 1/1 1 269 [] 1 287 [] 181.8 3.9e-55 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 269: score 140.1, E = 1.3e-42 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.k.eigaseee + +L +G FG+V ++ + t+ Kt+ k++ ++ e++ kb|RIPK1_H 1 FLESAELDSGGFGKVSLCFHR-----TQGLMIMKTVyKgP-NCIEHN 41 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG e++l+EA++M +l +H +V+LlGv+++ ++ + +V+Eyme+G kb|RIPK1_H 42 ---EALLEEAKMMNRL-RHSRVVKLLGVIIE-EGK----YSLVMEYMEKG 82 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL +L + L++ + + +l+ + + l+i +GM YL+ k+ +H DL N+L kb|RIPK1_H 83 NLMHVLKA---EMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENIL 129 VsenlvVKIsDFGLaRdi.......ysddyY.vrkrgggk..lPvkWmAP V++++++KI+D GLa ++ ++++ + + + ++ k++ mAP kb|RIPK1_H 130 VDNDFHIKIADLGLASFKmwsklnnEEHNELrEVDGTAKKngGTLYYMAP 179 Eslkygk..FtskSDVWSFGVlLWEiftlGeqPFYpgmsnee.vlellye E l++ + t+kSDV+SF V+LW if ++P Y++ e++++ + + kb|RIPK1_H 180 EHLNDVNakPTEKSDVYSFAVVLWAIFA-NKEP-YENAICEQqLIMCI-K 226 dGyRL...prPenCPdelYdlMlqCWaedPedRPtFselveeL<-* +G+R + +++ e+CP e+ +lM++CW+++Pe RPtF + e++ kb|RIPK1_H 227 SGNRPdvdDITEYCPREIISLMKLCWEANPEARPTFPGIEEKF 269 Pkinase: domain 1 of 1, from 1 to 269: score 181.8, E = 3.9e-55 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + l sG+fG+V ++ h+ g +K++ +++ ++ ++ +a++ kb|RIPK1_H 1 FLESAELDSGGFGKVSLCFHRTQGL-MIMKTV-YKGPNCIEHNEALL 45 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+++++rL+H +v+l++v +++++ lV+Ey+e+G L+++l+ kb|RIPK1_H 46 E-EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKG----NLMHVLK- 89 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv +++++pl + +i+l+i++g+ YLH +g+iH DLKPeNIL+dn+ + kb|RIPK1_H 90 AEMSTPL----SVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFH 135 vdaflKiaDFGlAkkls............t.sss.lttfvGTpwYmAPEv + KiaD GlA ++ ++ +++++++ + +++++ GT++YmAPE kb|RIPK1_H 136 I----KIADLGLASFKMwsklnneehnelReVDGtAKKNGGTLYYMAPEH 181 ll.ggngygtkvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkil l++ + + + k+Dv+S+ v+l+ + k P+ ++ ql + k + kb|RIPK1_H 182 LNdVNAKPTEKSDVYSFAVVLWAIFANKEPYENA---IcEQQLIMCIKSG 228 gpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeei +p d+ e ++ +e ++L+k c++ +P+ R+t++ i kb|RIPK1_H 229 NRPDVDDITEYCP-------------REIISLMKLCWEANPEARPTFPGI 265 lqHPwf<-* + f kb|RIPK1_H 266 EEK--F 269 // Query sequence: kb|RIOK3_Hsap|Atypical/RIO/RIO3|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain -160.1 0.011 1 Pkinase_Tyr Protein tyrosine kinase -250.1 0.72 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 26 243 .. 1 287 [] -160.1 0.011 Pkinase_Tyr 1/1 32 239 .. 1 272 [] -250.1 0.72 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 26 to 243: score -160.1, E = 0.011 *->yelleklGsGsfGtVykakhkgtgk..........iVAvKiikkrke ++ +++ G ++V++a+ + ++++++++ +++ A+K++k + kb|RIOK3_H 26 ETITGCISTGKESVVFHAYGGSMEDekedskviptECAIKVFKTTLN 72 kskkdktarrl......................sEiqilkrLs.....Hp + k + ++ + + +++ ++ ++++ ++ + E + l+r+++ + ++p kb|RIOK3_H 73 EFKNRDKYIKDdfrfkdrfsklnprkihrmwaeKEMHNLARMQragipCP 122 NIvrlidvfedkdhlylVlEycegGLrvldLf.dylsetrrkgpllfsed +v l+ lV+ + +++ l+ + +l + kb|RIOK3_H 123 TVVLLKKHI-------LVMSFIGHD----QVPaPKLK----EVKL--NSE 155 eakkialQilrgleYLHs.ngiiHRDLKPeNILldnngvvdaflKiaDFG e k +Q+l + L+ ++ +H DL N L + g v ++D kb|RIOK3_H 156 EMKEAYYQTLHLMRQLYHeCTLVHADLSEYNMLWH-AGKV----WLID-- 198 lAkklst.sss.lttfvGTpwYmAPEvllggngygtkvDvWSlGvilyel + s+++t++ G l kb|RIOK3_H 199 ------VsQSVePTHPHG---------LE--------------------- 212 ltGkpPFsgevqdsldqlqlirkilgpplefdspewdsisrsefrrlpnl ++F+++ ++ q ++k + kb|RIOK3_H 213 ----FLFRDC----RNVSQFFQKGGV------------------------ 230 seeakdLikkcLnkDPskRltaeeilqHPwf<-* +ea l+ +e+++ + kb|RIOK3_H 231 -KEA---------------LSERELFNA--V 243 Pkinase_Tyr: domain 1 of 1, from 32 to 239: score -250.1, E = 0.72 *->lklgkkLGeGaFGeVykGtlkg......sgdgteikVAVKtLk.... ++ gk+ +V++++ ++++++ + +++A+K+ k++ + kb|RIOK3_H 32 ISTGKE------SVVFHAYGGSmedekeDSKVIPTECAIKVFKttln 72 ....................eigaseeeieredFlr.EAsiMkklGd... + +++++ +++ + +++ ++ + ++ ++E+ + ++ ++ + kb|RIOK3_H 73 efknrdkyikddfrfkdrfsK-LNPRKI--HRMWAEkEMHNLARM-Qrag 118 ..HpNiVrLlGvctkegePggpglyiVtEymegGdLldfLrkhr...... ++p +V L k +++V+ + + d +++ ++ + kb|RIOK3_H 119 ipCPTVVLLK----K--------HILVMSFIGH----DQVPAPKlkevkl 152 ..egrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVsenlvVK ++e+ + + l+ ++Q ++ +vH DL N L + ++v kb|RIOK3_H 153 nsEEMKEAYYQTLHLMRQL------YHECTLVHADLSEYNMLWHAGKV-- 194 IsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkFtskSDVWSFG d+ kb|RIOK3_H 195 -----WLIDV---------------------------------------- 199 VlLWEiftlGeqP.........FYpgmsneevlellyedGyRLprPenCP + +P+++++ + F + v +++ ++G+ ++ kb|RIOK3_H 200 -------SQSVEPthphgleflF---RDCRNVSQFF-QKGGVKEALS--- 235 delYdlMlqCWaedPedRPtFselveeL<-* +eL kb|RIOK3_H 236 ------------------------EREL 239 // Query sequence: kb|RIOK2_Hsap|Atypical/RIO/RIO2|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain -166.7 0.028 1 Pkinase_Tyr Protein tyrosine kinase -244.2 0.35 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 23 247 .] 1 287 [] -166.7 0.028 Pkinase_Tyr 1/1 50 224 .. 1 272 [] -244.2 0.35 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 23 to 247: score -166.7, E = 0.028 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ++ + G G + y+ + ++ +A+K ++ +++ +k++r kb|RIOK2_H 23 ESVGNQMGVGKESDIYIVANEEGQQ-FALKLHRLGRTSFRNLKNKRD 68 l..................sEiqilkrLsHpNIvrlidvfed........ ++++++ + ++ + E +++k L +e++ + +++ kb|RIOK2_H 69 YhkhrhnvswlylsrlsamKEFAYMKAL-----------YERkfpvpkpi 107 kdhly.lVlEycegGLrvldLf..dylsetrrkgpll.fsedeakkialQ + + + +V+E+ +g L++ +++ + ++++ ++ + k a kb|RIOK2_H 108 DYNRHaVVMELINGY----PLCqiHHVE---DPASVYdEAMELIVKLA-- 148 ilrgleYLHsngiiHRDLKPeNILldnngvvdaflKiaDFGlAkklstss ++g iH D N+ ld+ +++ +DF kb|RIOK2_H 149 ---------NHGLIHGDFNEFNLILDESDHI----TMIDF---------- 175 slttfvGTpwYmAPEvllggngygtkvDvWSlGvilyelltGkpPFsgev v T++ A E+ + + k+ + ++ +++ + +e kb|RIOK2_H 176 --PQMVSTSHPNA-EWYF---DRDVKC--------IKDFFMKRFSYESE- 210 qdsldqlqlirkilgpplefdspewdsisrsefrrlpnlseeakdLikkc l+ +k+ +++ d + +a k + kb|RIOK2_H 211 ------LFPTFKDIRREDTLDVE-----------------VSASGYTKEM 237 LnkDPskRltaeeilqHPwf<-* + D e+l+ + kb|RIOK2_H 238 QADD--------ELLHP--L 247 Pkinase_Tyr: domain 1 of 1, from 50 to 224: score -244.2, E = 0.35 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie lkl + LG+ +F + K ++ + +++ kb|RIOK2_H 50 LKLHR-LGRTSF-------RN-----------LKNKRD-YHKHRH-- 74 redFlr..EAsiMkklGdHpNiVrLlGvct.........kegePggpgly + l + +s Mk++ + + ++ + +++ + + kb|RIOK2_H 75 NVSWLYlsRLSAMKEF------AYMKALYErkfpvpkpiD-YNR----HA 113 iVtEymegGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvH +V+E+ g L + +++ + + + L++++++H kb|RIOK2_H 114 VVMELINGYPLCQIHHVE--DPASVYDEAMELIVK-------LANHGLIH 154 RDLAARNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPE D +++ +i ++++ kb|RIOK2_H 155 GD--------FNEFN----------LILDESDH----------------- 169 slkygkFtskSDVWSFGVlLWEiftlGeqP....F.......Ypgmsnee +t + P+ ++++++ + Y + ++ kb|RIOK2_H 170 -----------------------ITMIDFPqmvsTshpnaewYFDRDVKC 196 vlellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFsel..veeL< +++++ ++r ++ e PtF+++++ L kb|RIOK2_H 197 IKDFF------MKRFS---------------YESELFPTFKDIrrEDTL 224 -* kb|RIOK2_H - - // Query sequence: kb|RIOK1_Hsap|Atypical/RIO/RIO1|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain -154.0 0.0048 1 Pkinase_Tyr Protein tyrosine kinase -236.6 0.13 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 26 241 .. 1 287 [] -154.0 0.0048 Pkinase_Tyr 1/1 32 231 .. 1 272 [] -236.6 0.13 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 26 to 241: score -154.0, E = 0.0048 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr e+ +++ G + Vy+a + + A+Ki k + k + + kb|RIOK1_H 26 TEINGCISTGKEANVYHASTANGES-RAIKIYKTSILVFKDRDKYVS 71 l......................sEiqilkrLsHpNIvrlidvfedkdhl + + +++ ++++++ ++ + E + l rL + ++ ++ + kb|RIOK1_H 72 GefrfrhgyckgnprkmvktwaeKEMRNLIRL------NTAEIPCPEPIM 115 y....lVlEycegGLrvldLfdylsetrrkgpllfsedeakkialQilrg +++ lV+ + +++ d + l ++ l se a+ lQ+++ kb|RIOK1_H 116 LrshvLVMSFIGKD----DMPAPLL---KNVQL--SESKARELYLQVIQY 156 leYLHs.ngiiHRDLKPeNILldnngvvdaflKiaDFGlAkklstssslt + ++++ + +H DL N L++ g v i+D kb|RIOK1_H 157 MRRMYQdARLVHADLSEFNMLYH-GGGV----YIID-------------- 187 tfvGTpwYmAPEvllggngygtkvDvWSlGvilyelltGkpPFsgevqds v + + +++++ e+l + + kb|RIOK1_H 188 ------------VSQ-SVEHDHPH--------ALEFLRK------D---- 206 ldqlqlirkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnk + ++ + ++ + a ++ ++++ kb|RIOK1_H 207 -CANVNDFFMRH-------------------------SVAVMTVRELFEF 230 DPskRltaeeilqHPwf<-* +t H+ + kb|RIOK1_H 231 VTDPSIT------HENM 241 Pkinase_Tyr: domain 1 of 1, from 32 to 231: score -236.6, E = 0.13 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie ++ gk+ +Vy++ ++ A+K+ ++s kb|RIOK1_H 32 ISTGKE------ANVYHASTA-----NGESRAIKIY---KTSILV-- 62 redFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd F + + ++ + + G c g P +V +e+ kb|RIOK1_H 63 ---FKDrDKYVSGEF-RFRH-----GYCK--GNP----RKMVKTWAEK-E 96 LldfLrkhr...............................egrpLtlkdL +++ r + + + +++ +++ + ++++ + + + +L+ + kb|RIOK1_H 97 MRNLIRLNTaeipcpepimlrshvlvmsfigkddmpapllKNVQLSESKA 146 lsfalQiAkGMeYLesknfvHRDLAARNcLVsenlvVKIsDFGLaRdiys + lQ+ + M R +y kb|RIOK1_H 147 RELYLQVIQYM----------------------------------RRMYQ 162 ddyYvrkrgggklPvkWmAPEslkygkFtskSDVWSFGVlLWEiftlGeq d + + + + ++ G kb|RIOK1_H 163 DARL-VHADLSEFN-----------------------------MLYHG-- 180 PFYpgmsneevlellyedGyR..LprPenCPdelYdl.MlqCWaedPedR g+ +v + + e+++ + L+ ++ + + d M++ a kb|RIOK1_H 181 -G--GVYIIDVSQSV-EHDHPhaLEFLRKDCANVNDFfMRHSVAVM---- 222 PtFselveeL<-* t +el e+ kb|RIOK1_H 223 -TVRELFEFV 231 // Query sequence: kb|RHOK_Hsap|AGC/GRK/GRK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 265.5 2.4e-80 1 Pkinase_Tyr Protein tyrosine kinase -1.6 5.7e-16 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 1 266 [] 1 287 [] 265.5 2.4e-80 Pkinase_Tyr 1/1 2 260 .. 1 272 [] -1.6 5.7e-16 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 1 to 266: score 265.5, E = 2.4e-80 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + ++lG+G+fG+V ++ k tgk++A+K+++k++ k+ k ++ + kb|RHOK_Hs 1 FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAM 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls. E +il ++++ +Iv l ++fe+k +l+lV+ ++gG d ++ + kb|RHOK_Hs 48 V-EKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGG----DIRYHIYn 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng + +++ ++ +e a ++ Qi++gle+LH+++i++RDLKPeN+Lldn+g kb|RHOK_Hs 93 VNEENPGF--PEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDG 140 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv +v +i+D GlA l ++ +s++++++GTp++mAPE+l+ g++y+ +v kb|RHOK_Hs 141 NV----RISDLGLAVEL-LdGQSkTKGYAGTPGFMAPELLQ-GEEYDFSV 184 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D ++lGv+lye++ + PF+ + +++ ++ ++++++++ ++d kb|RHOK_Hs 185 DYFALGVTLYEMIAARGPFRAR-----GEKVENKELKHRIISEPVKYPDK 229 isrsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf<- s ++ kd+++ +L+kDP+kRl+ ++++++ + HP f kb|RHOK_Hs 230 FS-----------QASKDFCEALLEKDPEKRLGfrdetCDKLRAHPLF 266 * kb|RHOK_Hs - - Pkinase_Tyr: domain 1 of 1, from 2 to 260: score -1.6, E = 5.7e-16 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.ke.igaseee l + ++LG+G FGeV + +k t+ A K+L+k++++ kb|RHOK_Hs 2 LDF-RVLGKGGFGEVSACQMK----ATGKLYACKKLnKKrLKKRKGY 43 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG + ++ E +i++k + iV+L + + l++V+ m gG kb|RHOK_Hs 44 --QGAMV-EKKILMKV-HSRFIVSLAYAFET-KAD----LCLVMTIMNGG 84 dLldfLrkhr.egrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNc d + + + +e++ ++ ++ l + +Qi +G+e+L+++++v RDL N+ kb|RHOK_Hs 85 DIRYHIYNVNeENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENV 134 LVsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkF L+++++ V+IsD GLa + d+ +++++g mAPE l+ ++ kb|RHOK_Hs 135 LLDNDGNVRISDLGLAVEL-LDG---QSKTKGYaGTPGFMAPELLQGEEY 180 tskSDVWSFGVlLWEiftlGeqPF..Ypgm.sneevlellyedGyRLprP D + GV+L+E++ + PF+ + n e+++++ + + P kb|RHOK_Hs 181 DFSVDYFALGVTLYEMIA-ARGPFraRGEKvENKELKHRII--SEPVKYP 227 enCPdelYdlMlqCWaedPedRPtFsel.veeL<-* ++ ++ d ++dPe+R F++ + +L kb|RHOK_Hs 228 DKFSQASKDFCEALLEKDPEKRLGFRDEtCDKL 260 // Query sequence: kb|RET_Hsap|TK/Ret|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 517.0 4.7e-156 1 Pkinase Protein kinase domain 149.7 1.8e-45 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 282 [. 1 272 [] 517.0 4.7e-156 Pkinase 1/1 1 282 [. 1 287 [] 149.7 1.8e-45 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 282: score 517.0, E = 4.7e-156 *->lklgkkLGeGaFGeVykGtlkg.sgdgteikVAVKtLkeigaseeei l+lgk+LGeG+FG+V+k+t++ +g + ++VAVK+Lke +as++e kb|RET_Hsa 1 LVLGKTLGEGEFGKVVKATAFHlKGRAGYTTVAVKMLKE-NASPSE- 45 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd ++d+l+E +++k+ +Hp++++L+G+c++ ++P l++++Ey+++G+ kb|RET_Hsa 46 -LRDLLSEFNVLKQV-NHPHVIKLYGACSQ-DGP----LLLIVEYAKYGS 88 LldfLrkhr.....................egrpLtlkdLlsfalQiAkG L+ fLr+ r+ +++ ++++++++++ +++++r+Lt+ dL+sfa+Qi++G kb|RET_Hsa 89 LRGFLRESRkvgpgylgsggsrnsssldhpDERALTMGDLISFAWQISQG 138 MeYLesknfvHRDLAARNcLVsenlvVKIsDFGLaRdiysddyYvrkrgg M+YL+++++vHRDLAARN+LV+e++++KIsDFGL+Rd+y++d Y +kr+ kb|RET_Hsa 139 MQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY-VKRSQ 187 gklPvkWmAPEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsnee g++PvkWmA Esl++ ++t++SDVWSFGVlLWEi+tlG+ P Ypg+++e+ kb|RET_Hsa 188 GRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP-YPGIPPER 236 vlellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFselveeL<-* +++ll + G+R++rP+nC++e+Y+lMlqCW+ +P++RP F+++ +L kb|RET_Hsa 237 LFNLL-KTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL 282 Pkinase: domain 1 of 1, from 1 to 282: score 149.7, E = 1.8e-45 *->yelleklGsGsfGtV.....ykakhkgtgkiVAvKiikkrkekskkd ++l+++lG+G fG+V + + ++ k + +VAvK + k++++++++ kb|RET_Hsa 1 LVLGKTLGEGEFGKVvkataFHLKGRAGYTTVAVKML-KENASPSEL 46 ktarrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLf + ++ E +lk ++Hp++++l++++ ++ l l+ Ey+ G +L kb|RET_Hsa 47 RDLLS--EFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYG----SLR 90 dyls...............e......trrkgpllfsedeakkialQilrg +l+++++ +++ ++++++++++ + ++++l ++ +++++a+Qi +g kb|RET_Hsa 91 GFLResrkvgpgylgsggsRnsssldHPDERAL--TMGDLISFAWQISQG 138 leYLHsngiiHRDLKPeNILldnngvvdaflKiaDFGlAkkls.t.sss. ++YL +++ +HRDL NIL+ +g Ki+DFGl++ +++++s+++ kb|RET_Hsa 139 MQYLAEMKLVHRDLAARNILVA-EGRK---MKISDFGLSRDVYeEdSYVk 184 lttfvGTpwYmAPEvllggngygtkvDvWSlGvilyellt.GkpPFsgev + +mA E l + y+t +DvWS+Gv+l+e +t G P++g kb|RET_Hsa 185 RSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTlGGNPYPGI- 232 qdsldqlqlirkilgpplefdspewdsisrsefrrlpnlseeakdLikkc + +++++ l++ + ++p +s ee+ L+ c kb|RET_Hsa 233 -----PPERLFNLLKTGHRMERPDNCS-------------EEMYRLMLQC 264 LnkDPskRltaeeilqHPwf<-* +++ P kR+ +++i ++ + kb|RET_Hsa 265 WKQEPDKRPVFADISKD--L 282 // Query sequence: kb|RAF1_Hsap|TKL/RAF/RAF|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 292.1 2.3e-88 1 Pkinase_Tyr Protein tyrosine kinase 224.6 5e-68 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 258 [. 1 272 [] 224.6 5e-68 Pkinase 1/1 1 258 [. 1 287 [] 292.1 2.3e-88 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 258: score 224.6, E = 5e-68 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + l +G+G+FG+VykG+++ +VAVK+Lk ++ ++e+ kb|RAF1_Hs 1 VMLSTRIGSGSFGTVYKGKWH-------GDVAVKILKVVDPTPEQ-- 38 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL ++F +E+++++k +H Ni+ ++G t ++ l iVt +eg +L kb|RAF1_Hs 39 FQAFRNEVAVLRKT-RHVNILLFMGYMT--KDN----LAIVTQWCEGSSL 81 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs +++L+ + + ++ + +L+++a+Q A+GM+YL++kn++HRD N+ ++ kb|RAF1_Hs 82 YKHLHVQ--ETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLH 129 enlvVKIsDFGLaRdi....ysddyYvrkrgggklPvkWmAPEslkygk. e+l+VKI+DFGLa ++ + s + +g v WmAPE+++ + kb|RAF1_Hs 130 EGLTVKIGDFGLATVKsrwsGSQQVE-QPTG----SVLWMAPEVIRMQDn 174 ..FtskSDVWSFGVlLWEiftlGeqPFYpgmsnee.vlellyedGyR... ++F+ +SDV+S+G++L+E++t Ge P Y + n ++++ ++ +Gy +++ kb|RAF1_Hs 175 npFSFQSDVYSYGIVLYELMT-GELP-YSHINNRDqIIFMV-GRGYAspd 221 Lpr.PenCPdelYdlMlqCWaedPedRPtFselveeL<-* L + +nCP+ + +l +C ++ e+RP F ++++ + kb|RAF1_Hs 222 LSKlYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI 258 Pkinase: domain 1 of 1, from 1 to 258: score 292.1, E = 2.3e-88 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr l ++GsGsfGtVyk+k++g+ VAvKi+k+++ +++ ++ r+ kb|RAF1_Hs 1 VMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRN 44 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+++l++ +H NI+ + +++ +kd+l +V+ +ceg +L+ +l+ kb|RAF1_Hs 45 --EVAVLRKTRHVNILLFMGYM-TKDNLAIVTQWCEGS----SLYKHLH- 86 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv +++++ ++ ++++ia+Q+++g++YLH+++iiHRD+K+ NI+l++ + kb|RAF1_Hs 87 -VQETKF--QMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLT 133 vdaflKiaDFGlAkkls.t.sss.lttfvGTpwYmAPEvll..ggngygt v Ki+DFGlA ++s+++ s++ ++G+ +mAPEv++ +++n+ + kb|RAF1_Hs 134 V----KIGDFGLATVKSrWsGSQqVEQPTGSVLWMAPEVIRmqDNNPFSF 179 kvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspe +Dv+S+G++lyel+tG++P+s+ +++dq+ ++ +++++++ + + kb|RAF1_Hs 180 QSDVYSYGIVLYELMTGELPYSHI---NnRDQIIFMVGRGYASPDLSKLY 226 wdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +++ ++++k L+ +c +k ++R+ +++il + + kb|RAF1_Hs 227 KNC------------PKAMKRLVADCVKKVKEERPLFPQILSS--I 258 // Query sequence: kb|QSK_Hsap|CAMK/CAMKL/QIK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 349.8 9.8e-106 1 Pkinase_Tyr Protein tyrosine kinase 96.2 2.2e-29 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 252 [] 1 272 [] 96.2 2.2e-29 Pkinase 1/1 1 252 [] 1 287 [] 349.8 9.8e-106 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 252: score 96.2, E = 2.2e-29 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei ++++++G+G+F +V ++t t+ kVA+K+++k + +ee+ kb|QSK_Hsa 1 YEIDRTIGKGNFAVVKRATHL----VTKAKVAIKIIdKT-QLDEEN- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd +++ +rE++iMk l Hp+i+rL+ v ++ +y+VtEy+ gG kb|QSK_Hsa 42 -LKKIFREVQIMKML-CHPHIIRLYQVMET-ERM----IYLVTEYASGGE 84 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV d+L +h ++ k+ Qi + + + +n+vHRDL A N L+ kb|QSK_Hsa 85 IFDHLVAH---GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL 131 senlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm......APEslky + nl +KI+DFG + + + ++ k W+++++ APE + kb|QSK_Hsa 132 DANLNIKIADFGFSNLF-------TPGQLLKT---WCgsppyaAPELFEG 171 gkFt.skSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLpr +++ + k D+WS GV+L+ ++ G+ P + g + + + +++ R p kb|QSK_Hsa 172 KEYDgPKVDIWSLGVVLYVLVC-GALP-FDGSTLQNLRARVLSGKFRIPF 219 PenCPdelYdlMlqCWaedPedRPtFsel..veeL<-* + + e +l+++ dP++R +++++ ++ + kb|QSK_Hsa 220 FM--STECEHLIRHMLVLDPNKRLSMEQIckHKWM 252 Pkinase: domain 1 of 1, from 1 to 252: score 349.8, E = 9.8e-106 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ye+ +++G+G+f++V++a+h t +VA+Kii+k +++ +k +r kb|QSK_Hsa 1 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFR 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+qi+k+L+Hp+I+rl+ v+e+++ +ylV+Ey+ gG + fd+l kb|QSK_Hsa 48 --EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG----EIFDHLV- 90 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++g++ e+ea++ ++Qi+ +++++H ++i+HRDLK eN+Lld n + kb|QSK_Hsa 91 --AHGRM--AEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 136 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD + KiaDFG++ + ++++ l+t +G+p+Y+APE+ g +++g+kvD kb|QSK_Hsa 137 I----KIADFGFSNL--FtPGQlLKTWCGSPPYAAPELFEGKEYDGPKVD 180 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi +WSlGv+ly l++G +PF+g+ + + l +++l+++++++++ + kb|QSK_Hsa 181 IWSLGVVLYVLVCGALPFDGS-----TLQNLRARVLSGKFRIPFFMS--- 222 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* e+ +Li+ +L +DP+kRl+ e+i++H+w+ kb|QSK_Hsa 223 ------------TECEHLIRHMLVLDPNKRLSMEQICKHKWM 252 // Query sequence: kb|QIK_Hsap|CAMK/CAMKL/QIK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 342.8 1.3e-103 1 Pkinase_Tyr Protein tyrosine kinase 85.6 3.4e-26 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 250 [. 1 272 [] 85.6 3.4e-26 Pkinase 1/1 1 252 [] 1 287 [] 342.8 1.3e-103 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 250: score 85.6, E = 3.4e-26 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei + +LG+G+F +V +G+ + t+++VA+K+++k + + + kb|QIK_Hsa 1 YDIEGTLGKGNFAVVKLGRHR----ITKTEVAIKIIdKS-QLDAVN- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd +e+ rE++iMk l dHp+i++L+ v + ly+VtEy+++G kb|QIK_Hsa 42 -LEKIYREVQIMKML-DHPHIIKLYQVMET-KSM----LYLVTEYAKNGE 84 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV d+L +h ++L+ ++ +Qi ++ +Y + +++vHRDL A N L+ kb|QIK_Hsa 85 IFDYLANH---GRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLL 131 senlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm......APEslky ++n+ +KI+DFG ++++ l W+++++ APE++ kb|QIK_Hsa 132 DNNMNIKIADFGFGNFF-------KSGE---LLATWCgsppyaAPEVFEG 171 gkF.tskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLpr ++ + D+WS GV+L+ ++ G+ P + g + + +++ e + R p kb|QIK_Hsa 172 QQYeGPQLDIWSMGVVLYVLVC-GALP-FDGPTLPILRQRVLEGRFRIPY 219 PenCPdelYdlMlqCWaedPedRPtFselveeL<-* + +++ +l+++ dP++R t +++ e+ kb|QIK_Hsa 220 FM--SEDCEHLIRRMLVLDPSKRLTIAQIKEHK 250 Pkinase: domain 1 of 1, from 1 to 252: score 342.8, E = 1.3e-103 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y ++++lG+G+f++V++++h+ t +VA+Kii+k+ + ++ r kb|QIK_Hsa 1 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYR 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+qi+k+L+Hp+I++l+ v+e+k+ lylV+Ey+ +G + fdyl kb|QIK_Hsa 48 --EVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNG----EIFDYLA- 90 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++g+l e ea++ ++Qil++++Y+H ++i+HRDLK eN+Lldnn++ kb|QIK_Hsa 91 --NHGRL--NESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMN 136 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD + KiaDFG+ + +s++ l t +G+p+Y+APEv g+++ g+ D kb|QIK_Hsa 137 I----KIADFGFGNF--FkSGElLATWCGSPPYAAPEVFEGQQYEGPQLD 180 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi +WS+Gv+ly l++G +PF+g + l +++l+++++++++ + kb|QIK_Hsa 181 IWSMGVVLYVLVCGALPFDGP-----TLPILRQRVLEGRFRIPYFMS--- 222 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* e++ +Li+++L +DPskRlt+++i++H+w+ kb|QIK_Hsa 223 ------------EDCEHLIRRMLVLDPSKRLTIAQIKEHKWM 252 // Query sequence: kb|PYK2_Hsap|TK/FAK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 477.8 2.9e-144 1 Pkinase Protein kinase domain 156.1 2e-47 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 255 [. 1 272 [] 477.8 2.9e-144 Pkinase 1/1 1 255 [. 1 287 [] 156.1 2e-47 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 255: score 477.8, E = 2.9e-144 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie ++l++ LGeG FGeVy+G+++ ++g++i VAVKt+k+ +++ ++ kb|PYK2_Hs 1 VVLNRILGEGFFGEVYEGVYT-NHKGEKINVAVKTCKK-DCTLDN-- 43 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL +e+F++EA iMk+l dHp+iV+L+G++ +eP +i++E+ ++G L kb|PYK2_Hs 44 KEKFMSEAVIMKNL-DHPHIVKLIGIIE--EEP----TWIIMELYPYGEL 86 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs ++L ++ +++L++ +L+ ++lQi+k+M+YLes n+vHRD+A RN+LV+ kb|PYK2_Hs 87 GHYLERN--KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVA 134 enlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkFtskS ++ +VK +DFGL+R+i +d++Y +k + ++lP+kWm+PEs+++++Ft++S kb|PYK2_Hs 135 SPECVKLGDFGLSRYI-EDEDY-YKASVTRLPIKWMSPESINFRRFTTAS 182 DVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPdel DVW+F V++WEi+++G+qP + + n +v+ l e+G RLp+P++CP+ l kb|PYK2_Hs 183 DVWMFAVCMWEILSFGKQP-FFWLENKDVIGVL-EKGDRLPKPDLCPPVL 230 YdlMlqCWaedPedRPtFselveeL<-* Y+lM++CW++dP+dRP+F+elv L kb|PYK2_Hs 231 YTLMTRCWDYDPSDRPRFTELVCSL 255 Pkinase: domain 1 of 1, from 1 to 255: score 156.1, E = 2e-47 *->yelleklGsGsfGtVykak...hkgtgkiVAvKiikkr..kekskkd +l ++lG+G fG+Vy+++ ++hkg+ + VAvK+ kk+ + ++++k kb|PYK2_Hs 1 VVLNRILGEGFFGEVYEGVytnHKGEKINVAVKTCKKDctLDNKEKF 47 ktarrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLf ++ E+ i+k+L+Hp+Iv+li++ e + ++++E+ + G +L kb|PYK2_Hs 48 MS-----EAVIMKNLDHPHIVKLIGIIE-EEPTWIIMELYPYG----ELG 87 dylsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILl +yl r+k++l ++ + lQi+++++YL s +++HRD+ NIL+ kb|PYK2_Hs 88 HYLE--RNKNSL--KVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILV 133 dnngvvdaflKiaDFGlAkklst.sss.lttfvGTpw...YmAPEvllgg +++ +K++DFGl++ + +++++ +T+ + ++m+PE ++ kb|PYK2_Hs 134 A-SPEC---VKLGDFGLSR---YiEDEdYYKASVTRLpikWMSPESIN-F 175 ngygtkvDvWSlGvilyellt.GkpPFsgevqds.ldqlqlirkilgppl + +t++DvW + v ++e l+ Gk PF ++ d + +++k + kb|PYK2_Hs 176 RRFTTASDVWMFAVCMWEILSfGKQPFFWL---EnKDVIGVLEKGDR--- 219 efdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHP + p ++ + + L+++c+++DPs+R+ ++e++++ kb|PYK2_Hs 220 -LPKPDLCP-------------PVLYTLMTRCWDYDPSDRPRFTELVCS- 254 wf<-* + kb|PYK2_Hs 255 -L 255 // Query sequence: kb|Wnk4_Hsap|Other/WNK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 209.1 2.3e-63 1 Pkinase_Tyr Protein tyrosine kinase 70.7 1e-21 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 259 [] 1 272 [] 70.7 1e-21 Pkinase 1/1 1 259 [] 1 287 [] 209.1 2.3e-63 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 259: score 70.7, E = 1e-21 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei lk++ ++G+G+F +Vy+G + +t+++VA L+ + s e kb|Wnk4_Hs 1 LKFDIEIGRGSFKTVYRGLDT----DTTVEVAWCELqTR-KLSRAE- 41 eredFlrEAsiMkklGdHpNiVrLl........GvctkegePggpglyiV r+ F +E++++k l +HpNiVr++++ ++ +G + + +V kb|Wnk4_Hs 42 -RQRFSEEVEMLKGL-QHPNIVRFYdswksvlrGQVC---------IVLV 80 tEymegGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLeskn..fvH tE+m G L+++Lr+ r + L +++Qi +G+ +L+s+ +++ H kb|Wnk4_Hs 81 TELMTSGTLKTYLRR---FREMKPRVLQRWSRQILRGLHFLHSRVppILH 127 RDLAARNcLVsenl.vVKIsDFGLaRdiysddyYvrkrgggklPv...kW RDL + N+ ++ + + VKI+D GLa + r++ +k ++++ kb|Wnk4_Hs 128 RDLKCDNVFITGPTgSVKIGDLGLATLK-------RASF-AKSVIgtpEF 169 mAPEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgm.sneevlelly mAPE + + k+ ++ DV++FG ++ E+ t e P Y +++ ++++ ++ kb|Wnk4_Hs 170 MAPE-MYEEKYDEAVDVYAFGMCMLEMAT-SEYP-YSECqNAAQIYRKV- 215 edGyR......LprPenCPdelYdlMlqCWaedPedRPtFsel..veeL< +G+ +++ ++ ++Pe + +++ C + d ++R t ++l + ++ kb|Wnk4_Hs 216 TSGRKpnsfhkVKIPE-----VKEIIEGCIRTDKNERFTIQDLlaHAFF 259 -* kb|Wnk4_Hs - - Pkinase: domain 1 of 1, from 1 to 259: score 209.1, E = 2.3e-63 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++ +G+Gsf tVy++ + +t +VA ++ rk + ++++ kb|Wnk4_Hs 1 LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSE 47 lsEiqilkrLsHpNIvrlidvfed..kdhly..lVlEycegGLrvldLfd E+++lk L+HpNIvr++d++ + ++ ++ lV+E++ G L++ kb|Wnk4_Hs 48 --EVEMLKGLQHPNIVRFYDSWKSvlRGQVCivLVTELMTSG----TLKT 91 ylsetrrkgpllfsedeakkialQilrgleYLHsn..giiHRDLKPeNIL yl+ r + + +++++++ +Qilrgl +LHs+ + i+HRDLK +N++ kb|Wnk4_Hs 92 YLR---RFREM--KPRVLQRWSRQILRGLHFLHSRvpPILHRDLKCDNVF 136 ld.nngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggn + + +g v Ki+D GlA +++ s ++++ GTp++mAPE + kb|Wnk4_Hs 137 ITgPTGSV----KIGDLGLAT---LkRASfAKSVIGTPEFMAPEM--YEE 177 gygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefd +y+ +vDv+++G + e++t + P+s++ + q++rk+ +++ + + kb|Wnk4_Hs 178 KYDEAVDVYAFGMCMLEMATSEYPYSEC----QNAAQIYRKVTSGRKPNS 223 spewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf< + + +e k++i++c++ D ++R t++++l H +f kb|Wnk4_Hs 224 FHKVKI-------------PEVKEIIEGCIRTDKNERFTIQDLLAHAFF 259 -* kb|Wnk4_Hs - - // Query sequence: kb|Wnk3_Hsap|Other/WNK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 220.8 6.7e-67 1 Pkinase_Tyr Protein tyrosine kinase 94.3 8.3e-29 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 259 [] 1 272 [] 94.3 8.3e-29 Pkinase 1/1 1 259 [] 1 287 [] 220.8 6.7e-67 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 259: score 94.3, E = 8.3e-29 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei lk++ +LG+GaF +VykG + +t ++VA L+ + + e kb|Wnk3_Hs 1 LKFDIELGRGAFKTVYKGLDT----ETWVEVAWCELqDR-KLTKAE- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpg.lyiVtEymegG ++ F +EA+++k l +HpNiVr++ + g+ + +VtE+m G kb|Wnk3_Hs 42 -QQRFKEEAEMLKGL-QHPNIVRFYDSWE--SILKGKKcIVLVTELMTSG 87 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLeskn..fvHRDLAARN L+++L++ + + k L s+++Qi kG+++L+ + ++++HRDL + N kb|Wnk3_Hs 88 TLKTYLKR---FKVMKPKVLRSWCRQILKGLQFLHTRTppIIHRDLKCDN 134 cLVsenl.vVKIsDFGLaRdiysddyYvrkrgggklPv...kWmAPEslk + ++ + + VKI+D GLa ++ r++ +k ++++ mAPE + kb|Wnk3_Hs 135 IFITGPTgSVKIGDLGLATLM-------RTSF-AKSVIgtpEFMAPE--M 174 ygk.FtskSDVWSFGVlLWEiftlGeqPFYpgm.sneevlellyedGyRL y +++ + DV++FG ++ E+ t e P Y +++ ++++ ++ +G kb|Wnk3_Hs 175 YEEhYDESVDVYAFGMCMLEMAT-SEYP-YSECqNAAQIYRKV-TSGIKP 221 pr.PenCPdelYdlMlqCWaedPedRPtFsel..veeL<-* + + + +e+ +++ C + + ++R + ++l ++ ++ kb|Wnk3_Hs 222 ASfNKVTDPEVKEIIEGCIRQNKSERLSIRDLlnHAFF 259 Pkinase: domain 1 of 1, from 1 to 259: score 220.8, E = 6.7e-67 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++ lG+G+f tVyk+ + t +VA ++ rk + ++++ kb|Wnk3_Hs 1 LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKE 47 lsEiqilkrLsHpNIvrlidvfed....kdhlylVlEycegGLrvldLfd E+++lk L+HpNIvr++d++e+ ++k+ + lV+E++ G L++ kb|Wnk3_Hs 48 --EAEMLKGLQHPNIVRFYDSWESilkgKKCIVLVTELMTSG----TLKT 91 ylsetrrkgpllfsedeakkialQilrgleYLHsn..giiHRDLKPeNIL yl+ r +++ +++++++++Qil+gl++LH +++ iiHRDLK +NI+ kb|Wnk3_Hs 92 YLK---RFKVM--KPKVLRSWCRQILKGLQFLHTRtpPIIHRDLKCDNIF 136 ld.nngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggn + + +g v Ki+D GlA + + s ++++ GTp++mAPE + kb|Wnk3_Hs 137 ITgPTGSV----KIGDLGLAT---LmRTSfAKSVIGTPEFMAPEM--YEE 177 gygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefd +y+ +vDv+++G + e++t + P+s++ + q++rk+ +++ + + kb|Wnk3_Hs 178 HYDESVDVYAFGMCMLEMATSEYPYSEC----QNAAQIYRKVTSGIKPAS 223 spewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf< + + + +e k++i++c++++ s+Rl+++++l+H +f kb|Wnk3_Hs 224 FNKVTD-------------PEVKEIIEGCIRQNKSERLSIRDLLNHAFF 259 -* kb|Wnk3_Hs - - // Query sequence: kb|PSKH2_Hsap|CAMK/PSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 291.6 3.3e-88 1 Pkinase_Tyr Protein tyrosine kinase 32.1 4.9e-18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 234 [. 1 272 [] 32.1 4.9e-18 Pkinase 1/1 1 258 [] 1 287 [] 291.6 3.3e-88 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 234: score 32.1, E = 4.9e-18 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + +G G+F +V++ + k t+ + A+K++ + e+e + kb|PSKH2_H 1 YDIKALIGTGSFSRVVRVEQK----TTKKPFAIKVM---ETRERE-G 39 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL re+ +E+s++++ +H iV+L+ + ++ +y+V+E++ gG L kb|PSKH2_H 40 REACVSELSVLRRV-SHRYIVQLMEIFET-EDQ----VYMVMELATGGEL 83 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs d L + ++++t d + + + +A+G YL++ ++ HR L N L kb|PSKH2_H 84 FDRLIA---QGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYY 130 e...nlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkFt +++++ ++ I+DFGLa + ++ ++++ + P APE+l + +t kb|PSKH2_H 131 HpgeESKILITDFGLAYSGKKSGDW-TMKTLCGTP-EYIAPEVLLRKPYT 178 skSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLpr.PenC s+ D W+ GV + +++ G P + + s ++++ ++ +G + + kb|PSKH2_H 179 SAVDMWALGVITYALLS-GFLP-FDDESQTRLYRKI-LKGKYNYTgEP-- 223 PdelYdlMlqCWaedPedRPtFselveeL<-* W P+ s l ++ kb|PSKH2_H 224 -----------W-------PSISHLAKDF 234 Pkinase: domain 1 of 1, from 1 to 258: score 291.6, E = 3.3e-88 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar y ++ +G Gsf++V + k t k +A+K+++ r++e + + + kb|PSKH2_H 1 YDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETReREGREACVS-- 45 rlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls E+++l+r+sH +Iv+l ++fe++d +y+V+E++ gG +Lfd+l kb|PSKH2_H 46 ---ELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGG----ELFDRLI 88 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng ++g++ +e++a +i+ ++ g+ YLH+ i HR LKPeN+L+ + g kb|PSKH2_H 89 ---AQGSF--TERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPG 133 vvdaflKiaDFGlAkkls..t.sss.lttfvGTpwYmAPEvllggngygt + +++ i+DFGlA +s++ + + +++t++GTp+Y+APEvll +++y++ kb|PSKH2_H 134 EE-SKILITDFGLA--YSgkKsGDWtMKTLCGTPEYIAPEVLL-RKPYTS 179 kvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspew +vD+W+lGvi y ll+G +PF++e +q l+rkil++++ + + w kb|PSKH2_H 180 AVDMWALGVITYALLSGFLPFDDE-----SQTRLYRKILKGKYNYTGEPW 224 dsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* sis akd+i+k+L + R +a ++l HPw+ kb|PSKH2_H 225 PSIS-----------HLAKDFIDKLLILEAGHRMSAGQALDHPWV 258 // Query sequence: kb|PSKH1_Hsap|CAMK/PSK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 323.9 6.2e-98 1 Pkinase_Tyr Protein tyrosine kinase 10.8 1e-16 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 234 [. 1 272 [] 10.8 1e-16 Pkinase 1/1 1 258 [] 1 287 [] 323.9 6.2e-98 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 234: score 10.8, E = 1e-16 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + +G+G+F +V++ + + t+++ A+K++ + +e kb|PSKH1_H 1 YDIKALIGRGSFSRVVRVEHR----ATRQPYAIKMI---ETKYRE-- 38 redFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd ++ ++E++++++ +H Ni++L v +e +y+V+E++ gG kb|PSKH1_H 39 GREVCEsELRVLRRV-RHANIIQLVEVFET-QER----VYMVMELATGGE 82 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L d + ++++t d + + +G YL++ ++ HRDL N L kb|PSKH1_H 83 LFDRIIA---KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLY 129 se...nlvVKIsDFGLaRdiysddyY.vrkrgggklPvkWmAPEslkygk +++++ ++ I+DFGLa + + d+ ++++ APE+l + kb|PSKH1_H 130 YHpgtDSKIIITDFGLASARKKGDDClMKTTC---GTPEYIAPEVLVRKP 176 FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLpr.Pe +t D W+ GV + +++ G +P +++ ++++ ++ +G + + kb|PSKH1_H 177 YTNSVDMWALGVIAYILLS-GTMP-FEDDNRTRLYRQI-LRGKYSYSgEP 223 nCPdelYdlMlqCWaedPedRPtFselveeL<-* W P+ s l ++ kb|PSKH1_H 224 -------------W-------PSVSNLAKDF 234 Pkinase: domain 1 of 1, from 1 to 258: score 323.9, E = 6.2e-98 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar y ++ +G+Gsf++V + h+ t++ +A+K i+ + +e +++++ kb|PSKH1_H 1 YDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKyREGREVCES-- 45 rlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls E+++l+r++H NI++l +vfe+ ++y+V+E++ gG +Lfd++ kb|PSKH1_H 46 ---ELRVLRRVRHANIIQLVEVFETQERVYMVMELATGG----ELFDRII 88 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng +kg++ +e++a +++ +l g+ YLH+ gi HRDLKPeN+L+ ++ kb|PSKH1_H 89 ---AKGSF--TERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYY-HP 132 vvdaflKiaDFGlAkkls.t.sss.lttfvGTpwYmAPEvllggngygtk +d+++ i+DFGlA +++ + + ++t +GTp+Y+APEvl +++y+ + kb|PSKH1_H 133 GTDSKIIITDFGLAS-ARkKgDDClMKTTCGTPEYIAPEVLV-RKPYTNS 180 vDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewd vD+W+lGvi y+ll+G PF ++ + l+r+il+++++++ + w kb|PSKH1_H 181 VDMWALGVIAYILLSGTMPFEDD-----NRTRLYRQILRGKYSYSGEPWP 225 sisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* s+s akd+i+++L++DP R ta ++l HPw+ kb|PSKH1_H 226 SVS-----------NLAKDFIDRLLTVDPGARMTALQALRHPWV 258 // Query sequence: kb|PRPK_Hsap|Other/Bud32|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain -102.8 4.1e-06 1 Pkinase_Tyr Protein tyrosine kinase -183.4 7.5e-05 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 1 220 [] 1 287 [] -102.8 4.1e-06 Pkinase_Tyr 1/1 4 212 .. 1 272 [] -183.4 7.5e-05 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 1 to 220: score -102.8, E = 4.1e-06 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + le + +G+ ++V++++ +g ++K ++ ++ +++++ kb|PRPK_Hs 1 LSGLELVKQGAEARVFRGRFQGRA--AVIKHRFPKGYRHPALEARLG 45 l....sEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfd ++++ E++ l+r++ I +f d + +l +E eg d kb|PRPK_Hs 46 RrrtvQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIEGS---VTVRD 92 ylsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld y++ + +++ +++ + + a+ i + l+ +H++ iH DL +N Ll+ kb|PRPK_Hs 93 YIQ-STMETEK--TPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLK 139 ...nngvvdaflKiaDFGlAkklstssslttfvGTpwYmAPEvllggngy ++ ++ ++ ++DFGl+ + + + kb|PRPK_Hs 140 pplEQLNI----VLIDFGLS----------------------FIS-ALPE 162 gtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdsp ++ vD + +l + ++ + + +++ l+ s+ kb|PRPK_Hs 163 DKGVDLY--------VLEKAFLSTHP-----NTETVFEAFLK------SY 193 ewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* ++s + a+ ++kk+ R + + kb|PRPK_Hs 194 STSS-------------KKARPVLKKL--DEVRLRG-----RKRSMV 220 Pkinase_Tyr: domain 1 of 1, from 4 to 212: score -183.4, E = 7.5e-05 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei l+l k +Ga +V++G+ + +K ++ g+ ++++ kb|PRPK_Hs 4 LELVK---QGAEARVFRGRFQ------GRAAVIKHRfPK-GYRHPAL 40 e....redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEym e + +r+ +EA+ + + + i + ++ + ++ +E kb|PRPK_Hs 41 EarlgRRRTVQEARALLRC-RRAGISAPVVFFVD-YAS----NCLYMEEI 84 egG.dLldfLrkhr..egrpLtlkdLlsfalQiAkGMeYLeskn...fvH eg +d+ ++ ++e+ p l+ L + Q+ L+++++++++H kb|PRPK_Hs 85 EGSvTVRDYIQSTMetEKTPQGLSNLAKTIGQV------LARMHdedLIH 128 RDLAARNcLVs...enlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm DL + N L++++ e+l + DFGL+ kb|PRPK_Hs 129 GDLTTSNMLLKpplEQLNIVLIDFGLSFIS-------------------- 158 APEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyed p+ + + ++ + kb|PRPK_Hs 159 -----------------------------A----LPEDKGVD--LYV-LE 172 GyRLprPenCPdelYdlMlqCWaedPedRPtFsel.veeL<-* L +n+ +++ + RP + l+ +L kb|PRPK_Hs 173 KAFLSTHPNTETVFEAFLKSYSTSSKKARPVLKKLdEVRL 212 // Query sequence: kb|PRP4_Hsap|CMGC/DYRK/PRP4|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 129.9 1.6e-39 1 Pkinase_Tyr Protein tyrosine kinase -60.2 2.2e-12 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 1 312 [. 1 287 [] 129.9 1.6e-39 Pkinase_Tyr 1/1 8 251 .. 1 272 [] -60.2 2.2e-12 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 1 to 312: score 129.9, E = 1.6e-39 *->yelleklGsGsfGtVykak.hkgtgkiVAvKiikkrkekskkdktar y + + G+G f+ V +a+++ +++VAvKii+ +++ ++kt + kb|PRP4_Hs 1 YNVYGYTGQGVFSNVVRARdNARANQEVAVKIIR---NNELMQKTGL 44 rlsEiqilkrLs........HpNIvrlidvfedkdhlylVlEycegGLrv + E++ lk+L++ +++++ H+ +rl++ f+ k+hl+lV+E + + kb|PRP4_Hs 45 K--ELEFLKKLNdadpddkfHC--LRLFRHFYHKQHLCLVFEPLSM---- 86 ldLfdylsetrrkgpll.fsedeakkialQilrgleYLHsngiiHRDLKP L ++l+ ++g+ ++ + ++++ Q++ +l+ L +++i+H D+KP kb|PRP4_Hs 87 -NLREVLK---KYGKDVgLHIKAVRSYSQQLFLALKLLKRCNILHADIKP 132 eNILldnngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvll +NIL+++ ++ lK++DFG+A + + + t + ++++Y+APE++ kb|PRP4_Hs 133 DNILVNESKTI---LKLCDFGSAS---HvADNdITPYLVSRFYRAPEIII 176 ggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgppl g+ y++ +D+WS+G++lyel+tGk +F+g+ +++++ +++++l+++ kb|PRP4_Hs 177 -GKSYDYGIDMWSVGCTLYELYTGKILFPGK---TNNHMLKLAMDLKGK- 221 efdspewdsisrse.fr................................. ++ + +r++ ++++ +++ + + ++ +++++ + + kb|PRP4_Hs 222 ----------MPNKmIRkgvfkdqhfdqnlnfmyievdkvterekvtvms 261 ...................r.l.pnlseeakdLikkcLnkDPskRltaee + +++++ + + ++ +++ ++++++ +kdL++ +L +DP+kR++ kb|PRP4_Hs 262 tinptkdlladligcqrlpEdQrKKVHQ-LKDLLDQILMLDPAKRIS--- 307 ilqHPwf<-* i q + kb|PRP4_Hs 308 INQA--L 312 Pkinase_Tyr: domain 1 of 1, from 8 to 251: score -60.2, E = 2.2e-12 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei G+G F +V++++ + +++VAVK+++++ +++ kb|PRP4_Hs 8 -------GQGVFSNVVRARDN---ARANQEVAVKIIrNN-ELMQKT- 42 eredFlrEAsiMkklGd.......HpNiVrLlGvctkegePggpglyiVt l+E++ +kkl ++ +++++ + + + + ++ l++V+ kb|PRP4_Hs 43 ----GLKELEFLKKL-NdadpddkFHCLRLFRHFYH--KQH----LCLVF 81 EymegGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDL E +L++ L+k + L +k s+++Q ++ L + n+ H D+ kb|PRP4_Hs 82 EPLSM-NLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADI 130 AARNcLVsenl.vVKIsDFGLaRdiysddyY.vrkrgggklPvkWmAPEs N+LV+e++++ K +DFG a + + d ++ ++ + APE kb|PRP4_Hs 131 KPDNILVNESKtILKLCDFGSASHVADNDITpYLVSR------FYRAPEI 174 lkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyed..Gy + + + D WS G++L+E++t G++ +pg +n+ +l+l +d +G kb|PRP4_Hs 175 IIGKSYDYGIDMWSVGCTLYELYT-GKIL-FPGKTNNHMLKLA-MDlkGK 221 RLprPenCPdelYdlMlqCWaedPedRPtFsel.veeL<-* + + + + + ++ F +++v + kb|PRP4_Hs 222 MPNKMI--RKGVFK------DQHFDQNLNFMYIeVDKV 251 // Query sequence: kb|PRKY_Hsap|AGC/PKA|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 228.7 2.9e-69 1 Pkinase_Tyr Protein tyrosine kinase -3.2 7.1e-16 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 1 215 [. 1 287 [] 228.7 2.9e-69 Pkinase_Tyr 1/1 5 213 .. 1 272 [] -3.2 7.1e-16 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 1 to 215: score 228.7, E = 2.9e-69 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr l + G G+fG+V + k+k + +A+K+++ ++ k++++++ kb|PRKY_Hs 1 CDALVTMGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRRKQEQHVH 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse + E ++lk++sHp+ +rl+ ++++++ ly+ +Ey++gG +Lf+yl+ kb|PRKY_Hs 48 N-EKSVLKEVSHPFLIRLFWTWHEERFLYMLMEYVPGG----ELFSYLR- 91 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++g + s + ++ +i++++eYLHs+ i++RDLKPeNILld++g+ kb|PRKY_Hs 92 --NRGHF--SSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGH 137 vdaflKiaDFGlAkklst.ssslttfvGTpwYmAPEvllggngygtkvDv + K++DFG+Ak ++++t++GTp+Y+APEv++ ++g+g++vD+ kb|PRKY_Hs 138 I----KLTDFGFAK---KlVDRTWTLCGTPEYLAPEVIQ-SKGHGRAVDW 179 WSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsis W+lG++++e+l+G pPF ++ +++ +++kil ++ kb|PRKY_Hs 180 WALGILIFEMLSGFPPFFDD-----NPFGIYQKILAGK------------ 212 rsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +f kb|PRKY_Hs 213 --------------------------------------LYF 215 Pkinase_Tyr: domain 1 of 1, from 5 to 213: score -3.2, E = 7.1e-16 *->lklgkkLGeGaFGeVykGtlkg.sgdgteikVAVKtL.ke.igasee +++ G G FG+V++ + k ++ A K+++ +++ + kb|PRKY_Hs 5 VTM----GTGTFGRVHLVKEKTaKHFF-----ALKVMsIPdVIRRKQ 42 eieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymeg e + +E s++k+ +Hp ++rL + t ++e ly+ +Ey++g kb|PRKY_Hs 43 E---QHVHNEKSVLKEV-SHPFLIRL--FWTWHEERF---LYMLMEYVPG 83 GdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNc G L ++Lr+ +++++ + l ++++i ++ eYL+sk +v RDL N+ kb|PRKY_Hs 84 GELFSYLRN---RGHFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENI 130 LVsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkF L+++++++K +DFG a+ + + r+ + +APE+++ + kb|PRKY_Hs 131 LLDRDGHIKLTDFGFAKKL-------VDRTWTLcGTPEYLAPEVIQSKGH 173 tskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenC + D W+ G+l++E+++ G +P + + ++ +++++ kb|PRKY_Hs 174 GRAVDWWALGILIFEMLS-GFPP-FFDDNPFGIYQKI------------- 208 PdelYdlMlqCWaedPedRPtFselveeL<-* l +L kb|PRKY_Hs 209 ------------------------LAGKL 213 // Query sequence: kb|PRKX_Hsap|AGC/PKA|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 319.5 1.4e-96 1 Pkinase_Tyr Protein tyrosine kinase 23.3 1.7e-17 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 249 [. 1 272 [] 23.3 1.7e-17 Pkinase 1/1 1 255 [] 1 287 [] 319.5 1.4e-96 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 249: score 23.3, E = 1.7e-17 *->lklgkkLGeGaFGeVykGtlkg.sgdgteikVAVKtL..keigasee + + + G G FG+V++ + k ++ A K+++ ++ + kb|PRKX_Hs 1 FDTLATVGTGTFGRVHLVKEKTaKHFF-----ALKVMsiPD-VIRLK 41 eieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymeg + + +E s++k+ +Hp ++rL + t ++e ly+ +Ey++g kb|PRKX_Hs 42 Q--EQHVHNEKSVLKEV-SHPFLIRL--FWTWHDERF---LYMLMEYVPG 83 GdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNc G L ++Lr+ +++++ + l ++++i ++ eYL+sk +v RDL N+ kb|PRKX_Hs 84 GELFSYLRN---RGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENI 130 LVsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkF L+++++++K +DFG a+ + + r+ + +APE+++ + kb|PRKX_Hs 131 LLDRDGHIKLTDFGFAKKL-------VDRTWTLcGTPEYLAPEVIQSKGH 173 tskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyR.LprPen + D W+ G+l++E+++ G +P + + ++ +++++ +G + pr kb|PRKX_Hs 174 GRAVDWWALGILIFEMLS-GFPP-FFDDNPFGIYQKI-LAGKIdFPRHL- 219 CPdelYdlMlqCWaedPedRP.tFselveeL<-* + dl+++ d +R + ++ ++ kb|PRKX_Hs 220 -DFHVKDLIKKLLVVDRTRRLgNMKNGANDV 249 Pkinase: domain 1 of 1, from 1 to 255: score 319.5, E = 1.4e-96 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + +l ++G G+fG+V + k+k + +A+K+++ ++ k++++++ kb|PRKX_Hs 1 FDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVH 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse + E ++lk++sHp+ +rl+ +++d++ ly+ +Ey++gG +Lf+yl+ kb|PRKX_Hs 48 N-EKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGG----ELFSYLR- 91 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++g++ s + ++ +i++++eYLHs+ i++RDLKPeNILld++g+ kb|PRKX_Hs 92 --NRGRF--SSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGH 137 vdaflKiaDFGlAkklst.ssslttfvGTpwYmAPEvllggngygtkvDv + K++DFG+Ak ++++t++GTp+Y+APEv++ ++g+g++vD+ kb|PRKX_Hs 138 I----KLTDFGFAK---KlVDRTWTLCGTPEYLAPEVIQ-SKGHGRAVDW 179 WSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsis W+lG++++e+l+G pPF ++ +++ +++kil ++++f++ + kb|PRKX_Hs 180 WALGILIFEMLSGFPPFFDD-----NPFGIYQKILAGKIDFPRHLD---- 220 rsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf<-* kdLikk+L +D ++Rl++ +++a ++++H wf kb|PRKX_Hs 221 -----------FHVKDLIKKLLVVDRTRRLGnmkngANDVKHHRWF 255 // Query sequence: kb|PAK6_Hsap|STE/STE20/PAKB|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 284.4 4.8e-86 1 Pkinase_Tyr Protein tyrosine kinase 92.5 2.9e-28 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 252 [] 1 272 [] 92.5 2.9e-28 Pkinase 1/1 1 252 [] 1 287 [] 284.4 4.8e-86 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 252: score 92.5, E = 2.9e-28 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie l k+GeG+ G V++++ k + + +VAVK++ + ++ kb|PAK6_Hs 1 LDSYVKIGEGSTGIVCLAREK----HSGRQVAVKMM---DLRKQQ-- 38 redFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd r+++l +E+ iM+ + +H N+V ++ + ge l++ +E+ +gG kb|PAK6_Hs 39 RRELLFnEVVIMRDY-QHFNVVEMYKSYLV-GEE----LWVLMEFLQGGA 82 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L d + +L+ +++ + + ++++YL++++ +HRD+ +L+ kb|PAK6_Hs 83 LTDIVSQV----RLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILL 128 senlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkFts + ++ VK sDFG + +i s+d + + ++ WmAPE+++ + + + kb|PAK6_Hs 129 TLDGRVKLSDFGFCAQI-SKD---VPKRKSLvGTPYWMAPEVISRSLYAT 174 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyR..LprPenC + D+WS G++ E++ Ge+P Y s+ + +++l +d ++L+ ++ kb|PAK6_Hs 175 EVDIWSLGIMVIEMVD-GEPP-YFSDSPVQAMKRL-RDSPPpkLKNSHKV 221 PdelYdlMlqCWaedPedRPtFsel..veeL<-* ++ l d + + +dP++R t +el ++ +L kb|PAK6_Hs 222 SPVLRDFLERMLVRDPQERATAQELldHPFL 252 Pkinase: domain 1 of 1, from 1 to 252: score 284.4, E = 4.8e-86 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + k+G+Gs G V++a++k +g++VAvK +++rk+ ++ +++ kb|PAK6_Hs 1 LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQR--RELLFN 45 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+ i++ +H N+v+++ ++ + +l++ +E+++gG L d++s kb|PAK6_Hs 46 --EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGG----ALTDIVS- 88 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv + +l e+++ ++ +l++l+YLH++g+iHRD+K++ ILl +g kb|PAK6_Hs 89 ---QVRL--NEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGR 133 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD v K++DFG+++++ + ++ +++vGTp++mAPEv+ ++ y t+vD kb|PAK6_Hs 134 V----KLSDFGFCAQI-SkDVPkRKSLVGTPYWMAPEVIS-RSLYATEVD 177 vWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspewds +WSlG++++e++ G+pP+ ++ s++ ++++r +p+l+ + + kb|PAK6_Hs 178 IWSLGIMVIEMVDGEPPYFSD---SpVQAMKRLRDSPPPKLKNSHKVS-- 222 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* + ++d+++++L +DP++R ta+e+l HP++ kb|PAK6_Hs 223 -------------PVLRDFLERMLVRDPQERATAQELLDHPFL 252 // Query sequence: kb|PAK5_Hsap|STE/STE20/PAKB|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 294.9 3.5e-89 1 Pkinase_Tyr Protein tyrosine kinase 85.6 3.4e-26 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 252 [] 1 272 [] 85.6 3.4e-26 Pkinase 1/1 1 252 [] 1 287 [] 294.9 3.5e-89 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 252: score 85.6, E = 3.4e-26 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie l k+GeG+ G V+ +t k +t+ +VAVK++ + ++ kb|PAK5_Hs 1 LANFIKIGEGSTGIVCIATEK----HTGKQVAVKKM---DLRKQQ-- 38 redFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd r+++l +E+ iM+ + +H+N+V ++ + g+ l++V+E+ egG kb|PAK5_Hs 39 RRELLFnEVVIMRDY-HHDNVVDMYSSYLV-GDE----LWVVMEFLEGGA 82 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L d + + + +++ +l + ++++YL++++ +HRD+ +L+ kb|PAK5_Hs 83 LTDIVTHT----RMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILL 128 senlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkFts ++++ +K sDFG + ++ s++ + + ++ WmAPE+++ + + kb|PAK5_Hs 129 TSDGRIKLSDFGFCAQV-SKE---VPKRKSLvGTPYWMAPEVISRLPYGT 174 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPd + D+WS G++ E++ Ge+P Y + ++ + + ++ +d + kb|PAK5_Hs 175 EVDIWSLGIMVIEMID-GEPP-YFNEPPLQAMRRI-RDSLPPRVKD--LH 219 elYdlMlqCWa....edPedRPtFsel..veeL<-* ++ ++++ + ++P++R t +el ++ +L kb|PAK5_Hs 220 KVSSVLRGFLDlmlvREPSQRATAQELlgHPFL 252 Pkinase: domain 1 of 1, from 1 to 252: score 294.9, E = 3.5e-89 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + k+G+Gs G V++a++k tgk+VAvK++++rk+ ++ +++ kb|PAK5_Hs 1 LANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQR--RELLFN 45 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+ i++ +H+N+v ++ ++ +d+l++V+E++egG L d+++ kb|PAK5_Hs 46 --EVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGG----ALTDIVT- 88 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++++ e+++ ++l +lr+l YLH++g+iHRD+K++ ILl ++g kb|PAK5_Hs 89 ---HTRM--NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGR 133 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD + K++DFG+++++ + ++ +++vGTp++mAPEv+ + +ygt+vD kb|PAK5_Hs 134 I----KLSDFGFCAQV-SkEVPkRKSLVGTPYWMAPEVIS-RLPYGTEVD 177 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi +WSlG++++e++ G+pP+ +e +lq +r+i+ +++ + kb|PAK5_Hs 178 IWSLGIMVIEMIDGEPPYFNE-----PPLQAMRRIRDSLPPRVKDLH--- 219 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* ++s+ ++ +++ +L + Ps+R ta+e+l HP++ kb|PAK5_Hs 220 ---------KVSSVLRGFLDLMLVREPSQRATAQELLGHPFL 252 // Query sequence: kb|PAK4_Hsap|STE/STE20/PAKB|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 298.1 3.6e-90 1 Pkinase_Tyr Protein tyrosine kinase 91.4 6e-28 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 252 [] 1 272 [] 91.4 6e-28 Pkinase 1/1 1 252 [] 1 287 [] 298.1 3.6e-90 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 252: score 91.4, E = 6e-28 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie l k+GeG+ G V+ +t + + + VAVK++ + ++ kb|PAK4_Hs 1 LDNFIKIGEGSTGIVCIATVR----SSGKLVAVKKM---DLRKQQ-- 38 redFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd r+++l +E+ iM+ + +H+N+V ++ + g+ l++V+E+ egG kb|PAK4_Hs 39 RRELLFnEVVIMRDY-QHENVVEMYNSYLV-GDE----LWVVMEFLEGGA 82 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L d + + + +++ +l + ++++ L++++ +HRD+ +L+ kb|PAK4_Hs 83 LTDIVTHT----RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILL 128 senlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkFts ++++ VK sDFG + ++ s++ + r ++ WmAPE ++ + kb|PAK4_Hs 129 THDGRVKLSDFGFCAQV-SKE---VPRRKSLvGTPYWMAPELISRLPYGP 174 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyR..LprPenC + D+WS G++ E++ Ge+P Y + ++ ++++ +d+ ++L+ ++ kb|PAK4_Hs 175 EVDIWSLGIMVIEMVD-GEPP-YFNEPPLKAMKMI-RDNLPprLKNLHKV 221 PdelYdlMlqCWaedPedRPtFsel..veeL<-* ++ l + + +dP++R t +el ++ +L kb|PAK4_Hs 222 SPSLKGFLDRLLVRDPAQRATAAELlkHPFL 252 Pkinase: domain 1 of 1, from 1 to 252: score 298.1, E = 3.6e-90 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + k+G+Gs G V++a+ +++gk+VAvK++++rk+ ++ +++ kb|PAK4_Hs 1 LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR--RELLFN 45 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+ i++ +H+N+v+++ ++ +d+l++V+E++egG L d+++ kb|PAK4_Hs 46 --EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGG----ALTDIVT- 88 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++++ e+++ ++l +l++l LH++g+iHRD+K++ ILl ++g kb|PAK4_Hs 89 ---HTRM--NEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR 133 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD v K++DFG+++++ + ++ +++vGTp++mAPE++ + +yg++vD kb|PAK4_Hs 134 V----KLSDFGFCAQV-SkEVPrRKSLVGTPYWMAPELIS-RLPYGPEVD 177 vWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspewds +WSlG++++e++ G+pP+ +e ++l +++ir +l+p+l+ + kb|PAK4_Hs 178 IWSLGIMVIEMVDGEPPYFNE---PpLKAMKMIRDNLPPRLKNLHKVS-- 222 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +++k +++++L +DP++R ta+e+l+HP++ kb|PAK4_Hs 223 -------------PSLKGFLDRLLVRDPAQRATAAELLKHPFL 252 // Query sequence: kb|NEK7_Hsap|Other/NEK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 265.5 2.4e-80 1 Pkinase_Tyr Protein tyrosine kinase 107.4 9.7e-33 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 252 [] 1 272 [] 107.4 9.7e-33 Pkinase 1/1 1 252 [] 1 287 [] 265.5 2.4e-80 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 252: score 107.4, E = 9.7e-33 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLk..eigaseee +++ kk+G+G+F eVy++ + ++++VA K++ + + ++ kb|NEK7_Hs 1 FRIEKKIGRGQFSEVYRAACL----LDGVPVALKKVQifD-LMDAKA 42 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG r+d ++E+ ++k+l +HpN++++++ ++ + l iV+E++ G kb|NEK7_Hs 43 --RADCIKEIDLLKQL-NHPNVIKYYASFIE-DNE----LNIVLELADAG 84 dLldfLrkhr.egrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNc dL ++ ++++r ++ + ++ +Q ++++e+ +s++ HRD+ N+ kb|NEK7_Hs 85 DLSRMIKHFKkQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANV 134 LVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkFt ++ ++vVK +D GL R + ++ ++ m+PE ++++ ++ kb|NEK7_Hs 135 FITATGVVKLGDLGLGRFF--SSKT-TAAHSLVGTPYYMSPERIHENGYN 181 skSDVWSFGVlLWEiftlGeqPFYpgm.sneevlellyed.GyRLprPen kSD+WS G+lL+E+ l +PFY + + +++++ e+ +y + ++ kb|NEK7_Hs 182 FKSDIWSLGCLLYEMAALQ-SPFYGDKmNLYSLCKKI-EQcDYPPLPSDH 229 CPdelYdlMlqCWaedPedRPtFselveeL<-* ++el +l +C ++dPe+RP + kb|NEK7_Hs 230 YSEELRQLVNMCINPDPEKRP-------DV 252 Pkinase: domain 1 of 1, from 1 to 252: score 265.5, E = 2.4e-80 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++++k+G+G f++Vy+a +g VA+K++ + + k +++ kb|NEK7_Hs 1 FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCI 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse Ei +lk L+HpN+++++ +f ++++l +VlE+++ G dL+++++ kb|NEK7_Hs 48 K-EIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAG----DLSRMIKH 92 .trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng ++k+ + +e+++ k++ Q++++le++Hs++++HRD+KP+N+++ +g kb|NEK7_Hs 93 fKKQKRLI--PERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATG 140 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv vv K++D Gl +++ ++ + ++++vGTp+Ym+PE + ngy k+ kb|NEK7_Hs 141 VV----KLGDLGLGRFF-SsKTTaAHSLVGTPYYMSPERIH-ENGYNFKS 184 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+WSlG++lye++ + PF+g+ + + + l +ki +++++ +s kb|NEK7_Hs 185 DIWSLGCLLYEMAALQSPFYGD---KMNLYSLCKKIEQCDYPPLPSDHYS 231 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* ee+++L++ c+n+DP+kR+ + kb|NEK7_Hs 232 -------------EELRQLVNMCINPDPEKRPD---------V 252 // Query sequence: kb|NEK6_Hsap|Other/NEK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 275.1 3.1e-83 1 Pkinase_Tyr Protein tyrosine kinase 100.0 1.6e-30 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 259 [. 1 272 [] 100.0 1.6e-30 Pkinase 1/1 1 261 [] 1 287 [] 275.1 3.1e-83 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 259: score 100.0, E = 1.6e-30 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLk..eigaseee +++ kk+G+G+F eVyk+t+ ++ +VA K++ e + ++ kb|NEK6_Hs 1 FQIEKKIGRGQFSEVYKATCL----LDRKTVALKKVQifE-MMDAKA 42 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG r+d +E+ ++k+l +HpNi+++l ++ + l iV+E++ G kb|NEK6_Hs 43 --RQDCVKEIGLLKQL-NHPNIIKYLDSFIE-DNE----LNIVLELADAG 84 dLl...dfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAAR dL + ++ +k+ +r ++ + ++ +Q +++ e+ +s++ HRD+ kb|NEK6_Hs 85 DLSqmiKYFKKQ--KRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPA 132 NcLVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygk N+ ++ ++vVK +D GL R ++ ++ ++ m+PE ++++ kb|NEK6_Hs 133 NVFITATGVVKLGDLGLGRFF--SSET-TAAHSLVGTPYYMSPERIHENG 179 FtskSDVWSFGVlLWEiftlGeqPFYpgm.sneevlellyed.GyRLprP ++ kSD+WS G+lL+E+ l +PFY + + +++++ e+ +y + kb|NEK6_Hs 180 YNFKSDIWSLGCLLYEMAALQ-SPFYGDKmNLFSLCQKI-EQcDYPPLPG 227 enCPdelYdlMlqCWaedPedRPtFselveeL<-* e+ +++l +l +C +dP +RP ++++ kb|NEK6_Hs 228 EHYSEKLRELVSMCICPDPHQRPDIGYVHQVA 259 Pkinase: domain 1 of 1, from 1 to 261: score 275.1, E = 3.1e-83 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++++k+G+G f++Vyka+ ++k+VA+K++ + + k +++ kb|NEK6_Hs 1 FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCV 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse Ei +lk L+HpNI++++d+f ++++l +VlE+++ G dL+ +++ kb|NEK6_Hs 48 K-EIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAG----DLSQMIKY 92 .trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng ++k+ + +e+++ k++ Q+++++e++Hs++++HRD+KP+N+++ +g kb|NEK6_Hs 93 fKKQKRLI--PERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATG 140 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv vv K++D Gl +++ + + ++++vGTp+Ym+PE + ngy k+ kb|NEK6_Hs 141 VV----KLGDLGLGRFF-SsETTaAHSLVGTPYYMSPERIH-ENGYNFKS 184 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+WSlG++lye++ + PF+g+ + + + l +ki +++++ e +s kb|NEK6_Hs 185 DIWSLGCLLYEMAALQSPFYGD---KMNLFSLCQKIEQCDYPPLPGEHYS 231 isrsefrrlpnlseeakdLikkcLnkDPskRlt...aeeilqHPwf<-* e +++L++ c+++DP++R+ + +++ + kb|NEK6_Hs 232 -------------EKLRELVSMCICPDPHQRPDigyVHQVAKQ--- 261 // Query sequence: kb|NEK5_Hsap|Other/NEK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 284.7 3.8e-86 1 Pkinase_Tyr Protein tyrosine kinase 117.8 6.7e-36 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 256 [] 1 272 [] 117.8 6.7e-36 Pkinase 1/1 1 256 [] 1 287 [] 284.7 3.8e-86 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 256: score 117.8, E = 6.7e-36 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei +k +G+GaFG+ y+++ k ++ ++ +K ++ e + +e kb|NEK5_Hs 1 YDVIKAIGQGAFGKAYLAKGK----SDSKHCVIKEInFE-KMPIQE- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd +e+ +E+ ++ k+ +HpNiV + + + l+iV+Ey+ gGd kb|NEK5_Hs 42 -KEASKKEVILLEKM-KHPNIVAFFNSFQE-NGR----LFIVMEYCDGGD 84 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L + ++ g ++ ++l++ +Qi+ G+ + +++++ HRD+ A N+ + kb|NEK5_Hs 85 LMKRINRQ-RGVLFSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFL 133 senl.vVKIsDFGLaRdiysddyYvrkrgggklPvkWmAPEslkygkFts s+n+ v+K +DFG aR + + + +r+ + ++PE +++ ++ kb|NEK5_Hs 134 SKNGmVAKLGDFGIARVL-NNSME-LART-CIGTPYYLSPEICQNKPYNN 180 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPd k+D+WS G++L+E++tl P ++g ++++ ++ + + p+ ++ + kb|NEK5_Hs 181 KTDIWSLGCVLYELCTLK-HP-FEGNNLQQLVLKI-CQAHFAPISPGFSR 227 elYdlMlqCWaedPedRPtFsel..veeL<-* el++l+ q + P dRP+ + ++ +L kb|NEK5_Hs 228 ELHSLISQLFQVSPRDRPSINSIlkRPFL 256 Pkinase: domain 1 of 1, from 1 to 256: score 284.7, E = 3.8e-86 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y +++ +G+G+fG+ y+ak k+++k ++K+i+ +k +++++ + kb|NEK5_Hs 1 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKK 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+ +l +++HpNIv ++ +f+++++l +V+Eyc+gG dL+ ++ kb|NEK5_Hs 48 --EVILLEKMKHPNIVAFFNSFQENGRLFIVMEYCDGG----DLMKRIN- 90 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv r++g+l fsed++ ++ Qi gl+++H+++i+HRD+K +NI+l++ng kb|NEK5_Hs 91 -RQRGVL-FSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGM 138 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD v+ K++DFG+A++l ++s + + t GTp+Y++PE+++ +++y k D kb|NEK5_Hs 139 VA---KLGDFGIARVL-NnSMElARTCIGTPYYLSPEICQ-NKPYNNKTD 183 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi +WSlG++lyel+t k PF g + +ql+ ki ++ + sp + kb|NEK5_Hs 184 IWSLGCVLYELCTLKHPFEGN-----NLQQLVLKICQAHFAPISPGFS-- 226 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +e+ +Li+ ++++ P +R+++ il+ P++ kb|NEK5_Hs 227 ------------RELHSLISQLFQVSPRDRPSINSILKRPFL 256 // Query sequence: kb|NEK4_Hsap|Other/NEK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 285.3 2.6e-86 1 Pkinase_Tyr Protein tyrosine kinase 134.7 5.5e-41 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 256 [] 1 272 [] 134.7 5.5e-41 Pkinase 1/1 1 256 [] 1 287 [] 285.3 2.6e-86 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 256: score 134.7, E = 5.5e-41 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei +++ G+G++GeV + + + ++ + +K+L+ +as++e kb|NEK4_Hs 1 YCYLRVVGKGSYGEVTLVKHR----RDGKQYVIKKLnLR-NASSRE- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd r++ +EA+++++l +HpNiV + ++ lyiV+ ++egGd kb|NEK4_Hs 42 -RRAAEQEAQLLSQL-KHPNIVTYKESWEGGDGL----LYIVMGFCEGGD 85 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L+ L+++ g+ L+ + +++ +QiA++++YL++k++ HRDL + N+ + kb|NEK4_Hs 86 LYRKLKEQ-KGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFL 134 senlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkFts ++++++K++D G aR + ++ ++ m+PE ++++ ++ kb|NEK4_Hs 135 TRTNIIKVGDLGIARVL---ENH-CDMASTLiGTPYYMSPELFSNKPYNY 180 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPd kSDVW+ G++ +E+ tl + + + ++ ++ +G p+P++ ++ kb|NEK4_Hs 181 KSDVWALGCCVYEMATLK-HA-FNAKDMNSLVYRI-IEGKLPPMPRDYSP 227 elYdlMlqCWaedPedRPtFsel..veeL<-* el +l++ + Pe+RP+ + + ++ + kb|NEK4_Hs 228 ELAELIRTMLSKRPEERPSVRSIlrQPYI 256 Pkinase: domain 1 of 1, from 1 to 256: score 285.3, E = 2.6e-86 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y+ l+++G+Gs+G+V + kh+ +gk++++K++++r+++s ++++a kb|NEK4_Hs 1 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQ 47 lsEiqilkrLsHpNIvrlidvfed.kdhlylVlEycegGLrvldLfdyls E+q+l L+HpNIv++++++e +++ ly+V+ +cegG dL++ l+ kb|NEK4_Hs 48 --EAQLLSQLKHPNIVTYKESWEGgDGLLYIVMGFCEGG----DLYRKLK 91 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng ++kg l ++e+++ ++ Qi+ +l+YLH++ i+HRDLK +N++l +++ kb|NEK4_Hs 92 --EQKGQL-LPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTN 138 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv + K++D G+A++l +++ ++t+ GTp+Ym+PE+ +++y +k+ kb|NEK4_Hs 139 II----KVGDLGIARVL-EnHCDmASTLIGTPYYMSPELFS-NKPYNYKS 182 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds DvW+lG+ +ye++t k F + d++ l+++i +++l+ + kb|NEK4_Hs 183 DVWALGCCVYEMATLKHAFNAK-----DMNSLVYRIIEGKLPPMPRDYS- 226 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +e+ +Li+ +L k P++R++ + il P++ kb|NEK4_Hs 227 -------------PELAELIRTMLSKRPEERPSVRSILRQPYI 256 // Query sequence: kb|MLK4_Hsap|TKL/MLK/MLK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 269.3 1.7e-81 1 Pkinase_Tyr Protein tyrosine kinase 265.0 3.3e-80 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 275 [] 1 272 [] 265.0 3.3e-80 Pkinase 1/1 1 275 [] 1 287 [] 269.3 1.7e-81 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 275: score 265.0, E = 3.3e-80 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie l+l + +G+G FG Vy++t+ +++VAVK ++ + +++ kb|MLK4_Hs 1 LELKELIGAGGFGQVYRATWQ------GQEVAVKAARQ-DPEQDA-A 39 ..redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG e+ rEA++ l +HpNi+ L Gvc+ ++P+ l++V+E++ gG kb|MLK4_Hs 40 aaAESVRREARLFAML-RHPNIIELRGVCL--QQPH---LCLVLEFARGG 83 dLldfLrkhr...........egrpLtlkdLlsfalQiAkGMeYLes... L L + ++++ ++++ r+++ + L+++a+QiA+GM YL+++ kb|MLK4_Hs 84 ALNRALAAANaapdprapgprRARRIPPHVLVNWAVQIARGMLYLHEeaf 133 knfvHRDLAARNcLVse........nlvVKIsDFGLaRdiysddyYvrkr ++ HRDL N+L+ e+ ++++ n++ KI+DFGLaR r++ kb|MLK4_Hs 134 VPILHRDLKSSNILLLEkiehddicNKTLKITDFGLAREW-----H-RTT 177 gggk.lPvkWmAPEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgms + + WmAPE++k + F+ SD+WS+GVlLWE++t Ge P Y g++ kb|MLK4_Hs 178 KMSTaGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVP-YRGID 225 neevlellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFselveeL v ++ + Lp+P CP++ +lM++CW+ dP RP+F+ ++e+L kb|MLK4_Hs 226 GLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL 275 <-* kb|MLK4_Hs - - Pkinase: domain 1 of 1, from 1 to 275: score 269.3, E = 1.7e-81 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar +el+e +G+G+fG+Vy+a+++g + VAvK + +++++ + + kb|MLK4_Hs 1 LELKELIGAGGFGQVYRATWQGQE--VAVKAARQDpEQDAAAAAESV 45 rlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls r+ E+++ ++L+HpNI++l++v+ +hl+lVlE+++gG L ++l kb|MLK4_Hs 46 RR-EARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGG----ALNRALA 90 ........e...trrkgpllfsedeakkialQilrgleYLHsn...giiH + ++++ ++ rr +++ +++++ ++a Qi+rg+ YLH++ i+H kb|MLK4_Hs 91 aanaapdpRapgPRRARRI--PPHVLVNWAVQIARGMLYLHEEafvPILH 138 RDLKPeNILldnngvvda....flKiaDFGlAkklst.sss.lttfvGTp RDLK++NILl ++ + d+ +++lKi+DFGlA+ + + ++ ++ +GT+ kb|MLK4_Hs 139 RDLKSSNILLLEKIEHDDicnkTLKITDFGLAR---EwHRTtKMSTAGTY 185 wYmAPEvllggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlql +mAPEv++ ++ ++ +D+WS+Gv+l+elltG+ P++g d l++ kb|MLK4_Hs 186 AWMAPEVIK-SSLFSKGSDIWSYGVLLWELLTGEVPYRGI-----DGLAV 229 irkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRl + + +l ++p +++ e++ +L+k c+++DP+ R+ kb|MLK4_Hs 230 AYGVAVNKLTLPIPSTCP-------------EPFAKLMKECWQQDPHIRP 266 taeeilqHPwf<-* +++ il+ + kb|MLK4_Hs 267 SFALILEQ--L 275 // Query sequence: kb|PLK4_Hsap|Other/PLK/SAK|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 302.1 2.2e-91 1 Pkinase_Tyr Protein tyrosine kinase 210.4 9.2e-64 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 254 [] 1 272 [] 210.4 9.2e-64 Pkinase 1/1 1 254 [] 1 287 [] 302.1 2.2e-91 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 254: score 210.4, E = 9.2e-64 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie +k g LG+G+F Vy+++ +t+++VA+K++ + +a+ ++ + kb|PLK4_Hs 1 FKVGNLLGKGSFAGVYRAESI----HTGLEVAIKMIDK-KAMYKA-G 41 .redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd + +E++i ++l +Hp i+ L+ + + +y+V+E++++G kb|PLK4_Hs 42 mVQRVQNEVKIHCQL-KHPSILELYNYFED-SNY----VYLVLEMCHNGE 85 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV + +L+++ +p++ + +f++Qi GM YL+s+++ HRDL N L+ kb|PLK4_Hs 86 MNRYLKNR--VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLL 133 senlvVKIsDFGLaRdi.ysddyYvrkrgggklPvkWmAPEslkygkFts ++n+ +KI+DFGLa +++++ + ++ +PE + kb|PLK4_Hs 134 TRNMNIKIADFGLATQLkMPHEKH-YTLC---GTPNYISPEIATRSAHGL 179 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPd +SDVWS G++ + ++ G++P + ++ +l++++ ++y +p + kb|PLK4_Hs 180 ESDVWSLGCMFYTLLI-GRPP-FDTDTVKNTLNKVVLADYEMPSFL--SI 225 elYdlMlqCWaedPedRPtFsel..veeL<-* e dl+ q +++P+dR + s + ++ ++ kb|PLK4_Hs 226 EAKDLIHQLLRRNPADRLSLSSVldHPFM 254 Pkinase: domain 1 of 1, from 1 to 254: score 302.1, E = 2.2e-91 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ++++ lG+Gsf+ Vy+a + tg +VA+K i+k+ + +++ kb|PLK4_Hs 1 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQ 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse + E++i+ L+Hp I++l+ +fed++++ylVlE c +G + +yl+ kb|PLK4_Hs 48 N-EVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNG----EMNRYLK- 91 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv r +p+ se+ea++++ Qi+ g+ YLHs+gi+HRDL ++N+Ll +n++ kb|PLK4_Hs 92 -NRVKPF--SENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMN 138 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD + KiaDFGlA +l + ++ +t++GTp+Y++PE+ ++ +g ++D kb|PLK4_Hs 139 I----KIADFGLATQL-KmPHEkHYTLCGTPNYISPEIAT-RSAHGLESD 182 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi vWSlG+++y ll G+pPF+ + + + + k+ +++e +s+ + kb|PLK4_Hs 183 VWSLGCMFYTLLIGRPPFDTD-----TVKNTLNKVVLADYEMPSFLS--- 224 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* eakdLi +L+++P++Rl+ +l HP++ kb|PLK4_Hs 225 ------------IEAKDLIHQLLRRNPADRLSLSSVLDHPFM 254 // Query sequence: kb|PLK3_Hsap|Other/PLK/PLK2|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 300.2 8.6e-91 1 Pkinase_Tyr Protein tyrosine kinase 86.9 1.4e-26 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 253 [] 1 272 [] 86.9 1.4e-26 Pkinase 1/1 1 253 [] 1 287 [] 300.2 8.6e-91 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 253: score 86.9, E = 1.4e-26 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLke.igaseeei +g+ LG+G F + y++t + +t+ AVK+++++ a +++ kb|PLK3_Hs 1 YLKGRLLGKGGFARCYEATDT----ETGSAYAVKVIPQsRVAKPHQ- 42 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd re+ l+E+++ + l +H +iVr+ + + +yi +E++ + kb|PLK3_Hs 43 -REKILNEIELHRDL-QHRHIVRFSHHFED-ADN----IYIFLELCSRKS 85 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L + ++ ++ L ++ + +Qi +G+ YL+++++ HRDL N + kb|PLK3_Hs 86 LAHIWKA---RHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFI 132 senlvVKIsDFGLaRdiysddyY.vrkrgggk.lPvkWmAPEslkygkFt +en+ K++DFGLa + + +r+++ APE+l kb|PLK3_Hs 133 TENMELKVGDFGLAARL-----EpPEQRKKTIcGTPNYVAPEVLLRQGHG 177 skSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCP + DVWS G++++ ++ G +P ++ + e++ + + y Lp+ + kb|PLK3_Hs 178 PEADVWSLGCVMYTLLC-GSPP-FETADLKETYRCIKQVHYTLPASL--S 223 delYdlMlqCWaedPedRPtFsel..veeL<-* + +l+ ++ P dRP+ ++ ++ ++ kb|PLK3_Hs 224 LPARQLLAAILRASPRDRPSIDQIlrHDFF 253 Pkinase: domain 1 of 1, from 1 to 253: score 300.2, E = 8.6e-91 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y +++ lG+G+f+++y+a++ tg +AvK+i+ ++ + ++++++ kb|PLK3_Hs 1 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKIL 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse + Ei++++ L+H +Ivr+ + fed d++y+ lE+c +L ++ + kb|PLK3_Hs 48 N-EIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRK----SLAHIWK- 91 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv r++ l e e++ +++Qil+gl+YLH++gi+HRDLK+ N+++ +n++ kb|PLK3_Hs 92 -ARHTLL---EPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENME 137 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD + K++DFGlA+ l +++ ++ +t++GTp+Y+APEvll ++g+g+++D kb|PLK3_Hs 138 L----KVGDFGLAARL-EpPEQrKKTICGTPNYVAPEVLL-RQGHGPEAD 181 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi vWSlG+++y ll+G pPF + d ++ +r i++ +++ p + s kb|PLK3_Hs 182 VWSLGCVMYTLLCGSPPFETA-----DLKETYRCIKQ--VHYTLPASLS- 223 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +a++L+ +L+ P +R+++++il H++f kb|PLK3_Hs 224 ------------LPARQLLAAILRASPRDRPSIDQILRHDFF 253 // Query sequence: kb|PLK2_Hsap|Other/PLK/PLK2|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 302.6 1.6e-91 1 Pkinase_Tyr Protein tyrosine kinase 100.3 1.3e-30 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 253 [] 1 272 [] 100.3 1.3e-30 Pkinase 1/1 1 253 [] 1 287 [] 302.6 1.6e-91 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 253: score 100.3, E = 1.3e-30 *->lklgkkLGeGaFGeVykGtlkgsgdgteikV.AVKtLke.igaseee gk+LG+G F + y+ t t+ kV A K+++++ a +++ kb|PLK2_Hs 1 YCRGKVLGKGGFAKCYEMTDL-----TNNKVyAAKIIPHsRVAKPHQ 42 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG re+ +E+++ + l +H+++V+++ + +e +yi +Ey+ kb|PLK2_Hs 43 --REKIDKEIELHRIL-HHKHVVQFYHYFED-KEN----IYILLEYCSRR 84 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL ++ + L++ ++ Lt ++ + +Qi +G+ YL+++ + HRDL N kb|PLK2_Hs 85 SMAHILKA---RKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFF 131 VsenlvVKIsDFGLaRdiysddyYvrkrgggklPv....kWmAPEslkyg ++e + K++DFGLa + ++++ + +++ ++PE+l+ kb|PLK2_Hs 132 INEAMELKVGDFGLAARL-------EPLEHRRRTIcgtpNYLSPEVLNKQ 174 kFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPe +SD+W+ G++++ ++ G++P ++ e++ + e++y +p kb|PLK2_Hs 175 GHGCESDIWALGCVMYTMLL-GRPP-FETTNLKETYRCIREARYTMPSSL 222 nCPdelYdlMlqCWaedPedRPtFsel..veeL<-* ++ +l+ + ++PedRP+ ++ ++ ++ kb|PLK2_Hs 223 --LAPAKHLIASMLSKNPEDRPSLDDIirHDFF 253 Pkinase: domain 1 of 1, from 1 to 253: score 302.6, E = 1.6e-91 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y+++++lG+G+f+++y+ ++ ++k++A Kii+ ++ + +++++ kb|PLK2_Hs 1 YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKID 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse Ei++++ L+H+++v+++++fedk ++y+ lEyc + ++l+ kb|PLK2_Hs 48 K-EIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRR----SMAHILK- 91 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++++l +e e++ +++Qi++gl+YLH++ i+HRDLK+ N+++++ ++ kb|PLK2_Hs 92 --ARKVL--TEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAME 137 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD + K++DFGlA+ l ++ ++ t++GTp+Y++PEvl+ +g+g ++D kb|PLK2_Hs 138 L----KVGDFGLAARL-EpLEHrRRTICGTPNYLSPEVLN-KQGHGCESD 181 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi +W+lG+++y +l+G+pPF + ++ +r i+++++ +s kb|PLK2_Hs 182 IWALGCVMYTMLLGRPPFETT-----NLKETYRCIREARYTMPSSLL--- 223 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +ak+Li ++L k+P++R++ ++i H++f kb|PLK2_Hs 224 ------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF 253 // Query sequence: kb|PLK1_Hsap|Other/PLK/PLK1|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 303.8 7.3e-92 1 Pkinase_Tyr Protein tyrosine kinase 92.8 2.3e-28 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 252 [. 1 272 [] 92.8 2.3e-28 Pkinase 1/1 1 253 [] 1 287 [] 303.8 7.3e-92 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 252: score 92.8, E = 2.3e-28 *->lklgkkLGeGaFGeVykGtlkg.sgdgteikVAVKtLke.igaseee + g+ LG+G F ++++ s+ +t+ A K++++++ +++ kb|PLK1_Hs 1 YVRGRFLGKGGF-----AKCFEiSDADTKEVFAGKIVPKsLLLKPHQ 42 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG re++ E+si ++l H+++V ++G+ + + +++V+E++ kb|PLK1_Hs 43 --REKMSMEISIHRSL-AHQHVVGFHGFFED-NDF----VFVVLELCRRR 84 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL +Ll+ L+k+ +++Lt ++ + +Qi G++YL++++ +HRDL N kb|PLK1_Hs 85 SLLE-LHKR--RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLF 131 VsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkFt ++e+l VKI+DFGLa + +y r+++ APE+l+ + + kb|PLK1_Hs 132 LNEDLEVKIGDFGLATKV---EYD-GERKKTLcGTPNYIAPEVLSKKGHS 177 skSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCP + DVWS G+ ++ ++ G++P ++ e++ ++ ++ y p+ kb|PLK1_Hs 178 FEVDVWSIGCIMYTLLV-GKPP-FETSCLKETYLRIKKNEYSIPKHI--N 223 delYdlMlqCWaedPedRPtFsel.veeL<-* + +l+++ + dP RPt el e+ kb|PLK1_Hs 224 PVAASLIQKMLQTDPTARPTINELlNDEF 252 Pkinase: domain 1 of 1, from 1 to 253: score 303.8, E = 7.3e-92 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y++++ lG+G+f+++++ + +t +++A Ki++k+ + ++++ kb|PLK1_Hs 1 YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMS 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse Ei+i+++L H ++v ++++fed+d + +VlE+c+ +l+L+ kb|PLK1_Hs 48 M-EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRR-SLLELH----- 90 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv +r+++l +e ea+ +++Qi+ g +YLH+n++iHRDLK+ N++l+++ + kb|PLK1_Hs 91 -KRRKAL--TEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLE 137 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD v Ki+DFGlA k+ + +++ +t++GTp+Y+APEvl +g++ +vD kb|PLK1_Hs 138 V----KIGDFGLATKV-EyDGErKKTLCGTPNYIAPEVLS-KKGHSFEVD 181 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi vWS+G+i+y ll GkpPF + + ++ + +i++ +e+++p+ ++ kb|PLK1_Hs 182 VWSIGCIMYTLLVGKPPFETS-----CLKETYLRIKK--NEYSIPKHIN- 223 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* + a +Li k+L+ DP+ R+t+ e+l++++f kb|PLK1_Hs 224 ------------PVAASLIQKMLQTDPTARPTINELLNDEFF 253 // Query sequence: kb|PKR_Hsap|Other/PEK/PKR|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 209.8 1.4e-63 1 Pkinase_Tyr Protein tyrosine kinase 52.9 2.7e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/1 1 270 [] 1 287 [] 209.8 1.4e-63 Pkinase_Tyr 1/1 1 270 [] 1 272 [] 52.9 2.7e-19 Alignments of top-scoring domains: Pkinase: domain 1 of 1, from 1 to 270: score 209.8, E = 1.4e-63 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ++ +e +GsG+fG+V+kakh+ +gk++++K++k+ +ek + kb|PKR_Hsa 1 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAER------ 41 lsEiqilkrLsHpNIvrlidvfed.......................... E++ l++L+H NIv + +++ d+ + ++++++++ ++++ ++++++++ kb|PKR_Hsa 42 --EVKALAKLDHVNIVHYNGCW-Dgfdydpetsddslessdydpenskns 88 ...kdhly.lVlEycegGLrvldLfdylsetrrkgpllfsedeakkialQ +++k+++ + +E+c++G L ++ rr+ +l + a + Q kb|PKR_Hsa 89 srsKTKCLfIQMEFCDKG----TLEQWIE-KRRGEKL--DKVLALELFEQ 131 ilrgleYLHsngiiHRDLKPeNILldnngvvdaflKiaDFGlAkklst.s i +g++Y+Hs++ iHRDLKP+NI+l+++ +v Ki+DFGl +++ kb|PKR_Hsa 132 ITKGVDYIHSKKLIHRDLKPSNIFLVDTKQV----KIGDFGLVTS--LkN 175 ss.lttfvGTpwYmAPEvllggngygtkvDvWSlGvilyelltGk.pPFs +++ t GT++Ym+PE + +++yg++vD ++lG+il+ell ++ F kb|PKR_Hsa 176 DGkRTRSKGTLRYMSPEQIS-SQDYGKEVDLYALGLILAELLHVCdTAFE 224 gevqdsldqlqlirkilgpplefdspewdsisrsefrrlpnlseeakdLi + +++ +l+ + +d++ + + k L+ kb|PKR_Hsa 225 TS---------KFFTDLRDGIISDIFDKKE----------------KTLL 249 kkcLnkDPskRltaeeilqHPwf<-* k+L k+P++R++ eil + kb|PKR_Hsa 250 QKLLSKKPEDRPNTSEILRT--L 270 Pkinase_Tyr: domain 1 of 1, from 1 to 270: score 52.9, E = 2.7e-19 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie +k ++ +G+G FG V+k++ + +++t + +K +k + e kb|PKR_Hsa 1 FKEIELIGSGGFGQVFKAKHR-IDGKTYV---IKRVKY-NNEKAE-- 40 redFlrEAsiMkklGdHpNiVrLlGvct...................... rE++ + kl dH NiV + G+ + + ++++++++ ++++ ++++ kb|PKR_Hsa 41 -----REVKALAKL-DHVNIVHYNGCWDgfdydpetsddslessdydpen 84 .......kegePggpglyiVtEymegGdLldfLrkhregrpLtlkdLlsf +++++++k + l+i +E++ +G L k+ g++L+ l+ kb|PKR_Hsa 85 sknssrsK-TKC----LFIQMEFCDKGTLEQWIEKR-RGEKLDKVLALEL 128 alQiAkGMeYLesknfvHRDLAARNcLVsenlvVKIsDFGLaRdiysddy Qi kG +Y +sk+++HRDL N+ + ++++VKI+DFGL + + d kb|PKR_Hsa 129 FEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL-KND- 176 YvrkrgggklPvkWmAPEslkygkFtskSDVWSFGVlLWEiftlGeqPFY kr+ +k + m+PE ++ + + D ++ G L E++ +++ F kb|PKR_Hsa 177 --GKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAF- 223 pgmsneevlellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFsel + ++ l +dG ++ + ++ +l+++ ++PedRP se+ kb|PKR_Hsa 224 ---ETSKFFTDL-RDGIISDIFD---KKEKTLLQKLLSKKPEDRPNTSEI 266 veeL<-* ++ L kb|PKR_Hsa 267 LRTL 270 // Query sequence: kb|PKN3_Hsap|AGC/PKN|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 279.2 1.8e-84 1 Pkinase_Tyr Protein tyrosine kinase 32.9 4.4e-18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 254 [. 1 272 [] 32.9 4.4e-18 Pkinase 1/1 1 260 [] 1 287 [] 279.2 1.8e-84 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 254: score 32.9, E = 4.4e-18 *->lklgkkLGeGaFGeVyk......GtlkgsgdgteikVAVKtL.ke.i ++ + +LG+G+FG+V + + +++G+++ A+K L+k+++ kb|PKN3_Hs 1 FRCLAVLGRGHFGKVLLvqfkgtGKYY----------AIKALkKQeV 37 gaseeeieredFlrEAsiMkklG..dHpNiVrLlGvctkegePggpglyi + +e +e++ E +i+ G + Hp +++Ll++ + + kb|PKN3_Hs 38 LSRDE---IESLYCEKRILEAVGctGHPFLLSLLACFQT-SSH----ACF 79 VtEymegGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHR VtE+++gGdL ++ h ++ ++ ++ + + + G+++L++k+++ R kb|PKN3_Hs 80 VTEFVPGGDL--MMQIH--EDVFPEPQARFYVACVVLGLQFLHEKKIIYR 125 DLAARNcLVsenlvVKIsDFGLaRdiysddyY.vrkrgggk.lPvkWmAP DL N L++ +++ KI+DFGL++ ++ r+++ +AP kb|PKN3_Hs 126 DLKLDNLLLDAQGFLKIADFGLCKEG-----IgFGDRTSTFcGTPEFLAP 170 EslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGy E+l +t + D W GVlL+E++ Ge P +pg + eev++ ++ kb|PKN3_Hs 171 EVLTQEAYTRAVDWWGLGVLLYEMLV-GECP-FPGDTEEEVFDCIV---- 214 RLprPenCPdelY....dlMlqCWaedPedRPtFsel.veeL<-* +++P P l ++ + +++ ++ Pe+R e + ee+ kb|PKN3_Hs 215 NMDAPY--PGFLSvqglEFIQKLLQKCPEKRLGAGEQdAEEI 254 Pkinase: domain 1 of 1, from 1 to 260: score 279.2, E = 1.8e-84 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++l +lG+G fG+V + + kgtgk +A+K +kk++ s +++ + kb|PKN3_Hs 1 FRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLY 47 lsEiqilkrLs...HpNIvrlidvfedkdhlylVlEycegGLrvldLfdy E +il ++ ++Hp+ + l+ +f++++h ++V+E+++gG dL+ kb|PKN3_Hs 48 C-EKRILEAVGctgHPFLLSLLACFQTSSHACFVTEFVPGG----DLMMQ 92 lsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldn ++ + ++ +e +a++++ ++ gl++LH+++ii+RDLK++N+Lld kb|PKN3_Hs 93 IH----EDVF--PEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDA 136 ngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygt +g + KiaDFGl+k ++ + +++tf+GTp+++APEvl ++ y++ kb|PKN3_Hs 137 QGFL----KIADFGLCKEG-IgFGDrTSTFCGTPEFLAPEVLT-QEAYTR 180 kvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspew +vD+W+lGv+lye+l G+ PF+g+ ++ ++++ i + +++ + + kb|PKN3_Hs 181 AVDWWGLGVLLYEMLVGECPFPGD-----TEEEVFDCIVNMDAPYPGFLS 225 dsisrsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf ++++i k+L+k+P+kRl+ ++++aeei+ P+f kb|PKN3_Hs 226 ---------------VQGLEFIQKLLQKCPEKRLGageqdAEEIKVQPFF 260 <-* kb|PKN3_Hs - - // Query sequence: kb|PKN2_Hsap|AGC/PKN|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 297.8 4.6e-90 1 Pkinase_Tyr Protein tyrosine kinase 106.3 2e-32 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 254 [. 1 272 [] 106.3 2e-32 Pkinase 1/1 1 260 [] 1 287 [] 297.8 4.6e-90 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 254: score 106.3, E = 2e-32 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.ke.igaseee ++ +LG+G+FG+V ++++k +t+ A+K L+k +i a +e kb|PKN2_Hs 1 FRCCAVLGRGHFGKVLLAEYK----NTNEMFAIKALkKGdIVARDE- 42 ieredFlrEAsiMkk...lGdHpNiVrLlGvctkegePggpglyiVtEym ++++ E +i + ++ +Hp +V+L ++ +e ++ V+Ey+ kb|PKN2_Hs 43 --VDSLMCEKRIFETvnsV-RHPFLVNLFACFQT-KEH----VCFVMEYA 84 egGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAAR +gGdL ++ h + ++ ++ + +a+ + G++YL+++++v RDL kb|PKN2_Hs 85 AGGDL--MMHIH--TDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLD 130 NcLVsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkyg N L++ +++VKI+DFGL++ + Y r+++ +APE+l + kb|PKN2_Hs 131 NLLLDTEGFVKIADFGLCKEGMG---Y-GDRTSTFcGTPEFLAPEVLTET 176 kFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPe +t + D W GVl++E++ Ge+P +pg + eev++ ++ d R pr kb|PKN2_Hs 177 SYTRAVDWWGLGVLIYEMLV-GESP-FPGDDEEEVFDSIVNDEVRYPRFL 224 nCPdelYdlMlqCWaedPedRPtFsel.veeL<-* + e ++M++ +++Pe+R se + e+ kb|PKN2_Hs 225 --STEAISIMRRLLRRNPERRLGASEKdAEDV 254 Pkinase: domain 1 of 1, from 1 to 260: score 297.8, E = 4.6e-90 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++ +lG+G fG+V +a k+t++++A+K +kk ++ + + kb|PKN2_Hs 1 FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLM 47 lsEiqilkrLs...HpNIvrlidvfedkdhlylVlEycegGLrvldLfdy E +i +++ +Hp+ v l+ +f++k h+++V+Ey+ gG dL+ + kb|PKN2_Hs 48 C-EKRIFETVNsvrHPFLVNLFACFQTKEHVCFVMEYAAGG----DLMMH 92 lsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldn ++ ++ se a ++a ++ gl+YLH+++i++RDLK++N+Lld kb|PKN2_Hs 93 IH----TDVF--SEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDT 136 ngvvdaflKiaDFGlAkklst.sss..lttfvGTpwYmAPEvllggngyg +g v KiaDFGl+k ++++++tf+GTp+++APEvl + y+ kb|PKN2_Hs 137 EGFV----KIADFGLCKE--GmGYGdrTSTFCGTPEFLAPEVLT-ETSYT 179 tkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspe ++vD+W+lGv++ye+l G+ PF+g+ d+ ++++ i +++++++ kb|PKN2_Hs 180 RAVDWWGLGVLIYEMLVGESPFPGD-----DEEEVFDSIVNDEVRYPRFL 224 wdsisrsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPw + ea+++++++L+++P++Rl+ ++++ae++++HP+ kb|PKN2_Hs 225 S---------------TEAISIMRRLLRRNPERRLGasekdAEDVKKHPF 259 f<-* f kb|PKN2_Hs 260 F 260 // Query sequence: kb|PKN1_Hsap|AGC/PKN|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 290.0 1e-87 1 Pkinase_Tyr Protein tyrosine kinase 89.8 1.9e-27 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 260 [] 1 272 [] 89.8 1.9e-27 Pkinase 1/1 1 260 [] 1 287 [] 290.0 1e-87 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 260: score 89.8, E = 1.9e-27 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.ke.igaseee +k++ +LG+G+FG+V + + + + A+K L+k +i a +e kb|PKN1_Hs 1 FKFLAVLGRGHFGKVLLSEFR----PSGELFAIKALkKGdIVARDE- 42 ieredFlrEAsiMkkl..GdHpNiVrLlGvctkegePggpglyiVtEyme e+++ E +i+ ++ Hp +V+L G+ e ++ V+Ey + kb|PKN1_Hs 43 --VESLMCEKRILAAVtsAGHPFLVNLFGCFQT-PEH----VCFVMEYSA 85 gGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARN gGdL L+ h + ++ ++ + +++ + G+++L+++++v RDL N kb|PKN1_Hs 86 GGDL--MLHIH--SDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDN 131 cLVsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygk L++ ++ VKI+DFGL++ + Y r+++ +APE+l + kb|PKN1_Hs 132 LLLDTEGYVKIADFGLCKEGMG---Y-GDRTSTFcGTPEFLAPEVLTDTS 177 FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPen +t + D W GVlL+E++ Ge+P +pg + eev++ ++ d R pr kb|PKN1_Hs 178 YTRAVDWWGLGVLLYEMLV-GESP-FPGDDEEEVFDSIVNDEVRYPRFL- 224 CPdelYdlMlqCWaedPedRP.....tFsel..veeL<-* ++e +M++ +++Pe+R +++++ ++++++ ++ kb|PKN1_Hs 225 -SAEAIGIMRRLLRRNPERRLgsserDAEDVkkQPFF 260 Pkinase: domain 1 of 1, from 1 to 260: score 290.0, E = 1e-87 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +++l +lG+G fG+V + + +g+++A+K +kk ++ + + + kb|PKN1_Hs 1 FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLM 47 lsEiqilkrL.s..HpNIvrlidvfedkdhlylVlEycegGLrvldLfdy E +il+ ++s +Hp+ v l+++f+++ h+++V+Ey gG dL+ + kb|PKN1_Hs 48 C-EKRILAAVtSagHPFLVNLFGCFQTPEHVCFVMEYSAGG----DLMLH 92 lsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldn ++ + ++ se a+++ ++ gl++LH+++i++RDLK++N+Lld kb|PKN1_Hs 93 IH----SDVF--SEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDT 136 ngvvdaflKiaDFGlAkklst.sss..lttfvGTpwYmAPEvllggngyg +g+v KiaDFGl+k ++++++tf+GTp+++APEvl ++ y+ kb|PKN1_Hs 137 EGYV----KIADFGLCKE--GmGYGdrTSTFCGTPEFLAPEVLT-DTSYT 179 tkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspe ++vD+W+lGv+lye+l G+ PF+g+ d+ ++++ i +++++++ kb|PKN1_Hs 180 RAVDWWGLGVLLYEMLVGESPFPGD-----DEEEVFDSIVNDEVRYPRFL 224 wdsisrsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPw + ea+ +++++L+++P++Rl++++++ae++++ P+ kb|PKN1_Hs 225 S---------------AEAIGIMRRLLRRNPERRLGsserdAEDVKKQPF 259 f<-* f kb|PKN1_Hs 260 F 260 // Query sequence: kb|PKG2_Hsap|AGC/PKG|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 311.3 4e-94 1 Pkinase_Tyr Protein tyrosine kinase 13.5 6.8e-17 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 250 [. 1 272 [] 13.5 6.8e-17 Pkinase 1/1 1 259 [] 1 287 [] 311.3 4e-94 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 250: score 13.5, E = 6.8e-17 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.ke.igaseee l+++ +LG G FG+V + + k ++++ A K+++k++i + + kb|PKG2_Hs 1 LEIIATLGVGGFGRVELVKVK----NENVAFAMKCIrKKhIVDTKQ- 42 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG +e +E +i+ +l p iV+L+ + + +y+ +E + gG kb|PKG2_Hs 43 --QEHVYSEKRILEEL-CSPFIVKLYRTFKD-NKY----VYMLLEACLGG 84 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL L + Lr+ +++++ ++ + + ++ +YL++ +++ RDL N kb|PKG2_Hs 85 ELWSILRD---RGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLI 131 VsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWm....APEslky ++ ++ K DFG a+ i ++g k++ +++ APE++ + kb|PKG2_Hs 132 LDAEGYLKLVDFGFAKKI---------GSGQKtWTFCGTpeyvAPEVILN 172 gkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprP + D WS G+l +E++t G +P + g++ +++l+ + + ++ P kb|PKG2_Hs 173 KGHDFSVDFWSLGILVYELLT-GNPP-FSGVDQMMTYNLILKGIEKMDFP 220 enCPdelYdlMlqCWaedPedRPtFselveeL<-* ++ + dl+++ + +P +R l + + kb|PKG2_Hs 221 RKITRRPEDLIRRLCRQNPTER--LGNLKNGI 250 Pkinase: domain 1 of 1, from 1 to 259: score 311.3, E = 4e-94 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +e++ +lG G+fG+V + k k+++ +A+K+i+k+++ + k+++++ kb|PKG2_Hs 1 LEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVY 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse + E +il +L++p+Iv+l+++f d++++y+ lE c gG +L+++l+ kb|PKG2_Hs 48 S-EKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGG----ELWSILR- 91 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++g++ +e + k+++ + ++ +YLH+ gii+RDLKPeN+ ld +g+ kb|PKG2_Hs 92 --DRGSF--DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGY 137 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD + K+ DFG+Akk ++s+++++tf+GTp+Y+APEv+l ++g++ +vD kb|PKG2_Hs 138 L----KLVDFGFAKK--IgSGQkTWTFCGTPEYVAPEVIL-NKGHDFSVD 180 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi WSlG+++yelltG+pPFsg dq+ + +il+++ + d+p +++ kb|PKG2_Hs 181 FWSLGILVYELLTGNPPFSGV-----DQMMTYNLILKGIEKMDFPRKIT- 224 srsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf<-* + dLi+++++++P++Rl++ ++++ +i++H w+ kb|PKG2_Hs 225 ------------RRPEDLIRRLCRQNPTERLGnlkngINDIKKHRWL 259 // Query sequence: kb|PKG1_Hsap|AGC/PKG|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 328.9 1.9e-99 1 Pkinase_Tyr Protein tyrosine kinase 21.2 2.3e-17 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 247 [. 1 272 [] 21.2 2.3e-17 Pkinase 1/1 1 260 [] 1 287 [] 328.9 1.9e-99 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 247: score 21.2, E = 2.3e-17 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.ke.igaseee + ++ +LG G FG+V + lk +++ + A K+L+k +i + + kb|PKG1_Hs 1 FNIIDTLGVGGFGRVELVQLK---SEESKTFAMKILkKRhIVDTRQ- 43 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG +e +E +iM + + iVrL+ + ++ ly+ +E + gG kb|PKG1_Hs 44 --QEHIRSEKQIMQGA-HSDFIVRLYRTFKD-SKY----LYMLMEACLGG 85 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL L + Lr+ ++++ ++ + + + ++ +YL+sk+++ RDL N kb|PKG1_Hs 86 ELWTILRD---RGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLI 132 VsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWm....APEslky +++ + +K DFG a+ i + g k++ +++ APE + + kb|PKG1_Hs 133 LDHRGYAKLVDFGFAKKI---------GFGKKtWTFCGTpeyvAPEIILN 173 gkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprP + + D WS G+l++E++t G +P + g ++ +++ + + + P kb|PKG1_Hs 174 KGHDISADYWSLGILMYELLT-GSPP-FSGPDPMKTYNIILRGIDMIEFP 221 enCPdelYdlMlqCWaedPedRPtFselveeL<-* ++ + +l+++ + +P++R + L kb|PKG1_Hs 222 KKIAKNAANLIKKLCRDNPSER------LGNL 247 Pkinase: domain 1 of 1, from 1 to 260: score 328.9, E = 1.9e-99 *->yelleklGsGsfGtVykakhkgtgk.iVAvKiikkrkekskkdktar + ++ +lG G+fG+V + + k+++ +++A+Ki+kkr++ + +++++ kb|PKG1_Hs 1 FNIIDTLGVGGFGRVELVQLKSEESkTFAMKILKKRHIVDTRQQEHI 47 rlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls r+ E qi++ ++++Ivrl+++f d+++ly+ +E c gG +L+++l+ kb|PKG1_Hs 48 RS-EKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGG----ELWTILR 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng ++g++ ++ + +++ ++++ +YLHs+gii+RDLKPeN+ ld++g kb|PKG1_Hs 93 ---DRGSF--EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRG 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv + K+ DFG+Akk ++ + +++tf+GTp+Y+APE++l ++g++ ++ kb|PKG1_Hs 138 YA----KLVDFGFAKK--IgFGKkTWTFCGTPEYVAPEIIL-NKGHDISA 180 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D WSlG+++yelltG pPFsg d+++ + il+++ ++++p+++ kb|PKG1_Hs 181 DYWSLGILMYELLTGSPPFSGP-----DPMKTYNIILRGIDMIEFPKKIA 225 isrsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf<- ++a Likk+++ +Ps+Rl++ +++ ++i +H+wf kb|PKG1_Hs 226 -------------KNAANLIKKLCRDNPSERLGnlkngVKDIQKHKWF 260 * kb|PKG1_Hs - - // Query sequence: kb|PKD3_Hsap|CAMK/PKD|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 258.1 4.1e-78 1 Pkinase_Tyr Protein tyrosine kinase -0.7 5e-16 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 252 [. 1 272 [] -0.7 5e-16 Pkinase 1/1 1 257 [] 1 287 [] 258.1 4.1e-78 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 252: score -0.7, E = 5e-16 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei + +++LG+G+FG Vy G+ + +t+ +VA+K+++k ++ kb|PKD3_Hs 1 IFADEVLGSGQFGIVYGGKHR----KTGRDVAIKVIdKM-RFPTKQ- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd + +E++i+ +l +Hp iV+L +++ +++V+E +g d kb|PKD3_Hs 42 -ESQLRNEVAILQNL-HHPGIVNLECMFETPER-----VFVVMEKLHG-D 83 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV +l+ + e+ +L+ + +Qi ++ L+ kn+vH DL N+L+ kb|PKD3_Hs 84 MLEMILSS-EKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLL 132 se...nlvVKIsDFGLaRdiysddyY.vrkrgggklPvkWmAPEslkygk ++ ++ +VK +DFG aR i +++ ++++++ +APE+l+ + kb|PKD3_Hs 133 ASaepFPQVKLCDFGFARIIGEKSFRrSVVGT-----PAYLAPEVLRSKG 177 FtskSDVWSFGVlLWEiftlGeqPFYpgm.sneevlellyedGyRLprPe ++ D WS GV ++ ++ G P + + ++ ++ ++ y + + kb|PKD3_Hs 178 YNRSLDMWSVGVIIYVSLS-GTFP-FNEDeDINDQIQNA-AFMYPPNPWR 224 nCPdelYdlMlqCWaedPedRPtFselveeL<-* + e dl+ + + +R + L kb|PKD3_Hs 225 EISGEAIDLINNLLQVKMRKR---YSVDKSL 252 Pkinase: domain 1 of 1, from 1 to 257: score 258.1, E = 4.1e-78 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + e+lGsG fG Vy +kh++tg+ VA+K+i+k + k++ ++r+ kb|PKD3_Hs 1 IFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRN 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E++il++L+Hp Iv l ++fe++ ++ +V+E + g d +++ kb|PKD3_Hs 48 --EVAILQNLHHPGIVNLECMFETPERVFVVMEKLHG-----DMLEMIL- 89 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld.nng +++k +l +e+ k++++Qil +l LH ++i+H+DLKPeN+Ll + ++ kb|PKD3_Hs 90 SSEKSRL--PERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLAsAEP 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv + +K++DFG+A+ ++ +s ++vGTp Y+APEvl+ ++gy ++ kb|PKD3_Hs 138 FP--QVKLCDFGFARI--IgEKSfRRSVVGTPAYLAPEVLR-SKGYNRSL 182 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+WS+Gvi+y l+G +PF ++ + ++i + ++++ w++ kb|PKD3_Hs 183 DMWSVGVIIYVSLSGTFPFNED-------EDINDQIQNAAFMYPPNPWRE 225 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* is ea+dLi+++L++++ kR++ + l HPw+ kb|PKD3_Hs 226 IS-----------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL 257 // Query sequence: kb|PKD1_Hsap|CAMK/PKD|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 275.9 1.8e-83 1 Pkinase_Tyr Protein tyrosine kinase 3.0 3e-16 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 237 [. 1 272 [] 3.0 3e-16 Pkinase 1/1 1 257 [] 1 287 [] 275.9 1.8e-83 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 237: score 3.0, E = 3e-16 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei + +++LG+G+FG Vy G+ + +t+ +VA+K+++k ++ kb|PKD1_Hs 1 IFPDEVLGSGQFGIVYGGKHR----KTGRDVAIKIIdKL-RFPTKQ- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd + +E++i+ +l +Hp +V+L +++ +++V+E +g d kb|PKD1_Hs 42 -ESQLRNEVAILQNL-HHPGVVNLECMFETPER-----VFVVMEKLHG-D 83 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV +l+ + e+++L+ + +Qi ++ +L+ kn+vH DL N+L+ kb|PKD1_Hs 84 MLEMILSS-EKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLL 132 se...nlvVKIsDFGLaRdiysddyY.vrkrgggklPvkWmAPEslkygk ++ ++ +VK +DFG aR i +++ ++++++ +APE+l+++ kb|PKD1_Hs 133 ASadpFPQVKLCDFGFARIIGEKSFRrSVVGT-----PAYLAPEVLRNKG 177 FtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPen ++ D WS GV ++ ++ G PF +e++ +++ ++ + +P kb|PKD1_Hs 178 YNRSLDMWSVGVIIYVSLS-GTFPF---NEDEDIHDQI-QNAAFMYPPN- 221 CPdelYdlMlqCWaedPedRPtFselveeL<-* P W+e + +l++ L kb|PKD1_Hs 222 -P----------WKEISHE---AIDLINNL 237 Pkinase: domain 1 of 1, from 1 to 257: score 275.9, E = 1.8e-83 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + e+lGsG fG Vy +kh++tg+ VA+Kii+k + k++ ++r+ kb|PKD1_Hs 1 IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRN 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E++il++L+Hp +v l ++fe++ ++ +V+E + g d +++ kb|PKD1_Hs 48 --EVAILQNLHHPGVVNLECMFETPERVFVVMEKLHG-----DMLEMIL- 89 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld.nng +++kg+l +e+ k+ ++Qil +l +LH ++i+H+DLKPeN+Ll + ++ kb|PKD1_Hs 90 SSEKGRL--PEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLAsADP 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv + +K++DFG+A+ ++ +s ++vGTp Y+APEvl+ ++gy ++ kb|PKD1_Hs 138 FP--QVKLCDFGFARI--IgEKSfRRSVVGTPAYLAPEVLR-NKGYNRSL 182 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+WS+Gvi+y l+G +PF ++ ++++i + ++++ w + kb|PKD1_Hs 183 DMWSVGVIIYVSLSGTFPFNED-------EDIHDQIQNAAFMYPPNPWKE 225 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* is ea+dLi+++L++++ kR++ + l HPw+ kb|PKD1_Hs 226 IS-----------HEAIDLINNLLQVKMRKRYSVDKTLSHPWL 257 // Query sequence: kb|PKD2_Hsap|CAMK/PKD|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 274.0 6.5e-83 1 Pkinase_Tyr Protein tyrosine kinase -2.9 6.8e-16 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 252 [. 1 272 [] -2.9 6.8e-16 Pkinase 1/1 1 257 [] 1 287 [] 274.0 6.5e-83 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 252: score -2.9, E = 6.8e-16 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei + +++LG+G+FG+Vy G+ + +t+ +VAVK+++k ++ kb|PKD2_Hs 1 IFPDEVLGSGQFGVVYGGKHR----KTGRDVAVKVIdKL-RFPTKQ- 41 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd + +E++i+ +l +Hp iV+L +++ +++V+E +g d kb|PKD2_Hs 42 -ESQLRNEVAILQSL-RHPGIVNLECMFETPEK-----VFVVMEKLHG-D 83 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV +l+ + e+++L+ +Qi ++ +L+ kn+vH DL N+L+ kb|PKD2_Hs 84 MLEMILSS-EKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLL 132 se...nlvVKIsDFGLaRdiysddyY.vrkrgggklPvkWmAPEslkygk ++ ++ +VK +DFG aR i +++ ++++++ +APE+l + kb|PKD2_Hs 133 ASadpFPQVKLCDFGFARIIGEKSFRrSVVGT-----PAYLAPEVLLNQG 177 FtskSDVWSFGVlLWEiftlGeqPFYpgm.sneevlellyedGyRLprPe ++ D WS GV ++ ++ G P + + ++ ++ ++ y + kb|PKD2_Hs 178 YNRSLDMWSVGVIMYVSLS-GTFP-FNEDeDINDQIQNA-AFMYPASPWS 224 nCPdelYdlMlqCWaedPedRPtFselveeL<-* + ++ dl+ + + +R + L kb|PKD2_Hs 225 HISAGAIDLINNLLQVKMRKR---YSVDKSL 252 Pkinase: domain 1 of 1, from 1 to 257: score 274.0, E = 6.5e-83 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + e+lGsG fG+Vy +kh++tg+ VAvK+i+k + k++ ++r+ kb|PKD2_Hs 1 IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRN 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E++il++L+Hp Iv l ++fe++ ++ +V+E + g d +++ kb|PKD2_Hs 48 --EVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG-----DMLEMIL- 89 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld.nng +++kg+l +e+ k+ ++Qil +l +LH ++i+H+DLKPeN+Ll + ++ kb|PKD2_Hs 90 SSEKGRL--PERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAsADP 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv + +K++DFG+A+ ++ +s ++vGTp Y+APEvll ++gy ++ kb|PKD2_Hs 138 FP--QVKLCDFGFARI--IgEKSfRRSVVGTPAYLAPEVLL-NQGYNRSL 182 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+WS+Gvi+y l+G +PF ++ + ++i + ++++ w+ kb|PKD2_Hs 183 DMWSVGVIMYVSLSGTFPFNED-------EDINDQIQNAAFMYPASPWSH 225 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* is a+dLi+++L++++ kR++ + l HPw+ kb|PKD2_Hs 226 IS-----------AGAIDLINNLLQVKMRKRYSVDKSLSHPWL 257 // Query sequence: kb|PKCz_Hsap|AGC/PKC/Iota|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 285.3 2.7e-86 1 Pkinase_Tyr Protein tyrosine kinase 45.1 8e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 267 [] 1 272 [] 45.1 8e-19 Pkinase 1/1 1 267 [] 1 287 [] 285.3 2.7e-86 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 267: score 45.1, E = 8e-19 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei + l++++G+G++ +V + +lk ++++ A K+++ke +++e kb|PKCz_Hs 1 FDLIRVIGRGSYAKVLLVRLK----KNDQIYAMKVVkKE-LVHDDE- 41 eredFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG d ++E + + ++p +V L+ + l++V Ey+ gG kb|PKCz_Hs 42 -DIDWVQtEKHVFEQASSNPFLVGLHSCFQT-TSR----LFLVIEYVNGG 85 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL dL ++++ +r+L+ ++ +a++i+ ++++L++++++ RDL N+L kb|PKCz_Hs 86 DLMFHMQR---QRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVL 132 VsenlvVKIsDFGLaRdiysddyY.vrkrgggk.lPvkWmAPEslkygkF ++ ++++K +D G+++ + ++++ APE l+ ++ kb|PKCz_Hs 133 LDADGHIKLTDYGMCKEG-----LgPGDTTSTFcGTPNYIAPEILRGEEY 177 tskSDVWSFGVlLWEiftlGeqPFYpgm.snee......vlellyedGyR D W+ GVl++E++ G++P + +++n + ++++ +++ + e+ R kb|PKCz_Hs 178 GFSVDWWALGVLMFEMMA-GRSP-FDIItDNPDmntedyLFQVILEKPIR 225 LprPenCPdelYdlMlqCWaedPedRP......tFsel..veeL<-* pr + + ++++ ++dP++R + ++++ Fs+++++ ++ kb|PKCz_Hs 226 IPRFL--SVKASHVLKGFLNKDPKERLgcrpqtGFSDIksHAFF 267 Pkinase: domain 1 of 1, from 1 to 267: score 285.3, E = 2.7e-86 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + l++++G+Gs+++V + + k++ +i+A+K++kk+ ++++d+ + kb|PKCz_Hs 1 FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQ 47 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls + E ++ +s p+ v l+ +f++ ++l lV Ey++gG dL+ +++ kb|PKCz_Hs 48 T-EKHVFEQAsSNPFLVGLHSCFQTTSRLFLVIEYVNGG----DLMFHMQ 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng r+++l +e++a+++a +i+ +l++LH++gii+RDLK++N+Lld +g kb|PKCz_Hs 93 ---RQRKL--PEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADG 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv ++ K++D G +k ++++ +++tf+GTp+Y+APE+l+ g++yg +v kb|PKCz_Hs 138 HI----KLTDYGMCKEG-LgPGDtTSTFCGTPNYIAPEILR-GEEYGFSV 181 DvWSlGvilyelltGkpPFsgev.q.ds.ldqlqlirkilgpplefdspe D+W+lGv+++e++ G+ PF+ ++++++ +++++l++ il++p++++++ kb|PKCz_Hs 182 DWWALGVLMFEMMAGRSPFD-IItDnPDmNTEDYLFQVILEKPIRIPRFL 230 wdsisrsefrrlpnlseeakdLikkcLnkDPskRlt......aeeilqHP + a +++k+ LnkDP++Rl+ ++++++ +i+ H kb|PKCz_Hs 231 S---------------VKASHVLKGFLNKDPKERLGcrpqtgFSDIKSHA 265 wf<-* +f kb|PKCz_Hs 266 FF 267 // Query sequence: kb|PKCt_Hsap|AGC/PKC/Delta|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 293.2 1.1e-88 1 Pkinase_Tyr Protein tyrosine kinase 57.2 1.4e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 249 [. 1 272 [] 57.2 1.4e-19 Pkinase 1/1 1 255 [] 1 287 [] 293.2 1.1e-88 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 249: score 57.2, E = 1.4e-19 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLke.igaseeei ++l k+LG+G+FG+V++++ k +t++ A+K Lk+++ ++++ kb|PKCt_Hs 1 FILHKMLGKGSFGKVFLAEFK----KTNQFFAIKALKKdVVLMDDD- 42 eredFlrEAsiMkklGdHpNiVrLlGvct.kegePggpglyiVtEymegG e + E ++++ Hp + + +ct +++e l+ V+Ey gG kb|PKCt_Hs 43 -VECTMVEKRVLSLAWEHPFLTHM--FCTfQTKEN----LFFVMEYLNGG 85 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL dL + ++ ++++l++ +a++i G+++L+sk++v RDL N+L kb|PKCt_Hs 86 DLMYHIQSC---HKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNIL 132 VsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkFt +++++++KI+DFG+++ + d +++++ APE l k++ kb|PKCt_Hs 133 LDKDGHIKIADFGMCKENMLGD----AKTNTFcGTPDYIAPEILLGQKYN 178 skSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCP + D WSFGVlL+E++ G++P + g + ee+++ + +d+ pr kb|PKCt_Hs 179 HSVDWWSFGVLLYEMLI-GQSP-FHGQDEEELFHSIRMDNPFYPRWL--E 224 delYdlMlqCWaedPedRPtFselveeL<-* +e dl+ + ++Pe+R ++ ++ kb|PKCt_Hs 225 KEAKDLLVKLFVREPEKRLG---VRGDI 249 Pkinase: domain 1 of 1, from 1 to 255: score 293.2, E = 1.1e-88 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + l++ lG+GsfG+V++a k+t++ +A+K +kk+ ++ d + + kb|PKCt_Hs 1 FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTM 47 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls E ++l Hp+ ++++f++k +l +V+Ey++gG dL+ +++ kb|PKCt_Hs 48 V-EKRVLSLAwEHPFLTHMFCTFQTKENLFFVMEYLNGG----DLMYHIQ 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng + ++ + a ++a +i+ gl++LHs+gi++RDLK++NILld++g kb|PKCt_Hs 93 ---SCHKF--DLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDG 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv ++ KiaDFG +k + +++tf+GTp+Y+APE+ll g++y ++v kb|PKCt_Hs 138 HI----KIADFGMCKEN-MlGDAkTNTFCGTPDYIAPEILL-GQKYNHSV 181 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+WS+Gv+lye+l G+ PF g+ d+ +l+ i++ + ++++ + kb|PKCt_Hs 182 DWWSFGVLLYEMLIGQSPFHGQ-----DEEELFHSIRMDNPFYPRWLE-- 224 isrsefrrlpnlseeakdLikkcLnkDPskRlt.aeeilqHPwf<-* +eakdL+ k++ + P+kRl+ +i qHP f kb|PKCt_Hs 225 -------------KEAKDLLVKLFVREPEKRLGvRGDIRQHPLF 255 // Query sequence: kb|PKCi_Hsap|AGC/PKC/Iota|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 304.0 6.3e-92 1 Pkinase_Tyr Protein tyrosine kinase 50.4 3.8e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 269 [] 1 272 [] 50.4 3.8e-19 Pkinase 1/1 1 269 [] 1 287 [] 304.0 6.3e-92 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 269: score 50.4, E = 3.8e-19 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei + l++++G+G++ +V + +lk +t+ A K+++ke ++e kb|PKCi_Hs 1 FDLLRVIGRGSYAKVLLVRLK----KTDRIYAMKVVkKE-LVNDDE- 41 eredFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG d ++E + + +Hp +V L+ + + l+ V Ey+ gG kb|PKCi_Hs 42 -DIDWVQtEKHVFEQASNHPFLVGLHSCFQT-ESR----LFFVIEYVNGG 85 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL dL ++++ +r+L+ ++ ++++i+ +++YL++++++ RDL N+L kb|PKCi_Hs 86 DLMFHMQR---QRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVL 132 VsenlvVKIsDFGLaRdiysddyYvrkrgggklPv....kWmAPEslkyg +++++++K +D G+++ g++ +++ APE l+ kb|PKCi_Hs 133 LDSEGHIKLTDYGMCKEG-------LRPGDTTSTFcgtpNYIAPEILRGE 175 kFtskSDVWSFGVlLWEiftlGeqPFYpgmsnee.........vlellye + D W+ GVl++E++ G++P + + ++++++++++ +++ + e kb|PKCi_Hs 176 DYGFSVDWWALGVLMFEMMA-GRSP-FDIVGSSDnpdqntedyLFQVILE 223 dGyRLprPenCPdelYdlMlqCWaedPedRP......tFsel..veeL<- + R pr + + +++++ ++dP++R + ++++ F++++++ ++ kb|PKCi_Hs 224 KQIRIPRSL--SVKAASVLKSFLNKDPKERLgchpqtGFADIqgHPFF 269 * kb|PKCi_Hs - - Pkinase: domain 1 of 1, from 1 to 269: score 304.0, E = 6.3e-92 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + ll+++G+Gs+++V + + k+t +i+A+K++kk+ ++++d+ + kb|PKCi_Hs 1 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ 47 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls + E ++ ++Hp+ v l+ +f+++++l +V Ey++gG dL+ +++ kb|PKCi_Hs 48 T-EKHVFEQAsNHPFLVGLHSCFQTESRLFFVIEYVNGG----DLMFHMQ 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng r+++l +e++a+++ +i +l+YLH++gii+RDLK++N+Lld++g kb|PKCi_Hs 93 ---RQRKL--PEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEG 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv ++ K++D G +k ++++ +++tf+GTp+Y+APE+l+ g++yg +v kb|PKCi_Hs 138 HI----KLTDYGMCKEG-LrPGDtTSTFCGTPNYIAPEILR-GEDYGFSV 181 DvWSlGvilyelltGkpPFsgev..q.ds.ldqlqlirkilgpplefdsp D+W+lGv+++e++ G+ PF+ +++++++++++++l++ il++++++++ kb|PKCi_Hs 182 DWWALGVLMFEMMAGRSPFDIVGssDnPDqNTEDYLFQVILEKQIRIPRS 231 ewdsisrsefrrlpnlseeakdLikkcLnkDPskRlt......aeeilqH + a +++k+ LnkDP++Rl+ ++++++++i H kb|PKCi_Hs 232 LS---------------VKAASVLKSFLNKDPKERLGchpqtgFADIQGH 266 Pwf<-* P+f kb|PKCi_Hs 267 PFF 269 // Query sequence: kb|PKCg_Hsap|AGC/PKC/Alpha|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 274.8 3.9e-83 1 Pkinase_Tyr Protein tyrosine kinase 13.4 6.9e-17 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 264 [] 1 272 [] 13.4 6.9e-17 Pkinase 1/1 1 264 [] 1 287 [] 274.8 3.9e-83 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 264: score 13.4, E = 6.9e-17 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLke.igaseeei ++++ +LG+G+FG+V++++ + g + A+K+Lk+++ +++ kb|PKCg_Hs 1 FSFLMVLGKGSFGKVMLAERR----GSDELYAIKILKKdVIVQDDD- 42 eredFlrEAsiMkklGdHp.....NiVrLlGvctkegePggpglyiVtEy + l E +++ G+ p+++++ + +L+ +++ ly V+Ey kb|PKCg_Hs 43 -VDCTLVEKRVLALGGRGPggrphFLTQLHSTFQTPDR-----LYFVMEY 86 megGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAA + gGdL + ++ ++++ ++ +a++iA G+ +L++++++ RDL kb|PKCg_Hs 87 VTGGDLMYHIQQ---LGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKL 133 RNcLVsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm....APEs N++++ ++++KI+DFG+++ + g + +++ APE kb|PKCg_Hs 134 DNVMLDAEGHIKITDFGMCKEN-------VFPGTTTRTFCGTpdyiAPEI 176 lkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRL ++y + D WSFGVlL+E++ G++P + g + ee+++ + e+ kb|PKCg_Hs 177 IAYQPYGKSVDWWSFGVLLYEMLA-GQPP-FDGEDEEELFQAIMEQTVTY 224 prPenCPdelYdlMlqCWaedPedR........PtFselveeL<-* p+ + e + + + P +R +++++++Pt ++ + ++ kb|PKCg_Hs 225 PKSL--SREAVAICKGFLTKHPGKRlgsgpdgePTIRA-HGFF 264 Pkinase: domain 1 of 1, from 1 to 264: score 274.8, E = 3.9e-83 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + +l +lG+GsfG+V +a ++g+ +++A+Ki+kk+ + + d ++ kb|PKCg_Hs 1 FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTL 47 lsEiqilkrL.sHp.....NIvrlidvfedkdhlylVlEycegGLrvldL E ++l+ ++ p++++++ +l+ +f+++d+ly+V+Ey+ gG dL kb|PKCg_Hs 48 V-EKRVLALGgRGPggrphFLTQLHSTFQTPDRLYFVMEYVTGG----DL 92 fdylsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNIL + +++ + g++ e +a ++a +i+ gl +LH++gii+RDLK++N++ kb|PKCg_Hs 93 MYHIQ---QLGKF--KEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVM 137 ldnngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggng ld +g++ Ki+DFG +k +++++ tf+GTp+Y+APE++ +++ kb|PKCg_Hs 138 LDAEGHI----KITDFGMCKEN-VfPGTtTRTFCGTPDYIAPEIIA-YQP 181 ygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefds yg++vD+WS+Gv+lye+l G+pPF+ge d+ +l++ i++ + ++ kb|PKCg_Hs 182 YGKSVDWWSFGVLLYEMLAGQPPFDGE-----DEEELFQAIMEQTVTYPK 226 pewdsisrsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqH + +ea ++k+ L+k P kRl++++++ + i H kb|PKCg_Hs 227 SLS---------------REAVAICKGFLTKHPGKRLGsgpdgEPTIRAH 261 Pwf<-* +f kb|PKCg_Hs 262 GFF 264 // Query sequence: kb|PKCh_Hsap|AGC/PKC/Eta|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 297.4 5.9e-90 1 Pkinase_Tyr Protein tyrosine kinase 54.3 2.2e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 255 [. 1 272 [] 54.3 2.2e-19 Pkinase 1/1 1 260 [] 1 287 [] 297.4 5.9e-90 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 255: score 54.3, E = 2.2e-19 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLke.igaseeei ++++++LG+G+FG+V++++ k +t+ AVK+Lk+++ +++ kb|PKCh_Hs 1 FEFIRVLGKGSFGKVMLARVK----ETGDLYAVKVLKKdVILQDDD- 42 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd e + E +i++ +Hp + +L + +++ l+ V+E++ gGd kb|PKCh_Hs 43 -VECTMTEKRILSLARNHPFLTQLFCCFQTPDR-----LFFVMEFVNGGD 86 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L + +k r+++ + +a++i +++ +L++k+++ RDL N+L+ kb|PKCh_Hs 87 LMFHIQK---SRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLL 133 senlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkFts ++++++K +DFG+++ + + + APE l+++ + kb|PKCh_Hs 134 DHEGHCKLADFGMCKEGICNGVT----TATFcGTPDYIAPEILQEMLYGP 179 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPd + D W+ GVlL+E++ G P ++ +++e + d p ++ kb|PKCh_Hs 180 AVDWWAMGVLLYEMLC-GHAP-FEAENEDDLFEAILNDEVVYPTWL--HE 225 elYdlMlqCWaedPedRPtFsel.....veeL<-* + ++++ + ++P +R l++++++ +L kb|PKCh_Hs 226 DATGILKSFMTKNPTMR--LGSLtqggeHAIL 255 Pkinase: domain 1 of 1, from 1 to 260: score 297.4, E = 5.9e-90 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +e++++lG+GsfG+V +a+ k tg+++AvK++kk+ + + d + + kb|PKCh_Hs 1 FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTM 47 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls + E +il ++Hp+ +l+++f+++d+l +V+E+++gG dL+ +++ kb|PKCh_Hs 48 T-EKRILSLArNHPFLTQLFCCFQTPDRLFFVMEFVNGG----DLMFHIQ 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng +++++ +e a+++a +i+++l +LH++gii+RDLK++N+Lld++g kb|PKCh_Hs 93 ---KSRRF--DEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEG 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv ++ K+aDFG +k + +++++ tf+GTp+Y+APE+l+ yg++v kb|PKCh_Hs 138 HC----KLADFGMCKEG-IcNGVtTATFCGTPDYIAPEILQ-EMLYGPAV 181 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+W++Gv+lye+l+G+ PF e +++ l++ il ++ ++ + kb|PKCh_Hs 182 DWWAMGVLLYEMLCGHAPFEAE-----NEDDLFEAILNDEVVYPTWLH-- 224 isrsefrrlpnlseeakdLikkcLnkDPskRlt......aeeilqHPwf< e+a ++k+ +k+P+ Rl++ ++++ + il HP+f kb|PKCh_Hs 225 -------------EDATGILKSFMTKNPTMRLGsltqggEHAILRHPFF 260 -* kb|PKCh_Hs - - // Query sequence: kb|PKCe_Hsap|AGC/PKC/Eta|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 300.6 6.3e-91 1 Pkinase_Tyr Protein tyrosine kinase 60.1 9.7e-20 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 246 [. 1 272 [] 60.1 9.7e-20 Pkinase 1/1 1 261 [] 1 287 [] 300.6 6.3e-91 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 246: score 60.1, E = 9.7e-20 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLke.igaseeei + ++k+LG+G+FG+V++++lk g++ AVK+Lk+++ +++ kb|PKCe_Hs 1 FNFIKVLGKGSFGKVMLAELK----GKDEVYAVKVLKKdVILQDDD- 42 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd + + E +i+ +Hp + +L+ +c ++++ l+ V+Ey+ gGd kb|PKCe_Hs 43 -VDCTMTEKRILALARKHPYLTQLY-CCFQTKDR----LFFVMEYVNGGD 86 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L ++ r+++ ++ +a+++ +++ +L++++ + RDL N+L+ kb|PKCe_Hs 87 LMFQIQR---SRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL 133 senlvVKIsDFGLaRdiysddyY.vrkrgggklPvkWmAPEslkygkFts + ++++K +DFG+++ + +++ g APE l++ ++ kb|PKCe_Hs 134 DAEGHCKLADFGMCKEGILNGVTtTTFCG----TPDYIAPEILQELEYGP 179 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLpr.PenCP D W+ GVl++E++ G++P ++ +++e + ++ L + + kb|PKCe_Hs 180 SVDWWALGVLMYEMMA-GQPP-FEADNEDDLFESI-LHDDVLYPvWL--S 224 delYdlMlqCWaedPedRPtFselveeL<-* +e ++++ + ++P +R + + kb|PKCe_Hs 225 KEAVSILKAFMTKNPHKR------LGCV 246 Pkinase: domain 1 of 1, from 1 to 261: score 300.6, E = 6.3e-91 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + ++++lG+GsfG+V +a kg +++AvK++kk+ + + d + kb|PKCe_Hs 1 FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTM 47 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls + E +il+ ++Hp+ +l+++f++kd+l +V+Ey++gG dL+ ++ kb|PKCe_Hs 48 T-EKRILALArKHPYLTQLYCCFQTKDRLFFVMEYVNGG----DLMFQIQ 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng r++++ +e +++a ++ ++l +LH++g+i+RDLK++NILld +g kb|PKCe_Hs 93 ---RSRKF--DEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEG 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv ++ K+aDFG +k + +++++ttf+GTp+Y+APE+l+ +yg++v kb|PKCe_Hs 138 HC----KLADFGMCKEG-IlNGVtTTTFCGTPDYIAPEILQ-ELEYGPSV 181 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+W+lGv++ye++ G+pPF + +++ l++ il+ ++ ++ + + kb|PKCe_Hs 182 DWWALGVLMYEMMAGQPPFEAD-----NEDDLFESILHDDVLYPVWLS-- 224 isrsefrrlpnlseeakdLikkcLnkDPskRlt.......aeeilqHPwf +ea +++k +k+P+kRl+ ++++ + i+qHP+f kb|PKCe_Hs 225 -------------KEAVSILKAFMTKNPHKRLGcvasqngEDAIKQHPFF 261 <-* kb|PKCe_Hs - - // Query sequence: kb|PKCd_Hsap|AGC/PKC/Delta|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 292.4 1.9e-88 1 Pkinase_Tyr Protein tyrosine kinase 56.3 1.7e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 255 [] 1 272 [] 56.3 1.7e-19 Pkinase 1/1 1 255 [] 1 287 [] 292.4 1.9e-88 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 255: score 56.3, E = 1.7e-19 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.ke.igaseee +++ k+LG+G+FG+V +G+lk g + A+K L+k+ + +++ kb|PKCd_Hs 1 FIFHKVLGKGSFGKVLLGELK----GRGEYFAIKALkKDvVLIDDD- 42 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG e + E ++++ +p + L+ ++ l+ V+E+ gG kb|PKCd_Hs 43 --VECTMVEKRVLTLAAENPFLTHLICTFQT-KDH----LFFVMEFLNGG 85 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL dL + ++ ++++ l + +a++i +G+++L+sk+++ RDL N+L kb|PKCd_Hs 86 DLMYHIQD---KGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 132 VsenlvVKIsDFGLaRdiysddyYvrkrgggklPvkWm....APEslkyg +++++++KI+DFG+++ ++++ +++ APE l+ kb|PKCd_Hs 133 LDRDGHIKIADFGMCKEN-------IFGESRASTFCGTpdyiAPEILQGL 175 kFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPe k+t D WSFGVlL+E++ G++P + g + e++e + d pr kb|PKCd_Hs 176 KYTFSVDWWSFGVLLYEMLI-GQSP-FHGDDEDELFESIRVDTPHYPRWI 223 nCPdelYdlMlqCWaedPedRPtFs...elveeL<-* ++e d++ + +++P +R +++ ++ ++ kb|PKCd_Hs 224 --TKESKDILEKLFEREPTKRLGVTgniKIHPFF 255 Pkinase: domain 1 of 1, from 1 to 255: score 292.4, E = 1.9e-88 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + ++++lG+GsfG+V ++ kg g+ +A+K +kk+ + d + + kb|PKCd_Hs 1 FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTM 47 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls E ++l p+ li++f++kdhl +V+E+++gG dL+ +++ kb|PKCd_Hs 48 V-EKRVLTLAaENPFLTHLICTFQTKDHLFFVMEFLNGG----DLMYHIQ 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng +kg++ + a ++a +i +gl++LHs+gii+RDLK++N+Lld++g kb|PKCd_Hs 93 ---DKGRF--ELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDG 137 vvdaflKiaDFGlAkklst.sss..lttfvGTpwYmAPEvllggngygtk ++ KiaDFG +k + ++++++tf+GTp+Y+APE+l+ g +y+ + kb|PKCd_Hs 138 HI----KIADFGMCKE--NiFGEsrASTFCGTPDYIAPEILQ-GLKYTFS 180 vDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewd vD+WS+Gv+lye+l G+ PF g+ d+++l++ i+ ++++++ + kb|PKCd_Hs 181 VDWWSFGVLLYEMLIGQSPFHGD-----DEDELFESIRVDTPHYPRWIT- 224 sisrsefrrlpnlseeakdLikkcLnkDPskRlt.aeeilqHPwf<-* +e kd+++k++++ P+kRl+ i+ HP+f kb|PKCd_Hs 225 --------------KESKDILEKLFEREPTKRLGvTGNIKIHPFF 255 // Query sequence: kb|PKCb_Hsap|AGC/PKC/Alpha|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 262.4 2e-79 1 Pkinase_Tyr Protein tyrosine kinase 25.8 1.2e-17 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 243 [. 1 272 [] 25.8 1.2e-17 Pkinase 1/1 1 259 [] 1 287 [] 262.4 2e-79 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 243: score 25.8, E = 1.2e-17 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + ++ +LG+G+FG+V++ + k gt+ AVK+Lk+ + ++ + kb|PKCb_Hs 1 FNFLMVLGKGSFGKVMLSERK----GTDELYAVKILKK-DVVIQD-D 41 .redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd + e + E +++ G+ p + +L+ + + ly V+Ey+ gGd kb|PKCb_Hs 42 dVECTMVEKRVLALPGKPPFLTQLHSCFQT-MDR----LYFVMEYVNGGD 86 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L + ++ ++++ ++ + +a++iA G+ +L sk+++ RDL N+++ kb|PKCb_Hs 87 LMYHIQQ---VGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVML 133 senlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkFts ++++++KI+DFG+++ d+ +++ APE ++y + kb|PKCb_Hs 134 DSEGHIKIADFGMCKENIWDGVT----TKTFcGTPDYIAPEIIAYQPYGK 179 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPd D W+FGVlL+E++ G+ P ++g + e+++ + e++ p+ + ++ kb|PKCb_Hs 180 SVDWWAFGVLLYEMLA-GQAP-FEGEDEDELFQSIMEHNVAYPKSM--SK 225 elYdlMlqCWaedPedRPtFselveeL<-* e + + + + P +R L kb|PKCb_Hs 226 EAVAICKGLMTKHPGKR---------L 243 Pkinase: domain 1 of 1, from 1 to 259: score 262.4, E = 2e-79 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + +l +lG+GsfG+V + +kgt +++AvKi+kk+ + d + + kb|PKCb_Hs 1 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM 47 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls E ++l+ ++ p+ +l+ +f++ d+ly+V+Ey++gG dL+ +++ kb|PKCb_Hs 48 V-EKRVLALPgKPPFLTQLHSCFQTMDRLYFVMEYVNGG----DLMYHIQ 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng + g++ e +a ++a +i+ gl +L s+gii+RDLK++N++ld++g kb|PKCb_Hs 93 ---QVGRF--KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv ++ KiaDFG +k + +++++tf+GTp+Y+APE++ +++yg++v kb|PKCb_Hs 138 HI----KIADFGMCKEN-IwDGVtTKTFCGTPDYIAPEIIA-YQPYGKSV 181 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+W++Gv+lye+l G+ PF ge d+++l++ i++ + ++ s kb|PKCb_Hs 182 DWWAFGVLLYEMLAGQAPFEGE-----DEDELFQSIME----HNVAYPKS 222 isrsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf<- +s +ea ++k++ +k P kRl+ ++++ ++i++H +f kb|PKCb_Hs 223 MS-----------KEAVAICKGLMTKHPGKRLGcgpegERDIKEHAFF 259 * kb|PKCb_Hs - - // Query sequence: kb|PKCa_Hsap|AGC/PKC/Alpha|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 291.3 4e-88 1 Pkinase_Tyr Protein tyrosine kinase 37.9 2.2e-18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 243 [. 1 272 [] 37.9 2.2e-18 Pkinase 1/1 1 259 [] 1 287 [] 291.3 4e-88 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 243: score 37.9, E = 2.2e-18 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + ++ +LG+G+FG+V+++ k gte A+K+Lk+ + ++ + kb|PKCa_Hs 1 FNFLMVLGKGSFGKVMLADRK----GTEELYAIKILKK-DVVIQD-D 41 .redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd + e + E +++ l + p + +L+ + + ly V+Ey+ gGd kb|PKCa_Hs 42 dVECTMVEKRVLALLDKPPFLTQLHSCFQT-VDR----LYFVMEYVNGGD 86 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L + ++ ++++ ++ + +a++i+ G+ +L+ ++++ RDL N+++ kb|PKCa_Hs 87 LMYHIQQ---VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVML 133 senlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkFts ++++++KI+DFG+++ ++ d+ + + APE ++y + kb|PKCa_Hs 134 DSEGHIKIADFGMCKEHMMDGVT----TRTFcGTPDYIAPEIIAYQPYGK 179 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPd D W++GVlL+E++ G++P + g + e+++ + e++ p+ ++ kb|PKCa_Hs 180 SVDWWAYGVLLYEMLA-GQPP-FDGEDEDELFQSIMEHNVSYPKSL--SK 225 elYdlMlqCWaedPedRPtFselveeL<-* e ++ + + + P++R L kb|PKCa_Hs 226 EAVSVCKGLMTKHPAKR---------L 243 Pkinase: domain 1 of 1, from 1 to 259: score 291.3, E = 4e-88 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + +l +lG+GsfG+V +a +kgt++++A+Ki+kk+ + d + + kb|PKCa_Hs 1 FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTM 47 lsEiqilkrL.sHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls E ++l+ L++ p+ +l+ +f++ d+ly+V+Ey++gG dL+ +++ kb|PKCa_Hs 48 V-EKRVLALLdKPPFLTQLHSCFQTVDRLYFVMEYVNGG----DLMYHIQ 92 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng + g++ e +a ++a +i gl +LH++gii+RDLK++N++ld++g kb|PKCa_Hs 93 ---QVGKF--KEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEG 137 vvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkv ++ KiaDFG +k + ++++ tf+GTp+Y+APE++ +++yg++v kb|PKCa_Hs 138 HI----KIADFGMCKEH-MmDGVtTRTFCGTPDYIAPEIIA-YQPYGKSV 181 DvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewds D+W++Gv+lye+l G+pPF+ge d+++l++ i++ ++++ + kb|PKCa_Hs 182 DWWAYGVLLYEMLAGQPPFDGE-----DEDELFQSIMEHNVSYPKSLS-- 224 isrsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf<- +ea +++k++ +k P+kRl+ ++++ +++ +H +f kb|PKCa_Hs 225 -------------KEAVSVCKGLMTKHPAKRLGcgpegERDVREHAFF 259 * kb|PKCa_Hs - - // Query sequence: kb|PKACg_Hsap|AGC/PKA|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 321.5 3.3e-97 1 Pkinase_Tyr Protein tyrosine kinase 58.6 1.2e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 246 [. 1 272 [] 58.6 1.2e-19 Pkinase 1/1 1 255 [] 1 287 [] 321.5 3.3e-97 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 246: score 58.6, E = 1.2e-19 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.ke.igaseee ++ +++LG G+FG+V++ + +t+ + A K+L+k+++ + + kb|PKACg_H 1 FERLRTLGMGSFGRVMLVRHQ----ETGGHYAMKILnKQkVVKMKQ- 42 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG e l+E +i+ + d p +V+L + k+ ly+V+Ey++gG kb|PKACg_H 43 --VEHILNEKRILQAI-DFPFLVKLQ-FSFKDNSY----LYLVMEYVPGG 84 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL + + L++ ++++ ++ + +a+Q+ + +YL+s ++HRDL N L kb|PKACg_H 85 EMFSRLQR---VGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLL 131 VsenlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkFt ++ ++ ++DFG a+ + + r+ + +APE + + ++ kb|PKACg_H 132 IDQQGYLQVTDFGFAKRV-------KGRTWTLcGTPEYLAPEIILSKGYN 174 skSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCP + D W+ GVl++E+ G +P ++ + +++e+++ +R P + + kb|PKACg_H 175 KAVDWWALGVLIYEMAV-GFPP-FYADQPIQIYEKIV--SGRVRFPSKLS 220 delYdlMlqCWaedPedRPtFselveeL<-* +l +l+++ + d +R F l++ kb|PKACg_H 221 SDLKHLLRSLLQVDLTKR--FGNLRNGV 246 Pkinase: domain 1 of 1, from 1 to 255: score 321.5, E = 3.3e-97 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +e+l++lG GsfG+V + +h+ tg +A+Ki++k+k + k+ ++++ kb|PKACg_H 1 FERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHIL 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse + E +il+ ++ p+ v+l +f d+++lylV+Ey++gG + f++l+ kb|PKACg_H 48 N-EKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGG----EMFSRLQ- 91 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv r g++ se +a+++a Q++ +++YLHs iHRDLKPeN+L+d++g+ kb|PKACg_H 92 --RVGRF--SEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY 137 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD + ++DFG+A + +++++t++GTp+Y+APE++l ++gy ++vD kb|PKACg_H 138 L----QVTDFGFA----KrVKGrTWTLCGTPEYLAPEIIL-SKGYNKAVD 178 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi +W+lGv++ye++ G pPF+ + ++q+++ki +++++f+s + kb|PKACg_H 179 WWALGVLIYEMAVGFPPFYAD-----QPIQIYEKIVSGRVRFPSKLS--- 220 srsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf<-* +++k+L++++L++D +kR ++ +++ +i++H+wf kb|PKACg_H 221 ------------SDLKHLLRSLLQVDLTKRFGnlrngVGDIKNHKWF 255 // Query sequence: kb|PKACb_Hsap|AGC/PKA|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 326.1 1.4e-98 1 Pkinase_Tyr Protein tyrosine kinase 44.1 9.1e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 249 [. 1 272 [] 44.1 9.1e-19 Pkinase 1/1 1 255 [] 1 287 [] 326.1 1.4e-98 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 249: score 44.1, E = 9.1e-19 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei ++ k+LG G+FG+V++ + k te+ A K+L+k+ + kb|PKACb_H 1 FERKKTLGTGSFGRVMLVKHK----ATEQYYAMKILdKQ-KVVKLKQ 42 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd +e l+E +i+ + p +VrL + + ly+V+Ey++gG kb|PKACb_H 43 -IEHTLNEKRILQAV-NFPFLVRLEYAFKD-NSN----LYMVMEYVPGGE 85 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV + ++Lr+ ++++ ++ +a+Qi eYL+s ++ RDL N L+ kb|PKACb_H 86 MFSHLRR---IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI 132 senlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkFts ++++ + ++DFG a+ + + r+ + +APE + + ++ kb|PKACb_H 133 DHQGYIQVTDFGFAKRV-------KGRTWTLcGTPEYLAPEIILSKGYNK 175 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPd + D W+ GVl++E+ G +P + + +++e+++ R p + kb|PKACb_H 176 AVDWWALGVLIYEMAA-GYPP-FFADQPIQIYEKIVSGKVRFPSHF--SS 221 elYdlMlqCWaedPedRPtFsel...veeL<-* +l dl++ + d +R F l+++v+++ kb|PKACb_H 222 DLKDLLRNLLQVDLTKR--FGNLkngVSDI 249 Pkinase: domain 1 of 1, from 1 to 255: score 326.1, E = 1.4e-98 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +e++++lG GsfG+V + khk t++ +A+Ki++k+k + k++++++ kb|PKACb_H 1 FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTL 47 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse + E +il+ ++ p+ vrl ++f d+++ly+V+Ey++gG + f++l+ kb|PKACb_H 48 N-EKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGG----EMFSHLR- 91 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv r g++ se +a+++a Qi+ eYLHs i+RDLKPeN+L+d++g+ kb|PKACb_H 92 --RIGRF--SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 137 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD + ++DFG+A + +++++t++GTp+Y+APE++l ++gy ++vD kb|PKACb_H 138 I----QVTDFGFA----KrVKGrTWTLCGTPEYLAPEIIL-SKGYNKAVD 178 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi +W+lGv++ye++ G+pPF + ++q+++ki +++++f+s + kb|PKACb_H 179 WWALGVLIYEMAAGYPPFFAD-----QPIQIYEKIVSGKVRFPSHFS--- 220 srsefrrlpnlseeakdLikkcLnkDPskRlt.....aeeilqHPwf<-* +++kdL++++L++D +kR ++ +++ +i+ H+wf kb|PKACb_H 221 ------------SDLKDLLRNLLQVDLTKRFGnlkngVSDIKTHKWF 255 // Query sequence: kb|PKACa_Hsap|AGC/PKA|Not_pseudogene| Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 319.8 1.1e-96 1 Pkinase_Tyr Protein tyrosine kinase 35.1 3.2e-18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase_Tyr 1/1 1 249 [. 1 272 [] 35.1 3.2e-18 Pkinase 1/1 1 255 [] 1 287 [] 319.8 1.1e-96 Alignments of top-scoring domains: Pkinase_Tyr: domain 1 of 1, from 1 to 249: score 35.1, E = 3.2e-18 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtL.keigaseeei ++ +k+LG G+FG+V++ + k +t+ + A K+L+k+ + kb|PKACa_H 1 FERIKTLGTGSFGRVMLVKHK----ETGNHYAMKILdKQ-KVVKLKQ 42 eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd +e l+E +i+ + p +V+L + k+ ly+V+Ey++gG kb|PKACa_H 43 -IEHTLNEKRILQAV-NFPFLVKLE-FSFKDNSN----LYMVMEYVPGGE 85 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV + ++Lr+ ++++ ++ +a+Qi eYL+s ++ RDL N L+ kb|PKACa_H 86 MFSHLRR---IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI 132 senlvVKIsDFGLaRdiysddyYvrkrgggk.lPvkWmAPEslkygkFts + ++ + ++DFG a+ + + r+ + +APE + + ++ kb|PKACa_H 133 DQQGYIQVTDFGFAKRV-------KGRTWTLcGTPEYLAPEIILSKGYNK 175 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPd + D W+ GVl++E+ G +P + + +++e+++ R p + kb|PKACa_H 176 AVDWWALGVLIYEMAA-GYPP-FFADQPIQIYEKIVSGKVRFPSHF--SS 221 elYdlMlqCWaedPedRPtFsel...veeL<-* +l dl++ + d +R F l+++v+++ kb|PKACa_H 222 DLKDLLRNLLQVDLTKR--FGNLkngVNDI 249 Pkinase: domain 1 of 1, from 1 to 255: score 319.8, E = 1.1e-96 *->yelleklGsGsfGtVykakhkgtgkiVA