Proteins labeled in network graphics: ----------------------------------------------------- Fig. 2: 42 amine-binding GPCRs ----------------------------------------------------- Swiss-Prot:P35348 Alpha-1A adrenergic receptor Swiss-Prot:P35368 Alpha-1B adrenergic receptor Swiss-Prot:P25100 Alpha-1D adrenergic receptor Swiss-Prot:P08913 Alpha-2A adrenergic receptor Swiss-Prot:P18089 Alpha-2B adrenergic receptor Swiss-Prot:P18825 Alpha-2C adrenergic receptor Swiss-Prot:P08588 Beta-1 adrenergic receptor Swiss-Prot:P07550 Beta-2 adrenergic receptor Swiss-Prot:P13945 Beta-3 adrenergic receptor Swiss-Prot:P21728 D1A dopamine receptor Swiss-Prot:P21918 D1B dopamine receptor Swiss-Prot:P14416 D2 dopamine receptor Swiss-Prot:P35462 D3 dopamine receptor Swiss-Prot:P21917 D4 dopamine receptor Swiss-Prot:P35367 Histamine H1 receptor Swiss-Prot:P25021 Histamine H2 receptor Swiss-Prot:Q9Y5N1 Histamine H3 receptor Swiss-Prot:Q9H3N8 Histamine H4 receptor Swiss-Prot:P11229 Muscarinic acetylcholine receptor M1 Swiss-Prot:P08172 Muscarinic acetylcholine receptor M2 Swiss-Prot:P20309 Muscarinic acetylcholine receptor M3 Swiss-Prot:P08173 Muscarinic acetylcholine receptor M4 Swiss-Prot:P08912 Muscarinic acetylcholine receptor M5 Swiss-Prot:P08908 Serotonin receptor 1A Swiss-Prot:P28222 Serotonin receptor 1B Swiss-Prot:P28221 Serotonin receptor 1D Swiss-Prot:P28566 Serotonin receptor 1E Swiss-Prot:P30939 Serotonin receptor 1F Swiss-Prot:P28223 Serotonin receptor 2A Swiss-Prot:P41595 Serotonin receptor 2B Swiss-Prot:P28335 Serotonin receptor 2C Swiss-Prot:Q13639 Serotonin receptor 4 Swiss-Prot:P47898 Serotonin receptor 5A Swiss-Prot:P50406 Serotonin receptor 6 Swiss-Prot:P34969 Serotonin receptor 7 Swiss-Prot:Q96RJ0 Trace amine-associated receptor 1 Swiss-Prot:Q9P1P5 Trace amine-associated receptor 2 Swiss-Prot:Q9P1P4 Trace amine-associated receptor 3 Swiss-Prot:O14804 Trace amine-associated receptor 5 Swiss-Prot:Q96RI8 Trace amine-associated receptor 6 Swiss-Prot:Q969N4 Trace amine-associated receptor 8 Swiss-Prot:Q96RI9 Trace amine-associated receptor 9 ----------------------------------------------------- Fig. 3: listed names are KinBase (http://kinase.com/kinbase/) identifiers. ----------------------------------------------------- ----------------------------------------------------- Fig. 4A: 605 human Class A: Rhodopsin-like GPCRs ----------------------------------------------------- Swiss-Prot:Q8NGV7 Olfactory receptor 5H2 Swiss-Prot:P30556 Angiotensin II receptor (AT1) Swiss-Prot:P35372 Mu opiod receptor Swiss-Prot:P07550 Beta-2 adrenoceptor Swiss-Prot:P21554 Cannabinoid receptor 1 Swiss-Prot:P14416 Dopamine D2 receptor Swiss-Prot:P08100 Rhodopsin Swiss-Prot:P23945 Follicle-stimulating hormone receptor Swiss-Prot:Q16570 Duffy antigen/chemokine receptor ----------------------------------------------------- Fig. 4B: all 766 GPCR domains ----------------------------------------------------- Swiss-Prot:Q8TE23 Taste receptor T1R2 (sweet) Swiss-Prot:P41180 Calcium sensing receptor Swiss-Prot:Q9UBS5 GABA-B1 receptor Swiss-Prot:Q9NYW7 Taste receptor T2R1 (bitter) Swiss-Prot:Q9NYV9 Vomeronasal type-1 receptor 1 Swiss-Prot:Q16570 Duffy antigen/chemokine receptor Swiss-Prot:P07550 Beta-2 adrenoceptor (PDB:2RH1, PDB:2RHR) Swiss-Prot:P08100 Rhodopsin (PDB:1F88) Swiss-Prot:Q9UP38 Frizzled 1 Swiss-Prot:Q99835 Smoothened Swiss-Prot:Q03431 Parathyroid hormone receptor Swiss-Prot:Q02643 Growth hormone-releasing hormone receptor Swiss-Prot:P43220 Glucagon receptor ----------------------------------------------------- Fig. 5D: Seqs involved in selected edges from the crotonase superfamily. Order: BOTTOM TO TOP listed gis are NCBI general identifiers ----------------------------------------------------- Example sequences -- human mitochondrial short chain ECH (sECH): gi|433413 human peroxisomal bifunctional enzyme (bECH): gi|585079 sECH - DDDCI gi|26990733,gi|20807045 gi|39584711,gi|68180388 (a) sECH - sECH gi|30585161,gi|55732128 (b) gi|17988228,gi|39647574 gi|70799772,gi|1903327 gi|17989366,gi|66046261 gi|66046261,gi|68205735 (c) sECH - MGCH2 gi|71038714,gi|48783046 (d) sECH - DNCS gi|28897705,gi|16124262 sECH - FCHL gi|46317719,gi|15921809 gi|67664863,gi|56420574 sECH - archae bECH gi|18311283,gi|15790352 (e) gi|56676809,gi|13542141 gi|11498722,gi|70607995 sECH - bECH gi|27382932,gi|68205735 (f) gi|68539420,gi|22957421 gi|66800507,gi|27382932 ----------------------------------------------------- Fig. 6B: Labeled ECH sequences. listed gis are NCBI general identifiers ----------------------------------------------------- gi|20127408 human mitochondrial trifunctional protein (alpha) gi|585079 human peroxisomal bifunctional enzyme gi|119826 PDB:2D3T gi|119119 PDB:1MJ3 gi|433413 human mitochondrial short chain ECH gi|56420137 Geobacillus kaustophilus ECH gi|18312600 Pyrobaculum aerophilum 3HCDH and ECH