Boltz Runtimes

Tom Goddard
July 11, 2025

These are prediction times for running Boltz versions 2.1.1, 1.0.0 and 0.4.1 using ChimeraX for PDB structures of different sizes and with different Boltz options.

Boltz prediction times in minutes. Failures report out of memory.

PDB code Tokens Mac
M1
16 GB
Mac
M1 Max
32 GB
Mac
M2 Ultra
64 GB
Linux
i9 CPU
64 GB
Linux
Nvidia 4090
16-bit
Linux
Nvidia 4090
32-bit
Windows
i7 CPU
64 GB
Windows
Nvidia 3070
16-bit
Windows
Nvidia 3070
32-bit
Windows
Nvidia 4070
32-bit
Number of residues and atoms and prediction error
8rf4 129 1.2 b2
1.4 b1
1.7 b0
3.4 b2s
3.9 b1s
3.7 b2a
0.8 b2
1.0 b1
0.9 b0
2.5 b2s
1.8 b2a
0.8 b2
0.9 b1
0.8 b0
2.1 b2s
1.5 b2a
1.1 b2
1.2 b1
2.3 b2s
3.7 b2a
0.3 b2
0.4 b1
0.5 b1s
0.6 b2a
0.4 b1
0.5 b0
0.5 b1s
2.0 b2
2.2 b1
2.2 b0
3.1 b1s
6.2 b2a
0.8 b2
1 b1
1.8 b2a
1 b1
1 b0
1.2 b1s
1.6 b0 118 amino acids, 11 ligand atoms, 0.8A RMSD 108 residues
1hho 382 fail b2
fail b1
fail b0
fail b2 1‑heme
fail b1 1‑heme
7 b0 1‑heme
fail b2 no ligands
4.2 b1 no ligands
1.5 b2
1.9 b1
2.1 b0
6.7 b2s
1.4 b2
1.3 b1
1.4 b0
3.8 b2s
3.4 b1s
8.0 b2
8.4 b1
11 b2s
0.5 b2
0.6 b1
0.7 b1s
0.6 b1
0.8 b0
0.8 b1s
11 b2
11 b1
12 b0
15 b1s
2.0 b2
1.9 b1
2.3 b1s
4.8 b1
5 b0
5.3 b1s
4 b0 287 amino acids, 95 ligand atoms, 0.4A RMSD 146 residues
9moj 660 18 b2
17 b1
fail b0
30 b2s
29 b1s
3.8 b2
3.7 b1
3.9 b0
7.3 b2s
2.3 b2
2.2 b1
2.5 b0
3.7 b2s
3.5 b1s
24 b2
23 b1
34 b2s
0.6 b2
0.7 b1
1.0 b1s
0.9 b1
1.2 b0
1.2 b1s
29 b2
27 b1
29 b0
2.5 b2
2.5 b1
3.6 b1s
7.1 b1
7 b0
8.2 b1s
3.2 b0 660 amino acids, heterotetramer, 0.8A RMSD 132 residues
9h1k 671 23 b2
22 b1
4.9 b2
4.3 b1
4.6 b0
11 b2s
2.7 b2
2.5 b1
2.7 b0
5.6 b2s
4.9 b1s
29 b2
27 b1
39 b2s
0.7 b2
0.8 b1
1.1 b1s
1.1 b1
1.5 b0
1.4 b1s
38 b2
31 b1
32 b0
9.5 b2
7.7 b1
9.3 b1s
17 b1
17 b0
20 b1s
27 b0 560 amino acids, 59 rna bases, 52 ligand atoms, 0.7A RMSD protein, RNA wrong
9b3h 911 fail b2
44 b1
10 b2
11 b1
17 b0
15 b2s
5.1 b2
4.4 b1
4.7 b0
6.9 b2s
5.9 b1s
60 b2
56 b1
75 b2s
1.1 b2
1.3 b1
1.7 b1s
1.7 b1
2.7 b0
2.1 b1s
67 b1
96 b0
28 b2
28 b1
80 b2
48 b1
49 b0
75 b0 911 amino acids, heterodimer, 1A RMSD 509 residues
9fz5 1025 fail b1 13 b2
12 b1
15 b0
18 b2s
7.0 b2
5.8 b1
6.6 b0
9.1 b2s
7.9 b1s
82 b2
78 b1
100 b2s
1.3 b2
1.7 b1
1.7 b0
2.0 b1s
fail b1
fail b0
fail b1s
40 b2
40 b1
1025 amino acids, heterotrimer, 3.7A RMSD 740 residues
9mcw 1154 fail b1 18 b2
>47 b1
13 b0
fail b2s
7.2 b2
6.8 b1
6.8 b0
fail b2s
fail b1s
96 b2
91 b1
175 b2s
1.4 b2
1.7 b1
2.0 b1s
2.5 b1
4.4 b0
fail b1s
54 b2 1154 rna bases, homodimer, wrong dimer and monomer conformations
8sa0 1371 28 b2
25 b1
fail b0
fail b2s
146 b2a
38 b2
12 b1
23 b0
41 b2s
17 b1s
34 b2a
164 b2
151 b1
186 b2s
171 b2a
fail b2
2.4 b1
2.4 b0
3.0 b1s
fail b1
fail b0
1274 amino acids, 97 ligand atoms, 3.4A RMSD 1151 residues
9gh4 1467 32 b2 41 b2
172 b1
188 b2 2.1 b2
fail b1
fail b0
Protein homotrimer, monomer 489 residues, 1.1A RMSD for 750 residues

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