------------------------------------------------------------------------------ residues apparently very important for folding/expression ------------------------------------------------------------------------------ I:18 oxytocinR N57A no srf bding Fanelli et al. Mol Pharm 56:214 (1999) I:18 GnRHR N53D,A,L not detectable Flanagan et al. JBC 274(41):28880 (1999) I:18 FPR N44A not srf-expr Miettinen et al. JBC 274(39):27934 (1999) IC1 (I:28) FPR R54A not srf-expr Miettinen et al. JBC 274(39):27934 (1999) II:14 GnRHR N87D,A,Q not detectable Flanagan et al. JBC 274(41):28880 (1999) III:0 conserved SS bond with EC2; varied results re expression of mutants III:24 m1R rat D122 Lu et al. Mol Pharm 51:234 (1997) III:24 GnRHR mouse D138A not exprsd Ballesteros et al. JBC 273(17):10445 (1998) III:24 beta2AR D130N,A decr stab (& CA) Rasmussen et al. Mol Pharm 56:175 (1999) III:24 oxytocinR D136A,Q no srf bding Fanelli et al. Mol Pharm 56:214 (1999) III:24 FPR D122A not srf-expr Miettinen et al. JBC 274(39):27934 (1999) III:26 m1R rat Y124 Lu et al. Mol Pharm 51:234 (1997) IV:21 LHR rat P479 Hong et al. JBC 272(7):4166 (1997) V:10 rhodopsin bovine H211P Hwa et al. PNAS USA 94:10571 (1997) but note ->P V:11 LHR rat N513G,A,Q,D poor memb-expr Angelova et al. Mol Endo 14:459 (2000) V:14 m3R rat P242 Wess et al. EMBO J 12:331 (1993) V:14 FPR P213A not srf-expr Miettinen et al. JBC 274(39):27934 (1999) VI:18 rhodopsin bovine P267R Hwa et al. PNAS USA 94:10571 (1997) VI:18 m3R rat P505 Wess et al. EMBO J 12:331 (1993) VII:18 m3R rat P540 Wess et al. EMBO J 12:331 (1993) but also function? VII:18 LHR rat P598 Hong et al. JBC 272(7):4166 (1997) VII:18 betaAR P323 Cho et al. Mol Pharm 50:1338 (1996) VII:18 FPR P298A not srf-expr Miettinen et al. JBC 274(39):27934 (1999) ------------------------------------------------------------------------------