id	summary	reporter	owner	description	type	status	priority	milestone	component	version	resolution	keywords	cc	blockedby	blocking	notify_on_close	platform	project
15100	diffplot: Cluster atomic models by projecting atom positions with UMAP	Tom Goddard	Tom Goddard	"Klim Verba, Katrina Black and Tom Goddard discussed on April 9, 2024 how to visualize differences in hundreds of B-Raf kinase structure from the PDB and AlphaFold.

Tom suggested using UMAP (we have R01 funding for exploring its uses) where we feed the C-alpha atom positions of residues near the binding site for each of the aligned structures as a vector (length 3 times the number of residues) and project to 2 dimensions.  If different clusters are observed we can try to morph between them to more clearly see how they differ."	enhancement	assigned	moderate		Structure Comparison								all	ChimeraX