id	summary	reporter	owner	description	type	status	priority	milestone	component	version	resolution	keywords	cc	blockedby	blocking	notify_on_close	platform	project
16903	Allow homolog chains with different residue numbering to be associated with mutation scores	Willow.Coyote-Maestas@…	Tom Goddard	"Willow would like to associate mutation scores with homologous structures which may use different residue numbering.  This will need to use a sequence alignment between the mutation score sequence and homologous sequence.

Begin forwarded message:

From: ""Coyote-Maestas, Willow""
Subject: Re: Small suggestion for DMS chimera
Date: February 2, 2025 at 4:43:32 PM PST
To: Tom Goddard 
Cc: ""O'Donnell, Ever""

Just adding a challenge that I faced when mapping scores across these structures that I think will be a common one - many structures are solved based on a mutated form of a protein. For instance, we did a DMS on human NTCP but  structures have been solved of homologs but also of a consensus sequence that is more stable. Mapping scores across these is challenging because the specific numberings may be slightly different. 

Again no rush on taking care of this just thought it would be helpful info.
Be well,
Willow"	enhancement	closed	moderate		Structure Analysis		fixed		Ever.ODonnell@… Elaine Meng				all	ChimeraX