Attendees

Tom Goddard, Zach, Eric, Greg, Elaine, Scooter, Tom Ferrin

February 26, 2026

Agenda

• Jason Gestwicki lab presenting web app for analyzing post-translational modifications
• Endowed viz position search
• Setup of server GPU nodes

Discussion Notes

• Chaperone equilibria
  • Jason described 180 human chaperone proteins, their function, and competition for forming many complexes.
  • Saugat Pokhrel, postdoc, showed web app he made to compute abundance of complexes at equilibrium from affinities and abundances of component proteins.
  • Two central proteins are HSP70 and HSP90 (each has variants).
  • CCTPR proteins recognize 5-mer or 10-mer C-terminal on HSP70/90 for binding.
  • Saugat's web app works with 31 CCTPR proteins
  • They have experimental affinity data for about 80% of those.
  • Scooter advised separating backend computation in a REST web service and trying to use existing tools for front-end visualization.

Action Items