Changes between Version 1 and Version 2 of 2026-2-26


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Timestamp:
Mar 3, 2026, 10:58:17 AM (4 hours ago)
Author:
Tom Goddard
Comment:

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  • 2026-2-26

    v1 v2  
    1313= Discussion Notes =
    1414
     15* Chaperone equilibria
     16 - Jason described 180 human chaperone proteins, their function, and competition for forming many complexes.
     17 - Saugat Pokhrel, postdoc, showed web app he made to compute abundance of complexes at equilibrium from affinities and abundances of component proteins.
     18 - Two central proteins are HSP70 and HSP90 (each has variants).
     19 - CCTPR proteins recognize 5-mer or 10-mer C-terminal on HSP70/90 for binding.
     20 - Saugat's web app works with 31 CCTPR proteins
     21 - They have experimental affinity data for about 80% of those.
     22 - Scooter advised separating backend computation in a REST web service and trying to use existing tools for front-end visualization.
     23
    1524= Action Items =