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Recent Citations

The molecular basis of force selectivity by PIEZO2. Mulhall EM, Yarishkin O et al. Nature. 2026 May 7;653(8113):297–305.

Human DHX29 detects nonoptimal codon usage to regulate mRNA stability. Hia F, Wu Y et al. Science. 2026 May 7;392(6798):eadw0288.

CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome. Shi H, Wang X et al. Nature. 2026 Apr 30;652(8112):1375–1383.

Complement inhibition by a unique cluster of immunomodulatory outer surface proteins of Borrelia recurrentis. Röttgerding F, Reyer F et al. Nat Commun. 2026 Apr 29;17(1):3900.

Pre-incision structures reveal principles of DNA nucleotide excision repair. Li ECL, Kim J et al. Nature. 2026 Apr 23;652(8111):1060–1067.

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News

December 25, 2025

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The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

September 22, 2025

Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.

March 6, 2025

Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (1.19 release notes).

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Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

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Blast Protein

The Blast Protein tool performs a blast or psiblast search of pdb or nr for sequences similar to a query, using a Web service hosted by the UCSF RBVI. The query can be:

  • a chain from a structure open in Chimera
  • a sequence pasted as plain text
  • a sequence from an alignment in Multalign Viewer
The output is a list of hits, from which all or a user-chosen subset can be retrieved:
  • as a pseudo-multiple sequence alignment (a consolidation of the pairwise alignments of individual hits to the query), automatically shown in Multalign Viewer
  • as structures (for hits from pdb), automatically superimposed according to the pseudo-multiple alignment

(More features...)

Gallery Sample

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Wasabi Receptor

The image shows the structure of the human TRPA1 ion channel (wasabi receptor) determined by electron cryo-microscopy, Protein Data Bank entry 3j9p. The four subunits of the tetramer are shown as ribbons in different colors over a dark-to-light gradient background. (More samples...)


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