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Featured Citations

The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation. Farnung J, Slobodyanyuk E et al. Nature. 2026 Apr 16;652(8110):784–793.

Non-equilibrium snapshots of ligand efficacy at the μ-opioid receptor. Robertson MJ, Modak A et al. Nature. 2026 Apr 16;652(8110):794–802.

The dynamic basis of G-protein recognition and activation by a GPCR. Kobayashi K, Kawakami K et al. Nature. 2026 Apr 16;652(8110):812–821.

Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Springstein BL, Javoor MG et al. Science. 2026 Apr 16;392(6795):eaea6343.

Structural basis for DNA processing and membrane translocation by ComEC in natural transformation. Hirano H, Tsuji N et al. Science. 2026 Apr 16;392(6795):311-316.

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News

December 25, 2025

computer generated image
The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

December 16, 2025

The ChimeraX 1.11 production release is available! See the change log for what's new.

November 21, 2025

The ChimeraX 1.11 release candidate is available – please try it and report any issues. See the change log for what's new. This will be the last release to support Red Hat Enterprise Linux 8 and its derivatives.

Previous news...

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

AMPA receptor with tube helices

Curved Helix Cylinders

Protein α-helices can be shown as curved-cylinder “tubes“ with the cartoon style command. Helix tube mode is an alternative to the standard spiraling ribbons, and both modes are fully integrated with coil and β-strand cartoons. The structure at left is an AMPA-subtype glutamate receptor bound to the antiepileptic drug perampanel (PDB 5l1f). The receptor is tetrameric, and each chain is rainbow color-coded from blue at the N-terminus to red at the C-terminus. Four molecules of perampanel (pink) are bound near the bottom, between the transmembrane domain and the rest of the receptor. For image setup other than orientation, see the command file ampar.cxc.

See also: Presets menu

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Example Image

potassium channel

Potassium Channel-Calmodulin Complex

KCNQ1 is the pore-forming subunit of a cardiac potassium channel. It binds to calmodulin, and mutations in either of these proteins can cause congenital long QT syndrome, a dangerous propensity for irregular heartbeats. In the image, a structure of the KCNQ1/calmodulin complex (PDB 5vms) has been assembled into the native tetrameric form with the sym command. The view is from the cytoplasmic side, with KCNQ1 shown as surfaces, calmodulin as cartoons, and calcium ions as balls. A pastel palette from ColorBrewer has been used to color the surfaces, darkened with color modify for the cartoons, and “rotated” 45° in hue for the ions. See the command file colormod.cxc.

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