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Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I. Grba DN, Wright JJ et al. Science. 2024 Jun 14;384(6701):1247-1253.

Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Zhang S, Sun A et al. Nature. 2024 Jun 13;630(8016):484–492.

Molecular mechanism of choline and ethanolamine transport in humans. Ri K, Weng TH et al. Nature. 2024 Jun 13;630(8016):501–508.

Membraneless channels sieve cations in ammonia-oxidizing marine archaea. von Kügelgen A, Cassidy CK et al. Nature. 2024 Jun 6;629(8015):230–236.

Structures of human γδ T cell receptor-CD3 complex. Xin W, Huang B et al. Nature. 2024 Jun 6;629(8015):222–229.

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News

June 17-18, 2024

Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable June 17-18 PDT.

June 13, 2023

The ChimeraX 1.8 production release is available! See the change log for what's new.

May 10, 2024

The ChimeraX 1.8 release candidate is available – please try it and report any issues. See the change log for what's new.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325, Chan Zuckerberg Initiative grant EOSS4-0000000439, and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

AMPA receptor with tube helices

Curved Helix Cylinders

Protein α-helices can be shown as curved-cylinder “tubes“ with the cartoon style command. Helix tube mode is an alternative to the standard spiraling ribbons, and both modes are fully integrated with coil and β-strand cartoons. The structure at left is an AMPA-subtype glutamate receptor bound to the antiepileptic drug perampanel (PDB 5l1f). The receptor is tetrameric, and each chain is rainbow color-coded from blue at the N-terminus to red at the C-terminus. Four molecules of perampanel (pink) are bound near the bottom, between the transmembrane domain and the rest of the receptor. For image setup other than orientation, see the command file ampar.cxc.

See also: Presets menu

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Example Image

neuraminidase flowers

Neuraminidase Flowers

Influenza neuraminidase is an enzyme that promotes the spread of influenza virus among host cells. It is the target of oseltamivir and related antiviral drugs. The image shows tetramers of neuraminidase (PDB 3k3a) styled as flowers. Three tetramers are in different shades of pink, with a central metal ion in white and nearby residues in yellow, and a fourth tetramer is colored green to resemble leaves. Each monomer or “petal” is a six-bladed β-propeller. For image setup other than orientation, see the command file flowers.cxc. The Chimera Image Gallery includes a similar image.

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