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Structural basis for strand transfer inhibitor binding to HIV intasomes. Passos DO, Li M et al. Science. 2020 Feb 14;367(6479):810-814.

Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy. Shahnawaz M, Mukherjee A et al. Nature. 2020 Feb 13;578(7794):273-277.

Structure of an active human histone pre-mRNA 3'-end processing machinery. Sun Y, Zhang Y et al. Science. 2020 Feb 7;367(6478):700-703.

Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly. Dick RA, Xu C et al. PLoS Pathog. 2020 Jan 27;16(1):e1008277.

Volatile and thermally stable polymeric tin trifluoroacetates. Bačić G, Rankine CD et al. Inorg Chem. 2020 Jan 21;59(2):996-1005.

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News

November 13, 2019

Chimera production release 1.14 is now available. See the release notes for what's new.

September 21, 2019

A production release candidate (version 1.14) is available; please try it and report any problems. See the release notes for what's new.

November 17, 2018

Chimera production release 1.13.1 is now available; see the release notes for what's new. The Mac version requires OS 10.10 or later.

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Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, nonprofit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), supported in part by the National Institutes of Health (P41-GM103311).

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the RBVI, following UCSF Chimera.

Feature Highlight

Volume Data

Volume Data

Chimera's Volume Viewer displays three-dimensional electron and light microscope data, X-ray density maps, electrostatic potential and other volumetric data. Contour surfaces, meshes and volumetric display styles are provided and thresholds can be changed interactively. Maps can be colored, sliced, segmented, and modifications can be saved. Markers can be placed and structures can be traced. The accompanying image shows a density map of Kelp fly virus from electron microscopy colored radially and with an octant cut out.

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Gallery Sample

Sliced Potassium Channel

Potassium channel (Protein Data Bank entry 1bl8) on a dark slate blue background with potassium ions shown in firebrick. The channel is comprised of four chains. Each chain has been rainbow-colored from blue at the N-terminus to red at the C-terminus, but only the surface of the channel is shown. The surface has been sliced with a per-model clipping plane. The surface cap color is plum except with opacity set to 0.8. The shininess and brightness have been set to 128 and 8, respectively, and the lights on the scene have been moved from their default positions. The subdivision quality (related to the smoothness of the spherical ions) is 5.0, and the molecular surface was computed with probe radius and vertex density set to 1.0 and 6.0, respectively. (More samples...)


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