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Recent Citations

Mutations in ATP6V1E1 or ATP6V1A cause autosomal-recessive cutis laxa. Van Damme T, Gardeitchik T et al. Am J Hum Genet. 2017 Feb 2;100(2):216-227.

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2. Wilkes M, Madej MG et al. Nat Struct Mol Biol. 2017 Feb;24(2):123-130.

Architecture of the yeast Elongator complex. Dauden MI, Kosinski J et al. EMBO Rep. 2017 Feb;18(2):264-279.

Structure of the immature Zika virus at 9 Å resolution. Prasad VM, Miller AS et al. Nat Struct Mol Biol. 2017 Feb;24(2):184-186.

Hydrogen positions in single nanocrystals revealed by electron diffraction. Palatinus L, Brázda P et al. Science. 2017 Jan 13;355(6321):166-169.

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News

December 2, 2016

Chimera production release 1.11.2 is now available. This version has been updated to work with changes in NCBI Blast and to avoid crashes on Mac Sierra (see the release notes for details).

September 24, 2016

Production release candidate (version 1.11.2) is available, superseding 1.11.1. The new version has been updated to work with changes in NCBI Blast (see release notes). Please try it and report any problems.

August 27, 2016

A production release candidate (version 1.11.1) is now available. Please try it and report any problems. See the release notes for what's been fixed since 1.11. The 1.11 release series will be the last to support 32-bit builds.

(Previous news...)

Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, nonprofit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), funded by the National Institutes of Health (NIGMS P41-GM103311).

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the RBVI, following UCSF Chimera.

Feature Highlight

phosphomannomutase morphing animation

Morphing

Different conformations and even different proteins can be compared by morphing from one structure to another. Users can specify the method of coordinate interpolation and how many intermediate structures should be generated. The result is displayed in Chimera's trajectory viewer, MD Movie. The morph can then be saved in coordinate form or recorded as an animation.

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Gallery Sample

Cavity and Tunnel Detection

Side-by-side views of a potassium channel structure (Protein Data Bank entry 1bl8) showing different approaches to cavity detection. On the left are molecular surface patches corresponding to the structure's two largest pockets by MS volume in the Computed Atlas of Surface Topography of proteins (CASTp) database. On the right is a tunnel in blue identified by the MolAxis server. Simple editing converted MolAxis output into a BILD file for display in Chimera. (More samples...)