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Recent Citations

A single-stranded architecture for cotranscriptional folding of RNA nanostructures. Geary C, Rothemund PW, Andersen ES. Science. 2014 Aug 15;345(6198):799-804.

Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis. Flex E, Jaiswal M et al. Hum Mol Genet. 2014 Aug 15;23(16):4315-27.

Structure of β-galactosidase at 3.2-Å resolution obtained by cryo-electron microscopy. Bartesaghi A, Matthies D et al. Proc Natl Acad Sci USA. 2014 Aug 12;111(32):11709-14.

Enabling membrane protein structure and dynamics with X-ray free electron lasers. Feld GK, Frank M. Curr Opin Struct Biol. 2014 Aug;27C:69-78.

Blind prediction performance of RosettaAntibody 3.0: Grafting, relaxation, kinematic loop modeling, and full CDR optimization. Weitzner BD, Kuroda D et al. Proteins. 2014 Aug;82(8):1611-23.

(Previously featured citations...)

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News

August 15, 2014

We are delighted to announce the publication of a new book, Computational and Visualization Techniques for Structural Bioinformatics Using Chimera, written by Forbes J. Burkowski (University of Waterloo).

May 13, 2014

Chimera production release 1.9 is now available. See the release notes for new features since the 1.8 release series.

April 23, 2014

A production release candidate (version 1.9) is now available; please try it and report any problems. See the release notes for changes relative to the previous release.

(Previous news...)

Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, non-profit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics, funded by the National Institutes of Health (NIGMS P41-GM103311).

Feature Highlight

2mnr metal site
2mnr metal site

Metal Geometry

The Metal Geometry tool facilitates analysis of metal-binding sites. It lists potential metal-coordinating atoms (nearby nucleophilic heteroatoms) and suggests likely coordination geometries. An idealized geometry can be depicted with solid arrows, as shown in the figure for the octahedral coordination of Mn++ by six atoms, and the coordination pseudobonds in the structure can be updated to match the chosen geometry.

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Gallery Sample

p53 Cancer Mutations

Mutations that inactivate the tumor suppressor p53 are found in over 50% of human cancers, and most of the cancer-associated mutations are within its DNA-binding domain. The image shows a tetramer of the p53 DNA-binding domain complexed with DNA (Protein Data Bank entry 2ac0). The tetramer subunits are shown as light blue, green, orange, and yellow ribbons, with red spheres marking several major "hot spots" of mutation. The DNA is shown in purple and blue. (More samples...)