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Recent Citations

A generalized knowledge-based discriminatory function for biomolecular interactions. Bernard B, Samudrala R Proteins. 2009 Jul;76(1):115-128.

Insights into positive and negative requirements for protein-protein interactions by crystallographic analysis of the Beta-Lactamase Inhibitory Proteins BLIP, BLIP-I and BLP. Gretes M, Lim DC et.al. J Mol Biol. 2009 Jun 5;389(2):289-305.

DOCK 6: Combining techniques to model RNA-small molecule complexes. Lang PT, Brozell SR et.al. RNA. 2009 Jun;15(6):1219-30.

LS-SNP/PDB: annotated non-synonymous SNPs mapped to Protein Data Bank structures. Ryan M, Diekhans M et.al. Bioinformatics. 2009 Jun 1;25(11):1431-2.

Crystallographic insights into the autocatalytic assembly mechanism of a bacteriophage tail spike. Xiang Y, Leiman PG et.al. Mol Cell. 2009 May 15;34(3):375-86.

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News

April 24, 2009

The LabelHash server searches the PDB for matches to a user-specified 3D motif (pattern of residues). Results are shown with Chimera images and can be downloaded for local viewing with the Chimera extension ViewMatch. LabelHash and ViewMatch are provided by the Kavraki Lab at Rice University.

April 17, 2009

The LS-SNP/PDB database features Chimera images of human nonsynonymous SNP locations in protein structures and molecular surfaces colored by sequence conservation and electrostatic potential. This database is provided by the Karchin Lab at Johns Hopkins University.

December 9, 2008

Chimera production release 1.3 is available for all platforms, including Mac Aqua (does not require X windows). It addresses Microsoft Windows graphics drivers problems and will be the last production release for IRIX and Tru64. See the release notes for changes since the previous production release (July 2008).

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Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, non-profit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics and funded by the NIH National Center for Research Resources (grant P41-RR01081).

Feature Highlight

hydrogen bonds

Chemical Knowledge

  • determination of atom types in arbitrary molecules, including non-standard residues
  • ability to add hydrogen atoms
  • high-quality hydrogen bond identification
  • selection of atoms/bonds by element, atom type, functional group, amino acid category
  • interactive bond rotation, distance and angle measurements

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Gallery Sample

RNA Bases

Large ribosomal RNA is shown with individual bases depicted using solvent excluded molecular surfaces. Bases A, C, G, U are colored red, yellow, green, and blue. The surfaces were made with the Chimera multiscale tool in combination with the nucleic acid blobs plug-in. The image was raytraced using POVray.

Protein Data Bank model 1s72.

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