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Recent Citations

Structural basis of omega-3 fatty acid transport across the blood-brain barrier. Cater RJ, Chua GL et al. Nature. 2021 Jul 8;595(7866):315-319.

PspA adopts an ESCRT-III-like fold and remodels bacterial membranes. Junglas B, Huber ST et al. Cell. 2021 Jul 8;184(14):3674-3688.e18.

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates. Galaz-Montoya JG, Shahmoradian SH et al. Commun Biol. 2021 Jul 8;4(1):849.

High-resolution crystal structures of transient intermediates in the phytochrome photocycle. Carrillo M, Pandey S et al. Structure. 2021 Jul 1;29(7):743-754.e4.

Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry. Felker D, Zhang H et al. Biophys Chem. 2021 Jul;274:106590.

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News

May 6, 2021

We're looking for somebody to join the ChimeraX development team! Please see the job posting for details.

December 18, 2020

Chimera production release 1.15 is now available. See the release notes for what's new.

December 11, 2020

The RBVI wishes you a safe and happy holiday season! See our 2020 card and the gallery of previous cards back to 1985.

(Previous news...)

Upcoming Events

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features. ChimeraX includes a significant subset of Chimera features (with more to come, see the missing features list) and is under active development. Users may choose to use both programs, and it is fine to have both installed.

Chimera is no longer under active development, and is only updated for critical maintenance. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

ribbon spline comparison

Ribbon Spline Options

The default ribbon path is a smooth bspline (semitransparent tan in the figure), which can diverge from the true positions of the backbone atoms (α-carbons shown as gray balls). A cardinal spline allows tracking the backbone more closely. Without smoothing (light blue), it follows the α-carbons exactly, or it can be combined with some “compromise” smoothing of strand and/or coil. Ribbon spline options can be set with the ribspline command or in the molecule model attributes.

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Gallery Sample

Peroxiredoxin Wreath

Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.

See also the RBVI holiday card gallery.

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