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DNA damage drives antigen diversification in Trypanosoma brucei. Smith JE, Wang KJ et al. Nature. 2026 Jun 4;654(8117):219–228.
Ultrastructure of dopaminergic varicosities revealed by cryo-correlative light and electron microscopy. Lycas MD, Morado DR et al. J Cell Biol. 2026 Jun 1;225(6):e202503059.
Selective autophagy fine-tunes plant immunity to promote cell survival during viral infection. Clavel M, Bianchi A et al. Science. 2026 May 28;392(6801):eadu9554.
Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity. Kleeman SO, Michalski K et al. Nature. 2026 May 28;(8116):1216–1228.
BCDX2-CX3 and DX2-CX3 complexes assemble and stabilize RAD51 filaments. Koo CW, Xiao J et al. Nature. 2026 May 21;653(8115):952–961.
News
May 7, 2026
The ChimeraX 1.12 release candidate is available – please try it and report any issues. See the change log for what's new.
December 25, 2025
December 16, 2025
The ChimeraX 1.11 production release is available! See the change log for what's new.
Upcoming Events
UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325.
ChimeraX on Bluesky: @chimerax.ucsf.edu
Feature Highlight
Atomic structures, including cartoons and molecular surfaces, can be colored by the conservation in an associated multiple sequence alignment. The figure shows a structure of the β2-adrenergic receptor signaling complex (PDB 3sn6) with receptor cartoon colored blue→white→red from least conserved to most conserved. The β2-adrenergic receptor is a member of the class A G-protein-coupled receptor superfamily. Conservation was calculated from a superfamily alignment from PASS2 using the entropy-based measure from AL2CO (included with ChimeraX courtesy of Pei and Grishin). The sequence alignment and step-by-step instructions for making this image are given in the Coloring by Sequence Conservation tutorial.
Example Image
Atomic B-factor values are read from PDB and mmCIF input files and assigned as attributes that can be shown with coloring and used in atom specification. This example shows B-factor variation within a structure of the HIV-1 protease bound to an inhibitor (PDB 4hvp). For complete image setup, including positioning, color key, and label, see the command file bfactor.cxc.
Additional color key examples can be found in tutorials: Coloring by Electrostatic Potential, Coloring by Sequence Conservation
More images...
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