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Featured Citations

Cryo-EM of cardiac AL-224L amyloid reveals shared structural motifs and mutation-induced differences in λ6 light chain fibrils. Hicks CW, Prokaeva T et al. J Mol Biol. 2026 Feb 1;438(3):169591.

Quantum spin resonance in engineered proteins for multimodal sensing. Abrahams G, Štuhec A et al. Nature. 2026 Jan 29;649(8099):1172–1179.

RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity. Dmytrenko O, Yuan B et al. Nature. 2026 Jan 29;649(8099):1312–1321.

Multiple protein structure alignment at scale with FoldMason. Gilchrist CLM, Mirdita M, Steinegger M. Science. 2026 Jan 29;391(6784):485-488.

An ATP-gated molecular switch orchestrates human mRNA export. Hohmann U, Graf M et al. Nature. 2026 Jan 22;649(8098):1042–1050.

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News

December 25, 2025

computer generated image
The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

December 16, 2025

The ChimeraX 1.11 production release is available! See the change log for what's new.

November 21, 2025

The ChimeraX 1.11 release candidate is available – please try it and report any issues. See the change log for what's new. This will be the last release to support Red Hat Enterprise Linux 8 and its derivatives.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

smoothed (tan) vs. unsmoothed (blue)

Adjustable β-Strand Smoothing

Cartoon ribbons are drawn to pass through the exact positions of peptide α-carbons in helix and coil, but by default, strands are smoothed to appear less ripply. This means that α-carbons in strands may not fall on the ribbon. A tether is drawn wherever a sidechain is displayed but would otherwise be detached from the ribbon. (Tether appearance can be adjusted with cartoon tether.)

However, β-strand ribbon smoothing can be tuned continuously between zero (off) and 1.0 (default, fully on), and this can be done for all residues or for specific residues only. The image compares ribbon positions for residues 139 and 164 in the active site of mandelate racemase (PDB 2mnr) with and without smoothing. The unsmoothed position (transparent blue) can be obtained with:

cartoon :139,164 smooth 0

This leaves ribbon smoothing at other residues unchanged. Values between 0 and 1 would give intermediate positions.

More features...

Example Image

potassium channel

Potassium Channel-Calmodulin Complex

KCNQ1 is the pore-forming subunit of a cardiac potassium channel. It binds to calmodulin, and mutations in either of these proteins can cause congenital long QT syndrome, a dangerous propensity for irregular heartbeats. In the image, a structure of the KCNQ1/calmodulin complex (PDB 5vms) has been assembled into the native tetrameric form with the sym command. The view is from the cytoplasmic side, with KCNQ1 shown as surfaces, calmodulin as cartoons, and calcium ions as balls. A pastel palette from ColorBrewer has been used to color the surfaces, darkened with color modify for the cartoons, and “rotated” 45° in hue for the ions. See the command file colormod.cxc.

More images...



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