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Featured Citations

Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity. Kleeman SO, Michalski K et al. Nature. 2026 May 28(8116):1216–1228.

BCDX2-CX3 and DX2-CX3 complexes assemble and stabilize RAD51 filaments. Koo CW, Xiao J et al. Nature. 2026 May 21;653(8115):952–961.

Structural energetics of cold sensitivity. Choi KY, Lin X et al. Nature. 2026 May 21;653(8115):962–970.

In situ structure of the human gap junction. Eshriew E, Kumpula EP et al. Sci Adv. 2026 May 15;12(20):eaea4183.

Structural basis of supercoiling-induced CRISPR-Cas9 off-target activity. Smith QM, Whittle S et al. Nature. 2026 May 14;653(8114):627–635.

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News

May 7, 2026

The ChimeraX 1.12 release candidate is available – please try it and report any issues. See the change log for what's new.

December 25, 2025

computer generated image
The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

December 16, 2025

The ChimeraX 1.11 production release is available! See the change log for what's new.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

3eeb assembly 1 Coulombic ESP coloring

Coulombic Electrostatic Potential

Coulombic electrostatic potential (ESP) can be calculated and displayed with surface coloring using the command coulombic or the Molecule Display icon computer generated image. No separate calculation or input ESP file is required. The image shows the first assembly defined for PDB 3eeb, the protease domain of a toxin from Vibrio cholerae, with the default Coulombic coloring: red-white-blue over the value range –10 to 10. For image setup other than orientation, see the command file coulombic.cxc.

For how to add a color key and associated label, see the Protein-Ligand Binding Sites tutorial.

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Example Image

2015 holiday card with ribosome image

The Human Ribosome

The architecture of the human ribosome has been determined at near-atomic resolution by electron microscopy (Anger et al., Nature 497:80 (2013)). The structure, comprising 82 proteins and five RNA molecules, is shown with shadows cast from all directions to accentuate depth. In the background are schematic representations of contacts between the component molecules.

See the image setup script card.cxc using the 'Tis the Season color palette (credit to MrsP). See also the RBVI holiday card gallery.

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