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Cryo-electron microscopy structures of human cone visual pigments. Peng Q, Li J et al. Science. 2026 Jun 25;392(6805):eadz8141.

Steric hindrance of antibody binding in an Omicron spike fusion intermediate. Bao Z, Liu Z et al. Nature. 2026 Jun 18;654(8119):762–770.

Structural basis of fungal β-1,3-glucan synthase inhibition by caspofungin. Ren Z, Chhetri A et al. Nature. 2026 Jun 10;654(8118):547–555.

Myosin forces remodel F-actin for mechanosensitive protein recognition. Carl AG, Reynolds MJ et al. Nature. 2026 Jun 4;654(8117):240–249.

A high-throughput selection system for fast-acting covalent protein drugs. Fan Q, Mei J et al. Science. 2026 May 28;392(6801):eadv3081.

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News

June 25, 2026

Chimera production release 1.20 is now available, fixing problems on Mac OS Tahoe (1.20 release notes).

December 25, 2025

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The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

September 22, 2025

Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.

Previous news...

Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

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1le4 sequence

Annotations from UniProt

The PDB/UniProt Info tool retrieves sequence and structure annotations for Protein Data Bank (PDB) entries using a Web service provided by the RCSB PDB. Sequences are displayed in Multalign Viewer, and feature annotations from UniProt are mapped onto the sequences as regions or colored boxes. In the region browser (figure at right):

  • making a region Active selects any corresponding structure residues for further operations; only one region can be active at a time
  • making a region Shown displays it in the sequence window
  • the square color wells show (and allow changing) the region interior and border colors
UniProt annotations can also be fetched along with a sequence or mapped to a sequence already in Multalign Viewer regardless of whether the sequence is associated with a structure.

(More features...)

Gallery Sample

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Orexin Receptor Complex

The image shows the structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant, Protein Data Bank entry 4s0v. The drug is shown as spheres colored by element, and the receptor as ribbons with secondary structure elements rainbow-colored from blue at the N-terminus to red at the C-terminus. (More samples...)


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