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Cryo-electron microscopy structures of human cone visual pigments. Peng Q, Li J et al. Science. 2026 Jun 25;392(6805):eadz8141.
Steric hindrance of antibody binding in an Omicron spike fusion intermediate. Bao Z, Liu Z et al. Nature. 2026 Jun 18;654(8119):762–770.
Structural basis of fungal β-1,3-glucan synthase inhibition by caspofungin. Ren Z, Chhetri A et al. Nature. 2026 Jun 10;654(8118):547–555.
Myosin forces remodel F-actin for mechanosensitive protein recognition. Carl AG, Reynolds MJ et al. Nature. 2026 Jun 4;654(8117):240–249.
A high-throughput selection system for fast-acting covalent protein drugs. Fan Q, Mei J et al. Science. 2026 May 28;392(6801):eadv3081.
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June 25, 2026
Chimera production release 1.20 is now available, fixing problems on Mac OS Tahoe (1.20 release notes).
December 25, 2025
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September 22, 2025
Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.
We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).
Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.
Feature Highlight
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The PDB/UniProt Info tool retrieves sequence and structure annotations for Protein Data Bank (PDB) entries using a Web service provided by the RCSB PDB. Sequences are displayed in Multalign Viewer, and feature annotations from UniProt are mapped onto the sequences as regions or colored boxes. In the region browser (figure at right):
Gallery Sample
The image shows the structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant, Protein Data Bank entry 4s0v. The drug is shown as spheres colored by element, and the receptor as ribbons with secondary structure elements rainbow-colored from blue at the N-terminus to red at the C-terminus. (More samples...)
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