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The RAD52 double-ring remodels replication forks restricting fork reversal. Honda M, Razzaghi M et al. Nature. 2025 May 8;641(8062):512–519.
Snapshots of acyl carrier protein shuttling in human fatty acid synthase. Schultz K, Costa-Pinheiro P et al. Nature. 2025 May 8;641(8062):520–528.
Structural dynamics of human fatty acid synthase in the condensing cycle. Choi W, Li C et al. Nature. 2025 May 8;641(8062):529–536.
Structural dynamics of DNA unwinding by a replicative helicase. Shahid T, Danazumi AU et al. Nature. 2025 May 1;641(8061):240–249.
Cryo-EM reveals mechanisms of natural RNA multivalency. Wang L, Xie J et al. Science. 2025 May 1;388(6746):545-550.
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May 7, 2025
The ChimeraX 1.10 release candidate is available – please try it and report any issues. See the change log for what's new.
March 19, 2025
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March 1, 2025
Upcoming Events
UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325.
Feature Highlight
Coulombic electrostatic potential (ESP) can be calculated
and displayed with surface coloring using the command
coulombic
or the
Molecule Display
icon
For how to add a color key and associated label, see the
Protein-Ligand Binding Sites tutorial.
Example Image
The GDP- and GTP-bound conformations of the transducin α-subunit
(1tag and
1tnd, respectively) differ primarily in three regions,
termed switch 1, switch 2, and switch 3. The structures have been superimposed with
matchmaker
and shown as cartoons,
with “empty” outlines where the structures are almost the same
(for simplicity, only one conformation's outlines are shown).
The GTP analog GTPγS is displayed as spheres color-coded by heteroatom.
For 2D labels
and image setup other than structure orientation,
see the command file switch.cxc.
Coulombic Electrostatic Potential
.
No separate calculation or input ESP file is required.
The image shows the first assembly defined for PDB
3eeb, the protease domain of a toxin from
Vibrio cholerae,
with the default Coulombic coloring: red-white-blue over the value range
–10 to 10. For image setup other than orientation, see the
command file coulombic.cxc.
G-Protein Switch Regions
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