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Computationally restoring the potency of a clinical antibody against Omicron. Desautels TA, Arrildt KT et al. Nature. 2024 May 23;629(8013):878–885.

Mechanism of single-stranded DNA annealing by RAD52-RPA complex. Liang CC, Greenhough LA et al. Nature. 2024 May 16;629(8012):697–703.

Structural and functional characterization of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA polymerase II. Keown J, Baazaoui A et al. J Virol. 2024 May 14;98(5):e0013824.

Structures and activation mechanism of the Gabija anti-phage system. Li J, Cheng R et al. Nature. 2024 May 9;629(8011):467–473.

Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus. Ketaren NE, Mast FD et al. eLife. 2024 May 7;12:RP89423.

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News

January 22, 2024

ChimeraX 1.7.1 is available, with fixes for a few miscellaneous bugs that were identified after the 1.7 release.

December 19, 2023

The ChimeraX 1.7 production release is available! See the change log for what's new. Future Mac releases will require macOS 11 or higher.

November 6, 2023

The ChimeraX 1.7 release candidate is available – please try it and report any issues. See the change log for what's new.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325, Chan Zuckerberg Initiative grant EOSS4-0000000439, and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

DNA/protein complex with struts

Struts for 3D Printing

Structures can be reinforced for 3D printing with pseudobonds. In this DNA-transcription factor complex (PDB 5ego), proteins are shown as ribbons and the DNA as a molecular surface. The pseudobonds in blue were read in from a manually created file, 5ego.pb, and further reinforcements in light gray were added automatically with the struts command. For image setup other than orientation, see the command file struts.cxc.

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Example Image

CaM-CaMKI peptide

Calmodulin and Target Peptide

Calmodulin (CaM) acts as a calcium sensor. When its four Ca++ sites are fully occupied, it binds and modulates the activity of various downstream proteins, including CaM-dependent protein kinase I (CaMKI). Here, a complex between CaM and its target peptide from CaMKI (PDB 1mxe) is shown with cartoons, a transparent molecular surface, silhouette outlines, and light soft ambient occlusion. (If you prefer a less smudgy/rustic appearance, try using light gentle instead.) For image setup other than positioning, see the command file cam.cxc.

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