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The RAD52 double-ring remodels replication forks restricting fork reversal. Honda M, Razzaghi M et al. Nature. 2025 May 8;641(8062):512–519.

Snapshots of acyl carrier protein shuttling in human fatty acid synthase. Schultz K, Costa-Pinheiro P et al. Nature. 2025 May 8;641(8062):520–528.

Structural dynamics of human fatty acid synthase in the condensing cycle. Choi W, Li C et al. Nature. 2025 May 8;641(8062):529–536.

Structural dynamics of DNA unwinding by a replicative helicase. Shahid T, Danazumi AU et al. Nature. 2025 May 1;641(8061):240–249.

Cryo-EM reveals mechanisms of natural RNA multivalency. Wang L, Xie J et al. Science. 2025 May 1;388(6746):545-550.

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News

May 7, 2025

The ChimeraX 1.10 release candidate is available – please try it and report any issues. See the change log for what's new.

March 19, 2025

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UCSF ChimeraX: Tools for structure building and analysis is one of the 10 most cited papers published in Protein Science in 2023!

March 1, 2025

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

3eeb assembly 1 Coulombic ESP coloring

Coulombic Electrostatic Potential

Coulombic electrostatic potential (ESP) can be calculated and displayed with surface coloring using the command coulombic or the Molecule Display icon . No separate calculation or input ESP file is required. The image shows the first assembly defined for PDB 3eeb, the protease domain of a toxin from Vibrio cholerae, with the default Coulombic coloring: red-white-blue over the value range –10 to 10. For image setup other than orientation, see the command file coulombic.cxc.

For how to add a color key and associated label, see the Protein-Ligand Binding Sites tutorial.

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Example Image

transducin switch regions

G-Protein Switch Regions

The GDP- and GTP-bound conformations of the transducin α-subunit (1tag and 1tnd, respectively) differ primarily in three regions, termed switch 1, switch 2, and switch 3. The structures have been superimposed with matchmaker and shown as cartoons, with “empty” outlines where the structures are almost the same (for simplicity, only one conformation's outlines are shown). The GTP analog GTPγS is displayed as spheres color-coded by heteroatom. For 2D labels and image setup other than structure orientation, see the command file switch.cxc.

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