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Recent Citations

Structural insights into the activation mechanism of the human metabolite receptor HCAR1. Gao M, Zang S et al. Sci Signal. 2026 Jan 6;19(919):eadw1483.

Crystal structure of Methanococcus jannaschii dihydroorotase with substrate bound. Vitali J, Nix JC et al. Acta Crystallogr F Struct Biol Commun. 2026 Jan 1;82(Pt 1):23-31.

Correlation between solvation free energy and solute-solvent interaction energy in energy representation theory. Maruyama Y, Matubayasi N. J Phys Chem B. 2025 Dec 25;129(51):13230-13241.

Structural snapshots capture nucleotide release at the μ-opioid receptor. Khan S, Tyson AS et al. Nature. 2025 Dec 18;648(8094):755–763.

Bottom-up design of Ca2+ channels from defined selectivity filter geometry. Liu Y, Weidle C et al. Nature. 2025 Dec 11;648(8093):468–476.

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December 25, 2025

The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

September 22, 2025

Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.

March 6, 2025

Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (details...).

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Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.
computer generated image

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

Fly-through Animation

The fly command can animate a flight through molecular structures. Click the example image to fly along the RNA being copied by rotavirus RNA polymerase (PDB 2r7r), an enzyme that replicates the 11 segments of viral RNA. See a video showing how this animation was made.

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Gallery Sample

Peroxiredoxin Wreath

Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.

See also the RBVI holiday card gallery.

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