Structure of a signaling cannabinoid receptor 1-G protein complex. Krishna Kumar K, Shalev-Benami M et al. Cell. 2019 Jan 24;176(3):448-458.e12.
Structural adaptations of photosynthetic complex I enable ferredoxin-dependent electron transfer. Schuller JM, Birrell JA et al. Science. 2019 Jan 18;363(6424):257-260.
Calicivirus VP2 forms a portal-like assembly following receptor engagement. Conley MJ, McElwee M et al. Nature. 2019 Jan 17;565(7739):377-381.
Ribosome-NatA architecture reveals that rRNA expansion segments coordinate N-terminal acetylation. Knorr AG, Schmidt C et al. Nat Struct Mol Biol. 2019 Jan;26(1):35-39.
CRISPR RNA-guided autonomous delivery of Cas9. Wilkinson RA, Martin C et al. Nat Struct Mol Biol. 2019 Jan;26(1):14-24.See also: RCSB PDB Images
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New Virtual Reality at UCSF website shares information on VR projects, resources, and related issues.Previous news...
UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see licensing.
ChimeraX development is supported in part by grants from the National Institutes of Health (currently R01-GM129325, previously P41-GM103311).
Morphing between atomic structures can be calculated wih the morph command and played back in an animation. This movie shows morphing between two conformations of the FGFR1 kinase domain:
Morphing and other setup was done with the command file kmorph-prep.cxc, followed by interactively positioning the structure and saving the view, then running kmorph-play.cxc to add 2D labels and record the movie.More features...
KCNQ1 is the pore-forming subunit of a cardiac potassium channel. It binds to calmodulin, and mutations in either of these proteins can cause congenital long QT syndrome, a dangerous propensity for irregular heartbeats. In the image, a structure of the KCNQ1/calmodulin complex (PDB 5vms) has been assembled into the native tetrameric form with the sym command. The view is from the cytoplasmic side, with KCNQ1 shown as surfaces, calmodulin as cartoons, and calcium ions as balls. A pastel palette from ColorBrewer has been used to color the surfaces, darkened with color modify for the cartoons, and “rotated” 45° in hue for the ions. See the command file colormod.cxc.
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