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Featured Citations

Conformational transitions of a neurotensin receptor 1-Gi1 complex. Kato HE, Zhang Y et al. Nature. 2019 Aug 1;572(7767):80-85.

A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2. Garaeva AA, Guskov A et al. Nat Commun. 2019 Jul 31;10(1):3427.

Structural insights into flagellar stator-rotor interactions. Chang Y, Moon KH et al. eLife. 2019 Jul 17;8. pii: e48979.

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit. Tsai CJ, Marino J et al. eLife. 2019 Jun 28;8. pii: e46041.

Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis. Su T, Izawa T et al. Nature. 2019 Jun 27;570(7762):538-542.

See also: RCSB PDB Images
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News

June 20, 2019

ChimeraX virtual reality shown on PBS Newshour: How Close are Scientists to a Universal Flu Vaccine?

June 6, 2019

The ChimeraX 0.9 production release is available. See the change log for what's new.

May 30, 2019

From the Rochester Institute of Technology: Student develops tool to visualize molecular dynamics of proteins in virtual reality with ChimeraX.

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Upcoming Events

September 24, 2019

At 12 pm EDT, Tristan Croll will give a live webinar on using ISOLDE, a ChimeraX plugin for interactively building high-quality atomic models into density maps of low-to-medium resolution. Later, the presentation will be posted on SBGridTV.


UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325 and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

multichannel 3D image of hiPSCs from AICS

Multichannel Light Microscopy

3D images and time series from multichannel optical microscopy are shown in the Volume Viewer tool, with easy access to hiding/showing individual channels, changing their colors, and adjusting threshold levels with the mouse. The menu of style options includes “volume” (translucent blobs, as in the image), surface, mesh, maximum intensity projection, single plane, and orthoplanes. For convenience, the step size, region bounds, and display style of different channels of the same dataset are coupled, in that changing the setting of one channel automatically changes it for the others.

The image shows human induced pluripotent stem cells, with plasma membrane in violet red, EGFP-tagged fibrillarin (as a marker for nucleolus) in yellow, and DNA (nucleus) in turquoise. The data are publicly available from the Allen Cell Explorer website, dataset: AICS-14_0.

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Example Image

photosynthetic reaction center

Photosynthetic Reaction Center

The photosynthetic reaction center from a purple sulfur bacterium is shown as a cartoon with “tube” helices and membrane boundaries from the OPM database (Orientations of Proteins in Membranes, entry 1eys). Blue and red balls represent the cytoplasmic and periplasmic sides of the bacterial inner membrane, respectively. The title and other text labels were added with the 2dlabels command and repositioned interactively with the move label mouse mode . ChimeraX session file: prc.cxs

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